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    Impact of childhood trauma history on premenstrual syndrome in women of reproductive age: A cross-sectional study

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    Aim: Premenstrual syndrome is a women's health problem affecting women of reproductive age. Early traumas may have negative effects on women's health. Childhood traumas are thought to be an important risk factor for the emergence of premenstrual syndrome. The aim of this study was to investigate the relationship between premenstrual syndrome and childhood traumas in women. Method: This is a cross-sectional study. This study was conducted online between September 2023 and January 2024. The sample of the study consisted of 437 women of reproductive age, between the ages of 18–49, who did not have any obstacles to participating in the study. Personal Information Form, Premenstrual Syndrome Scale and Childhood Trauma Scale were used to collect the data. SPPS statistical program was used to analyze the data. Results: The prevalence of premenstrual syndrome was 55.6%. Emotional neglect, physical abuse, emotional abuse and sexual abuse levels were found to be higher in women with premenstrual syndrome (p < 0.05). It was determined that childhood traumas increased the level of premenstrual syndrome in women (ß = 0.266). Childhood trauma explained 6.8% of the total change in premenstrual syndrome level (R2 = 0.068). Emotional neglect (ß = 0.163) and physical abuse (ß = 0.121) increased the level of premenstrual syndrome. Conclusion: Childhood traumas were found to be an important factor affecting the occurrence of premenstrual syndrome and exacerbating its symptoms. Early detection of childhood traumas may prevent long-term problems that may occur in individuals

    Associations between stages of diabetic polyneuropathy and quality of life, neuropathic pain, and well-being: A multicenter, cross-sectional analysis based on electroneuromyographic findings

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    Aim: This study aimed to investigate the relationship between electrophysiological findings of diabetic neuropathy (DN) and patients' quality of life, neuropathic pain levels, and well-being. Materials and Methods: A cross-sectional study was conducted in 12 centers in Turkey. DN patients were categorized into four stages based on electrophysiological findings using the Baba classification. Scales such as Short Form-36 (SF-36), Douleur Neuropathique 4-Questions (DN4), Brief Pain Inventory (BPI), and WHO-5 Well-Being (WHO-5 WB) were used to assess quality of life, pain, and well-being. Additional factors like HbA1c levels and diabetes duration were analyzed. Results: Among 323 DN patients, 90 were in stage 1, 84 in stage 2, 72 in stage 3, and 77 in stage 4. There were no significant differences in age or gender between the stages. Diabetes duration and HbA1c levels were significantly lower in stage 1 compared to later stages. SF-36 and WHO-5 WB scores declined, while DN4 and BPI pain interference scores increased in the later stages. These findings persisted after adjusting for confounders such as age, BMI, comorbidities, and diabetes duration. Conclusion: Patients with advanced-stage DN experienced a poorer quality of life, greater pain, and more frequent comorbidities compared to early-stage patients. Electrophysiological findings should be considered in the clinical management of DN

    Trans-umbilical management of OHVIRA syndrome by a thoracic trocar technique: A case report

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    Introduction: Cervical atresia in cases of obstructed hemivagina and ipsilateral renal agenesis (OHVIRA) syndrome is rare. To prevent complications that may occur due to the association of cervical atresia with OHVIRA syndrome, a left hemihysterectomy and salpingectomy is occasionally needed. Case presentation: A 14-year-old female was referred to us due to abdominal pain. She had never experienced menstrual pain until three periods preceding her presentation. Abdominal ultrasound (US) showed that the left horn of the uterus was hypoplastic and compatible with hematosalpinx. Computerized tomography (CT) of the abdomen showed a 3-cm left endometrial cavity, and an 8-cm septated lesion in the left adnexa. The left ovary could not be visualized. Magnetic resonance (MR) revealed uterus didelphys and a 6–8 cm septated lesion in the left adnexa. The left kidney was not present. The left cervix was absent. Based on these findings, OHVIRA syndrome was diagnosed. She was taken to the operating room for a hysteroscopy, which showed a single cervix, normal uterine mucosa, and a single tubal ostium. No septum was seen in the vagina. She then underwent a laparoscopy, which revealed uterus didelphys, widespread endometriosis, a large left hematosalpinx, left tubal torsion, no left ovary, and a normal right ovary. We proceeded with a left hemihysterectomy and salpingectomy using a transumbilical single-incision approach. The foci of endometriosis were suctioned and the specimen retrieved through the umbilical incision. She recovered well from the operation and was discharged home 5 days later. Conclusion: OHVIRA syndrome should be suspected in patients with renal agenesis and an ipsilateral adnexal mass. Patients with OHVIRA and cervical atresia may need a left hemihysterectomy and salpingectomy, which can be done through a transumbilical single-incision approach

    Evaluation of Proopiomelanocortin (POMC) and neuropeptide Y (NPY) levels in bipolar and unipolar patients

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    Objective: Evidence suggests that stressful life experiences contribute significantly to the aetiology of mood disorders. Hypothalamic neuropeptides are thought to be biomarkers used to differentiate patients with mood disorders. In our study, we aimed to evaluate the concentrations of hypothalamic neuropeptides NPY and POMC in patients with bipolar (BP) and unipolar (UP) depression. Methods: The study included 26 UP and 28 BP patients, 27 healthy controls.NPY and POMC concentrations were quantified in peripheral blood specimens.The Hamilton Depression Rating Scale(HAM-D), Epworth Sleepiness Scale and Three-Factor Eating Questionnaire were administered. Results: Serum NPY and POMC levels were significantly lower in UP and BP patients compared to the control group (p = 0.001).NPY level was lower in the depression group compared to the bipolar group but not statistically significant (p˃0.05).POMC level was decreased in the bipolar group compared to the depression group, but the results were not statistically significant (p˃0.05). No significant correlation was found between any scale score and NPY and POMC(p>0.05). Conclusion: This study suggests that changes in serum NPY and POMC levels in UP and BP patients may have a potential role in disease pathophysiology. In particular, it is the first study to investigate the interaction between NPY, POMC and changes in eating behaviour in depressed patients, highlighting the need for further research in this area

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