Zonguldak Bülent Ecevit University Institutional Repository
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Two-Variable q-General-Appell Polynomials Within the Context of the Monomiality Principle
No full textIn this study, we consider the two-variable q-general polynomials and derive some properties. By using these polynomials, we introduce and study the theory of two-variable q-general Appell polynomials (2VqgAP) using q-operators. The effective use of the q-multiplicative operator of the base polynomial produces the generating equation for 2VqgAP involving the q-exponential function. Furthermore, we establish the q-multiplicative and q-derivative operators and the corresponding differential equations. Then, we obtain the operational, explicit and determinant representations for these polynomials. Some examples are constructed in terms of the two-variable q-general Appell polynomials to illustrate the main results. Finally, graphical representations are provided to illustrate the behavior of some special cases of the two-variable q-general Appell polynomials and their potential applications.</jats:p
The Effect of Preheating on Fissure Sealant Viscosity
No full textObjective: Fissure sealant application is used for the prevention of caries. The viscosity of the fissure sealant directly affects the retention of the material to the tooth. Heating resin-containing materials before polymerization decrease the viscosity of the material. The purpose of this study was to examine the fluidity levels of four different fissure sealants containing resin with different filling ratios at different temperatures before polymerization and to evaluate the obtained data by comparing them. Methods: The study of four different fissure sealant materials with resin content with different filler ratios (0%, 30%, 55%, and 70%) were heated at different temperatures (4ºC, 23ºC, 39ºC, and 55ºC) before polymerization. With the fluidity measurement between the two glasses, 20 fluidity measurement values were obtained at each temperature value, and a total of 320 measurements were made. The data were statistically evaluated with a two-way robust ANOVA analysis. Results: The study it was determined that the fluidity values of the fissure sealants increased with the heating process before polymerization. The best result in terms of fluidity in the fissure sealants without filler was obtained at a temperature of at least 23ºC. In the fissure sealants containing 30% and 55% filler, there was a significant difference in fluidity values when the temperature difference was large. Conclusion: It is thought that the filling ratio and temperature affect the fluidity in fissure sealants and that the appropriate temperature should be selected by considering the filling ratios to obtain the best result in terms of fluidity. Keywords: fluidity, viscosity, preheating, fissure sealant, the heating device.</jats:p
Effects of valproic acid, levetiracetam, carbamazepine, lamotrigine, and topiramate on LIF, E-cadherin, and FOXO1 mediator molecules in rat embryo implantation
No full textThis study investigated the effects of valproic acid (VPA), levetiracetam (LEV), carbamazepine (CBZ), lamotrigine (LTG), and topiramate (TPM) on LIF, E-cadherin, and FOXO1 mediator molecules during implantation in rat embryos.Sixty female rats were divided into six experimental groups, and the control solution and drugs were administered by gavage for 90 days. At the end of three months, implantation sites were obtained, and histological and immunohistochemical staining protocols were applied.Embryonic trophectoderm cells were surrounded by inflammatory cells in the VPA group. Increased eosinophilic staining was seen in the primary decidual zone cells in the CBZ group, mast cells in the LTG group, and intense inflammatory cells in the TMP group. LIF staining in the VPA, CBZ, LTG, and TPM groups showed weak to moderate LIF expression (p < 0.001). In E-cadherin staining, the LTG group showed moderate and the TPM group showed weak immune reactions (p < 0.001). Embryonic cells and primary decidual zone cells in control, LEV, CBZ, and LTG groups showed weak to strong expression of FOXO1, while VPA and TPM groups showed no reaction (p < 0.001).In summary, antiseizure medication use had a negative effect on the expression of proteins that play key roles in embryo implantation in young non-epileptic rats to varying degrees
Diffusion and Adoption of Quality Management in Turkish Higher Education
No full textGlobal developments in higher education have made quality management afundamental tool of legitimacy. In parallel with the whole world, qualitymanagement has started to be institutionalized at the national level and thediffusion of quality management among higher education institutions hasaccelerated in the Turkish higher education system with the establishment ofthe Turkish Higher Education Quality Council (THEQC) in 2015. In the study,the diffusion of quality management in Turkish higher education institutions isdiscussed in detail and it is presented that quality management in highereducation has spread throughout Türkiye as a dominant management style andparadigm. The successful studies of THEQC for the normative adoption ofquality management are discussed and Opinions-Suggestions on the GeneralSituation of the Turkish Higher Education System are provided in the study, inwhich the Theoretical Framework of Quality Management in Turkish HigherEducation is discussed in detail. The study presents a general framework for thequality journey of Turkish higher education, which has come a long way inreaching world standards
Determination of Cobalt in Tap Water by Deep Eutectic Solvent-Dithizone Assisted Liquid Phase Microextraction (LPME) Preconcentration with Flame Atomic Absorption Spectrometry (FAAS)
No full textThis study aimed to develop an analytical method for preparing samples to preconcentrate cobalt from water in advance for determination using flame atomic absorption spectrometry (FAAS). The aforementioned outcome was attained through the complexing of cobalt ions with dithizone (Co-DTZ) and subsequently extracting the resulting complex from aqueous solution using a deep eutectic solvent (DES). The DES/DTZ probe was used as a complexing and extracting agent in the developed liquid phase microextraction (LPME) procedure. The most suitable experimental conditions were determined for the highest extraction efficiency. Consequently, 8.0 mL of standard/sample solution was adjusted to pH 6.0 using 1.0 mL of phthalate buffer. 250 µL of the DES/DTZ probe (10 mL DES: 5.0 mg DTZ) was added to the aqueous solution to extract cobalt with the best efficiency. The DES/DTZ-LPME-FAAS system achieved a detection limit of 9.6 µg/L with a wide linear working range between 30 and 500 µg/L by applying the optimum procedure. The relative standard deviation of the proposed method was 6.9% for a 30 µg/L cobalt standard. Spike recovery experiments were conducted with tap water to evaluate the accuracy and feasibility of the developed method. By performing matrix matching, the results demonstrated good recoveries from 90% to 112%
Omitting Axillary Dissection in Triple-Negative and HER2-Overexpressed Breast Cancers With Positive Sentinel Lymph Nodes During Upfront Surgery: SENATURK-OTHELLO Study
No full textRandomized trials including ACOSOG Z0011 and SENOMAC mostly included patients with hormone receptor-positive breast cancer, but a limited number of patients with aggressive tumor biology. Therefore, we assessed the oncological safety of omitting axillary dissection in patients with SLN-positive HER2-positive or triple-negative breast cancer at upfront surgery.This retrospective cohort study included patients with clinically node-negative HER2-positive and triple-negative breast cancer who had sentinel lymph node biopsy (SLNB) alone with pN+ disease. Almost all patients (97.5%) received nodal irradiation.Between 2015 and 2020, 118 patients with HER2-positive (n = 79, 67%) and triple-negative (n = 39, 33%) tumors were included in the study from 8 centers. Of those, 94.9% were cT1-2 and 72% underwent breast-conserving surgery. Most patients (n = 98, 83.1%) had 1 metastatic sentinel lymph node. Among those with involved sentinel lymph nodes, 59 (50%) had macrometastasis, 43 (36.4%) had micrometastasis and 16 (13.6%) had isolated tumor cells. After a median follow-up of 53 months, the locoregional recurrence rate was 2.5% without any axillary recurrence, and systemic recurrence rate was 11.9%. Factors associated with worse disease-free survival were having a cT2-3 stage and a triple-negative subtype disease. Having triple-negative tumor was the only significant factor associated with worse disease-specific survival.Patients with cN0 HER2-positive and triple-negative breast cancer with low-volume axillary metastases treated with upfront SLNB-alone showed excellent local control with nodal irradiation
Omission of axillary dissection after neoadjuvant systemic treatment in initially node-positive HER2-overexpressed and triple-negative breast cancer patients: SENATURK OTHER-NAC study
No full textMore data is needed for those patients with aggressive tumor biology with a high recurrence risk for de-escalating axillary surgery in clinically N+ breast cancer. We, therefore, investigated the outcome in cN+ patients with HER2+ or triple-negative breast cancer who were treated with sentinel lymph node biopsy alone following neoadjuvant systemic treatment.Clinically N+ patients (cT1-4N1-3M0) with HER2+ and triple-negative breast cancer at admission and downstaged to cN0 with neoadjuvant systemic treatment were included in the study. All patients were treated with sentinel node biopsy alone without further axillary dissection but followed by regional nodal irradiation.Of 259 patients, the pathologic complete response rate was 47.1 %. Overall, 171 (66 %) patients had HER2+ and 88 (34 %) had triple-negative cancer. Of 56 ypN+ patients, the lymph node metastases were macrometastases in 24 (42.9 %) patients. After a median follow-up of 46 months, irrespective of ypN status, isolated axillary, locoregional, and distant recurrence rates were 0.8 %, 2.7 %, and 7.7 %, respectively. Recurrence and disease-specific death rates were not different between HER2+ and triple-negative cancer as well as ypN+ and ypN0 patients. Advanced cT stage (cT3-4) was the only significant factor associated with poor disease-free and disease-specific survivals.Irrespective of the final ypN status and tumor subtype, omission of axillary dissection resulted with low axillary recurrence rate in initially cN+ HER2+ and triple-negative breast cancer patients who were downstaged to cN0 with neoadjuvant systemic treatment and did not receive axillary dissection
Predictors of Malignancy in Patients With a Repeated Diagnosis of Bethesda Category in Thyroid Nodules Who Underwent Surgery
No full textABSTRACTFine Needle Aspiration Biopsy (FNAB) is a diagnostic modality commonly utilized in thyroid nodules, and the incorporation of the Bethesda System further enhances its diagnostic performance. However, category III nodules according to the Bethesda System are challenging due to their suspicious cytology, which renders an indeterminate risk of malignancy and requires repeated FNAB. Previous studies emphasize the possible advantage of repeated FNAB and some clinical and radiological markers in stratification of malignancy risk, though the exact predictive factors for malignancy among Bethesda III cases remain inadequately known. The aim of this study is to focus on the analysis of clinical and radiological predictors influencing malignancy risk in patients with repeated Bethesda III diagnoses. In this retrospective study, the authors reviewed three hospitals from 2015 to 2022 and retrospectively identified 120 patients with a repeat FNAB diagnosis of Bethesda III who underwent thyroid surgery. Demographic, clinical, and ultrasound data were collected, and logistic regression was performed to identify independent predictors of malignancy. The rate of malignancy was 39.2%, which was much higher than in previous reports. There were strong associations with gender, male gender, and increased risk of malignancy, with a cumulative odds ratio of 3.67. These findings suggest that repeat FNAB in association with patient‐specific factors and nodule‐specific factors, such as gender and ultrasound findings, may improve the prediction of the risk of malignancy in Bethesda III thyroid nodules. This could translate into better clinical decision‐making, avoiding unnecessary surgery, and improved outcomes for the patient overall.</jats:p
