International Journal of Ayurveda and Pharma Research
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Evaluation of In Vitro and In Vivo Antioxidant Potential of the Ethyl Acetate Fraction of Cyperus Pangorei Rhizome
Get PDFBackground and Aim: Antioxidants derived from natural sources, particularly those rich in flavonoids and phenolic compounds, have attracted considerable interest for their potential health benefits in combating oxidative stress-related diseases. This study aimed to evaluate the antioxidant potential of the ethyl acetate (EtAc) fraction obtained from Cyperus pangorei rhizome, focusing on both in vitro and in vivo assessments. Methods: The EtAc fraction was subjected to RP-HPLC analysis to identify and quantify phenolic compounds and flavonoids. Acute toxicity testing was performed to assess the safety profile of the EtAc fraction. In vitro antioxidant activity was determined using DPPH and ABTS+ radical scavenging assays. In vivo evaluation of antioxidant activity was conducted in Triton X-100-induced oxidative stress model in mice, measuring malondialdehyde (MDA) content, glutathione (GSH) levels, and superoxide dismutase (SOD) activity in liver tissues. Results: RP-HPLC analysis confirmed the presence of quercetin, luteolin, and apigenin in the EtAc fraction. The fraction exhibited significant dose-dependent antioxidant activity in both DPPH and ABTS+ assays, with IC50 values indicating potent scavenging effects. In the Triton X-100-induced stress model, administration of the EtAc fraction led to a reduction in MDA levels, restoration of GSH levels, and enhancement of SOD activity in mouse liver tissues. Conclusion: The findings suggest that the EtAc fraction from C. pangorei possesses promising antioxidant properties, as evidenced by its ability to mitigate oxidative stress-related damage both in vitro and in vivo
Exploring the Anti-Inflammatory Potential of Cyperus pangorei Rhizome Extracts An In Vitro and In Vivo Study
Get PDFBackground and aim: Inflammation is a pivotal process implicated in various physiological and pathological conditions, necessitating the exploration of alternative anti-inflammatory agents with minimal side effects. This study aimed to investigate the anti-inflammatory potential of the standardized ethyl acetate (EtAc) fraction derived from Cyperus pangorei rhizomes. Methods: The rhizomes of C. pangorei were collected, processed, and subjected to extraction and fractionation to obtain the EtAc fraction. RP-HPLC analysis was employed to standardized the EtAc fraction against standard quercetin, luteolin, and apigenin. In vitro studies utilized peritoneal macrophages isolated from male Swiss albino rats to assess NO production and cytokine levels (IL-1β, IL-6, TNF-α) upon treatment with the EtAc fraction. In vivo evaluation was conducted using a carrageenan-induced rat paw edema model. Results: RP-HPLC analysis revealed the presence of quercetin, luteolin, and apigenin in the EtAc fraction. In vitro studies demonstrated dose-dependent inhibition of LPS-induced NO production and suppression of inflammatory cytokines (IL-1β, IL-6, TNF-α) by the EtAc fraction. Furthermore, in the carrageenan-induced rat paw edema model, the EtAc fraction exhibited dose-dependent inhibition of paw edema. Conclusion: The findings of this study highlight the significant anti-inflammatory potential of C. pangorei rhizome extracts, particularly the EtAc fraction. The identified compounds, quercetin, luteolin, and apigenin, contribute to its anti-inflammatory activity by modulating key inflammatory mediators. These results support the potential therapeutic use of C. pangorei in managing inflammation-related disorders. Further research is warranted to elucidate the underlying mechanisms and evaluate the long-term efficacy and safety of C. pangorei extracts as anti-inflammatory agents
Ayurvedic Approach for Management of Secondary Infertility due to Artavakshaya (PCOD)
Get PDFThe World Health Organization defines infertility as a disorder of the male or female reproductive system characterized by the inability to conceive after 12 months or more of consistent unprotected sexual activity. Secondary infertile if they have successfully became pregnant at least once in the past. 30-40% of infertility is caused by ovulatory disruption. PCOS is characterized by oligo/anovulation, excess androgen-related symptoms, and numerous ovarian cysts. Infertility correlates with Vandhyatha in Ayurveda. Acharya Harita described that failure to achieve a Praja known as Vandhayatwa. Praja is achieve by Garbha and to achieve Garbha purity of many component (Ritu, Kshetra, Ambu, Beeja) is necessary. Regarding this case, Ritu is disturbed in form of Artavkshaya, managed through principles like use of Agneya dravya, Agni Deepana, Vata Shamana and Piita Vardhna. Case presentation: A female patient, 25 years old, visited Prasuti Tantra and Stri- Roga OPD of National Institute of Ayurveda, Jaipur, on 28 august 2023 with secondary infertility associated with delayed and scanty menses for 3 years. Methodology: Detailed history with all clinical, physical examination and laboratory investigations were carried out which were normal. Ultrasonography reveals bilateral PCOD. So the treatment was planned accordingly. Patient was treated with Shatapushpa churna in 2 consecutive cycles. Result: Patient got her menstruation after one month of drug intake with improvement in menstrual pattern. She continued to take drug during the second month and missed her period consequently after that.UPT was done and was found positiv
Management of Traumatic Perforation of Tympanic Membrane Through Ayurveda
Get PDFTraumatic tympanic perforations can occur due to various reasons, such as concussion, insertion of objects, temporal bone fractures, barotrauma, etc. Slap injuries are a common cause. Symptoms include sudden conductive deafness, pain and/or blood-stained discharge. Tinnitus and vertigo may complicate the condition. Appropriate and timely management is crucial to reduce the risk of permanent impairment, as studies indicate that spontaneous healing occurs within 1.5 to 3 months. While Ayurvedic texts don’t directly mention traumatic tympanic perforations, they can be categorized as ‘Agantuja Vrana’ (wounds caused by external factors). Ayurvedic treatment includes both local and systemic approaches. In this case study, medicines were used internally for 2 months: Sarivadi Vati, Lakshadi Guggul, Mahayograj Guggul, Gandha Taila capsules and a combination of Vatashamaka Churnas. This combination led to significant improvement; the perforation completely healed in 2 months. Thus, internal use of these drugs helped in the healing of traumatic perforations
Hepatoprotective Activity of Patra Swarasa of Guduchi (Tinospora Cordifolia) Against- Paracetamol Induced
Get PDFGuduchi (Tinospora cordifolia (Willd.) Miers], Menispermaceae family, it is important medicinal plant is widely distributed through India. It is categorized as "Rasayana" and the whole plant is used medicinally. The aim of the present study is to evaluate the protective effect of Guduchi patra swaras against paracetamol induced liver damage in Wister albino rats. Material & Methods: Wistar Albino rats (140-250g) will be divided into 6 group and each group 6 rats, into control group, paracetamol control, standard group, test group. The test drug Guduchi patra swarasa was administered orally for 10 consecutive days and two dose of the toxicant (paracetamol) were administered orally to each group, on two alternate days i.e., 7th and 9th day, 1hr after test drug administration. After 48 hours of toxicant paracetamol, and standard group. The blood was collected in EDTA tube and sent for biochemistry laboratory for biochemical investigations. Result: The analysis of serum biochemical parameters shows that administration of paracetamol leads to significant change in majority of the parameters. The overall activity profile indicated reversal of important parameters like SGOT, SGPT, total bilirubin, total protein, blood sugar level, serum globulin, serum albumin, serum total cholesterol and serum triglycerides. All three test groups of Guduchi patra Swarasa administered are found to be effective heapto-protective especially based on histo-pathological study. Among the three groups, the double dose group and therapeutic group has shown good results in comparison with the other two groups. Conclusion: In the present study, the overall activity profile of Guduchi patra Swarasa administered are found to be effective hepatoprotective among the three groups therapeutic double dose shows good results in comparison with the other group
Critical Analysis on the Role of Nidra in the Maintenance of Health - An Ayurvedic Review
Get PDFSleep which is often considered to be a “passive activity” is increasingly being recognized as an essential aspect in both heath promotion as well as prevention of chronic diseases. Insufficient sleep, either directly or indirectly, is associated with a number of chronic diseases such as diabetes mellitus, cardiovascular diseases, obesity as well as depression. Insufficient sleep is associated with the onset of these diseases and also posses’ important implications for their management and its outcome. Ayurveda considers Nidra as one among the Trayo upasthambha’s along with Ahara and Brahmacharya. These 3 factors maintained in optimum quantity and quality is essential for living a healthier disease free life. Lack of sleep is considered as Nidranasha in Ayurveda which is attributed to the development of multiple chronic life style disorders in longer run. The role of improper Nidra in the development of different chronic diseases should be understood properly to prevent the damage from them and to promote healthy living among the human beings around the world
A Comprehensive Review of Dietetic Regimen (Pathya- Apathya) in Skin Disorders
Get PDFFor decades, it was thought that there was no relation between the dermatological conditions or the skin disorders and the diet. But recent studies have made an attempt to explore the relationship between the diet and its role in skin disorders. Ayurvedic system of Medicine also known as the Indian traditional medicine has contributed vastly for the diet and the management of skin disorders. In Ayurveda skin disorders are explained under the name Kustha which are twenty in number and two types as Mahakustha and Kshudra kustha. Since 5000yrs, Ayurveda is serving the society with the objective of curing of the disease and prevention of the same. Ahara has been given the prime importance in Ayurveda and is placed one among the Trayopasthambas or the three pillars of life such as Aaahara (diet), Nidra (sleep) and Brahmacharya (celibacy) In depth of diet for the healthy and also the specific diet for the disorders has been described in Ayurveda and is being practiced by Ayurvedic practitioners since centuries which is witnessed in the latest research studies. The present study has made an attempt to assess both the Modern and Ayurvedic concepts of diet that is presently practiced and their importance in the management of skin disorders
Effect of Tennetti-Tilla (Dried Figs and Sesame Seeds Laddu) Supplementation in Type 2 Diabetes
Get PDFDiabetes mellitus is a metabolic disorder affecting every age group worldwide. Sedentary lifestyle, obesity and lack of physical activity are the main causes of type 2 diabetes. Hyperglycemia is not controlled; it may result in macrovascular and microvascular complications which are the major causes of morbidity and mortality in diabetic patients. Doing exercise regularly and consumption of low-calorie diet can help diabetic patients in keeping blood glucose levels under control. Present case study was a 67-year-old woman who was diagnosed with type 2 diabetes. Her anthropometric measurements were recorded as height was 152 cm, weight was 70.75 kg and BMI was 30.4 kg/m2. Her biochemical parameters are HDL is 38, triglycerides are 163, and cholesterol is 184, VLDL is 33, FBS is 115mg/dl, PLBS is 250mg/dl and HbA1c is 9.5mg/dl. She was supplemented with 10gm of Tennetti-tilla (dried fig and sesame seed laddu) daily for 90 days. After the period of intervention of 90 days, the changes observed as reduction in weight to 68kg, FBS 87mg/dl, PLBS 106, cholesterol is 188, triglycerides are 71, HDL is 45, and HbA1c is 6.3 and VLDL is 14.2mg/dl. The study reveals that supplementation of 10g of Tennetti-tilla (dried fig and sesame seed laddu) for 90 days can reduce hyperglycemia in type 2 diabetic patients
Management of Ovarian Endometrioma: A Detailed Case Analysis
Get PDFWomen play an integral role in the society, there health and well-being are vital in such journey, certain health conditions like endometriomas often affect the quality of life of many women. These endometriomas are cystic lesions that stem from endometriosis. And are most commonly found in the ovaries. Ovarian endometrioma is the most common form of endometriosis, with its prevalence ranging between 17% and 44%. The clinical challenges include persistent pain, dysmenorrhea, and infertility, all of which adversely affect women\u27s quality of life and their ability to reproduce. In Ayurveda, this condition is comparable to Udavartini Yonivyapad, a known gynecological disorder. It has a significant prevalence among women, reflecting its widespread impact on female reproductive health. Methods: Case study of a 30-year-old married woman came with severe pain during menstruation along with prolonged bleeding during cycles in the last 4 years and the patient was initially diagnosed with an ovarian endometrioma through sonography before she approached us. Based on the Lakshanas and Nidana Panchaka it was diagnosed as Udavartini Yonivyapad. This case was effectively managed using Shodhana therapy combined with internal medications. Results: Following Shodhana her condition exhibited signs of improvement, and there was noticeable reduction in the size of endometrioma. Conclusion: This case is an example to explain the Ayurveda’s role in managing such disease conditions by demonstrating the improvement in the pain and size of the endometrioma which was confirmed by a sonography before and after the treatmen
Pratimarsh Nasya: The Philosophical Nexus Connecting Pran Vayu and Consciousness in Ayurvedic Healing
Get PDFIn the rich tapestry of Ayurvedic medicine, Pratimarsh Nasya emerges as a profound practice that harmonizes the breath (Pran Vayu) with the mind\u27s consciousness. This ancient therapy not only revitalizes the senses but also bridges the gap between physical and spiritual well-being.
Ayurveda, the science of life, intertwines the physical and metaphysical through various practices. Among these, Pratimarsh Nasya stands out for its unique ability to connect the vital life force, Pran Vayu, with the deeper realms of consciousness, offering a holistic approach to healing. This gentle yet potent ritual not only revitalizes the senses but also holds the promise of enhancing the quality of sleep, aligning the body\u27s rhythms with a harmonious balance. By channeling the subtle energies of Pran Vayu and fostering a serene state of consciousness, Pratimarsh Nasya offers a holistic approach to healing that extends its benefits to improving sleep quality and overall well-being. It offers a pathway to enhance mental clarity and spiritual balance by aligning the breath with the mind\u27s essence.
Pratimarsh Nasya, a revered practice in Ayurveda, serves as a bridge between the vital force of Pran Vayu and the profound depths of consciousness. By exploring its philosophical and therapeutic dimensions, we gain insights into its transformative impact on holistic health. In the pursuit of optimal health and wellness, Pratimarsh Nasya stands out as a beacon of Ayurvedic wisdom. This practice harmonizes the dynamic energies of Pran Vayu with the contemplative aspects of consciousness, paving the way for improved sleep and profound healing. Delving into its effects reveals how this ancient tradition can be a key player in modern holistic health strategies