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Celluloid, un écosystème pour instrumenter la recherche sur les corpus audiovisuels
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A comparison of anticipatory processes between gait and step initiation: The role of the final state
No full textInternational audienceBACKGROUND: Whole-body movement initiation with change of base of support is a common paradigm used to assess balance-movement coordination. During clinical evaluation, two transitions are commonly used: gait or step initiation. During their respective anticipatory periods, two mechanisms regulate the whole-body centre of mass acceleration: a shift in the centre of pressure (CoP); and modulation of internal wholebody angular momentum (HM). These transitions have different final states, and we do not know whether the two mechanisms are used similarly during the anticipatory period.RESEARCH QUESTION: Is the final state already taken into account during the anticipatory period of a whole-body movement initiation?METHODS: We compared the time evolution of the CoP and HM in the sagittal plane during the anticipatory period of both gait and step initiation in 13 young, healthy participants.RESULTS: During gait initiation, we observed a larger backward CoP shift (31-56% and 75-100% of the anticipatory period), a larger forward-directed HM (45-68%), and a lower backward-directed HM (84-100%) compared to step initiation.SIGNIFICANCE: Our results show that mechanical instability is larger during gait initiation, while HM modulation is larger during step initiation. These findings suggest that the final state of a transition is taken into account during the anticipatory period. Based on our results, we suggest future research should use gait and step initiation to evaluate the generation of mechanical instability, and the use of free segments, respectively, in populations with balance deficits
Efficacy of adjuvant therapy in patients with stage IIIA cutaneous melanoma.
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Validity of the DF-MOT to detect motor developmental delays in preterm children: A comparative study with the Bayley-III
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Online Clustering of Massive Text Data Streams
No full textInternational audienceClustering large text data streams is a complex and computationally demanding task due to its unique challenges including high dimensionality, data sparsity, evolving data distributions, and the curse of dimensionality. Traditional clustering techniques often struggle to keep up with these dynamic changes and high-velocity nature of streaming text data while maintaining efficiency and accuracy. In this paper, we introduce OMTStream, a novel approach that combines an adaptive text representation technique with an online clustering based CluStream. Our method continuously learns meaningful semantic representations of text while reducing dimensionality, allowing for fast and efficient real-time clustering. By leveraging micro-clusters that evolve over time, OMTStream can track emerging patterns and adapt to shifting data distributions without the need for retraining from scratch.We evaluate our approach on real-world datasets, demonstrating its superior performance compared to existing techniques. Through a comprehensive set of experiments, we also validate the effectiveness of OMTStream across various scenarios, highlighting its robustness, adaptability, and computational efficiency in handling large, continuously evolving text data streams
Uremic toxins levels are associated with miR-223 in Chronic Kidney Disease-associated anemia.
No full textInternational audienceChronic kidney disease (CKD) poses a significant threat, with increased rates of cardiovascular and all-cause mortality. Anemia, common in CKD, is associated with accumulation of uremic toxins in the bloodstream. We previously demonstrated that the uremic toxin indoxyl sulfate (IS) impacts the regulation of erythropoiesis in cellular and preclinical CKD models. Here, the role of non-coding RNAs in this toxic effect was evaluated. The effect of IS on microRNA expression was measured in human erythropoietic cell line UT7/EPO, using nanostring. We found a significant increase of miR-223 in cells treated with IS. This finding was further validated in human primary CD34+ cells, a more physiological model for human erythropoiesis. Finally, serum levels of miR-223 correlated with representative uremic toxins, including IS, in patients with various stages of CKD, and also with endothelial dysfunction markers, indicating a link with vascular damage. These correlations varied according to erythropoietin treatment and dialysis. These findings suggest that miR-223 may play a role in the development of anemia in CKD. Further investigation into the involvement of miR-223 in erythropoiesis is needed for a better understanding of the mechanisms underlying anemia in CKD and the potential role of uremic toxins. Ultimately, this may open up new therapeutic possibilities for the management of anemia in CKD
Task-blind adaptive virtual reality: Is it possible to help users without knowing their assignments?
No full textInternational audienceThe exploration of complex environments (reconstructed locations, immersive data visualisation, etc.) is one of the primary applications of virtual reality (VR) because of the feeling of immersion and the natural interactions that it provides. When exploration is completely free, users easily become disoriented and frustrated due to multiple factors such as task difficulty, interaction techniques, spatial understanding, immersion breaches, etc. Adaptive VR systems aim to overcome these difficulties and increase performance by providing clues to help the user and delivering effective feedback. Current adaptive VR systems are mainly task-based, meaning that they have explicit knowledge about what users must achieve. We assess a new task-blind approach, which aims to enhance users’ attention and recall processes instead of helping directly with their assignment by trying to infer in real time the task a user is performing. We compare three VR help-system configurations (task-based, task-blind, and no-help) through a controlled user study involving 66 participants. The results show that the group assisted by our task-blind system developed a different behavioural pattern while maintaining similar performance scores in comparison to the task-based approach. This paper shows a new way to offer more flexibility in help-system design and opens up the field of task-blind adaptive VR
Changes in Liver Function Tests, Congestion, and Prognosis After Acute Heart Failure: The STRONG-HF Trial
No full textInternational audienceBackground: Elevated alanine aminotransferase (ALT), aspartate aminotransferase (AST), and total bilirubin (tBil) may reflect congestion and liver dysfunction in acute heart failure (AHF), while lower ALT also associates with sarcopenia.Objectives: The purpose of this study was to assess ALT, AST, and tBil levels in AHF patients during high-intensity care (HIC) vs usual care (UC) follow-up.Methods: ALT, AST, and tBil were measured 1 to 2 days predischarge in 1,062 AHF patients, and again after 90 days of either HIC or UC according to the STRONG-HF (Safety, Tolerability and efficacy of Rapid Optimization, helped by NT-proBNP testinG, of Heart Failure therapies) protocol. The primary endpoint was 180-day all-cause death or HF hospitalization.Results: Median (Q1-Q3) baseline ALT, AST, and tBil were 21 (15-32) U/L, 23 (17-32) U/L, and 14(10-21) umol/L, respectively. Patients with lower ALT had lower body mass index. Patients with lower ALT, but not tBil or AST, were more likely to have edema, elevated jugular venous pressure, and orthopnea, and use more diuretics prerandomization. A nonsignificant inverse association between ALT and the primary outcome (HR: 0.82 [95% CI: 0.66-1.01] per log-unit, P = 0.06) was observed. Greater reductions of ALT, AST, and tBil to 90 days were associated with greater improvement of edema, rales, NYHA functional class, and N-terminal pro-B-type natriuretic peptide. After 90 days, the HIC group had a greater reduction in AST and tBil than the UC group, while nonsignificant for ALT. The treatment effect of HIC over UC on the primary outcome was consistent across the baseline ALT, AST, and tBil range (all P interaction >0.10), but patients with lower ALT experienced greater health status improvement from HIC.Conclusions: Lower ALT was associated with lower body mass index and more congestion in AHF, supporting previous studies suggesting ALT as a sarcopenia marker. The beneficial effect of HIC on health status was greater in low baseline ALT patients. (Safety, Tolerability and Efficacy of Rapid Optimization, Helped by NT-proBNP testinG, of Heart Failure Therapies [STRONG-HF]; NCT03412201)
Clinical management and therapeutic optimization of patients with heart failure with reduced ejection fraction and low blood pressure. A clinical consensus statement of the Heart Failure Association (HFA ) of the ESC
No full textInternational audienceDespite major advancements in heart failure (HF) management and guideline recommendations over the past two decades, real‐world evidence highlights suboptimal implementation of guideline‐directed medical therapy (GDMT) for HF with reduced ejection fraction (HFrEF). Low blood pressure (BP) is common in HFrEF patients and represents a major perceived barrier to implementing life‐saving treatments in clinical practice, as physicians are often concerned about symptomatic hypotension and its consequences. Although low BP can be seen in those hospitalized with signs of shock, the most common scenario involves non‐severe, asymptomatic hypotension in patients receiving foundational therapy for HFrEF, where premature down‐titration or discontinuation of GDMT should be avoided. This clinical consensus statement provides a comprehensive overview of low BP in HFrEF, including its definition, risk factors, and effects of HF therapies on BP. We propose management pathways to optimize HFrEF treatment in the context of low BP, ultimately aiming to improve patient outcomes
