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Une expérience personnelle des séismes : Étude des commentaires sur les réseaux socionumériques autour de la géothermie en Alsace
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Christianisme et discours global sur la modernité Colloque international (24 et 25 Avril 2025, Institut Catholique de Paris)
No full textIn face of contemporary globalization processes, Western civilization (in its dual aspect of modern science and democracy) has increasingly become an ambivalent object of reflection. Positive, critical, and/or culturalist evaluations of this civilization are now an integral part of post- and de-colonial theories themselves, which reveal the need for an intercultural discussion on the multiple configurations of modernity. The theoretical challenge that arises here consists in the possibility of legitimizing a rational community between different modern civilizations, one that rescues the spheres of science, politics, and economics from both identity particularisms and abstract universalism. As a central aspect of Western modernity, Christianity is also called upon as a phenomenon that exemplifies the current transformations in the relationship between civilizations. In being originally a contamination between two cultures (Jewish and Greco-Roman), the history of Christianity can be seen both as a dialectical process in which the West deconstructs itself by opening up to ever further configurations of its tradition and as an epistemic injustice that imposes the absoluteness of certain categories of the divine, man, and the world on other cultures. This point has been amplified by recent investigations into the key role played by the Renaissance and the Jesuit missions in shaping the concept of modernity. As a result, Christianity needs to be reinterrogated as an agent of the sometimes ambivalent processes of globalization (J. Casanova), de-limitation (H. Schelkschorn) and de-coincidence (F. Jullien). This international colloquium aims to understand whether and how Christian thinkers or notions have contributed, and still contribute, to a global discourse about modernity based on the mutual dialogue between Western and non-Western philosophical-religious traditions. Intended as an interdisciplinary reflection between philosophy, theology, political science and anthropology, this scientific event marks a first significant cooperation initiative between German-speaking and French-speaking intercultural research centers
Synthesis of single-crystalline sp2-carbon-linked covalent organic frameworks through imine-to-olefin transformation
No full textsp2-carbon-linked covalent organic frameworks (sp2c-COFs) are crystalline porous polymers with repeat organic units linked by sp2 carbons, and have attracted increasing interest due to their robust skeleton and tunable semiconducting properties. Single-crystalline sp2c-COFs with well-defined structures can represent an ideal platform for investigating fundamental physics properties and device performance. However, the robust olefin bonds inhibit the reversible-reaction-based crystal self-correction, thus yielding polycrystalline or amorphous polymers. Here we report an imine-to-olefin transformation strategy to form single-crystal sp2c-COFs. The isolated single crystals display rectangular nanotube-like domains with sizes up to approximately 24 μm × 0.8 μm × 0.8 μm, and permanent pore distribution around 1.1 nm. The highly conjugated olefin linkage endows the crystals with enhanced electronic connectivity which determines a remarkable room-temperature metal-free ferromagnetism (8.6 × 10−3 emu g−1). Our protocol is robust and generally applicable for the synthesis of single-crystalline sp2c-COFs for future spin-electron devices
Synthesis of single-crystalline sp2-carbon-linked covalent organic frameworks through imine-to-olefin transformation
No full textsp2-carbon-linked covalent organic frameworks (sp2c-COFs) are crystalline porous polymers with repeat organic units linked by sp2 carbons, and have attracted increasing interest due to their robust skeleton and tunable semiconducting properties. Single-crystalline sp2c-COFs with well-defined structures can represent an ideal platform for investigating fundamental physics properties and device performance. However, the robust olefin bonds inhibit the reversible-reaction-based crystal self-correction, thus yielding polycrystalline or amorphous polymers. Here we report an imine-to-olefin transformation strategy to form single-crystal sp2c-COFs. The isolated single crystals display rectangular nanotube-like domains with sizes up to approximately 24 μm × 0.8 μm × 0.8 μm, and permanent pore distribution around 1.1 nm. The highly conjugated olefin linkage endows the crystals with enhanced electronic connectivity which determines a remarkable room-temperature metal-free ferromagnetism (8.6 × 10−3 emu g−1). Our protocol is robust and generally applicable for the synthesis of single-crystalline sp2c-COFs for future spin-electron devices
Tracking cancer-related fatigue during chemotherapy: Insights from a comparative cohort study of early breast cancer patients.
No full textCancer-related fatigue (CRF) is a multifactorial symptom commonly experienced by breast cancer patients treated with chemotherapy (CT) that impairs quality of life and may influence cancer recurrence by reducing treatment compliance. This cohort study examined the kinetics of CRF throughout CT in breast cancer patients and determined its relationship with exercise-related variables. One hundred breast cancer patients were included. Three time points were investigated: pre-CT, 8 weeks, and post-CT. Patients were categorized as fatigued or non-fatigued according to their FACIT-F score. Exercise capacity (assessed using the 6-minute walking test), muscle mass and force, neuromuscular fatigue, and physical activity level were measured. Among the seven patterns of CRF trajectories identified, three represented 78% of the fatigued patients. Fatigued patients exhibited reduced exercise capacity compared to non-fatigued patients during CT (p = 0.001). This was associated with greater knee extensor (p < 0.001) and handgrip (p = 0.009) neuromuscular fatigue and lower physical activity level (p < 0.001) in fatigued patients. The model combining knee extensors neuromuscular fatigue (p = 0.007) and force (p = 0.081), 6-minute walking test distance (p < 0.001) and physical activity level (p = 0.029) explained 39% of the variance in the FACIT-F score evolution from pre- to post-CT. The dissociation between fatigued versus non-fatigued patients highlighted that CRF was associated with altered exercise capacity and neuromuscular fatigue. Exercise-related variables seem to play an important role in CRF evolution during CT, suggesting that exercise training should be initiated at the start of CT.journal articlecomparative study2025 Oct 152025 06 10importe
Uncovering the role of prokineticin pathway on Epicardial Adipose Tissue (EAT) development and EAT-associated cardiomyopathy
No full textEpicardial adipose tissue (EAT), a unique fat depot surrounding the heart, plays a multifaceted role in glucose and lipid metabolism, thermogenesis, and the secretion of bioactive molecules that influence cardiac structure and function. Its proximity to the myocardium allows it to contribute directly to CVDs, including coronary artery disease, arrhythmias, and heart failure. In particular, excessive EAT has emerged as a significant factor in heart failure with preserved ejection fraction (HFpEF), the most common form of heart failure, especially in individuals with obesity and diabetes. Traditional metrics like body mass index (BMI) fail to capture the complexities of visceral fat, as patients with similar BMIs can exhibit varying CVD risks. EAT accumulation induces mechanical stress and fosters a pro-inflammatory and fibrotic environment, driving cardiac remodeling and dysfunction. Pharmacological modulation of EAT has shown promise in delivering cardiometabolic benefits. Recent advancements in diabetes therapies, such as SGLT2 inhibitors and GLP-1 receptor agonists, and antilipidemic drugs have demonstrated their potential in reducing pro-inflammatory cytokine production and improving glucose regulation, which directly influences EAT. These discoveries suggest that EAT could be a significant therapeutic target, though further investigation is necessary to elucidate its role in HFpEF and other CVDs. Recent advances have identified the prokineticin/PKR1 signaling pathway as pivotal in EAT development and remodeling. This pathway regulates epicardial progenitor cells (EPDCs), promoting angiogenesis while reducing EAT accumulation and metabolic stress on the heart, particularly under high-calorie conditions. Prokineticin, acting through its receptor PKR1, limits visceral adipose tissue growth, enhances insulin sensitivity, and offers cardioprotection by reducing oxidative stress and activating cellular survival pathways. In this review, we provide a comprehensive analysis of EAT's role in CVDs, explore novel therapeutic strategies targeting EAT, and highlight the potential of prokineticin signaling as a promising treatment for HFpEF, obesity, and diabetes
A Co-catalytic nanosystem based on molybdenum disulfide and Prussian blue for synergistic chemodynamic and photothermal therapy through mitochondrial damage and ferroptosis
No full textChemodynamic therapy (CDT) is regarded as an emerging strategy with high specificity for tumor therapy by producing highly toxic reactive oxygen species (ROS) in tumor cells by a Fenton or Fenton-like reaction. Excessive ROS can cause mitochondrial damage and induce ferroptosis in cells, leading to the death of cancer cells. However, the generally low efficiency of the Fenton reaction has limited the effectiveness of CDT. Herein, two-dimensional MoS2 decorated with PB NPs is used as a co-catalyst to promote FeIII/FeII conversion and thus enhance the efficiency of the Fenton reaction. The photothermal properties of both MoS2 and PB NPs further enhance the Fenton reaction, eventually producing a large amount of ROS. Mitochondrial damage and ferroptosis caused by ROS are evidenced in vitro and in a tumor-bearing mouse model and jointly lead to a decrease in heat shock protein content, further enhancing the photothermal effect of PB NP/MoS2 nanosystem. This chemodynamic/photothermal synergistic therapy allows achieving good anticancer therapeutic effect