International Journal of Ayurveda and Pharma Research
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Pharmacognostical study of Damanak - Artemisia nilagirica (C.B CLARKE) Pamp.)
No full textDamanak- Artemisia nilagirica is a tall, aromatic, pubescent or villous shrub-like herb found throughout India\u27s hilly regions. The plant has been mentioned in various Nighantu about its use as Hrudya, Vrushya, Grahani, Visha, Kustha, Kleda, Kandu and in Tridosha (disease of all the three Doshas). There are many ethnobotanical uses which indicates this herb should be studied more extensively to confirm these results and reveal other potential therapeutic effects. Davana oil has a deep, mellow, persistent rich fruity odour. Oil of Davana is used in expensive perfume compositions. It is understood that the oil is also being used for flavouring cakes and pastries. This also marks the use of Damanak as commercial plant. The present article intends to study the plant for its pharmacognosy and to know its therapeutic uses mentioned in various Nighantu
Comparative Acute Toxicity Profile of Rasapushpa Prepared by Classical and Conventional Methods
Get PDFRasapushpa, an Ayurvedic mercurial preparation, is a very potent formulation due to its therapeutic properties but carries potential risks due to the presence of mercury. The acute toxicity of Rasapushpa, prepared by two distinct methods- the classical Valukayantra method (RPVY) and the conventional Electric Muffle Furnace method (RPEMF)- was assessed in Wistar rats. Using the OECD Test Guideline 423, the study determined the lethal dose (LD50) and observed any clinical signs of toxicity following oral administration. Objectives: To evaluate the Acute toxicity study of Rasapushpa prepared by both methods. Materials and Methods: This comparative Acute toxicity study was conducted at the Ribosome Research Centre, Kudsad, Surat, using two samples of Rasapushpa: RPVY (classical method) and RPEMF (conventional method). By adopting OECD Test Guideline 423. Discussion: Rasapushpa prepared by Valukayantra (RPVY) exhibited LD50 at 300mg/kg body weight, while Rasapushpa prepared by Electric Muffle Furnace (RPEMF) showed LD50 higher than 2000 mg/kg. Conclusion: After human dose conversion, both samples were found safe in the dose range given by Rasatarangini for Rasapushpa (62.5 to 312.5 mg)
Maricha (Piper Nigrum Linn.): An Integrative Review of Ayurvedic Perspectives and Modern Pharmacological Insights
Get PDFBackground: Piper nigrum Linn. (Maricha), commonly known as black pepper, is a prominent spice in Ayurvedic pharmacopeia known for its Deepana (appetizing), Pachana (digestive), and Krimighna (anthelmintic) properties. Scientific research increasingly supports its traditional use in treating metabolic, respiratory, and gastrointestinal disorders. Objective: This study presents a comprehensive review of the Ayurvedic significance, classical references, phytochemical composition, and pharmacological activities of Maricha, aiming to bridge traditional wisdom with modern scientific validation. Methods: Extensive literature was reviewed from classical Ayurvedic texts, including Charaka Samhita, Sushruta Samhita, Bhavaprakasha Nighantu, and modern pharmacological research indexed in PubMed, Scopus, and Google Scholar. The phytoconstituents and pharmacological activities were analyzed and summarized based on experimental and clinical findings. Results: Piper nigrum contains alkaloids (notably piperine), essential oils (sabinene, limonene), flavonoids (quercetin, catechin), and minerals. It exhibits antioxidant, anti-inflammatory, anticancer, antimicrobial, lipid-lowering, immunomodulatory, and insecticidal properties. These findings support its use in managing lifestyle disorders and microbial infections. Its classical indications correlate well with its modern pharmacological activities. Conclusion: The integration of classical Ayurvedic understanding with recent pharmacological evidence highlights the therapeutic versatility of Maricha. It holds potential for development into multi-target phytopharmaceutical agents, especially in metabolic and inflammatory diseases
Standardization and Analytical Profiling of Shirashooladi Vajra Rasa: A Comparative Study with Marketed Samples
Get PDFShirahshooladi vajra rasa is a potent mercurial preparation widely used in the treatment of Shirahshoola (headache). It consists of processed mercury and sulphur, incinerated copper and iron along with other herbal ingredients like Triphala, Yastimadhu, Pippali, Shunthi, Vidanga, Dashamula and Guggulu. This formulation is enriched with Vatashamaka (mitigates Vata dosha) herbs like Dashamula, Guggulu etc. Aim and objective: This study aims at developing standard manufacturing procedure (SMP) and analytical parameters of Shirahshooladi vajra rasa along with analysis of its available marketed samples. Methodology: The formulation was prepared in three batches to standardize its pharmaceutical processing. Also, six other available different samples of the Shirashooladi vajra rasa were collected from market and all the seven samples were assessed for quality control parameters to compare their quality. Observations & Result: All the quality control parameters conducted for inhouse and marketed samples were not similar, some variations were found. Conclusion: The average yield obtained from three batches is 99.1%. Analytically, slight variation was observed among all the samples
Effect of Vamana Karma in Hypothyroidism
Get PDFBackground: Hypothyroidism is one of the metabolic and lifestyle diseases that is having a high prevalence worldwide. The clinical presentation of hypothyroidism includes tiredness, more sensitivity to cold, constipation, dry skin, weight gain, a puffy face, a hoarse voice, coarse hair and skin, muscle weakness, muscle aches, tenderness and stiffness, menstrual cycles that are heavier than usual or irregular, thinning hair, a slowed heart rate (bradycardia), depression, and memory problems. In the Ayurvedic perspective, these symptoms can be correlated to Jatharagni and Dhatwagni abnormalities, as well as Kapha dosha anomalies. Hence, in this clinical experiment, Vamana karma will be used to see how it affects hypothyroidism. Because in Ayurveda, the greatest remedy for vitiated Kapha dosha is Vamana karma. Aim and Objective: To evaluate the effect of Vamana karma in hypothyroidism. Methodology: A single subject was administrated with Deepana Pachana, followed by Snehapana, Swedana, Vamana, and Samsargana krama. Result: There are relevant changes in the thyroid profile
Establishing Ashtanga Hridaya as the Pratisamskrita Version of Brihatrayi: A Panchavayava Vakya Analysis
Get PDFThe relentless pursuit of knowledge and continuous learning is essential to keep any field of science relevant and applicable to the needs of society. The same is applicable to Ayurveda. In Ayurveda, Caraka Samhita recognized the importance of Pratisamskarana as a tool for updating earlier literature. Pratisamskarana includes the elaboration of portions those are brief and unclear, summarisation of those which are elaborate, thus making a new version of the original. This strong tradition of Pratisamskarana was already prevalent during the Samhita-kala. Ashtanga Hridaya, the third major treatise on Ayurveda, acknowledges that it has collected and presented the essence of knowledge from earlier textbooks. In order to establish “Ashtanga Hridaya is the Pratisamskrita version of Brihatrayi”, the technique of Panchavaya vakya was employed to establish a statement. Panchavaya vakya as described in the Nyaya system and included in the 44 Vadamarga by Acarya Caraka contains five components -Pratijna, Hetu, Udhaharana, Upanaya, Nigamana. A literary study has been done to understand Pratisamskarana, and to compare the detailed and concise portion of Caraka Samhita and Susruta Samhita with the later text in Samhita kala, Ashtanga Hridaya. This attempt aims to establish that the Ashtanga Hridaya is an updated version of Brihatrayi, based on the analysis through Panchavaya vakya
Ayurvedic Management of Recurrent Pregnancy Loss
Get PDFRecurrent pregnancy loss is relatively common event occurring in 15-25% of pregnancies and increasing in prevalence with maternal age which in turn leads to infertility. The prognosis for couples with recurrent pregnancy loss is generally good, although the likelihood of a successful pregnancy depends on maternal age and the number of previous losses. Recurrent pregnancy loss can be caused by chromosomal errors, anatomical uterine defects, autoimmune disorders and endometrial dysfunction. This is a case report of a 25 year old female with complaints of inability to conceive a viable fetus even after 1 and ½ years of unprotected sexual intercourse. She has regular menstrual cycles and has been conceived twice but was met with spontaneous abortion in both instances. As per Ayurveda, it could be considered Garbhasravi vandhya since both abortions occurred in the first trimester. Treatment plan included internal medications as well as Sodhana procedures for future healthy uneventful pregnancy. The integrative approach of Ayurveda offers promising solutions for addressing RPL by focusing on correcting systemic imbalances, improving reproductive health, and enhancing overall immunity. The case study discussed highlights the therapeutic potential of Ayurvedic interventions
Effect of Bhavana on Qualitative Phytochemical Profile and Elemental Composition of Shilajathu: A Comparative Pharmaceutical Study With Ekanayaka Kwatha Bhavitha Shilajathu
Get PDFShilajathu, a revered Ayurvedic Rasayana, is subjected to Bhavana, a traditional processing technique. This study investigates the effect of Bhavana on Shilajathu\u27s phytochemical profile and elemental composition using Ekanayak Kwatha Bhavitha Shilajathu. Ekanayaka (Salacia chinensis) is a prominently featured drug in various Kashayas recommended for Prameha Chikitsa in esteemed Kerala texts, such as Sahasrayoga and Chikitsamanjari. Ekanayaka Kwatha Bhavitha Shilajathu was prepared through a seven-fold Bhavana process. Phytochemical screening revealed a diverse profile of bioactive compounds. HPTLC analysis confirmed the presence of Mangiferin, a standard biomarker for Ekanayaka in Ekanayak Kwatha Bhavitha Shilajathu, and also revealed enhanced bioactive compounds in Bhavitha Shilajathu compared to Shilajathu before Bhavana. Energy Dispersive X-ray Analysis showed increased weight % of certain elements, C, Na, Mg, Cl, and K in Bhavitha Shilajathu. The findings demonstrate enhanced absorption of Ekanayaka Kwatha\u27s active principles into Shilajathu during Bhavana. The formulation\u27s safety was confirmed by detecting heavy metal levels within permissible limits. The study provides insights into the Ayurvedic concept of Bhavana and its effects on Shilajathu\u27s phytochemical and elemental composition
Effect of a Selected Ayurveda Treatment Protocol on Multiple Sclerosis
Get PDFMultiple Sclerosis (MS) is a progressive neurodegenerative disease characterized by demyelination and plaque formation and having manifestations in multiple systems of the body. Signs and symptoms depend on the site of lesion. Prevalence of MS is estimated to be 2.8 million cases worldwide, the mean age being 20 to 40 mostly affecting females. Genetic factors also contribute greatly. Considering the etiological factors, pathogenesis and symptoms it can be correlated to different types of Avarana. A cluster of symptoms seen in different types of Avarana can be observed here. Along with Avarana the treatment principles of Jwara, Vatavyadhi, Vatashonita, Manasika vyadhis can also be adopted in this condition at different stages. The present work is a case report of a 22 year old male diagnosed with MS and treated effectively. This work is done in an effort to understand MS in terms of the basic principles of Ayurveda and to discuss the effectiveness of Ayurvedic treatment protocol in MS
Exploring the Relationship Between Sharirika Prakriti and Medha: An Ayurvedic Perspective on Intelligence
Get PDFEkavimshatika Guggulu is mentioned in Bhavaprakasha Madhyamakhanda Kushta Adhyaya and Bala Taila mentioned in Bhela Samhita Vata Vyadhi Adhyaya. Most of the drugs in Ayurveda, a holistic medical science, emphasizes the importance of Prakriti, a unique concept that determines an individual\u27s physical, mental, and socio-behavioral health. Prakriti is determined at the time of fertilization by the dominance of Dosha in Shukra (sperm) and Shonita (ovum) and remains unchanged throughout life. Medha, or intellect, is another crucial concept in Ayurveda that encompasses both grasping power (Grahanshakti) and understanding (Dharanshakti). This study aimed to explore the relationship between Sharirika Prakriti and Medha by analysing classical Ayurvedic literature, dictionaries, and research publications, as well as comparing the concept of Medha with the modern psychological concept of intelligence quotient (IQ). The analysis reveals that Vata Prakriti individuals have good short-term memory but poor long-term memory, while Pitta Prakriti individuals are intelligent and dominate conversations. Kapha Prakriti individuals exhibit self-control, strong faith in Sastras, and exceptional memory, although they take longer to grasp the subjects. The seat of the Medha is inferred to be the Hridaya (heart), as it is the location of Sadhaka Pitta, which is responsible for the manifestation of Medha. This study highlights the potential of integrating traditional Ayurvedic wisdom with contemporary psychological assessments to develop a more comprehensive understanding of human intelligence and cognitive functioning