International Journal of Ayurveda and Pharma Research
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Scientific Validation of Amalaki Rasayana through Pharmacognostic and Phytochemical Analysis
Get PDFClassical Ayurveda textbooks explain numerous medicinal formulations that have been effectively utilized in wide range of therapeutic conditions. Rasayana is the branch of Ayurveda, focuses on rejuvenation, tissue regeneration, modulating immune system, and promoting healthy aging process. Amalaki rasayana (AR) is a Vayasthapana rasayana explained in Charaka samhitha. AR is extensively reported to influence various biological activities to promote longevity and prevent geriatric symptoms. Considering these factors, AR is planned to administer in age related cataract in its early stage. To improve the acceptance of medicinal preparations globally, it is necessary to revalidate them with the help of advanced scientific techniques, without losing the vital elements of science. Methods: The preparation was properly evaluated regarding safety, and quality. In the present study, pharmacognostical analysis of AR was done to ensure the quality standards of the raw drug and the finished product. Organoleptic character analysis, physiochemical analysis, heavy metal analysis, microbial analysis and HPTLC analysis were done. Result: Established standards were met in physicochemical, heavy metal and microbial analyses. These validate the formulation’s compliance with quality and safety requirements. HPTLC helped in detecting the marker compound gallic acid in the formulation. Conclusion: From the observations, the results of this study could serve as a baseline for future research works
Effect of Panchakarma Therapy in the Management of Spinocerebellar Ataxia
Get PDFSpino cerebellar ataxia is a progressive cerebellar ataxia inherited by autosomal dominant transmission, it occurs as a result of derangement of cerebellum and its afferent and efferent pathways. Signs and symptoms of ataxia includes gait impairment, scanning speech, blurred vision due to nystagmus, incoordination of hand and tremor with movement. The present case involves a patient diagnosed as spino cerebellar ataxia which was successfully managed with ayurvedic treatment. A 36 year old female patient having complaints of imbalance, slurred speech, poor coordination with tremors diagnosed as Vatavyadhi due to Avarana. The treatment was based on the principles of Kaphahara and Marutha anulomana. Treatment adopted was Swedana, Udwartana, Virechana, Utsadana, Balaguduchyadhi vasti, Navadhanya kizhi, Nasya and Shirovasti. Assessment of the patient was done using SARA scale before and after the treatment
Ayurvedic Management of Herpes Zoster
Get PDFHerpes zoster, commonly known as shingles, is a viral disease caused by the reactivation of the varicella zoster virus. In India, from January 2015 to May 2021, there were 1,269 chickenpox outbreaks, resulting in 27,257 cases. Diagnosis of herpes zoster is based on severe pain, unilateral distribution, and the presence of grouped vesicles on erythematous, edematous skin, which rapidly evolve into pustules and then crust. Complications such as postherpetic neuralgia (10.2-54.7%) and secondary bacterial infections (3.5-21.0%), pose significant challenges in treatment. Contemporary medicine approaches cases with antiviral medications, antihistamines, NSAIDs, topical soothing powders, and symptomatic relief through analgesics. The herpes zoster is understood as vitiation of Tridosha, Twak, Rakta, Mamsa, Lasika and Sweda as per Ayurveda. Due to similar Dosha-dooshya vitiation Loota visha chikitsa and Visarpa chikitsa are being adopted. Dooshivisha chikitsa and Dosha-based management are also being incorporated by some Vaidyas based on individual condition. This case study is focusing on a 53-year-old female patient from Kerala, presented in the outpatient department of Agadatantra, illustrates the practical application of Dosha-based Ayurvedic management. She presented with reddish skin lesions over the right upper back region, extending to the axilla associated with severe pain and burning sensation. This Ayurvedic treatment approach demonstrated significant effect, promotes healing without complications and offers a cost-effective alternative to conventional management. This case study suggests the potential of Ayurvedic management protocol in not only reducing symptoms but also fundamentally addressing the underlying imbalances that contribute to herpes zoster
Effect of Mudgadi Kashaya Peya and Selected Yoga Techniques in Prediabetes
Get PDFPrediabetes, an intermediate state of hyperglycemia is the precursor stage of type 2 diabetes mellitus. Prediabetes and diabetes has been emerged as a major challenging health problem worldwide due to their high mortality and morbidity rates. Sedentary lifestyle, unhealthy diet, physical inactivity, mental stress associated with urbanisation contributes the increasing prevalence of Prediabetes and diabetes. Since type 2 diabetes and their complications results in poor quality of life and significant economic burden to family and society due to the increased medical expenditure and loss of productivity, an effective intervention is required. Life style interventions comprising a healthy diet, and physical activity in the prediabetic stage will be a best measure to halt the further progression in to type 2 diabetes. In this study an Ayurvedic diet, Mudgadi Kashaya peya and selected yoga techniques were given for a period of 90 days to evaluate their effect in Prediabetes. Statistical analysis of the data obtained revealed that Mudgadi Kashaya peya and selected yoga techniques has significant effect in reduction of FBS, PPBS, HbA1c and Total Cholesterol values
The Therapeutic Potential of Lashuna (Allium sativum) in Gynecological Disorders: An Integrative Review
Get PDFLashuna (Allium sativum), commonly known as garlic, holds a significant place in Ayurvedic medicine for its diverse therapeutic properties. This review aims to integrate classical Ayurvedic references with contemporary scientific research to evaluate the efficacy of Lashuna in managing gynecological disorders, including premenstrual syndrome (PMS), polycystic ovary syndrome (PCOS), vaginal infections, and menopausal symptoms. Ayurvedic texts such as the Charaka Samhita and Sushruta Samhita describe Lashuna as a potent Rasayana with Vata-Kapha pacifying, digestive stimulant, and antimicrobial properties, making it beneficial for reproductive health. Modern studies corroborate these claims, demonstrating garlic\u27s antimicrobial, anti-inflammatory, and hormonal regulatory effects. Clinical trials have reported significant reductions in PMS symptoms and improvements in insulin resistance among PCOS patients following garlic supplementation. Additionally, garlic exhibits antimicrobial activity against pathogens responsible for vaginal infections and may offer cardiovascular and antioxidant benefits pertinent to menopausal women. While these findings are promising, further rigorous clinical trials are necessary to establish standardized guidelines for Lashuna\u27s therapeutic application in gynecological health
Pharmaceutical Standardization and Preliminary Analysis of Vishatindukadi Vati Prepared by two References
Get PDFStandardization of herbo-mineral drugs is essential to certify their quality, purity and reproducibility. Vishatindukadi Vati is a herbo-mineral formulation mentioned in Rasatantrasaara and Siddhaprayoga Sangraha (RTSSPS) with two references and different ingredients. The formulation mentioned in Gutika Prakarana contains Kupilu (Strychnos nux- vomica Linn), Maricha (Piper nigrum Linn.), Puga Phala (Araca catechu Linn.) and Chincha Beeja (Tamarindus indica Linn). while the formulation mentioned in Vatavyadhi Prakarana contains Kupilu (Strychnos nux-vomica Linn.) and Maricha (Piper nigrum Linn.) with Bhavana of Nagavalli (Piper betel Linn.) Patra Svarasa. It is mentioned in context of various diseases i.e., Jirna Vatavyadhi (chronic disorders due to Vata), Jirna Jvara (chronic fever), Ajirna (indigestion), Mandagni (subdued digestive power) and many more. In pharmaceutical process; 3 batches of Kupilu Shodhana and using both references three batches of Vishatindukadi Vati were prepared and its organoleptic and physico-chemical analysis were performed. Organoleptic and physicochemical analysis of raw materials, in-process and finished products were done. In physico-chemical pH, loss on drying at 105°C, total ash (%w/w), acid insoluble ash (%w/w), water-soluble extractive (%w/w), alcohol soluble extractive (%w/w), uniformity of weight (mg), friability (%), hardness (kg/cm2) and disintegration time (min.) were carried out for VTV1 and VTV2. An average value of VTV1 and VTV2 were 5.3, 6.48%, 1.55%, 0.24%, 22.5%, 6.96%, 124.3mg, 0.16%, 4.6kg/cm2, 37.6min and 5.05, 7.24%, 2.39%, 0.26%, 23.7%, 6.69%, 124mg, 0.14%, 3.63kg/cm2 and 32 min. respectively. It needs further preclinical and clinical studies to prove its safety profile and therapeutic efficacy
A Comparative Clinical Study of Trikatu Churna and Pippali Churna in Artavakshaya w.s.r. to PCOS
Get PDFArtavakshaya, a condition described in Ayurveda, is characterised by scanty and irregular menstruation, which closely correlates with the Polycystic Ovary Syndrome (PCOS). PCOS is a common endocrine disorder affecting reproductive-aged women, leading to menstrual irregularities, anovulation, and metabolic disturbances. Trikatu Churna, a combination of Pippali (Piper longum Linn.), Maricha (Piper nigrum Linn.), and Shunti (Zingiber officinale Roscoe.), is known for its Deepana, Pachana and Kaphavatahara properties, which may help in correcting metabolic imbalances associated with PCOS. Pippali Churna is recognized for its Rasayana and Lekhana actions, which may aid in improving ovarian function and hormonal balance. This study aims to compare the clinical efficacy of Trikatu Churna and Pippali Churna in managing Artavakshaya for PCOS. The effects of both formulations were evaluated based on clinical parameters such as duration of bleeding, irregular menstruation, amount of bleeding and quantity of menstrual blood, pain during the menstruation, hirsutism and BMI. This comparative clinical study was conducted on a total of 40 patients diagnosed with PCOS presenting with Artavakshaya symptoms and were randomly divided into two groups. Group A received Trikatu Churna, and Group B received Pippali Churna for 90 days. The primary outcome measures included improvements in duration of bleeding, irregular menstruation, amount of bleeding and quantity of menstrual blood, and pain during the menstrual period. The secondary outcomes included improvements in hirsutism and BMI. Both treatments showed significant improvements in the management of PCOS symptoms. However, Trikatu Churna was found to be slightly more effective in regulating menstrual cycles. This study suggests that Trikatu Churna and Pippali Churna can be beneficial in the management of Artavakshaya associated with PCOS, with Trikatu Churna showing marginally superior efficacy
Ayurvedic Management of Motor Neuron Disease
Get PDFMotor neuron disease (MND) is a neurodegenerative disorder characterized by the degeneration of both upper and lower motor neurons. Amyotrophic lateral sclerosis (ALS) is the most common form of MND. ALS is a severe neurodegenerative disorder with upper and lower motor neuron deficits in the limbs, affecting about 2 per 100,000 person/years. Brachial amyotrophic diplegia (BAD), a rare ALS variant, primarily presents with asymmetric lower motor neuron weakness, mostly affecting the upper extremities. A 75-year-old male patient diagnosed as motor neuron disease was admitted to Sri Sri College of Ayurvedic Science and Research in Bengaluru, Karnataka, on April 22, 2023 for 12 days, presenting with complaints of weakness and heaviness of both upper limbs associated with muscle wasting predominantly on right shoulder and wrist for 1 year. The clinical and laboratory features suggested a diagnosis of brachial amyotrophy diplegia, a regional variant of ALS. According to Ayurveda, Avarana vatavyadhis are found to have close resemblance to Motor Neuron Diseases and his symptoms can be correlated to Kaphavruta Vyanavata. The patient received Avaranagna and Vata vyadhi chikitsa. Assessment was done before and after treatment by using the ALSFRS-R. A satisfactory improvement was observed in the clinical findings as well as marked reduction was noted in the assessment scale. This case study suggests that brachial amyotrophic diplegia can be effectively managed symptomatically with Ayurvedic therapy
Rasayana - A Solution to Menopausal Syndrome
Get PDFIntroduction: The growth of a country depends on the population, including both youth and old age, in which 48% of female will suffer from menopausal complications at one point of life. Acharyas have mention very few references on Rajonivritti. They have mentioned fifty years as the age of Rajonivritti. The concept behind the age of Rajonivritti is that Raja is byproduct of Rasadhatu which function better in Tarunavastha and its function reduces with age. Rajonivritti is a physiological process but when it causes discomfort either to mind or body it attains Vyadhisvarupa which may require medical interference. Sedentary lifestyle and unhealthy habits are one of the main causes for metabolic imbalance which leads to Rajonivruthi Lakshanas which manifest as Vyadhi. Method: This article has been made by reviewing various Samhitas, Nighantus, Sangrahas, Granthas to attain proper knowledge about the effect of Rasayana in improving the quality of life after menopause and in reducing Rajonivrithi Lakshana. Discussion: Acharya Sushruta contributed aging and diseases as the cause for the menopause. According to Jararog Chikitsasutra - Rasayana is the only way to combat symptoms associated with Jara. Result: By definition Rasayana, ‘Labhopayo hi shastanam Rasadinam Rasayanam’. As menopause is often associated with aging, it is signified by Dhatu Kshaya and Vata vitiation. Rasayana acts on the nutritional dynamics and rejuvenate the body on both physical and mental level. By proper administration of Rasayana therapy as preventive tool one can help in reducing the complication in menopause and can improve the quality of life. Hence the importance of Rasayana is highlighted here
Quantification and Bioaccessibility of β-Sitosterol in Lasuna (Allium sativum Linn) Before and After Processed with Taila and its Bioavailability Using CACO-2 Cell Lines
Get PDFLasuna (Allium sativum Linn) is a potent herb, which is widely used in food and in various Ayurvedic formulations. Acharya recommends the use of Lasuna in raw and in processed form. Acaryas have advised to process Lasuna along with Taila in various contexts. As per the studies, the active phytoconstituents of Lasuna tends to decrease as a result of thermal processing. Previous studies reveal the abundance of a phytosterol named β-sitosterol in Lasuna. Based on the recent studies, β-sitosterol possess thermal stability and hydrophobicity and are less bioavailable. β-sitosterol was found to a lipophilic phytonutrient. Since lipophilic phytonutrients are absorbed only after emulsification and micellization, it is necessary to add the raw drug into a suitable vehicle for facilitating the solubility of the lipophilic phytonutrient for improving the solubility and bioavailability. This research aims to determine if the processing of Lasuna with Taila possess the ability to enhance the quantity, bioaccessibility and Bioavailability of β-sitosterol