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Mental Multimorbidity Among General-Population Adults: Sex-Specific Sociodemographic Profiles of Anxiety, Insomnia, and Eating Disorders. Response to M. Zhang
No full textLetter to the editor. This article mentions parts of: Mental Multimorbidity Among General-Population Adults: Sex-Specific Sociodemographic Profiles of Anxiety, Insomnia, and Eating DisordersInternational audienc
Le fer héminique du régime maternel favorise la formation luminale de produits de lipoperoxydation et l’hypersensibilité viscérale chez la descendance murine
No full textNational audienc
Heme iron from red meat is associated with functional intestinal disorders in the French NutriNet-Santé cohort
No full textInternational audienc
Timelike curves: homotopies and domain of determinacy
No full textThis paper studies domains of determination of linear strictly hyperbolic second order operators . For an open set \caO, a set is a domainof determination when the values of solutions of the differential equation are determined on by their values in \caO. Fritz John's global H\"olmgren theorem implies that points that canbe reached by deformations of noncharacteristic hypersufaces with initial surface and boundaries in \caO belong to a domain of determination provided thatlocal uniqueness holdsat noncharacteristic surfaces. Using spacelike hypersurfacesyields sharp finite speed results whose domains of determinationare described in terms of influence curves that never exceedthe local speed of propagation.This paper studies deformations of noncharacteristicnonspacelike hypersurfaces. We prove that points reachable by (repeated) deformations by noncharacteristic nonspacelikehypersurfaces coincide exactly with the set of pointsreachable by (repeated) homotopies of timelike arcs whoseinitial curves and endpoints belong to \caO. When the set \caO is a small neighborhood of a forward timelikearc connecting to , a natural candidate for is the intesection of the future of with the past of . This candidate is exact for D'Alembert's equation.We prove that it is also exact when are points close together on a fixed timelikearc. The timelike homotopy criterion fuels the construction of surprising examples for which the domain of determination is strictly larger (resp. strictly smaller) than the future-intersect-past candidate
GlobalDoc: A Cross-Modal Vision-Language Framework for Real-WorldDocument Image Retrieval and Classification
No full textInternational audienc
Practical Abstractions for Model Checking Continuous-Time Multi-Agent Systems
No full textInternational audienc
Disjoint end-to-end walks for Service Function Chain provisioning and protection
No full textInternational audienceService Function Chains (SFCs) enable traffic to flow through Virtual Network Functions (VNFs) deployed on physical servers to deliver network services. While SDN (Software Defined Network)/NFV (Network Function Virtualization) provides flexible network management, ensuring service continuity remains challenging and requires robust protection mechanisms.Network failures can be addressed through local or end-to-end protection approaches. Local protection relies on multiple detours, potentially protecting against failures of the same components, which leads to complex management and multiple detour activations for single failures. End-to-end protection ensures service continuity through two end-to-end disjoint SFC provisioning paths, significantly reducing both route maintenance overhead and resource allocations.This paper addresses the challenge of finding two end-to-end disjoint paths for SFC provisioning and protection. We first model the problem using ILP and prove its completeness, even in over-resourced networks where single SFC provisioning is polynomial-time solvable. To address this complexity, we propose a novel three-step heuristic that enhances protection through transient route computation that is intended to “leave room” and facilitate disjoint provisioning identification. Recomputation of the transient route is established to enhance the resource allocation while improving the protection efficiency. Our extensive simulations demonstrate significant improvements over conventional approaches, showing notable enhancement in both protection efficiency and SFC path quality without incurring additional costs
Serum Procalcitonin: A Novel Tumor Biomarker for Diagnosis and Follow-Up in Fibrolamellar Hepatocellular Carcinoma
No full textFibrolamellar carcinoma (FLC) is a rare primary liver cancer that predominantly affects young patients with normal known serum tumor biomarkers (alpha-fetoprotein (AFP) and CA19-9). An observation of a markedly elevated procalcitonin (PCT) in one patient prompted us to investigate the potential role of PCT as a biomarker in a larger cohort of FLC. Methods We measured serum PCT levels in 34 samples from 18 patients with metastatic FLC and in 64 patients with hepatocellular carcinoma (HCC), 24 with cholangiocarcinoma (CCA), and 20 with cirrhosis. Using RNA sequencing, we analyzed CALCA expression, the gene encoding PCT, in 27 FLC tumors, 331 HCC tumors, 39 CCA tumors, 71 hepatoblastomas, 34 hepatocellular adenomas, and 55 non-tumor liver samples. Spatial transcriptomics was performed on three FLC and PCT immunohistochemistry was conducted on 13 FLC and 34 other primary or secondary liver cancers. Results In 8 FLC from the European cohort, median serum PCT was significantly elevated (55.2 µg/l) compared to patients with HCC (0.14 µg/l), CCA (0.16 µg/l), and cirrhosis (0.11 µg/l; P=0.0005). These findings were independently validated in a U.S. cohort of 10 FLC patients compared to HCC and CCA (P=0.0002). Across these cohorts, elevated serum PCT was observed in 83% of FLC cases versus 3% of HCC and CCA cases (P<0.0001). In four patients with longitudinal measurements, changes in PCT levels correlated with radiologic response according to RECIST 1.1. RNA sequencing demonstrated significant overexpression of CALCA in FLC compared to other primary liver tumors (P<0.0001), and spatial transcriptomics localized CALCA expression specifically to tumor cells. Immunohistochemistry confirmed PCT overexpression in 77% of FLC but not in other liver cancers. Conclusion Procalcitonin is a sensitive and specific biomarker for FLC at both the serum and tumor levels among primary liver cancers, with potential utility in diagnosis and monitoring of treatment response. Evidence before this study We searched PubMed from 01th January 2000 to 03th October 2025 using the terms “fibrolamellar carcinoma”, “fibrolamellar hepatocellular carcinoma” “biomarker”, “serum”, in articles written in English Language. This analysis identified numerous studies describing the clinical, molecular, and histopathological features of fibrolamellar carcinoma (FLC), but none of them have identified a serum biomarker robustly validated for clinical use. FLC is a rare primary liver cancer typically arising in adolescents and young adults with normal liver, and current serum biomarkers used for hepatocellular carcinoma, hepatoblastoma or cholangiocarcinoma (such as alpha-fetoprotein and CA19-9) are systematically normal in FLC. Prior molecular studies have focused mainly on the DNAJB1–PRKACA fusion gene, which is pathognomonic for FLC, but no reliable circulating biomarker has been established for FLC diagnosis or disease monitoring. Added value of this study Our study identifies procalcitonin as a sensitive and specific biomarker for FLC, both at the serum and tumor levels. Across two independent cohorts, elevated serum PCT distinguished FLC from other primary liver cancers and from cirrhosis with high accuracy. Serum PCT level correlated with radiologic tumor response or progression, suggesting utility for disease monitoring. Transcriptomic analyses demonstrated that the CALCA gene, encoding PCT, is overexpressed in FLC compared with other liver tumors, and spatial transcriptomics localized CALCA expression specifically to tumor cells bearing the DNAJB1–PRKACA fusion gene. Immunohistochemistry confirmed PCT protein expression in most FLC tumors but not in other primary hepatic cancer. These findings establish a novel and readily measurable serum biomarker for FLC. Implications of all the available evidence Taken together, current evidence indicates that serum PCT is a robust diagnostic biomarker for FLC, distinguishing it from other primary liver cancers and chronic liver diseases. Routine measurement of serum PCT could facilitate earlier recognition of FLC and also provide a non-invasive tool to track treatment response. Future research should validate these findings prospectively, explore the biological mechanisms underlying CALCA overexpression in FLC, and assess whether PCT-guided monitoring can predict prognosis, improve patient outcomes or clinical trial design in this rare malignanc
Reassessed Ability of Carbon-Based Physisorbing Materials to Keep Pace with Evolving Practical Targets for Hydrogen Storage
No full textThis study provides a comprehensive overview of research and advancements on carbon materials with regard to practical targets for hydrogen storage in terms of gravimetric and volumetric capacities. For the sake of clarity, only the most relevant references on hydrogen storage by adsorption are presented, although the study was conducted in the same exhaustive manner as the one initially carried out by Anne C. Dillon and Michael J. Heben [Appl. Phys. A 2001, 72, 133–142] with a particular emphasis on emerging technologies and potential applications in various sectors, and focusing on the importance of carbon-based materials with high specific surface areas and porous structures optimised to maximise adsorption — including at high pressure —, while primarily limiting references herein to experimentally validated results. It therefore offers insights into the porous materials as well as the methodologies — including a fully comprehensive and so far proven highly transferable intermolecular hydrogen model combining van-der-Waals's and Coulomb's forces — used to improve hydrogen solid storage efficiency