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Charte de mutualisation et ouverture des données du projet Flex-Mediation
No full textThe charter applies to all researchers contributing to or supporting the research activities of the Flex-Mediation project, and participants undertake to respect the principles set out in the charter. The charter sets out a framework to facilitate collaborative research, the sharing of resources between team members (documents, raw data, etc.) and opening up research data.La charte concerne l’ensemble des chercheur.es contribuant à l’activité de recherche ou y apportant un appui dans le cadre du projet Flex-Mediation. Les participant.es s’engagent à respecter les principes énoncés dans la charte. Cette dernière fixe un cadre pour faciliter la recherche en collectif, la mutualisation des ressources (documents, données brutes, etc.) et l'ouverture des données
Monoallelic de novo variants in DDX17 cause a neurodevelopmental disorder
No full textInternational audienceDDX17 is an RNA helicase shown to be involved in critical processes during the early phases of neuronal differentiation. Globally, we compiled a case series of 11 patients with neurodevelopmental phenotypes harbouring de novo monoallelic variants in DDX17. All 11 patients in our case series had a neurodevelopmental phenotype, whereby intellectual disability, delayed speech and language, and motor delay predominated. We performed in utero cortical electroporation in the brain of developing mice, assessing axon complexity and outgrowth of electroporated neurons, comparing wild-type and Ddx17 knockdown. We then undertook ex vivo cortical electroporation on neuronal progenitors to quantitatively assess axonal development at a single cell resolution. Mosaic ddx17 crispants and heterozygous knockouts in Xenopus tropicalis were generated for assessment of morphology, behavioural assays and neuronal outgrowth measurements. We further undertook transcriptomic analysis of neuroblastoma SH-SY5Y cells, to identify differentially expressed genes in DDX17-KD cells compared to controls. Knockdown of Ddx17 in electroporated mouse neurons in vivo showed delayed neuronal migration as well as decreased cortical axon complexity. Mouse primary cortical neurons revealed reduced axon outgrowth upon knockdown of Ddx17 in vitro. The axon outgrowth phenotype was replicated in crispant ddx17 tadpoles and in heterozygotes. Heterozygous tadpoles had clear neurodevelopmental defects and showed an impaired neurobehavioral phenotype. Transcriptomic analysis identified a statistically significant number of differentially expressed genes involved in neurodevelopmental processes in DDX17-KD cells compared to control cells. We have identified potential neurodevelopment disease-causing variants in a gene not previously associated with genetic disease, DDX17. We provide evidence for the role of the gene in neurodevelopment in both mammalian and non-mammalian species and in controlling the expression of key neurodevelopment genes
Molecular Diversity of Arbuscular Mycorrhizal Fungi Associated with the Rhizosphere of Vachellia seyal Del. from Selected Saline Soils in Senegal
No full textInternational audienceDrought and salinity are major environmental constraints that severely limit crop production, particularly in arid and semi-arid zones. We investigated the genetic diversity of arbuscular mycorrhizal fungi isolated from the rhizosphere of Vachellia seyal in three different soils from Senegal with varying levels of salinity. Soil and root samples were collected from under V. seyal and in the vicinity of the trees. After DNA extraction, nested PCR, and sequencing of the large subunit region of the rRNA gene, different phylotypes from rhizospheric soils, roots, and spores were compared by phylogeny in order to investigate the role of salinity in arbuscular fungal diversity. This study revealed several unidentified arbuscular fungi and a particularly high host specificity in V. seyal roots. The vast majority of operational taxonomic units (OTUs) isolated in this study had no homologous sequences in the databases
Comment la vigne parvient-elle à se défendre contre ses ennemis ?
No full textoral, conférence, webinaires à destination des professionnels et/ou du grand publicNational audienc
La commanderie antonine de Boutiers (Charente) - Nouveaux apports architecturaux (début XVIe s.)
No full textNonlinear dynamics in breathing-soliton lasers
No full textInternational audienceOur recent work demonstrates that lasers operating in the breathing-soliton regime [1] offer a powerful platform for investigating complex synchronisation and chaotic dynamics in nonlinear systems, all within a single oscillator—eliminating the need for external sources or coupled systems. In these lasers, harmonics of the breathing frequency can lock to the cavity repetition rate through competition between the system’s two intrinsic frequencies. In this talk I will review the key findings of this research, which include higher-order Farey hierarchies and self-similar fractal dynamics (devil’s staircases) [2], nonstandard synchronisation domains (unusual Arnold tongues) [3], a novel modulated subharmonic regime bridging synchrony and desynchrony [4], and a new route to chaos via modulated subharmonics [5]. References1.J. Peng, S. Boscolo, Z. Zhao, and H. Zeng, “Breathing dissipative solitons in mode-locked fiber lasers,” Sci. Adv., vol. 5, eaax1110, 2019.2.X. Wu, Y. Zhang, J. Peng, S. Boscolo, C. Finot, and H. Zeng, “Farey tree and devil’s staircase of frequency-locked breathers in ultrafast lasers,” Nat. Commun., vol. 13, 5784, 2022.3.X. Wu, J. Peng, B. Yuan, S. Boscolo, C. Finot, and H. Zeng, “Unveiling the complexity of Arnold’s tongues in a breathing-soliton laser,” Sci. Adv., vol. 11, eads3660, 2025. 4.X. Wu, J. Peng, S. Boscolo, C. Finot, and H. Zeng, “Synchronization, desynchronization, and intermediate regime of breathing solitons and soliton molecules in a laser cavity,” Phys. Rev. Lett., vol. 131, 263802, 2023. 5.H. Kang et al., “Observation of optical chaotic solitons and modulated subharmonic route to chaos in mode-locked laser,” Phys. Rev. Lett., vol. 133, 263801, 2024
Corrosion behavior of Mg72Zn27Pt1 alloy in Hanks’ solution: comparison between amorphous and crystalline structures
No full textInternational audienc
Computational design of a large dataset of viscoelastic metastructures for inverse design in low-frequency vibration attenuation
No full textInternational audienceIn the context of acoustic stealth, the attenuation of low-frequency vibrations generated by submarine rotating machinery remains a major challenge. Existing passive and active solutions still have limitations to effectively mitigate vibrations across varying operating conditions. The research work introduces a computational design approach that integrates generative design and finite element analysis to build a comprehensive dataset of viscoelastic meta-structures, characterized by their transmissibility. This dataset will serve as a foundation for future machine learning-enabled inverse design, paving the way for optimized vibration attenuation strategies
Quand un poème peut devenir une inspiration pour la recherche sur l’enseignement supérieur…: Note de lecture : Laure Catherin, Howl2122. Éditions Koïnè, 2022, 59 pages, 12 euros
No full textInternational audienceThis note encourages educational researchers to step outside their usual reading habits by presenting Howl2122, a poem by Laure Catherin. A powerful testimony about the experiences of French university students during the COVID-19 pandemic, this poem provides fresh perspectives and multiple sources of inspiration to revitalise research in higher education..Cette note invite les chercheurs en éducation à sortir de leurs habitudes de lecture en proposant une présentation du poème de Laure Catherin, Howl2122. Témoignage sur la jeunesse des universités françaises pendant la pandémie de Covid-19, ce poème offre de multiples inspirations pour renouveler la recherche sur l’enseignement supérieu
L'esthétique transgressive du populisme
No full textInternational audienceThis article consolidates the emerging discursive-performative paradigm in populist studies by presenting the idea of populism as an aesthetic transgression, bridging the gap between discursive and sociocultural-performative strands. The article is broadly inspired by Jacques Rancière's notion of aesthetics as the 'partage du sensible' and critically employs it to understand how populism transgresses the rules establishing what can appear in politics. The article claims that populism is aesthetically transgressive in two ways: (1) by making visible subalternised subjects through the discursive articulation of the 'people' and (2) by naming the 'elite' in a way that makes visible underlying modes of domination. The article argues that this framework allows for a more fruitful understanding of the relationship between populism and topics such as crisis and institutionalism. Moreover, the article employs this framework to differentiate between emancipatory and reactionary forms of populism, connecting emancipatory populism to queer aesthetic practices and explaining how it reinvigorates liberal democracy. Conversely, reactionary populism mobilises what Hannah Arendt called the 'mob' and ends up reinforcing modes of domination.Cet article consolide le paradigme discursif-performatif émergent dans les études sur le populisme en présentant l'idée du populisme comme une transgression esthétique, comblant ainsi le fossé entre les approches discursives et socioculturelles / performatives. L'article s'inspire largement de la notion d'esthétique de Jacques Rancière en tant que « partage du sensible » et l'utilise de manière critique pour comprendre comment le populisme transgresse les règles établissant ce qui peut apparaître en politique. L'article affirme que le populisme est esthétiquement transgressif de deux manières : (1) en rendant visibles les sujets subalternisés à travers l'articulation discursive du « peuple » et (2) en nommant l'« élite » d'une manière qui rend visibles les modes de domination sous-jacents. L'article soutient que ce cadre permet une compréhension plus fructueuse de la relation entre le populisme et des sujets tels que la crise et l'institutionnalisme. En outre, l'article utilise ce cadre pour différencier les formes émancipatrices et réactionnaires du populisme, en reliant le populisme émancipateur aux pratiques esthétiques queer et en expliquant comment il revigore la démocratie libérale. À l'inverse, le populisme réactionnaire mobilise ce que Hannah Arendt appelait la « populace » et finit par renforcer les modes de domination