Rubatosis Publications (E-Journals)
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Bromelain as an anti-inflammatory and anti-cancer compound
Get PDFInflammation is a complicated problem for today’s human beings. Large numbers of people have been diagnosed with arthritis along with inflammation. This is beside the others that suffer inflammation caused by an injury. There are alternatives that can be considered as temporary or permanent treatments of chronic inflammatory diseases. Plants, as well as other biological resources, are most welcomed to the therapeutic area. Using the plants’ compounds with high potential as novel techniques are today’s bio-pharmacologist concern. Bromelain has been more attractive due to its characteristics. This review is an overview of anti-inflammatory and anti-cancer effect of bromelain as a confident treatment for all inflammatory disease
Formulation and evaluation of matrix tablets of Eperisone hydrochloride
Get PDFThe aim of the present research is to develop and optimize Eperisone Hydrochloride extended release matrix tablets. Eperisone Hydrochloride is an antispasmodic drug mainly used to relieve pains it acts by relaxing the skeletal and smooth vascular muscles by blocking spinal reflexes drug which has oral bioavailability of 70% due to hepatic metabolism. Sustained release matrix tablets of Eperisone Hydrochloride were prepared through wet granulation technique by using HPMC K4M and EC as polymers, PVPK30 as binder, Magnesium stearate as lubricant and Talc as glidant. The granules of different formulations were determined for pre compression parameters. The prepared granules along with the excipients were then compressed. The formulated tablets were evaluated for physical characteristics viz. Hardness, Thickness, % Weight variation, Friability and the drug content. Furthermore the tablets evaluated for the in vitro release studies. Out of all the 8 formulations F7 showed desired characteristics in the physical parameters and in vitro drug release of 85.48% in 12hrs.The F7 dissolution data was best fitted to the Zero order model. The prepared Eperisone Hydrochloride matrix tablets found to be having a potential extended drug release
Development and validation of RP-HPLC method for the simultaneous estimation of Valsartan and Sacubitril in pharmaceutical dosage form
Get PDFThe Present work was to develop a simple, fast, accurate, precise, reproducible, Reverse Phase High Performance Liquid Chromatographic Method for simultaneous estimation of Valsartan and Sacubitril in Pharmaceutical dosage form. Chromatographic separation trials were done using three columns and four mobile phases in different ratios. Columns used are Thermosil C18 column(100mm×4.6mm)5µm, Xterra C18 column(150mm×4.6mm)5µm and Chromosil C18 column having dimension of (150mm x 4.6 mm)5µm and mobile phase used are water, methanol, acetonitrile, phosphate buffer in different logic ratios based on polarity, with mobile phase consisting of Phosphate buffer (KH2PO4 and K2HPO4) pH 3 ±0.02 pH adjusted with ortho phosphoric acid and Acetonitrile (25:75 %v/v), flow rate was adjusted to 1ml/min and detection wavelength at 254nm. The retention times of Valsartan and Sacubitril was found to be 2.589 and 3.711mins. The proposed method has been validated for accuracy, precision, linearity, robustness and range were within the acceptance limit according to ICH guidelines. Linearity for Valsartan and Sacubitril were found in range of 0.2µg-0.6µg and 0.1µg-0.3µg and correlation coefficient were found to be 0.999 and 0.999 respectively. %RSD for intermediate precision was found to be 0.1 and 0.2, for repeatability was 0.2 and 0.5, % mean recovery for Valsartan and Sacubitril was found to be 99.77% to 100.12% respectively. The method was found to be robust even by change in the mobile phase ±5% and in less flow condition. The developed method can be successfully employed for the routine analysis of Valsartan and Sacubitril in API and Pharmaceutical dosage forms
A new analytical method for determination of ledipasvir and sofosbuvir in pharmaceutical formulations by HPLC method
No full textA simple, Accurate, precise method was developed for the simultaneous estimation of the Sofosbuvir and Ledipasvir in Tablet dosage form. Chromatogram was run through Std Discovery C8 150 x 4.6 mm, 5m. Mobile phase containing Buffer 0.1% OPA: Acetonitrile taken in the ratio 60:40 was pumped through column at a flow rate of 1 ml/min. Buffer used in this method was 0.1% OPA buffer. Temperature was maintained at 30°C. Optimized wavelength selected was 260 nm. Retention time of Sofosbuvir and Ledipasvir were found to be 2.367 min and 3.436 min. %RSD of the Sofosbuvir and Ledipasvir were and found to be 0.6 and 0.5 respectively. %Recovery was obtained as 99.61% and 99.80% for Sofosbuvir and Ledipasvir respectively. LOD, LOQ values obtained from regression equations of Sofosbuvir and Ledipasvir were 0.67, 2.02 and 0.70, 2.12 respectively. Regression equation of Sofosbuvir is y = 4266.x + 7700, and y = 4861.x + 2656.of Ledipasvir. Retention times were decreased and run time was decreased, so the method developed was simple and economical that can be adopted in regular Quality control test in Industries
Formulation characterisation and in-vitro evaluation of liposomal drug delivery system of sitagliptin for prolonged release
Get PDFSitagliptin is widely used for the treatment of diabetes; the intention of the present study was to formulate Sitagliptin liposomes for a Prolonged drug delivery system. It have the advantages of dose reduction, less dosing frequency, minimize the side effect, prolong the action of drug and thus achieve better patient compliance. The liposomes were prepared by physical dispersion and ether injection method. Soya lecithin and cholesterol were used for encapsulating the drug, it facilitates to release the medicaments in sustained manner. Chloroform, ether and methanol were used as a solvent. Phosphate buffer pH 6.8 was used as a hydration medium for loading the drug. The final liposome was evaluated in various quality parameters of drug entrapment efficiency, morphological analysis, particle size analysis, in-vitro drug release studies and stability studies. In the two methods of Sitagliptin liposome formulation the ether injection method showed prolonged action when compared to physical dispersion method. In the parameters of drug entrapment and stability physical dispersion method was shows better results
Osmotic drug delivery system of valsartan
No full textThe objective of this study is to design and evaluate a new EOP called swellable elementary osmotic pump (SEOP) of the freely water soluble drug, amitriptyline hydrochloride (1 g /mL) by adding water swellable polymers in the core. The hydrophilic polymers included in the core retard the highly water soluble drug by producing hydrogel within the core, which may restrict and delay the solvent contact with drug molecules and may increase the diffusional length of the solvent to achieve a constant release rate. Thus, this technology can be exploited to achieve constant drug release at predetermined rate especially for highly water soluble drugs
ODFs: a multi-faceted aid to the formulator
No full textThe first films introduced into market are around 1970, from then there are many new technologies are developed in preparation and also using polymers. From Natural to synthetic polymers each polymer has their advantages over one another. Various techniques in preparation of oral films such as solvent casting, semi-solid casting, hot-melt extrusion, solid dispersion extrusion and rolling to the modern techniques are developed from time to time. The most recent technique used is 3D printing which forms the films by forming layer on layer. In this literature along with polymers used, methods for preparing of films; approved drugs in orange books and present clinical trial studies were discussed
DESIGN AND SYNTHESIS OF ANTIMICROBIAL LINEAR TETRAPEPTIDES AND HETEROCYCLIC RING CONJUGATED TETRAPEPTIDES: A COMPREHENSIVE REVIEW
No full textABSTRACT:
Peptides having a number of therapeutic activities, In which sequence of antimicrobial peptides plays an important role in antimicrobial activity. Antimicrobial peptides are potential alternatives for conventional antibiotics. Our objective is to collect important different types of linear antimicrobial peptides . We are doing a comprehensive review on linear antimicrobial tetrapeptides.
 
Survey on Cosmetic Consumption in Delhi and NCR
No full textThe aim of this study was to conduct an online survey to investigate the consumption of cosmetics by general public and more specifically by the student community in Delhi and NCR. An 11-point structured questionnaire was prepared and posted online to the study participants. A total of 206 responses were received out of which 191 (92.7%) were received from the students. Most of the participants (n= 195) belonged to the age group of 20-30 years (94.7%). A higher number of the respondents (45%) believe that expensive cosmetic items are superior to a cheaper ones as compared to those who were not in agreement to the above observation (36%). Majority of the respondents preferred to use cosmetics with natural ingredients (66%) as compared to those who were willing to purchase synthetic ones (30%). Accordingly, most of the consumers were willing to pay more for herbal cosmetics (70%). Facial care was the most considered factor for buying cosmetics (n=119, 57.8%). Most of the participants preferred to purchase cosmetic from community pharmacies and e-commerce sites (25% each) rather than departmental store and shopping mall. A good number of participants (33%) purchased cosmetics based on the claims of the manufacturer whereas a significant majority of the respondents were more judgemental and considered quality of cosmetic products as a major factor. In the wake of plethora of available information resources; it is recommended that the consumers should make informed choices prior to the purchase of cosmetics rather than being influenced by the manufacturer claims. The present study might help various cosmetic companies to formulate their strategies for marketing the cosmetic products
Development and validation of UV-visible spectrophotometric method for determination of Bicalutamide in bulk and in pharmaceutical dosage form
Get PDFThe aim of the present study, simple and sensitive spectrophotometric method was developed for the estimation and validation of Bicalutamide in bulk and Pharmaceutical dosage form by UV spectroscopy as per ICH guidlines. The maximum absorbance (λmax) of Bicalutamide in methanol was found to be 272 nm against methanol as a blank. The Bicalutamide obeys the Beers law in the concentration range 2.5 to 15 μg/ml with a correlation coefficient of 0.999. The proposed method was applied for the estimation of Bicalutamide in pharmaceutical dosage form and % purity was found to be 99.96 to 100.06 that indicate the good agreement with the label claim. The accuracy of the proposed method was determined by recovery study at three different levels (50%, 100%, and 150%). The % recovery was found to be 99.6 to 100.2%. The precision study was carried out by intraday and interday. The % RSD was found to be < 2 which indicates that the method is precise. The proposed method was a fast technique for the routine analysis of Bicalutamide in bulk and pharmaceutical dosage form