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Gebelerin Kişilik Özelliklerinin Prenatal Emzirme Öz Yeterliliğine ve Bilgiye Erişimde Yapay Zekâ Tutumuna Etkisi
No full textEvaluation of factors affecting Pneumonia Severity Index and antibiotic resistance status in culture-proven bacterial pneumonia
No full textThe effect of quercetin on ischemia-reperfusion injury in skeletal muscle in rats Sıçanlarda iskelet kasında iskemi-reperfüzyon hasarında kuersetinin koruyucu rolü
No full textBACKGROUND: Ischemia-reperfusion (I/R) injury of the lower limbs is a significant clinical challenge that can arise due to surgical procedures, thrombotic events, embolism, or traumatic vascular damage. This study aimed to evaluate the antioxidative and histopathological protective effects of quercetin, a potent flavonoid antioxidant, on skeletal muscle subjected to I/R injury. METHODS: Eighteen Wistar Albino rats were randomly assigned into three groups: Control (sham laparotomy), Ischemia-Reperfusion (IR) group (2 hours of ischemia followed by 2 hours of reperfusion), and Ischemia-Reperfusion plus quercetin treatment (IR-Q) group, receiving 20 mg/kg quercetin intraperitoneally 30 minutes before ischemia induction. After the experimental protocols, skeletal muscle samples were collected for biochemical assays measuring malondialdehyde (MDA) levels and superoxide dismutase (SOD) activity, as well as for histopathological examination. RESULTS: The IR group demonstrated a significant increase in MDA concentration compared to controls (p<0.0001), whereas administration of quercetin in the IR-Q group significantly attenuated MDA levels relative to the untreated IR group (p=0.012). SOD activity was markedly diminished in the IR group (p<0.0001) but was significantly restored in the IR-Q group compared to IR alone (p=0.012). Histological analyses revealed pronounced muscle atrophy, degeneration, leukocyte infiltration, and fiber fragmentation/ hyalinization in the IR group, which were significantly alleviated by quercetin treatment (p<0.05). CONCLUSION: These findings indicate that quercetin exerts a protective effect against oxidative stress and structural damage induced by ischemia-reperfusion in skeletal muscle, potentially through enhancement of endogenous antioxidant defenses. Quercetin thus holds promise as a therapeutic agent in mitigating I/R injury; however, further studies are needed to elucidate its precise mechanisms and clinical applicability
Glycaemic control and complications in haemodialysis patients: The TURK-HEMODIAB Study
No full textBackground The most common cause of end-stage kidney disease is diabetes mellitus (DM). The most commonly used renal replacement therapy in Turkey and in many countries around the world is haemodialysis (HD). Glycaemia control is important in these populations. In this study we aimed to screen for glycaemic control and complications in a large population of diabetic HD patients in Turkey. Methods A total of 16 043 patients were screened in 253 dialysis centres in Turkey and 5038 diabetic HD patients were included in the study. At participating centres, patients' diabetes history, complications, medications, haemoglobin A1c (HbA1c) and other laboratory data were reviewed and recorded by nephrologists. Results The average age of the patients was 64.0 ± 11.2 years and 56% were male. The mean HbA1c was 7.4 ± 1.5%. Patients were divided into three groups according to the HbA1c level (8%). As the HbA1c levels increased, the mean systolic blood pressure and diastolic blood pressure increased significantly. In addition, as the HbA1c levels increased, the number of patients with coronary artery disease, patients undergoing coronary artery bypass graft surgery and the rate of patients with diabetic retinopathy and vision loss increased. Diabetic foot disease and amputation rates were also higher in the group with poor glycaemic control. The number of patients using intensive or mixed insulin was also higher in the group with high HbA1c levels. In ordinal logistic regression analysis, age significantly decreased and higher body mass index slightly increased the risk of a higher HbA1c. Also, the need for a diabetic diet was greater in those with high HbA1c levels. Conclusion Our study highlights that the target values for diabetic HD patients in Turkey are partially compatible with the 2022 Kidney Disease: Improving Global Outcomes guidelines for diabetes management. Nevertheless, more effort and teamwork are needed to improve patient outcomes
Hibrit Modelle Verilen Emzirme Eğitiminin Emzirme Etkinliğine ve Doğum Sonu Konfor Düzeyine Etkisi: Randomize Kontrollü Çalışma
No full textThe Effect of Vitamin D Level on Blood Glucose Regulation, Lipid Profile and İnflammation Markers in Diabetic Patients: A retrospective cross-sectional study
No full textAim: In our study, we aimed to evaluate the frequency of anxiety in patients with type 2 diabetes and the effect of blood glucose regulation and vitamin B12levels on anxiety.Material and Methods: The study comprised 174 patients with Type 2 DM aged 18-65 years and 62 healthy controls. The study used a questionnaire formconsisting of the Sociodemographic Characteristics Form, Clinical Data Form, and Beck Anxiety Scale as a data collection tool. Mann Whitney U test, t-test forindependent variables, chi-square test, and Spearman correlation test were used to analyze the data. p<0.05 was accepted as a statistical significance value.Results: Two hundred thirty-six people participated in our study, 174 in the case group and 62 in the control group. The mean age of the patient group was53.7±9.0 years, and 51.1% were male. The study showed that HbA1c levels were regulated in 50.6% of diabetic patients, and vitB12 levels were adequate in59.2%. There was no statistically significant difference between the anxiety levels and scores of Type 2 diabetic patients according to the regulation of HbA1clevels and vitB12 levels (p>0.05). The anxiety level and scores of diabetes patients were significantly higher than the control group (p<0.005).Discussion: Anxiety is more common in patients with diabetes. Diabetes patients should be evaluated in terms of anxiety disorders that may accompany them.In addition, studies aimed at understanding the causes of anxiety in diabetic patients can determine the areas of intervention in this regard.Keywords: Anxiety, Vitamin B12, Type 2 Diabetes Mellitus</p
Cerrahi Olarak Rezeke Edilen Küçük Hücreli Akciğer Kanseri: Beş Olguluk Tek Merkez Deneyimi
No full textRole of anesthetic techniques in trigeminocardiac reflex during oral surgery of the mandible under local anesthesia
No full textİntroduction: The trigeminocardiac reflex is a clinically important autonomic response to trigeminal stimulation, particularly characterized by heart rate reduction; however, its behavior under local anesthesia is not well defined. This prospective clinical study investigated the impact of different local anesthesia techniques on the incidence and hemodynamic characteristics of the trigeminocardiac reflex (TCR) during mandibular nerve stimulation in awake patients. Materials and Methods: Forty individuals undergoing surgical extraction of impacted mandibular teeth were enrolled. To minimize vasovagal influence, anxious patients were excluded. Group-1 received a Gow-Gates mandibular nerve block, whereas Group-2 received an inferior alveolar nerve block with supplementary buccal anesthesia. Heart rate (HR) and mean arterial blood pressure (MABP) were continuously monitored throughout local anesthesia administration and all surgical stages. Results: TCR-compatible bradycardia occurred in 30% (12/40) of patients, most frequently during anesthetic injection and mucosal manipulation, including flap elevation, and suturing.A significantly higher incidence of the TCR was observed in Group 1.The maximum HR reduction recorded was 43.5%. The linear progression of stage-specific baseline MABP and HR values showed a significant decrease during curettage/irrigation and suturing. Conclusion: These findings demonstrate that the TCR can occur during oral surgery performed under local anesthesia, typically at mild levels, and that the anesthesia technique influences its incidence. This study contributes to the current literature by evaluating the prophylactic potential of different local anesthesia techniques in oral surgery and by integrating anxiety assessment to enhance methodological robustness
