Rubatosis Publications (E-Journals)
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Buccal films: A review of therapy possibilities, treatment plans and appropriate evaluation techniques
Get PDFDue to apparent greater patient acceptance compared to buccal tablets and enormous therapeutic opportunities compared to traditional oral drug delivery methods, particularly for those who suffer from dysphagia, the potential of the mucoadhesive film technology is difficult to ignore. Despite this, there are currently no authorised mucoadhesive buccal films, and the translation of published literature into the commercial market is essentially non-existent. In order to help this patient-centred dosage form become more widely used, this review aims to give an overview of mucoadhesive buccal film technology and highlight crucial areas on which to concentrate scientific efforts. While discussing the patient-related aspects influencing the utilisation of various dosage forms, a number of indications and development potential were noted. A technical description of the processes used to create these films, including solvent casting, hot melt extrusion, inkjet printing, and three-dimensional printing, was also offered. The utilisation of more than thirty mucoadhesive polymers in film formulations was found, and information about their mucoadhesive properties as well as their inclusion with other essential formulation ingredients was supplied
SCREENING OF NOVEL AMINOPYRIMIDINE DERIVATIVES AGAINST HUMAN CDK-8 ENZYME: AN INSILICO APPROACH
Get PDFThe Human CDK8-CYCC in complex with compound 4: N-methyl-4-(4-pyridyl)-1H-pyrrole-2-carboxamide (PDB ID: 5XQX) was obtained from Protein Data Bank . These aminopyrimidine compounds are designed insilico with help of Chemsketch. The molecular docking study was performed using AutoDock vina software. The active binding site of the compounds were screened in the Biovia-2019.ds2019client. The pharmacokinetics and physiochemical properties were calculated in SwissADME. The toxicity of the compound is studied by using PreADME and PreTox-Ⅱ Prediction software.The designed compounds shows a better binding affinity than the standard drug 5-fluro uracil and based on the toxicity studies performed , the compounds are non-toxic in nature. This study leads to the development of novel aminopyrimidine derivatives as anticancer agent against Human cyclic dependent kinase (CDK-8) enzyme
Formulate and evaluate once daily sustained release tablet of highly soluble drug of metformin HCL
No full textThe aim of the present study was to design an oral sustained release matrix tablet of highly water soluble biguanide anti diabetic drug. The matrix tablets are prepared by melt granulation method using HPMC K 200M as hydrophilic drug release retarding polymer, and stearic acid as melt able binder as well as hydrophobic carrier. The drug and excipients compatibility was studied by FT – IR. The formulated matrix tablets were characterized for physical parameters and in vitro dissolution profile. FT – IR spectra revealed the absence of drug excipients interaction. The physical parameters of the tablets were found within the limits. The drug release kinetics demonstrated that by increasing the concentration of hydrophilic polymer and hydrophobic carrier the drug release rate was retarded proportionally. Kinetic modelling of in vitro release profile revealing that the drug release from the matrix tablets following first order kinetics, and the drug release mechanism of optimized (F7) formula following non fickian transport mechanism. Accelerated stability studies were performed according to ICH guide lines. Temperature 40±20 c and relative humidity 75±5% RH to study physical and chemical changes of formulation. No physical or chemical changes were observed after t accelerated stability studies
Formulation And Evaluation Of Dutasteride Coated Microneedles For The Treatment Of Hair Loss
No full textCoated microneedles have been shown to deliver proteins and DNA into the skin in a minimum invasive manner. Still, detailed studies of preparing coated microneedles and their breadth of applicability are lacking. Male androgenetic alopecia is the most commonly known form of scalp hair loss in men and as a part of hormone therapy in transgender women. Till now, in India dutasteride is marketed as a topical solution in an aqueous vehicle in the treatment of alopecia. A high percentage of alcohol present in marketed formulations as a permeation enhancer was known to damaged hair, hair follicle, and scalp epidermal cells due to dehydration. The goal of the study was to enhance the permeation of drugs with the aid of microneedles, thus reducing the concentration of alcohol and damage of scalp cells. A microsyringe was used to coat each needle present on the roller. Coated microneedles were studied for coating uniformity, in-vitro drug release. The drug release profile of coated microneedles was found to be comparable with the marketed solution of minoxidil of the same strength
Challenges in Neonatal Screening in Health Care System
No full textNeonatal screening is a vital process that identifies apparently healthy neonates with serious inherited disorders, which are generally metabolic in origin and correctable by dietary or drug interventions. Comprehensive screening programs for congenital diseases of newborn infants are lacking at an international level.This article will review the challenges involved in the implementation of a sustainable program of new born screening
Need of silver nanoparticles for better antidiabetic drug delivery – an overview
Get PDFGrowth and applications of nano science and nanoparticles have a great footprint in recent years. There is increasing optimism that nanotechnology, as applied to medicine, will bring significant advances in the diagnosis and treatment of disease.Working with these extremely small structures is very much interesting due to its unique properties. Drug delivery and related pharmaceutical development in the context of nanomedicine should be viewed as science and technology of nanometer scale complex systems, consisting of at least two components, one of which is a pharmaceutically active ingredient. Hyperglycaemia occurs because of uncontrolled hepatic glucose output and reduced uptake of glucose by skeletal muscle with reduced glycogen synthesis. Nowadays, to develop nanoscaled systems has become a prominent strategy to improve the drug delivery of phytochemicals. In this review, we primarily summarized the significance of nanotechnology followed by its importance in herbal antidiabetic drug delivery. Equipped With high scale production possibility, Long stability and Freeze dried to form powder formulation silver nanoparticles are determined for better herbal drug targeting in Diabetes Mellitus
Formulation And Evaluation Of Mucoadhesive Buccal Films Of Enalapril Maleate
Get PDFNowadays, extensive research is being carried out on the design and development of innovative drug delivery systems to improve safety, efficacy, and patient compliance. One such delivery system is the buccal film technology. The buccal mucosa is the best-suited site for local, as well as systemic delivery of drugs due to its physiological features. The goal of designing oral mucoadhesive buccal film for the anti-hypertensive drug Enalapril maleate is to increase the bioavailability. The formulation and evaluation of oral mucoadhesive buccal films of Enalapril maleate by solvent casting method. The Enalapril maleate is an anti-hypertensive drug that has high first-pass metabolism and shows 40-60% of bioavailability. Due to this condition, we took this drug to convert into films, which increases its bioavailability by decreasing the first mass metabolism. The preparation contains different formulations by using different polymers like Hydroxypropyl methylcellulose E 5 (HPMC), Hydroxypropyl methylcellulose E 50 (HPMC), and different plasticizers like PEG 400 & PG. The films of physicochemical evaluations like thickness (0. 14±0.004 mm), tensile strength 120.23 (g/cm2), % Drug content uniformity (97.6± 1.040%), surface pH (6.74±0.051), the swelling index is in the optimum range, folding endurance ( 175±2), and diffusion studies showed the optimum release of drug in the predetermined time
Validation of high performance liquid chromatography mass spectrometric method in positive ion mode for the estimation of Clopidogrel in human plasma using Clopidogrel D4 as internal standard
Get PDFThe present project work was to develop a robust, rapid, simple and sensitive liquid chromatography mass spectrometry (LC-MS/MS) assay method for the quantification of clopidogrel in human plasma. A high performance liquid chromatography mass spectrometric method for the estimation of clopidogrel, in human plasma in positive ion mode was developed and validated using clopidogrel d4 as internal standard (is). Sample preparation was accomplished by solid phase extraction method. The eluted samples were chromatographed on kromasil 100 5c18, 100 x 4.6 mm, 5 µm (make: akzo nobel) using a mobile phase consisting of hplc grade acetonitrile: milli q/hplc grade water (90:10, v/v) the method was validated over a concentration range of 0.031 ng/ml to 15.077 ng/ml for clopidogrel. This validation report provides the results of analyte selectivity, matrix selectivity, matrix effect, sensitivity determinations, calibration standards and quality control samples data, precision and accuracy data, the results of recovery, various stabilities, run size evaluation and dilution integrity along with all pertinent documentation
Development and validation of new analytical method for the simultaneous estimation of amitriptyline and perphenazine in bulk and pharmaceutical dosage form by RP-HPLC
No full textA new, simple, precise, accurate and reproducible RP-HPLC method for simultaneous estimation of Amitriptyline and Perphenazine in bulk and pharmaceutical formulations was developed. Separation of Amitriptyline and Perphenazine was successfully achieved on Inertsil ODS (250x4.6mm) 5µm column in an isocratic mode utilizing Methanol: ACN: Water (50:30:20) at a flow rate of 1.0 ml/min and eluents were monitored at 253nm with a retention time of 2.440 and 5.503 minutes for Amitriptyline and Perphenazine respectively. The method was validated and it was found to be linear. The values of the correlation coefficient were found to 0.992 for Amitriptyline and 0.9992 for Perphenazine respectively. The LOD for Perphenazine and Amitriptyline were found to be and 33.8µg/ml and 4.2 µg/ml. The LOQ for Perphenazine and Amitriptyline were found to be 20.88µg/ml and 12.12µg/ml respectively. The percentage recoveries for Amitriptyline and Perphenazine were found to be within the limit indicates that the proposed method is highly accurate. The method was extensively validated according to ICH guidelines
Dendritic nanoparticulated carriers for the delivery of Rifampicin
No full textThe present study was aimed at developing and exploring the use of PPI dendrimers for delivery of anti-tuberculosis drug, Rifampicin (RMP). RMP was selected for incorporation into dendrimers based on its antitubercular activity, short biological half-life and solubility characteristics. For this study, poly(propyleneimine) dendritic architecture was loaded with Rifampicin.Various physicochemical and physiological parameters like UV, FT-IR, TEM, DSC, zeta potential, drug entrapment and drug release of formulations were determined. By constructing drug release kinetics, the release mechanism followed was a non fickian diffusion. In this, the system was found to have increased their drug-loading capacity, reduced their drug release rate. Therefore the system was found to be suitable for prolonged delivery of Rifampicin