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PROTECTIVE EFFECTS OF INTERMITTENT FASTING AND PROBIOTICS USAGE ON OXIDATIVE STRESS AND MOLECULAR ALTERATIONS IN AGING LUNG
Get PDFObjective: Aging is associated with increased oxidative stress and diminished cellular repair mechanisms, particularly in the lungs. This study investigates the protective effects of intermittent fasting (IF), SCD probiotics, and their combination on oxidative stress and molecular alterations in the lungs of aging rats. Materials and Methods: Sprague-Dawley rats (24 months old) were divided into four groups: control, intermittent fasting, probiotics, and a combination of both treatments. Malondialdehyde (MDA), advanced oxidation protein products (AOPP), and myeloperoxidase (MPO) activity were measured as markers of oxidative stress. Attenuated Total Reflectance-Fourier Transform Infrared (ATR-FTIR) spectroscopy was employed to detect molecular changes in lung tissues. Results: Our findings demonstrated that both IF and probiotics, individually and in combination, reduced the MDA and AOPP levels, as well as MPO activity, compared to the control group, indicating a reduction in oxidative stress. Spectral analyses revealed molecular changes in lipid composition, protein conformation and oxidation, as well as phosphodiester groups of nucleic acids. The highest classification accuracy (93.18%) was obtained in the 1300-800 cm-1 region by LDA analysis. Conclusion: Intermittent fasting and probiotics may ameliorate age-related oxidative damage in the lungs and offer promising therapeutic potential for maintaining lung health in aging populations
Efficacy of Exogenous Abscisic Acid on Cholinesterase Enzyme Activity and Phenolic Compound Variability in Hypericum perforatum calli
Get PDFThe aim of this study was to investigate the effect of abscisic acid (ABA) on cholinesterase enzyme activities and bioactive components of in vitro calli of Hypericum perforatum. Calli were obtained from Linsmaier Skoog (LS)/B5 medium containing 0.5 mg L-1 thidiazuron (TDZ) and 0.5 mg L-1 indole butyric acid (IBA). Different abscisic acid (0.01 mg L-1, 0.05 mg L-1,and 0.1 mg L-1) applications were performed on the calli obtained in tissue culture and extracted in 80% methanol. Hispidulin, fumaric acid, acacetin, epicatechin, and naringenin compounds were analyzed in Liquid chromatography-high-resolution mass spectrometry (LC-HRMS). While epicatechin (1.09 mg L-1) was found at the highest 0.05 mg L-1 ABA in callus samples, fumaric acid (2.30 mg L-1) and hispidulin (0.78 mg L-1) compounds were detected in the highest containing of 0.1 mg L-1 ABA. Acacetin (0.10 mg L-1) was produced in only 0.01 mg L-1 ABA, whereas naringenin (0.01 mg L-1) was produced in medium containing 0.05 mg L-1 ABA. The strongest Acetylcholinesterase (AChE) (0.207 +/- 0.012) and Butyrylcholinesterase (BChE) (0.243 +/- 0.019) inhibition activity was shown the best with 0.1 mg L-1 ABA application. This study has shown that ABA can be used as an elicitor in callus culture of H. perforatum, and the amounts of related metabolites can be changed via elicitors.Mus Alparslan University Scientific Research Coordination Unit, Mus, Turkey [18-FEF-4901-02]This research was financially supported by grants from the Mus Alparslan University Scientific Research Coordination Unit, 18-FEF-4901-02, Mus, Turkey. The author thanks Dr. Zueleyha Almaz for her help Anticholinesterase activity study
Abdullâh b. Ebû Evfâ's life and narrations
Get PDFHz. Peygamber'e olan inancın gereği olarak İslâm dininin anlaşılması ve yaşanılması için sahâbe neslinin de araştırılması gerekmektedir. Abdullâh b. Ebû Evfâ'nın hayatı, rivayetleri ve râvilerinin incelendiği bu çalışma giriş, üç bölüm ve sonuçtan ibarettir. Çalışmanın giriş kısmında araştırmanın konusu, önemi, amacı, metodu ve kaynakları hakkında bilgi verilmiş; ayrıca sahâbe kavramı, İbn Ebû Evfâ'nın hayatı, kişilik özellikleri, ailesi, katıldığı savaşlar gibi önemli olaylar anlatılmıştır. Temel hadis kitaplarında ona isnad edilen rivayetlerin sayılarına ve kendisinden hadis alan talebelerine değinilmiştir. Hz. Peygamber'den rivayet edilen hadisler sened ve metin olmak üzere iki kısımdan oluşmaktadır. Hadislerin sıhhat durumlarının belirlenmesi için ilk incelenen kısım seneddir. Senedin içerisinde bulunan râvileri bilmek, onları tanımak rivayetin anlaşılmasını ve rivayet hakkında bir sonuca ulaşmayı kolaylaştıracaktır. Birinci bölümde İbn Ebû Evfâ'nın Hz. Peygamber'den ibadetlerle ilgili rivayet ettiği hadisler, ikinci bölümde cihad ile ilgili rivayet ettiği hadisler, üçüncü bölümde diğer konularla ilgili rivayet ettiği hadisler Kütüb-i Tis'a içerisinden tespit edilmiştir. Rivayetlerin sened ve metin kısmı Arapça olarak verilmiş ve tercümesi yapılmıştır. Rivayetlerde yer alan râvilerin isimleri, künyeleri, hocaları, talebeleri, cerh ve ta'dîl âlimlerinin kendileri hakkındaki görüşlerine yer verilmiş ve râvilerin güvenirliklerine değinilmiştir. Her bir rivayetin sened zinciri ayrı ayrı çıkarılmış ve rivayetin sened yönünden değerlendirilmesi yapılmıştır. Daha sonra o konu dâhilinde olan rivayetlerin isnad şeması çıkarılmış ve metin kısmının lafız ve mâna yönünden genel değerlendirmesi yapılmıştır. Çalışma sonuç kısmı ile tamamlanmıştır.As a requirement of belief in the Prophet Muhammed, the generation of the companions must also be investigated in order to understand and live the religion of Islam. This study, which examines Abdullâh b. Ebû Evfâ's life, narrations and narrators, consists of an introduction, two parts and a conclusion. In the introduction, the subject, importance, purpose, method, sources of the study, Ibn Ebû Evfâ's life, his personality traits, his family, important events such as the wars he participated in, the number of hadiths narrated from him in the basic hadith books and scholars who took hadiths from him have been mentioned. The hadiths narrated from the Prophet Muhammad consist of the chain and the text parts. The first part examined to determine the authenticity of the hadiths is the chain part. Knowing the narrators in the chain, getting to know them will make it easier to understand the narration and reach a conclusion about the narration. In the first section, the hadiths narrated by Ibn Ebû Evfâ from the Prophet about worships; in the second section, the hadiths narrated about jihad; and in the third section, the hadiths narrated about other subjects have been identified from Kutub-i Tis'a. The chain and text parts of the narrations have been given in Arabîc and translated. The names of the narrators in the narrations, their identities, their teachers, their students, opinions of the reputation and correction scholars about them have been given and the reliability of the narrators has been mentioned. The chain of each narration has been extracted separately and the narration has been evaluated in terms of the chain. Then, the general chain chart of the narrations within that subject has been prepared and a general evaluation of the text part of the narrations has been made in terms of wording and meaning. The study has been completed with the conclusion part
Effects of gastrocnemius functional massage on lower extemity spasticity, spatio- temporal gait variables and fall risk in patients with stroke: A randomized controlled trial
No full textAim This randomized controlled clinical trial investigated the effects of gastrocnemius functional massage (GFM) combined with neurodevelopmental treatment (NDT) on spasticity, gait parameters, and functional mobility in stroke patients. Methods A total of 28 chronic stroke survivors were randomized into an experimental group (EG, n = 13) and a control group (CG, n = 15). Both groups received NDT twice a week for six weeks, while the EG received additional GFM. Spasticity (Modified Ashworth Scale), gait parameters (LegSys), and functional mobility (Timed Up and Go test) were assessed pre- and post-treatment. Results The results showed significant improvements in spasticity within the EG for the hip adductor (p = 0.002), knee extensor (p = 0.006), and ankle plantar flexor muscles (p = 0.002), compared to minimal changes in the CG (p > 0.05). Gait analysis revealed significant improvements in the EG for stride number (p = 0.0001), stride length (p = 0.006), stride time (p = 0.001), and stride velocity (p = 0.002), whereas the CG showed no significant changes (p > 0.05). Functional mobility improvements in the EG included reduced sit-to-stand time (p = 0.021) and total Timed Up and Go time (p = 0.001), indicating enhanced dynamic balance and lower extremity strength. Conclusion These findings suggest that combining GFM with NDT significantly enhances spasticity reduction, gait parameters, and functional mobility in stroke patients. Future studies are needed to explore the long-term effects and underlying mechanisms of this combined approach. © 2025 Elsevier B.V., All rights reserved
In the shadow of stigmatization: The psychological effects of having a child with special needs on parents in Türkiye: A qualitative research
No full textAim: This study aimed to conduct an in-depth examination of the psychological effects experienced by parents of children with special needs, as well as their encounters with stigmatization in T & uuml;rkiye. Background: Raising children with special needs presents considerable psychological and social challenges for parents. Notably, experiences of stigmatization can adversely affect parents' mental health, leading to exclusion and social isolation. There is a paucity of scientific research on the stigmatizing experiences of parents of children with special needs in T & uuml;rkiye. This study sought to elucidate the effects of stigmatization on mental health by conducting an in-depth examination of parental experiences. Methods: This study employed interpretative phenomenological analysis, a qualitative research method. The study was conducted with 26 parents residing in eastern T & uuml;rkiye from January 6 to February 28, 2025. The interviews were conducted online, using a semi-structured interview form. Thematic content analysis was performed and the data obtained were evaluated using the MAXQDA 22 program. Results: Data collected from the interviews were systematically analyzed across six thematic categories: meeting the obstacle, impact on the parenting roles, reactions to the obstacle, experiences of stigmatization, coping strategies, and proposed solutions. Conclusions: This study elucidates significant findings regarding the stigmatization experiences encountered by parents of children with special needs as well as their coping strategies. The results indicated that parents frequently experienced feelings of burnout, loneliness, inadequacy, and exclusion as a consequence of stigmatization. However, they endeavored to overcome these challenges through social support and individual coping mechanisms. The findings advocate for the reduction of stigmatization and enhancement of parents' access to psychosocial support systems. Implications for nursing and health policy: Mental health nurses and other healthcare professionals must comprehend the stigmatization experiences encountered by parents of children with special needs, and demonstrate sensitivity to their psychosocial support requirements. Educational programs and awareness campaigns aimed at reducing stigma should be integrated into the health care system. Furthermore, the establishment of psychological counseling and support groups for families of children with special needs is essential to prevent parental isolation. Health policies should be structured to promote comprehensive and accessible services for children with special needs and for their families. (c) 2025 Published by Elsevier Inc
Geotechnical characteristics of clayey soil stabilized with fly ash and marble dust
No full textThis study investigates the separate and combined impacts of Class-F fly ash (FA) and marble dust (MD) on the geotechnical properties and resilient modulus (MR) of clayey soil. An intensive series of laboratory tests, including plasticity, swelling-shrinkage, compaction, unconfined compressive strength (UCS), shear strength, California Bearing Ratio (CBR), cyclic triaxial, and microstructural analyses, were conducted on soil specimens containing FA and MD at different percentages varying from 0 % to 12 %. The results showed that FA and MD additions significantly reduced the plasticity, free swell, and linear shrinkage potential of the soil, whilst UCS and CBR values increased up to a threshold value of 6 % to 9 % and then declined. The incorporation of FA, MD, and their combination (FA + MD) enhanced the soil's CBR by approximately 45.1 %, 55.9 %, and 85.1 %, respectively. Similarly, the UCS of the soil cured for 7 days improved by 14.1 %, 44.0 %, and 72.5 %, respectively. The cyclic triaxial tests yielded the highest MR values with FA alone, leading to a 51.1 % increase. When FA and MD were used together, MR values increased by 31.6 %, which was relatively higher than the 28.1 % increase observed with the use of MD alone. Furthermore, statistical modeling to predict the MR values was proposed, evaluated comparatively with already available applications, and hereby confirmed its superiority over traditional models to save time for future researchers
Temperature-dependent electrical characteristics analysis of the Al/p-type Si structures with GO and PTCDA interlayer: structural properties
No full textIn this study, the electrical characteristics of Al/p-type Si semiconductor structures with PTCDA and GO interlayer were analyzed using current-voltage (I-V) measurements a wide temperature range (from 80 to 420 K with 20 K intervals and +/- 2.0 V). The ideality factor (n) and barrier height (Phi bo) values changed between 6.398 and 1.330 and 0.221 eV and 0.999 eV (for thermionic emission, TE, method), 0.243 eV and 1.084 eV (for Norde method) in temperature range of 80 K and 420 K, respectively. The experimental findings revealed that values of ideality factors (n), rectification ratio (RR) and series resistance (RS) decreases with increasing temperature, while barrier heights (Phi bo) and saturation currents (I0) values increases with increasing temperature. The Phi bo-n and Phi bo-q/(2kT) curves were obtained to explain the high n values and non-ideal situations of the Richardson curves. Two linear regions were found at low temperatures (from 80 to 180 K) and high temperatures (from 200 to 420 K). Thus, for low and high temperatures, Gaussian distributions (GDs) values of the I - V plot of the Al/(PTCDA:GO)/p-type Si semiconductor structure yielded average barrier heights of 0.7017 and 1.3342 eV with standard deviations (sigma 0) of 83.06 mV and 168.80 mV, respectively. Also, this values of barrier height have also been confirmed by updated ln(I0/T2) - (q2 sigma s2)/(2k2T2) vs. q/(kT) curves, which correspond to two distinct temperature regions. Richardson constant (A*) value with 1.153 x 10-6A/(K2cm2) is lower than the known value of p-type Si. But nevertheless, for distribution 1, Richardson's constant of 80.64 A/(K2cm2) is approximately three times larger than the known theoretical value of 32 Acm-2 K-2 for p-type silicon.Scientific and Technological Research Council of Turkiye (TUBITAK)Open access funding provided by the Scientific and Technological Research Council of Turkiye (TUBITAK). The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper
The Effects of Omega-3 Supplementation Combined with Strength Training on Neuro-Biomarkers, Inflammatory and Antioxidant Responses, and the Lipid Profile in Physically Healthy Adults
No full textObjectives: This study aimed to comprehensively investigate the physiological effects of omega-3 fatty acid supplementation combined with resistance training on the lipid profile, inflammatory and antioxidant responses, neuro-biomarkers, and physical performance parameters in physically healthy young adults. Methods: Thirty physically active male participants were randomly assigned to an experimental group (omega-3 + resistance training) or a control group (resistance training only). Over eight weeks, both groups performed a standardized resistance training program three times per week. The experimental group additionally received 3150 mg/day of omega-3 fatty acids (EPA and DHA). Pre- and post-intervention assessments included blood biomarkers (LDL, HDL, triglycerides, IL-6, TNF-alpha, CRP, GSH, MDA, BDNF, serotonin, and dopamine) and physical performance tests (1RM, CMJ, RSI, 10 m sprint, and Illinois agility). Results: The experimental group showed significant improvements in the lipid profile, with decreases in LDL and triglyceride levels and an increase in HDL levels. Levels of the inflammatory cytokines IL-6 and TNF-alpha were significantly reduced, while GSH levels increased and MDA levels decreased, indicating an enhanced antioxidant status. The neuro-biomarker analysis revealed increased levels of BDNF, dopamine, and serotonin. Physical performance tests demonstrated greater improvements in muscular strength, power, speed, agility, and reaction-based performance in the omega-3 group compared to controls. Conclusions: These findings suggest that omega-3 supplementation, when combined with resistance training, has a multi-systemic enhancing effect on both physiological markers and physical performance. This combination may represent a promising strategy for optimizing athletic adaptations and recovery in physically active populations. Future studies should further explore these effects across different populations and training modalities
TÜRK YAZILI BASININDA HAMAS LIDERI ISMAIL HENIYYE'NIN ÖLÜMÜ: MEDYA VE IDEOLOJI PERSPEKTIFINDEN BIR INCELEME
Get PDFThis study, which deals with the function of the media as an ideological tool and the power of events to shape social perception, analyses how four different Turkish newspapers present the news of the assassination of Hamas leader Ismail Heniyye in terms of ideological and hegemonic discourse. In this context, it is analysed whether the news language, imagery and discursive structure in the news reports aim to direct the reader into a certain frame and create an ideological structure. The study shows that the newspapers Cumhuriyet, Sözcü, Sabah and Yeni Safak, which were included in the sample, each frame the incident according to their own political and ideological stance. While Cumhuriyet treated the incident as an international crisis, Sözcü newspaper criticised Israel's actions and portrayed the incident as part of the Palestinian-Israeli conflict. The newspapers Sabah and Yeni Safak, which take a conservative stance, treated Heniyye's death in the context of resistance and martyrdom and emphasised Turkey's role.Medyanin ideolojik bir araç olarak nasil islev gördügü ve olaylarin toplumsal algiyi sekillendirme gücünün konu edindigi bu çalismada, dört farkli Türk ulusal gazetesinin, Hamas lideri Ismail Heniyye'nin suikast sonucu ölümüne iliskin haberleri ideolojik ve hegemonik söylem açisindan nasil sunduklari analiz edilmektedir. Bu baglamda incelenen gazete haberlerinde, haber dili, görseller ve söylemsel yapi, okuyucuyu belirli bir çerçevede yönlendirme ve ideolojik bir yapi olusturma amacinin tasinip tasinmadigi irdelenmektedir. Çalismada, örnekleme dahil edilen Cumhuriyet, Sözcü, Sabah ve Yeni Safak gazetelerinin her birinin kendi politik ve ideolojik duruslarina göre olayi çerçeveledigi ortaya çikarilmistir. Cumhuriyet gazetesi olayi uluslararasi bir kriz olarak ele alirken, Sözcü gazetesi Israil’in eylemlerini elestirerek olayi Filistin-Israil çatismasinin bir parçasi olarak sunmustur. Muhafazakâr bir bakis açisina sahip olan Sabah ve Yeni Safak gazeteleri ise Heniyye'nin ölümünü direnis ve sehadet çerçevesinde ele almis, Türkiye’nin rolü öne çikartilmistir
BAL ARISI VE ÜRÜNLERİNE VERİLEN YÖRESEL ADLAR
Get PDFTürkiye, geniş coğrafi sınırları ve köklü tarihi nedeniyle farklı kültürlerin bir arada yaşadığı kozmopolit bir yapıya sahiptir. Bu durum, ülke genelinde çeşitli dillerin ve yerel söylemlerin ortaya çıkmasına neden olmuştur. Bu çalışmada, arıcılıkta yaygın olarak kullanılan kraliçe arı, bal, polen, arı sütü gibi bazı bilimsel terimlerin Türkiye’nin farklı bölgelerinde nasıl adlandırıldığı incelenmiştir. Elde edilen bulgular, bazı terimlerin (örneğin perga, işçi arı, arı sütü) bilimsel adlarıyla yaygın olarak kullanıldığını, bazı terimlerin ise (özellikle kraliçe arı ve propolis) bölgesel farklılıklar gösterdiğini ortaya koymuştur. Öte yandan, apilarnil, bal sirkesi ve arı zehri gibi ürünlerin tanınırlığı düşük olduğundan, yöresel karşılıkları belirlenememiştir. Çalışma sonuçlarına göre; Türkiye’de arıcılıkla ilgili terminolojik çeşitliliğin son derece zengin olduğu ve bölgesel ölçekte çeşitlilik gösterdiği anlaşılmıştır