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Le nouveau visage de la péremption d'instance
No full textLe Village de la justice est le 1er site de la communauté des métiers du Droit, en accès libre, créé en 1997.Le Village de la justice https://www.village-justice.com/articles/L'article 386 du Code de procédure civile relatif à la péremption d'instance donne lieu à une jurisprudence abondante. La Cour de cassation continue de développer sa jurisprudence en matière de péremption d'instance afin de trouver un équilibre entre une bonne administration de la justice et le respect du droit fondamental des justiciables d'accéder à un juge. La Haute juridiction a redéfini certaines notions et souligné la nécessité de proportionnalité dans l'application des sanctions pour non-respect des règles procédurales.Au sommaire de cet article... I. La péremption : la sanction de l’inaction des parties. A- Les enjeux liés à la péremption.B- La direction de l’instance. II. Une définition renouvelée de la notion de diligence interruptive. A- Les éléments objectifs.B- Une certaine dimension subjective.Lire le document sur : https://www.village-justice.com/articles/nouveau-visage-peremption-instance,53471.htmlParue le 23 mai 2025. Reproduction interdite sans autorisation de l'auteur
Clarification of factors associated with post-artesunate delayed hemolysis (PADH): analysis of 327 patients with severe imported Plasmodium falciparum malaria in France
No full textInternational audienceBackground: Post-Artesunate delayed hemolysis (PADH) occurs in approximately 15 % of treated patients 2–3 weeks after artesunate administration. Identifying riskmarkers for PADH would help predict which patients are at higher risk.Methods: In this prospective national cohort study conducted in a non-malaria endemic area from 2011 to 2016, a Cox proportional hazards model was used to assessthe association between clinical and biological data available at Day 0 and the occurrence of PADH within 30 days of artesunate administration.Results: In the analyzed population (n = 327), 49 PADH events occurred after a median time of14 days (IQR, 13–17) after artesunate initiation. Higher initial parasitemia was associated with an increased risk of PADH, with a significant interaction found withpatient origin. The cumulative probability of PADH event at Day 30 post-artesunate was 65 % (95 % confidence interval [CI], 44–79) for European patients vs. 14 %(95 % CI, 0–26) for those with recent African ancestry [RAA] when the initial parasitemia was >10 %. After adjustment for weight, history of malaria, initialhemoglobin, very severe malaria and residence in an endemic area, compared to recent African ancestry with initial parasitemia <4 %, the adjusted hazard ratio forPADH occurrence was 18.8 (95 % CI, 4–89) for Europeans and 4.77 (95 % CI, 0.8–29.2) for recent African ancestry with initial parasitemia >10 %.Conclusions: This study showed that initial parasitemia and patient origin were the main predictors of developing PADH, with the highest risk observed in Europeanswith an initial parasitemia >10 %
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Redefining physiological whole-body alignment according to pelvic incidence: normative values and prediction models
No full textInternational audienceBackground context: Spinopelvic alignment assessment needs to account for pelvic incidence (PI).Purpose: This study aimed at providing normative values for commonly used parameters in whole-body alignment analysis based on PI.Design: Multicentric prospective study.Patient sample: This study included healthy volunteers with full-body biplanar radiograph in free-standing position.Outcome measures: All radiographic data were collected from 3D reconstructions: Sagittal vertical axis (SVA), T1 pelvic angle (TPA), spino-sacral angle (SSA), sagittal odontoid-hip axis angle (ODHA), pelvic parameters, sacro-femoral angle (SFA), knee flexion angle (KFA), ankle flexion angle (AA), Pelvic shift (PSh), lumbar lordosis (LL), thoracic kyphosis (TK) and cervical lordosis (CL).Methods: Population was divided into five groups according to PI. Normative values were described for each group. Linear regressions including age and PI provided prediction formulas for PT, TPA, SSA and SFA.Results: 642 subjects were included. Mean age was 37.7 ± 16.3 years (range: 18-90). Mean PI in the cohort was 49.3 ± 9.5°. LL, PT, SFA, SSA and TPA correlated with PI and age. ODHA, TK, CL and the other lower limb parameters were not associated with PI. All normative values across PI groups are provided for segmental, regional and global alignment parameters. Prediction formulas were: PT=-12.7 + 0.38*PI + 0.14*Age, TPA=-16.9 + 0.34*PI + 0.15*Age, SSA = 109.8 + 0.58*PI-0.19*Age, and SFA = 173 + 0.39*PI + 0.11*Age.Conclusions: SSA, PT, TPA and SFA must be assessed according to patient's PI. This study provides normative values for each PI group, and predictive formulas taking age and PI into account. PI cannot be used to define thoracic and cervical curvatures.Level of evidence: II
An international observational study validating gene-expression sepsis immune subgroups
No full textInternational audienceBackground Sepsis gene-expression sub-phenotypes with prognostic and theranostic potential have been discovered. These have been identified retrospectively and have not been translated to methods that could be deployed at the bedside. We aimed to identify subgroups of septic patients at high-risk of poor outcome, using a rapid, multiplex RNA-based test. Methods Adults with sepsis, in the intensive care unit (ICU) were recruited from 17 sites in the United Kingdom, Sweden and France. Blood was collected at days 2–5 (S1), 6–8 (S2) and 13–15 (S3) after ICU admission and analyzed centrally. Patients were assigned into ‘high' and ‘low' risk groups using two models previously developed for the Immune-Profiling Panel prototype on the bioMérieux FilmArray® system. Results 357 patients were recruited (March 2021–November 2022). 69% were male with a median age of 67 years, APACHE II score of 21 and a 30% 90-day mortality rate. The proportions of high-risk patients decreased over the three sampling times (model 1: 53%, 40%, 15% and model 2: 81%, 74%, 37%). In model 1, 90-day mortality was higher in a high-risk group at each time (S1: 35% vs 24%, p = 0.04; S2: 43% vs 20%, p < 0.001; S3: 52% vs 24%, p = 0.007). In model 2, mortality was only significantly different at the second sampling time (S1: 30% vs 27%, p = 0.77; S2: 34% vs 14%, p = 0.002; S3: 35% vs 23%, p = 0.13). Conclusions Gene-expression diagnostics can identify patients with sepsis at high-risk of poor outcomes and could be used to identify patients for precision medicine trials. Registration ISRCTN11364482 Registered 24th September 2020
Socio-economic inequalities in access to COVID-19 tests in France in 2020: evidence from the EPICOV socio-epidemiological cohort
No full textInternational audienceTesting for COVID-19 has been strongly recommended for individuals experiencing COVID-19-like symptoms or those with a close relative who tested positive. In France, tests were free of charge until mid-October 2021 and became widely available after June 2020. Our main objective was to investigate whether access to COVID-19 testing in France was associated with socio-economic conditions, considering gender and ethno-racial status. Methods A random population-based cohort survey was conducted in France in May 2020 and November 2020, including 95,388 participants aged 18 and over. We used logistic regressions to identify how having been tested in 2020 was associated with socio-economic status and exposure factors among two groups of individuals. The first group consisted of individuals who had no close relative test positive but reported experiencing Covid-19-like symptoms, such as cough, fever, dyspnea, or sudden onset of ageusia, dysgeusia, or anosmia (N=12,729). The second group included individuals, with or without symptoms, who reported that a close relative had tested positive for Covid-19 (N=5,360). Findings In both groups, testing was more frequent among individuals living in urban areas. For individuals who had no close relative test positive but reported Covid-19-like symptoms, women were 1.04 (95%CI [1.01-1.06]) more likely than men to be tested, and testing decreased with age up to 35. Individuals holding a university degree were 1.08 [1.04-1.12]) more likely than those who only completed high school to be tested, as well as those in one of the three top income deciles with reference to the bottom decile (OR 1.07, [1.02-1.13] for the top decile). Ethno-racial status was not significantly associated with testing. For respondents who had a close relative test positive, testing was strongly associated with having experienced some symptoms, especially after September 1 (OR 1.34, 95%CI [1.30-1.39]). However, there was no link between testing and income, education, or ethno-racial status. Interpretation When an individual experiences symptoms but has no close relative who is positive, the motivation to test to avoid transmitting the virus to relatives by isolating oneself is particularly strong. This strategy makes sense when there are actual possibilities to isolate, which may explain why higher income and education positively impact the propensity to test. For individuals who had a close relative test positive, most socio-economic variables were no longer related to testing once infection risk was controlled for. The availability of tests at no cost is not sufficient in itself to eliminate socio-economic inequalities in testing
« Lectures amusantes et variées » : littératures étrangères en traduction dans Le Journal des demoiselles (1834-1847)
No full textInternational audienceLe Journal des demoiselles, founded in 1833, was one of the leading magazines for young girls in the 19th century. Among its many sections, it offered an insight into foreign literature through the publication of texts published in their original version and in translation. For the period studied in this paper (1834-1847), the literary genres chosen and the languages favoured provide information about the educational and social issues involved in educating young girls. Another section, the ‘Revue littéraire’, offers other perspectives on foreign literature in translation, diversifying languages and genres, paying particular attention to the modernity of translations and exchanges, and revealing reading practices geared towards orality and shared reading.Le Journal des demoiselles, créé en 1833, est l’un des principaux magazines à destination des jeunes filles au XIXe siècle. Parmi de nombreuses rubriques, une ouverture vers les littératures étrangères est proposée par la publication de textes publiés en version originale et en traduction. Pour la période étudiée dans cet article (1834-1847), les genres littéraires choisis et les langues privilégiées renseignent sur les enjeux pédagogiques et sociaux de l’éducation des jeunes filles. Une autre rubrique, la « Revue littéraire », offre d’autres perspectives sur la littérature étrangère en traduction, en diversifiant les langues et les genres, en faisant preuve d’une attention particulière à la modernité des traductions et des échanges et en laissant apparaître des pratiques de lecture tournées vers l’oralité et la lecture partagée
