RISalud-ANDALUCÍA
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Age- and gender-based social inequalities in palliative care for cancer patients: a systematic literature review.
No full textObjectives: Cancer is a major public health problem worldwide, given its magnitude and growing burden, in addition to the repercussions on health and quality of life. Palliative care can play an important role improving quality of life and it is cost-effective, but some population groups may not benefit from it or benefit less based on age and gender inequalities. The aim of this systematic review was to analyze the available evidence on age- and gender-based social inequalities in access to and use of palliative care in cancer patients.
Methods: A systematic review was conducted following the PRISMA guidelines. An exhaustive literature research was performed in Pubmed, CINHAL and Embase until November 2022 and were not restricted by language or date of publication. Eligible studies were observational studies analyzing the access and use of palliative care in cancer patients.
Results: Fifty-three studies were included in the review. Forty-five analyzed age and 44 analyzed gender inequalities in relation to use of and access to palliative care. Our results show that older people receive poorer quality of care, worst symptom control and less preferences for palliative care. In relation to gender, women have a greater preference for the use of palliative care and generally have more access to basic and specialized palliative care services and palliative care facilities.
Conclusion: This review reveals difficulties for older persons and men for access to key elements of palliative care and highlights the need to tackle access barriers for the most vulnerable population groups. Innovative collaborative services based around patient, family and wider community are needed to ensure optimal care.Ye
Guía para el abordaje sanitario de la violencia de género en mujeres con problemas de salud mental.
No full textEste documento pretende ser una vía de sensibilización y hacer visible el triple estigma del que son objeto las mujeres con problemas de salud mental que, pueden tener una discapacidad y, además, sufren o han sufrido violencia de género. Asimismo, pretende ofrecer pautas de actuación que permitan a las y los profesionales de ámbito sanitario ofrecer un apoyo adecuado a las mujeres.N
Guía clínica de adecuación y prescripción de la diálisis peritoneal
No full textIn recent years, the meaning of adequacy in peritoneal dialysis has changed. We have witnessed a transition from an exclusive achievement of specific objectives -namely solute clearances and ultrafiltration- to a more holistic approach more focused to on the quality of life of these patients. The purpose of this document is to provide recommendations, updated and oriented to social and health environment, for the adequacy and prescription of peritoneal dialysis. The document has been divided into three main sections: adequacy, residual kidney function and prescription of continuous ambulatory peritoneal dialysis and automated peritoneal dialysis. Recently, a guide on the same topic has been published by a Committee of Experts of the International Society of Peritoneal Dialysis (ISPD 2020). In consideration of the contributions of the group of experts and the quasi-simultaneity of the two projects, references are made to this guide in the relevant sections. We have used a systematic methodology (GRADE), which specifies the level of evidence and the strength of the proposed suggestions and recommendations, facilitating future updates of the document.En los últimos años e ha modificado el significado de adecuación en diálisis peritoneal. Hemos asistido a una transición desde un concepto de adecuación enfocado esencialmente a la obtención de unos objetivos en determinados parámetros –aclaramiento de solutos y ultrafiltración– a una aproximación más holística centrada en la calidad de vida del paciente. El propósito de este documento es proporcionar a sus destinatarios recomendaciones, actualizadas y centradas en nuestro entorno sociosanitario, para la adecuación y prescripción de la diálisis peritoneal. El documento se ha estructurado en tres grandes apartados: adecuación, función renal residual y prescripción en diálisis peritoneal continua ambulatoria y diálisis peritoneal automática. Recientemente se ha publicado una guía sobre el mismo tema, elaborada por un Comité de Expertos de la Sociedad Internacional de Diálisis Peritoneal (ISPD) (2020). En consideración a las aportaciones del grupo de expertos de la ISPD apartados pertinentes. Se ha seguido una metodología sistemática (GRADE), que especifica el nivel de evidencia y la fuerza de las sugerencias y recomendaciones propuestas, y facilita actualizaciones futuras de la guíaYe
European Society of Clinical Microbiology and Infectious Diseases/European Committee on infection control clinical guidelines on pre-operative decolonization and targeted prophylaxis in patients colonized by multidrug-resistant Gram-positive bacteria before surgery
No full textThe aim of these guidelines is to provide recommendations for decolonization and perioperative antibiotic prophylaxis (PAP) in multidrug-resistant Gram-positive bacteria (MDR-GPB) adult carriers before inpatient surgery. These European Society of Clinical Microbiology and Infectious Diseases/European Committee on Infection Control guidelines were developed following a systematic review of published studies targeting methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci, methicillin-resistant coagulase-negative Staphylococci, and pan-drug-resistant-GPB. Critical outcomes were the occurrence of surgical site infections (SSIs) caused by the colonizing MDR-GPB and SSIs-attributable mortality. Important outcomes included the occurrence of SSIs caused by any pathogen, hospital-acquired infections, all-cause mortality, and adverse events associated with the interventions, including resistance development to the agents used and the incidence of Clostridioides difficile infections. The last search of all databases was performed on 1 November 2023. The level of evidence and the strength of each recommendation were defined according to the Grading of Recommendations Assessment, Development, and Evaluation approach. Consensus of a multidisciplinary expert panel was reached for the final list of recommendations. Antimicrobial stewardship considerations were included. The guideline panel reviewed the impact of decolonization, targeted PAP, and combined interventions (e.g. decolonization and targeted PAP) on the risk of SSIs and other outcomes in MDR-GPB carriers, according to the type of bacteria and type of surgery. We recommend screening for S. aureus before high-risk operations, such as cardiothoracic and orthopaedic surgery. Decolonization with intranasal mupirocin with or without a chlorhexidine bath is recommended in patients colonized with S. aureus before cardiothoracic and orthopaedic surgery and suggested in other surgeries. The addition of vancomycin to standard prophylaxis is suggested for MRSA carriers in cardiothoracic surgery, orthopaedic surgery, and neurosurgery. Combined interventions (e.g. decolonization and targeted prophylaxis) are suggested for MRSA carriers undergoing cardiothoracic and orthopaedic surgery. No recommendation could be made regarding screening, decolonization and targeted prophylaxis for vancomycin-resistant enterococci because of the lack of data. No evidence was retrieved for methicillin-resistant coagulase-negative Staphylococci and pan-drug-resistant-GPB. Careful consideration of the laboratory workload and involvement of antimicrobial stewardship and infection control teams are warranted before implementing screening procedures or performing changes in PAP policy. Future research should focus on novel decolonizing techniques, on the monitoring of resistance to decolonizing agents and PAP regimens, and on standardized combined interventions in high-quality studies.Ye
The Evolving Field of Acute Coronary Syndrome Management: A Critical Appraisal of the 2023 European Society of Cardiology Guidelines for the Management of Acute Coronary Syndrome
No full textAcute coronary syndromes (ACS), encompassing conditions like ST-elevation myocardial infarction (STEMI) and non-ST-elevation acute coronary syndromes (NSTE-ACS), represent a significant challenge in cardiovascular care due to their complex pathophysiology and substantial impact on morbidity and mortality. The 2023 European Society of Cardiology (ESC) guidelines for ACS management introduce several updates in key areas such as invasive treatment timing in NSTE-ACS, pre-treatment strategies, approaches to multivessel disease, and the use of imaging modalities including computed tomography (CT) coronary angiography, magnetic resonance imaging (MRI), and intracoronary imaging techniques, such as optical coherence tomography (OCT) and intravascular ultrasound (IVUS). They also address a modulation of antiplatelet therapy, taking into consideration different patient risk profiles, and introduce new recommendations for low-dose colchicine. These guidelines provide important evidence-based updates in practice, reflecting an evolution in the understanding and management of ACS, yet some potentially missed opportunities for more personalized care and technology adoption are discussed.institutional support with research funding from the Italian Ministry of Health RFGR-2021-12374500 and the Italian Ministry of University and Research—PRIN P2022RJS7X. RP: institutional support with research funding from the Italian Ministry of University and Research— PRIN P2022RJS7XYe
Socio-Economic Inequalities in Beliefs About Cancer and its Causes: Evidence From two Population Surveys.
No full textObjective
People's beliefs about cancer can affect the actions they take to prevent and detect the disease. We investigated socio-economic inequalities in beliefs about cancer and its causes in the general population.
Methods
We analyzed data from the representative probabilistic Spanish Oncobarometer survey (N = 4769, 2020) and the non-probabilistic weight-corrected Spanish Cancer Awareness Survey (N = 1029, 2022). Beliefs about cancer, recognition of cancer symptoms, and recognition of risk factors were measured with the Awareness and Beliefs about Cancer questionnaire. Endorsement of mythical causes was measured with the CAM-Mythical Causes questionnaire. The effects of socio-economic status (SES) were investigated in multiple regression analyses adjusted for age, sex, and personal and family cancer history.
Results
Individuals with lower SES were more likely to endorse pessimistic beliefs (e.g., “cancer is a death sentence”), and less likely to endorse optimistic beliefs about cancer (e.g., “people with cancer continue with normal activities”). Individuals with lower SES also recognized fewer cancer symptoms and risk factors and endorsed more mythical causes of cancer. The gap in knowledge regarding cancer causes was wider among people with low SES, who were more likely to endorse several mythical causes than some established risk factors included in cancer prevention recommendations.
Conclusions
Socio-economic inequalities in beliefs about cancer are robust and multidimensional and indicate worse preparedness to act against the disease among lower socio-economic groups. Differences in beliefs about disease outcomes and causes are likely one of the multiple contributors to cancer disparities and should be targeted and monitored in prevention efforts.The Onco‐barometer survey was funded by the Cancer Observatory of the Spanish Association against Cancer (Asociación Española contra el Cáncer, www.aecc.es). This research was partially supported by grants from the Spanish Association against Cancer (High‐Resolution Study of Social Inequalities in Cancer (HiReSIC), PROYE20023SÁNC), the Cancer Epidemiological Surveillance Subprogram of the CIBER of Epidemiology and Public Health and the Health Institute Carlos III (VICA), CIBERESP CB06/02/0073, 2021SGR01354 and PI18/01593 EU/FEDER, and the Ministry of Science and Innovation (PDC2022‐133293‐100, CEX2020‐001105‐M/AEI/10.13039/501100011033 Spain), Strategic Action in Health (DTS23/00032, Spain). This research was also supported by the Mexican Government through the CONAHCYT scholarship program “Becas de Posgrado para Maestrías y Doctorados en Ciencias y Humanidades en el extranjero 2024”, awarded to SIGP. DP is supported by a Miguel Servet Fellowship (CP23/00024) from the Health Institute Carlos III. Funding for open access charge: Universidad de Granada /CBUA. The funders had no role in study design, analysis, decision to publish, or preparation of the manuscript.Ye
Estrategia de promoción de una vida saludable en Andalucía: 2024-2030
No full textAprobada por el Consejo de Gobierno de la Junta de Andalucía el 2 de abril de 2024.Esta estrategia pretende promover los hábitos saludables en toda la población y edades, mediante intervenciones en el ámbito local, en todos los entornos de vida y en todas las políticas, y actuaciones sobre los determinantes que generan desigualdades en salud. Así mismo, propone potenciar los activos personales y comunitarios que generan salud a lo largo de la vida, para que la ciudadanía pueda afrontar el día a día con mayores cotas de bienestar.N
Vol. 29, nº 26. Brote de gastroenteritis por Norovirus genogrupo II en una casa rural de Granada: utilidad de las encuestas epidemiológicas a través de REDCap.
No full textEnfermedades de Declaración Obligatoria por provincias. Semana 25/2024 y acumulado desde la semana 01/2024. Datos provisionales. Incluye además el artículo titulado “Brote de gastroenteritis por Norovirus genogrupo II en una casa rural de Granada: utilidad de las encuestas epidemiológicas a través de REDCap.”, de “María Ángeles Rubín Gómez, Basilio Gómez Pozo, Begoña López Hernández, Diego Almagro Nievas.”.N
Libro de Abstracts del V Simposio del Área de Medicina de Precisión del ibs.GRANADA (2024)
No full textIdentification of novel biomarkers in the diagnosis and prognostic of heritable thoracic aortic disease and bicuspid aortic valve by
untargeted liquid chromatography coupled to high resolution mass spectrometry-based metabolomics: a pilot study - P01 -
Control del metabolismo inmunológico como una estrategia para el tratamiento de la disfunción vascular y la hipertensión en un
modelo murino genético de lupus eritematoso sistémico - P02 -
Acumulación de variantes raras en genes expresados en estereocilios de células ciliadas, membrana tectoria y estría vascular en la
arquitectura genética de la Enfermedad de Meniere - P03 -
Acúfeno crónico y su relación con la pérdida auditiva y la función cognitiva - P04 -
Evaluación del uso de nuevas herramientas de valoración de la composición corporal en pacientes con anorexia nerviosa - P05 -
Estandarización de la evaluación clínica de pacientes con ojo seco en cavidades anoftálmicas en un estudio de vida real - P06 -
Tratamiento del ojo seco mediante inyección de toxina botulínica en el músculo orbicular de los párpados - P07 -
Identificación y caracterización funcional de variantes genéticas en los genes CDKN2A y Bcl2 como nuevos biomarcadores de
susceptibilidad para el riesgo de desarrollar leucemia linfática crónica - P08 -
Cambios en el perfil de expresión de miRNA tras suplementación de la dieta con Aceite de Oliva Virgen Extra en pacientes con
Lupus Eritematoso Sistémico - P09 -
Exercise, diet and psychological support improves surgical prognosis in patients undergoing resection of colon cancer: preliminary
results from the oncofit randomized controlled trial - P10 -
Water biosense Ⓡ, una tecnología innovadora para la monitorización a tiempo real de agentes infecciosos y biomarcadores en aguas
residuales - P11 -
Valor predictivo del índice de salud prostática (PHI) en el diagnóstico del cáncer de próstata - P12 -
Tratamiento adyuvante intravesical en pacientes con cáncer de vejiga no músculo invasivo: Resultados de un estudio prospectivo
comparativo entre BCG y Mitomicina C aplicada con COMBAT o EMDA - P13 -
Mitomicina C con Hipertermia Conductiva vs. Energía Electromotriz en el Tratamiento del Cáncer de Vejiga No Músculo Invasivo:
Resultados Iniciales - P14 -
Effects of Gestational Diabetes on their Children’s Brain Structure at 8-Year-Old: The GD-Brain Project - P15 -
Intervention with "mHealth coaching" to optimize health in pregnant women at high risk of gestational diabetes and their children:
The Impact Diabetes B2B EU Project - P16 -
Nueva estrategia terapéutica para revertir la quimioresistencia mediante la modulación de NRF2 y del metabolismo mitocondrial:
efectos de la melatonina - P17 -
Mecanismos moleculares de la sarcopenia: Efecto protector del ejercicio y la melatonina en un modelo de ratón knockout para
Bmal1 - P18 -
Consecuencias conductuales y desarrollo de abuso de alcohol en la adolescencia tras la exposición prenatal al alcohol en ratas
gestantes: estrategias de tratamiento y prevención mediante una dieta antioxidante - P19 -
El antagonismo SIGMA-1 y la inhibición de la epóxido hidrolasa soluble inhiben sinérgicamente la alodinia táctil inducida por
capsaicina y por una incisión quirúrgica - P20 -
La inhibición de la epóxido hidrolasa soluble potencia el efecto analgésico del antagonismo SIGMA-1 en el dolor asociado a la
artritis reumatoide - P21 -
Nueva estrategia para la detección precoz de VIH oculto desde los servicios de microbiología - P22 -
Análisis de 16 Años de Transmisión de Resistencia a ARV en Nuevos Diagnósticos de VIH en España (2007-2023): Actualización de
2023 e Impacto de la PrEP en la Detección de M184V - P23 -
Uso de los cuadruplex de guanina como nueva diana terapéutica en infecciones - P24 -
Mortalidad intra-hospitalaria y tardía en pacientes con hemorragia digestiva alta en tratamiento antitrombótico. Efectos de la
suspensión y reintroducción - P25 -
Papel crucial de las células T CD4+ en el desarrollo de la disfunción endotelial inducida por la microbiota intestinal de pacientes
con lupus e hipertensión - P26 -
Hidroxiprolina como marcador urinario en pacientes trasplantados renales - P27 -
Papel regulador de la actividad quinasa de LRRK2 en la función proteolítica del lisosoma en la enfermedad de Parkinson - P28 -
El probiótico Lactobacillus fermentum CECT5716 aumenta la respuesta antihipertensiva de la hidroclorotiazida en ratas
espontáneamente hipertensas - P29 -
Función barrera intestinal y fosfatasa alcalina no específica de tejido - P30 -
Evaluación del efecto del aceite de oliva virgen extra rico en compuestos minoritarios sobre el estado oxidativo e inflamatorio
en niños y adolescentes con obesidad e hipertensión - P31 -
La vasorina regula la adipogénesis y el metabolismo lipídico en adipocitos marrones - P32 -
Dietary patterns derived by reduced-rank regression and cardiometabolic risk factors: a cross-sectional analysis of the Spanish
pediatric cohort IBEROMICS - P33 -
El metaboloma de Limosilactobacillus fermentum protege frente a la tumorigénesis colorrectal a través de la via TLR5-NF-kB-p53 - P34 -
Implante de marcapasos sin electrodo en pacientes sometidos a extracción de electrodos de dispositivos de electroestimulación - P35 -
Tratamiento endovascular de la aorta ascendente mediante técnica combinada de implante TAVI y TEVAR - P36 -
Aplicación de un panel NGS para investigar las reacciones adversas antiplaquetarias en pacientes con SCA sometidos a ICP con
implantación de STENT - P37 -
Proteínas β-conglutinas del altramuz azul (Lupinus angustifolius L.) como nuevos radiosensibilizadores naturales en cáncer de mama - P38 -El ibs.GRANADA organiza el V SIMPOSIO DE MEDICINA DE PRECISIÓN, que tendrá lugar el viernes 27 de septiembre de 2024 en el Salón de Actos de la Facultad de Medicina de la Universidad de Granada.
El objetivo de este simposio es presentar las principales líneas de investigación llevadas a cabo en el área de la medicina de precisión por grupos del ibs.GRANADA y grupos afines a estas áreas de conocimiento, así como proporcionar conocimiento sobre la investigación biomédica que se está realizando en el ibs.GRANADA.N
Associations of milk, dairy products, calcium and vitamin D intake with risk of developing Parkinson´s disease within the EPIC4ND cohort.
No full textLiterature indicates a potential association between dairy consumption and risk of Parkinson´s disease (PD), especially among men, yet the results remain inconclusive. We investigated this association in a large prospective European cohort. Dietary and non-dietary data was collected from 183,225 participants of the EPIC-for-Neurodegenerative-Diseases (EPIC4ND) cohort, a sub-cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Crude and multivariable-adjusted Cox proportional hazards models were employed to examine potential associations between baseline dietary intake of dairy, calcium and vitamin D with incident PD risk. No relationship was observed between dairy consumption (HR 1.07, 95% CI 0.82-1.39), individual dairy products (milk: HR 0.95, 95% CI 0.73-1.23; yogurt: HR 1.03, 95% CI 0.82-1.29; cheese: HR 1.13, 95% CI 0.85-1.51), or vitamin D (HR 1.08, 95% CI 0.80-1.45) with PD risk. However, we observed a risk-increasing association with higher calcium intakes (HR 1.33, 95% CI 1.00-1.78, p for trend = 0.031), which was more pronounced in men (HR 1.50, 95% CI 1.00-2.25, p for trend = 0.044) and in ever smokers (HR 1.64, 95% CI 1.06-2.53, p for trend = 0.014). No compelling evidence was found for an association between dairy products or vitamin D intake and PD risk indicating a potentially limited relevance of dairy intake in PD risk than previously described. Our observations of a positive association between dietary calcium intake and PD risk in men and in ever smokers require further validation.Ye