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Oral mucosal wound healing: A photograph‐based prospective study
No full textInternational audienceAbstract Background Oral mucosa heals with minimal scar formation compared with other tissues. The aim of this study was to explore the differential healing properties between keratinized gingiva and non‐keratinized alveolar mucosa, and to analyze the healing dynamic of these tissues through a clinical photograph‐based prospective study. Methods Fourteen patients received 26 interdental piezocisions as part of orthodontic therapy. Piezocisions penetrated through the oral mucosa, the periosteum, and the cortical bone. They overlapped both keratinized gingiva and non‐keratinized alveolar mucosa. Wounds were evaluated at four time points (1, 3, 8, and 20 weeks) by measuring the Mucosal Scarring Index (MSI) on standardized photographs. Results The analysis included 364 incisions evaluated at four time‐points. The scar length showed a significant reduction up to 3 weeks in the alveolar mucosa ( p < 0.001) and up to 8 weeks in the gingiva ( p = 0.048). At 1 week, the posterior regions had higher MSI scoring than the anterior regions, particularly in the mandibular alveolar mucosa. No significant changes in the scar length or MSI scores were observed after 8 weeks, indicating stabilization of the healing processes. By 20 weeks, 64.05% and 52.22% of the incisions were devoid of scars in the gingiva and alveolar mucosa, respectively. Conclusion The study confirmed that both oral mucosa and gingiva heal with no scar or minimal scarring, following full‐thickness incisions. Neither keloid nor hypertrophic scars were observed. No significant differences were found between gingiva and alveolar mucosa in terms of final scar visibility. However, healing outcomes were notably less favorable in the posterior regions, highlighting the influence of anatomical location. Plain language summary Oral mucosa exhibits minimal scar formation compared with other tissues. Studies evaluating the healing dynamics of the various intraoral tissue types remain limited. This prospective study investigates the healing characteristics of keratinized gingiva and non‐keratinized alveolar mucosa, by focusing on scar formation following piezocision. Complete wound closure was observed at all sites 1 week after surgery. More than half of the piezocisions produced no visible scarring. Notably, even though the incisions penetrated the full thickness of the tissue and involved perforation of the vestibular cortical bone, no significant scarring was observed. However, increased scar visibility was noted in patients with pigmented gingiva. The healing results appear to vary according to anatomical regions
Intentions, practices, and social representations regarding breastfeeding among women experiencing social disadvantage: findings from the qualitative component of the ECAIL trial
No full textInternational audienc
Induction Nivolumab Before Chemoradiation in High-Risk Human Papillomavirus–Driven Oropharynx Cancers: IMMUNEBOOST-HPV, a Multicenter Randomized Phase II Trial
No full textInternational audiencePURPOSE Patients with human papillomavirus (HPV)–positive oropharyngeal cancer (OPC) and advanced stage and/or significant smoking history are at higher risk of relapse. Induction immunotherapy before chemoradiation (CRT) may improve outcomes. This randomized phase II trial assessed the feasibility and safety of induction nivolumab before CRT in this high-risk population. METHODS Eligible patients had HPV-positive OPC with either T4 and/or N2/N3 disease or a smoking history >10 pack-years. Patients were randomly assigned 1:2 to receive either standard CRT (70 Gy with cisplatin, control arm [CA], n = 20) or two infusions of nivolumab followed by CRT (experimental arm [EA], n = 41). The primary end point was the rate of patients who received full treatment in due time (FTDT), defined as (1) two nivolumab infusions on days 1 and 13-17, (2) CRT started between days 27-37 after the first nivolumab infusion, (3) no radiotherapy break ≥7 days, (4) >95% of theoretical/prescribed RT dose, and (5) cisplatin dose received ≥200 mg/m 2. If two patients or less in the EA failed FTDT, the strategy would be considered feasible. Secondary end points included oncologic outcomes and toxicity. RESULTS Between July 2019 and September 2021, 62 patients were randomly assigned. Median follow-up was 37.5 months. The primary end point was not met: four of 41 patients in EA received <200 mg/m 2 cisplatin. Grade 4 to 5 acute adverse events occurred only in EA, in seven patients. The 2-year cumulative incidence (95% CI) of relapse was 7.3% (1.9 to 18.0) in EA versus 15.0% (3.6 to 34.0) in CA. CONCLUSION Induction nivolumab before CRT did not meet the predefined feasibility threshold because of reduced cisplatin dosing after toxicity in 10% of patients. The relapse incidence was numerically lower in the EA but this finding is exploratory and requires confirmation
HIV persistence in tissues on dolutegravir-based therapy is not associated with resistance mutations to dolutegravir
No full textInternational audienceBackgroundRelatively few studies have investigated HIV-1 persistence in tissues, especially in healthy people-living-with-HIV-1 (PLWH) on a successful antiretroviral regimen containing second generation integrase inhibitors.MethodsIn the ANRS EP64 DOLUVOIR, we explore HIV-1 persistence in five accessible anatomical sites in 20 PLWH on an efficient first-line ART regimen containing dolutegravir with virological load <50 copies/mL: PBMCs, rectum, adipose tissue, lymph node and sperm. We quantify total HIV-DNA and cell-associated HIV-1 RNA in different compartments. We sequence HIV-1 DNA for searching drug resistance mutations (DRM) (in RT and INT) and for studying HIV diversity within tissues (ENV). Intact proviral DNA is estimated in PBMCs with an adapted IPDA assay.ResultsBroad ranges of total HIV-DNA and transcripts levels are detected in lymph nodes, PBMCs, adipose tissue and rectum with the highest levels being found in lymph nodes (2.77 log copies HIV-1-DNA/106 cells and 1.50 log copies of HIV-1 cell-associated-RNA/µg RNA). HIV-1 DNA is undetected in all sperm samples (n = 19) except for one (1.52 log copies HIV-1-DNA/106 cells). No difference is noted between the diversity in the four compartments. DRMs to the current regimen are found archived in compartments of six participants. Only two major DRMs to dolutegravir (G118R and R263K) are found archived in two participants. They are the results of APOBEC hypermutations.ConclusionsDespite ongoing transcriptional activity, persistence of HIV-1 in deep tissues is not associated with the selection of DRMs to dolutegravir on intact proviruses. Our results suggest that the detectable transcriptional activity stems predominantly from defective proviral DNA
Editorial: Agency in posttraumatic stress disorder: theoretical approach and therapeutic perspectives
No full textInternational audienc
Knowledge, attitudes and practices relating to HIV self-testing following its introduction in the Bas-Sassandra region of Côte d’Ivoire: the case of the ATLAS project
No full textInternational audienceBackground: Awareness of HIV status is crucial for accessing HIV care and prevention but remains suboptimal in West Africa. The ATLAS initiative, launched in Côte d’Ivoire, Mali, and Senegal, addressed this gap by distributing approximately 380,000 HIV self-testing (HIVST) kits from 2019 to 2021, primarily to key populations and their social networks. This study assessed levels and correlates of Knowledge, Attitudes, and Practices (KAP) related to HIVST in the Bas-Sassandra region of Côte d’Ivoire following ATLAS’s introduction. Method: A cross-sectional population-based survey was conducted in the Bas-Sassandra region in 2021 among individuals aged 15–49. A total of 6,271 people (3,203 men and 3,068 women) were interviewed. They were selected using a three-stage stratified sampling approach in the Bas-Sassandra region. Bivariate statistics and multivariable logistic regressions were used to assess KAP levels and the associated factors.Results: Although few participants reported having heard about HIVST (11%) or having used it (3%), most of them reported that if it were freely available, they would be interested/very interested in using it for themselves (76%), as well as for their sexual partners (75%). Education and wealth were positively associated with knowledge and positive attitudes towards HIVST among both men and women, whereas age was positively correlated to knowledge and use of HIVST among men only. The number of sexual partners over the last 12 months was positively associated with knowledge of HIVST and willingness to use HIVST for themselves or their sexual partners among both sexes. We also found that high HIV-related knowledge and low levels of negative attitude were positively associated with positive attitudes towards HIVST, while exposure to the media appeared to be correlated to knowledge of HIVST. Conclusion: The high level of positive attitudes towards HIVST calls for a scaling up of access to HIVST in the region. Specific attention to groups with the worst KAP, such as the less educated, the poor or those with more HIV-related negative attitude, could enhance the success of such initiatives
Le déploiement de l'exigence de pertinence en matière d'évaluation du travail des salariés
No full textInternational audienceSoc. 15 octobre 2025, no 22-20.716 (publié au Bulletin
Lower limb compensation in adult spinal deformity: can we identify different patterns?
No full textInternational audienceObjective Lower limbs can play a major compensating role for sagittal malalignment; however, little is known about the different types of compensation. This study aimed to identify different patterns of lower limb compensation and to determine which parameters may affect the recruitment of knee flexion versus hip extension. Methods This study included adult spinal deformity (ASD) patients with full-body X-rays in erect position from a multicentric prospective database. All parameters were measured at baseline: demographics, clinical scores and radiographic parameters: pelvic parameters, pelvic incidence-lumbar lordosis (PI-LL) mismatch, T1 pelvic angle (TPA), sacro-femoral angle (SFA), knee flexion angle (KA), ankle dorsi-flexion angle (AA), pelvic shift (PSh), hip and knee osteoarthritis (OA) grade. A K-means cluster analysis was conducted to identify patterns of lower limb compensation based on SFA and KA. The optimal number of clusters was determined using the silhouette score. The different parameters were then compared across clusters. Results 871 ASD patients were included, of whom 66.9% were females. Mean age was 62.3±14.6 years, mean BMI was 27.7±5.5 kg.m -2 . Four patterns of lower limb compensations were identified: "No compensators", "Recliners" (mainly hip extension), "Squatters" (mainly knee flexion) and "Mixed compensators" (both)."Mixed" and "Squatters" had significantly larger BMI. The proportion of females was the least in the "Squatters" cluster (47.0%) while it was the highest in the "Recliners" group (79.3%) (p<0.001). The proportion of patients with severe hip OA was the lowest in the "Recliners" (38.5%) while it was the highest in the "Squatters" group (71.9%). Knee OA rate was the highest in the"Squatters" group (72.7%). "Mixed compensators" had the greatest PI-LL mismatch (30.4±20.0°) and "No compensators" the lowest (5.3±21.3°). Pelvic incidence values were the highest in "Recliners" and "Mixed compensators" (59.2±13.1° and 57.0±14.1° respectively). TPA values were the highest in the "Mixed compensators" and the lowest in the "No compensators" (33.3±11.7° versus 16.1±11.5°). The "Squatters" presented the significantly poorest values for disability, frailty, and SRS score. Conclusions Cluster analysis determined four types of lower limb compensation:"Recliners" using only hip extension, "Squatters" using only knee flexion,"Mixed compensators" and "No compensators". Lower limb compensatory mechanisms recruitment is multifactorial and varies with age, sex, BMI, frailty, knee and hip OA, pelvic incidence, and spinal alignment
Look-Ahead-Bench: a Standardized Benchmark of Look-ahead Bias in Point-in-Time LLMs for Finance
No full textWe introduce Look-Ahead-Bench, a standardized benchmark measuring look-ahead bias in Point-in-Time (PiT) Large Language Models (LLMs) within realistic and practical financial workflows. Unlike most existing approaches that primarily test inner lookahead knowledge via Q\&A, our benchmark evaluates model behavior in practical scenarios. To distinguish genuine predictive capability from memorization-based performance, we analyze performance decay across temporally distinct market regimes, incorporating several quantitative baselines to establish performance thresholds. We evaluate prominent open-source LLMs---Llama 3.1 (8B and 70B) and DeepSeek 3.2---against a family of Point-in-Time LLMs (Pitinf-Small, Pitinf-Medium, and frontier-level model Pitinf-Large) from PiT-Inference. Results reveal significant lookahead bias in standard LLMs, as measured with alpha decay, unlike Pitinf models, which demonstrate improved generalization and reasoning abilities as they scale in size. This work establishes a foundation for the standardized evaluation of temporal bias in financial LLMs and provides a practical framework for identifying models suitable for real-world deployment. Code is available on GitHub: \url{https://github.com/benstaf/lookaheadbench