The Egyptian Cardiothoracic Surgeon (ECTS - E-Journal)
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Grandparents’ Stories of Family Life After Donor Conception (Parents of lesbian couples with children conceived using donor sperm)
No full textThis leaflet is written for the parents of lesbian couples who have, or are planning, children using donor conception. It is based on many hours of research interviews, during which parents and grandparents of donor conceived children told us about their experiences of family life after donor conception.This leaflet is one of a four part series written for parents and grandparents of donor-conceived children. It is based on research from the 'Relative Strangers' project, which was funded by the ESRC
A validated mouse frailty index to assess longevity interventions: Impact of species, calorie restriction and resveratrol.
No full textModeling the facet growth rate dispersion of beta l-glutamic acid - Combining single crystal experiments with nD particle size distribution data
No full textMaintenance pazopanib versus placebo in Non-Small Cell Lung Cancer patients non-progressive after first line chemotherapy: A double blind randomised phase III study of the lung cancer group, EORTC 08092 (EudraCT: 2010-018566-23, NCT01208064).
No full textBACKGROUND: Switch maintenance is an effective strategy in the treatment of advanced Non-Small Cell Lung Cancer (NSCLC). Pazopanib is an oral, multi-targeted tyrosine kinase inhibitor (TKI). EORTC 08092 evaluated pazopanib given as maintenance treatment following standard first line platinum-based chemotherapy in patients with advanced NSCLC. METHODS: Patients with non-progressive disease after 4-6 cycles of chemotherapy were randomised to receive either pazopanib 800mg/day or matched placebo until progression or unacceptable toxicity. The primary end-point was overall survival and secondary end-points were progression-free survival (PFS) and safety. RESULTS: A total of 600 patients were planned to be randomised. The trial was prematurely stopped following an early interim analysis, after 102 patients were randomised to pazopanib (n=50) or placebo (n=52). Median age was 64years in both arms. Median overall survival was 17.4 months for pazopanib and 12.3 months for placebo (adjusted hazard ratio (HR) 0.72 [95% confidence interval (CI) 0.40-1.28]; p=0.257). Median PFS was 4.3 months versus 3.2 months (HR 0.67, [95% CI 0.43-1.03], p=0.068). PFS rates at 4 months were 56% and 45% respectively. The majority of treatment-related adverse events (AEs) were grade 1-2. Grade 3-4 AEs (pazopanib versus placebo) were hypertension (38% versus 8%), neutropenia (8% versus 0%), and elevated SGPT (6% versus 0%). Of the patients randomised to pazopanib, 22% withdrew due to a treatment-related AE. CONCLUSIONS: Switch maintenance with pazopanib following platinum-based chemotherapy in advanced NSCLC patients had limited side-effects. This study was stopped due to lack of efficacy by stringent criteria for PFS at a futility interim analysis
Electrochemical assessment of characteristics and corrosion behavior of Zr-containing coatings formed on titanium by plasma electrolytic oxidation
No full textCommercially pure (CP) titanium was treated by plasma electrolytic oxidation in phosphate and zirconate electrolytes. The microdischarge behavior and corrosion properties of plasma electrolytic oxidation coatings containing zirconium on CP-Ti prepared in electrolytes containing various additive concentrations under different duty cycles were studied by scanning electron microscopy (SEM) and electrochemical impedance spectroscopy (EIS). Electrochemical corrosion tests indicated that the PEO coating formed in zirconate solution under an appropriate duty cycle showed a much superior stability during the corrosion tests and provided an efficient corrosion protection. Relationships are drawn between PEO applied duty cycle, electrolyte concentration and corrosion performance. The protective coatings treated at lower duty cycles had higher corrosion resistance during long time immersion in sodium chloride solution due to more compact microstructural features. The EIS analysis of the PEO coating provided information about the evolution of internal structure of the coating with duty cycle of the process
Post-irradiation annealing of Ni-Mn-Si-enriched clusters in a neutron-irradiated RPV steel weld using Atom Probe Tomography
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Inappropriate Neural Activity during a Sensitive Period in Embryogenesis Results in Persistent Seizure-like Behavior.
No full textMaturation of neural circuits requires activity-dependent processes that underpin the emergence of appropriate behavior in the adult. It has been proposed that disruption of these events, during specific critical periods when they exert maximal influence, may lead to neurodevelopmental diseases, including epilepsy [1-3]. However, complexity of neurocircuitry, coupled with the lack of information on network formation in mammals, makes it difficult to directly investigate this hypothesis. Alternative models, including the fruit fly Drosophila melanogaster, show remarkable similarities between experimental seizure-like activity and clinical phenotypes [4-6]. In particular, a group of flies, termed bang-sensitive (bs) mutants have been extensively used to investigate the pathophysiological mechanisms underlying seizure [7-12]. Seizure phenotype can be measured in larval stages using an electroshock assay, and this behavior in bs mutants is dramatically reduced following ingestion of typical anti-epileptic drugs (AEDs; [13]). In this study we describe a critical period of embryonic development in Drosophila during which manipulation of neural activity is sufficient to significantly influence seizure behavior at postembryonic stages. We show that inhibition of elevated activity, characteristic of bs seizure models, during the critical period is sufficient to suppress seizure. By contrast, increasing neuronal excitation during the same period in wild-type (WT) is sufficient to permanently induce a seizure behavior. Further, we show that induction of seizure in WT correlates with functional alteration of motoneuron inputs that is a characteristic of bs mutants. Induction of seizure is rescued by prior administration of AEDs, opening a new perspective for early drug intervention in the treatment of genetic epilepsy