4926 research outputs found
Sort by
Immunological Maladaptation as a Predictor of Spontaneous Preterm Birth in Human Pregnancies
No full textThis data set of single cell RNA sequencing was generated from maternal blood samples collected from pregnant women (n=10) in their first and second pregnancy, respectively, either experiencing a healthy term (n=10) or a spontaneous preterm birth (n=10).
The analysis of this data set is part of the manuscript entitled "Immunological Maladaptation as a Predictor of Spontaneous Preterm Birth in Human Pregnancies" which is currently under consideration for publication with Nature Communications.
Abstract:
Dysregulated maternal immune adaptation during pregnancy plays a central role in the pathogenesis of spontaneous preterm birth (sPTB). However, predictive models of sPTB based on maternal immune features, ideally before clinical symptoms arise, remain limited. In a nested case-control study embedded within a population-based, low-risk pregnancy cohort, we decoded a pattern of abnormal immune response in mothers' blood that precedes sPTB by weeks to months. Prominent features include heightened sensitivity to adrenergic signals within myeloid and T cell populations in early pregnancy, followed by increased production of pro-inflammatory cytokines in the third trimester. CD4+ T cells exhibited gene expression patterns indicative of a Th17-skewed, neuroactive protein–responsive phenotype. Our study provides a multi-omics resource and a conceptual framework for identifying individuals at increased risk for sPTB with broad translational implications for advancing targeted preventive measures
A igualdade linguística como base para a justiça social e educativa
No full textEste módulo tem como objetivo compreender a relação entre a (des)igualdade linguística e a justiça social e educativa. Depois de explicitar o significado dos três conceitos básicos (igualdade linguística, justiça social, justiça educativa) e as suas relações, este módulo analisa situações práticas de justiça social e escolar na sala de aula e a injustiça criada pelas desigualdades linguísticas. Por fim, o módulo propõe a análise de propostas de intervenção escolar concebidas para reduzir as injustiças causadas por e/ou justificadas com base em critérios linguísticos
Global Bias-Corrected CORDEX Datasets at Half Degree Resolution
No full textAbstract: This dataset provides globally consistent, bias-corrected climate data at 0.5° spatial resolution, consisting of a set of seven climate variables derived from three General Circulation Models (GCMs) participating in CMIP5, downscaled by 10 CORDEX Regional Climate Model (RCM) simulations and bias-corrected globally for the period 1950/1960–2099. It includes data from three climate change scenarios, namely RCP2.6, RCP4.5 and RCP8.5. The three GCMs are: ICHEC-EC-EARTH, MPI-M-MPI-ESM-LR, NOAA-GFDL-GFDL-ESM2M. Data are originally available as one netCDF file per GCM (3) per variable (7, NOAA-GFDL-GFDL-ESM2M: 5) per run (4, NOAA-GFDL-GFDL-ESM2M: 3). Available here are netCDF files per quantity (see TableOfContents), run (historical, rcp26, rcp45, rcp85), and GCM (see Size for the overall sum per GCM).
TableOfContents: daily mean 2m-air temperature (tas); daily minimum 2m-air temperature (tasmin), daily maximum 2m-air temperature (tasmax); daily sum of precipitation (pr); daily mean surface downwelling longwave radiation (rlds)*; daily mean 10m wind speed (sfcWind)*; daily mean relative humidity (hurs)
*: These variables are NOT included in the NOAA-GFDL-GFDL-ESM2M driven data.
TechnicalInfo: dimension: 720 columns x 360 rows; temporalExtent_startDate_Historlcal: 1950-01-01 00:00:00; temporalExtent_endDate_Historical: 2019-12-31 23:59:59; temporalDuration_Historical: 70; temporalDurationUnit_Historical: a; temporalExtent_startDate_RCPs: 2020-01-01 00:00:00; temporalExtent_endDate_RCPs: 2099-12-31 23:59:59; temporalDuration_RCPs: 80; temporalDurationUnit_RCPs: a; temporalResolution: 1; temporalResolutionUnit: d; spatialResolution: 0.5; spatialResolutionUnit: degree; horizontalResolutionXdirection: 0.5; horizontalResolutionXdirectionUnit: degree; horizontalResolutionYdirection: 0.5; horizontalResolutionYdirectionUnit: degree; verticalResolution: none; verticalResolutionUnit: none
*) For MPI-M-MPI-ESM-LR: temporalExtent_startDate_Historlcal: 1960-01-01 00:00:00; temporalExtent_endDate_Historical: 2019-12-31 23:59:59; temporalDuration_Historical: 60;
Methods: The ISIMIP3BASD v2.5 bias correction method (see Lange [2019; 2021]) was applied to adjust systematic biases using the GSWP3-W5E5 observational dataset. The regional climate models (RCMs) used are: (listed are Institution/working group, RCM Model, Driving GCM):
Climate Service Center Germany (GERICS), REMO2009, MPI-ESM-LR
Swedish Meteorological and Hydrological Institute (SMHI), RCA4, MPI-ESM-LR
Climate Limited-area Modelling Community (CLMcom), CCLM4-8-17-CLM3-5, MPI-ESM-LR
Climate Limited-area Modelling Community (CLMcom), CCLM5-0-2, MPI-ESM-LR
Universite du Quebec a Montreal, CRCM5, MPI-ESM-LR
Swedish Meteorological and Hydrological Institute (SMHI), RCA4, ICHEC-EC-EARTH
Climate Limited-area Modelling Community (CLMcom), CCLM4-8-17-CLM3-5, ICHEC-EC-EARTH
Climate Limited-area Modelling Community (CLMcom), CCLM5-0-2, ICHEC-EC-EARTH
Swedish Meteorological and Hydrological Institute (SMHI), RCA4, NOAA-GFDL-GFDL-ESM2M
National Center for Atmospheric Research, WRF, NOAA-GFDL-GFDL-ESM2M
The historical runs begin 1950-01-01 (ICHEC-EC-EARTH and NOAA-GFDL-GFDL-ESM2M) or 1960-01-01 (MPI-M-MPI-ESM-LR) and end 2005-12-31. Historical runs are appended by rcp85 runs for years 2006-01-01 to 2019-12-31. All projection runs begin 2020-01-01 and end 2099-12-31.
The routines (python) used to create and work with the data sets are available from this web page as well: Discontinuity_Analysis_GlobCORD-HC.py; IBICUS-BIAS-CORRECTION.py
For more information please take a look at this publication: Yakubu et al., 2025.
Quality: Not all of the domains have been downscaled by CORDEX RCMs. Therefore, data files for scenario rcp26 only contain 7 CORDEX domains; all other files contain 8 domains (see also https://cordex.org/domains/cordex-domain-description/)
Units (see TableOfContents): K; K; K; kg m-2 s-1; W m-2; m s-1; percent
GeoLocation: westBoundCoordinate: -167.0; westBoundCoordinateUnit: degrees East; eastBoundCoordinate: 180.0; eastBoundCoordinateUnit: degrees East; southBoundCoordinate: -56.0; southBoundCoordinateUnit: degrees North; northBoundCoordinate: 76.0; northBoundCoordinateUnit: degrees North
Size: ICHEC-EC-EARTH: 137.7 GByte, MPI-M-MPI-ESM-LR: 130.6 GByte, NOAA-GFDL-GFDL-ESM2M: 55.5 GByte
Format: netCDF
DataSources: See the file "GloBCORD-HD_ESMs-RCMs.pdf"
Contact: fuseini.yakubu (at) uni-hamburg.de; shabeh.hasson (at) uni-hamburg.de
Webpage: https://www.geo.uni-hamburg.de/geographie/abteilungen/physische-geographie/arbeitsgruppen/ag-hareme.htm
The DLA-RMR dataset: Annotated subset of RMR notebooks for CVC development
No full textWhat’s new in this version: This is the first complete version (v1.0). All images are in .png format, and the dataset annotations are divided into training (80 images) and test (20 images) sets.
This dataset is structured into four components, each serving a distinct role in the development of a document analysis system.
Word-level annotations are provided in the file word_annotations_for_cropped_images.json. These annotations describe the images contained in the cropped_images folder. Each entry specifies the location of a word as a polygon, together with its orientation (horizontal, vertical, or tilted) and the type of writing implement used (ink or pencil). Additional metadata, such as bounding boxes and segmentation areas, is also included.
Cropped images are stored in the cropped_images folder. This set comprises 50 images, each containing only the primary page extracted from the corresponding full notebook scans.
Full images are located in the full_images folder. This collection also contains 50 items, representing the complete notebook scans in which the primary page appears alongside other material.
Page-level annotations are contained in the page_annotations folder. These are provided in YOLO format, with a single class (page) defined in classes.txt. Each annotation file specifies the bounding box of the primary page within the corresponding image in the full_images folder.
Examples illustrate the annotation structure. In the JSON file, a typical word annotation records polygon coordinates, the attribute "orientation": "horizontal", and "writing_tool": "pencil". In the YOLO annotations, a sample entry such as 0 0.499023 0.500776 0.777344 0.816912 denotes the normalised coordinates of the primary page bounding box.
Acknowledgement:
The research for this work was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s Excellence Strategy - EXC 2176 ‘Understanding Written Artefacts: Material, Interaction and Transmission in Manuscript Cultures’, project no. 390893796. The research was conducted within the scope of the Centre for the Study of Manuscript Cultures (CSMC) at Universität Hamburg.
The images are taken from notebook pages of Rainer Maria Rilke, from the Deutsche Literaturarchiv Marbach (DLA), A:Rilke-Archiv Gernsbach.
We thank Hui Xu for her support in annotating the images
BOLD modules implementation report
No full textThis document provides an overview of how the BOLD open-access modules were integrated into higher education curricula across partner institutions. It outlines the template used to document this process and summarises insights from 13 completed implementations, highlighting contexts, pedagogical approaches, and feedback from teachers and students. The report illustrates how the modules supported reflection on linguistic and cultural diversity, social action, and inclusive education, offering evidence of their relevance and adaptability within diverse European teacher education settings
Menschen in Deutschland: International (MiDInt). Untersuchungsdesigns, Stichproben, Erhebungsinstrumente und Codebuch zu den Wellen 7 bis 14. MOTRA Forschungsbericht No. 18 aus dem Institut für Kriminologie an der Fakultät für Rechtswissenschaft der Universität Hamburg. Hamburg: Universität Hamburg.
No full textDer vorliegende Forschungsbericht beschreibt das Erhebungsdesign, die erreichten Stichproben, die erhobenen Konstrukte und die dazu verwendeten Messinstrumente mehrerer Erhebungswellen der Studie "Menschen in Deutschland: Internationa) (MidInt). Es handelt sich um die Wollen 7-14 die von Dezember 2023 bis Januar 2025 durchgeführt wurden. Im Anhang zu diesem Methodenbericht finden sich die Erhebungsinstrumente jeder Welle im Wortlaut sowie ein Codebuch, dem der Einsatz der jeweiligen Konstrukte in den verschiedenen Wellen, die Bezeichnungen der Variablen sowie deren Inhalte und Codierungen entnommen werden können
Höflichkeit in der Behördenkommunikation.
No full textDieses Arbeitspapier entstammt dem Projekt "Höflichkeit in der interkulturellen Kommunikation". Die Leitung des Projektes lag bei Prof.Dr. Jochen Rehbein (Universität Hamburg). Finanziell gefördert wurde das Projekt von der Volkswagenstiftung
Armenian Manuscript Culture and the Development of Armenian Palaeography from Late Antiquity to Early Printed Books
No full text“Armenian Manuscript Culture and the Development of Armenian Palaeography from Late Antiquity to Early Printed Books”, Weston Library (Bodleian Libraries), University of Oxford
New Witnesses of the Jerusalem-Rite Lectionary: Georgian Palimpsests Ivir. georg. 47 and Ivir. georg. 59
No full textIn Jost Gippert, José Maksimczuk, Hasmik Sargsyan (eds): Palimpsests and Related Phenomena across Languages and Cultures. Berlin / Boston: de Gruyter (Studies in Manuscript Cultures, 42), 309-329
