Rubatosis Publications (E-Journals)
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Evaluation of pharmacological activity of chadraprabha vati on serum of albino wistar strain rats
No full textThe current study is to develop the acute and sub-acute toxicity profile of some ayurvedic Bhasma and un-derstand the side effects due to the presence of heavy metals. Chandraprabha vati pill were weighed, powdery and suspended in water had made into liquid formulation. The animals were classified and treated with the doses of Chandraprabha vati (50and five hundred mg/kg) in rat. The dose was calculat-ed by extrapolating the equivalent human dose (1 and ten times) and was administered orally between ten and eleven after median daily for twenty eight days, during alylin a very volume not exceeding one ml/100 g rat weight. Blood was collected on seven, fourteen and twenty eight days, later they were sacri-ficed for histopathological studies
The self-medication practice in primary dysmenorrhea among pharmacy students-a cross-sectional questionnaire study
Get PDFPrimary dysmenorrhea is one of the most common gynecological problems among adolescent females which interferes with daily activities, affecting their physical and emotional aspects and has a negative impact on the quality of life. The pain is usually in the pelvis or lower abdomen. Self-medication for primary dysmenorrhea is a very common practice. The aim of this study was to observe and evaluate self-medication practice in primary dysmenorrhea among pharmacy students. This is a cross-sectional questionnaire study to be conducted among 50 females of age group between 18-25 of pharmacy college. The self-medication practice and features of dysmenorrhea were to be assessed with a 15 pre-validated questionnaire and the data is analyzed using descriptive statistics. A total of 50 students participated in this study in which 81.8% had regular periods. Dysmenorrhea was experienced in 79.6% with mild (30.4%),moderate(23.9%) and with severe(28.3%) dysmennohea. In this study 64.3% preferred self-medication pattern. The majority were Pharm.D students. The most commonly used drug was Meftal spas (mephenamic acid+dicyclomine) and for 96.8% the treatment was found to be effective. Among the 50 students, 57.6% have experienced ADR , majority with decreased blood flow. The Self-medication practice in dysmenorrhea was more among pharmacy students probably due to the knowledge of drugs, better awareness and greater access to drug information during their curriculum. This highlights the importance of creating awareness among students to consume drugs only in severe discomfort after prescription by the registered medical practitioners
Development and validation of new analytical method for the estimation of fluoxetine in bulk and dosage form by UV spectrophotometry
No full textA simple, rapid and precise method is developed for the quantitative determination of Fluoxetine in combined pharmaceutical-dosage forms. The method was based on UV Spectrophotometric determination of Fluoxetine drug using Beer-Lamberts Law. It involves absorbance measurement at 224 nm (λmax of Fluoxetine) in water. For UV Spectrophotometric method, linearity was obtained in concentration range of 5-30 mcg/ml with regression 0.999 for Fluoxetine respectively. Recovery was in the range of 98 -102%; the value of standard deviation and %R.S.D was found to be < 2 shows high precision of the method.
Knowledge and attitudes towards appropriate antibiotics usage among students-a survey
No full textAntibiotics are used to treat bacterial infections. WHO estimates that more than half of all medicines are prescribed, dispensed or sold inappropriately, and that half of all patients fail to take them correctly. The overuse, underuse or misuse of medicines results in wastage of scarce resources and widespread health hazard. The objective of the study is to evaluate the knowledge and Attitude towards appropriate antibiotic use among students. A 15 item web based questionnaire was developed and employed to collect data from pharmacy students at Ezhuthachan College of pharmaceutical sciences. The survey will gather demographic information and collect data on knowledge, expectations and current antibiotic usage among students.A total of 55 students participated in the study, among the respondents about 60% of respondents believed that they could stop taking antibiotics if their symptoms of infection improved. over a half of the respondents (68%) believed that antibiotics are effective for most of the colds and around half of them (40%) stated that, they prefer to keep antibiotics at home for emergencies. About 58% would give their antibiotics to a family member if they caught an infection, 44% of respondents identified that, they have bought an antibiotic from community pharmacies without a prescription.The study shows that the pharmacy students has a number of misconceptions relating to appropriate antibiotic use, particularly relating to use of antibiotics for treatment of viral infections. As antibiotics are widely used in students, proper education should be given about rational use of antibiotics
Prescription auditing in rural area
No full textPrescription is an order written by a physician, dentist or any other medical practitioner to the pharmacist to compound and dispense a specific medication for individual patient. Prescription auditing is a quality improvement process that seeks to improve patient care. The parameters which has to analyzed in the process of prescription auditing are, patient demographics, clinical diagnosis, department, prescribing standards, doctors name and signature. It is a prospective survey carried out in a rural area. About 50 prescription was collected. The study provides the effect of prescription auditing. Patients age sex, date of prescription ,drugs name and signature of the prescriber, dose, dosage form, duration of treatment was collected and analyzed. About 96% of prescription contain patient name, 88% contain patient age, all of these prescription are written in brand names and 96% are written in small letter. About 60% of the prescription contain dose of the drug and 90% of drug dosage forms are included. Among 50 prescription, 36% are eligible for reading, 48% are partially eligible and 16% are not eligible for reading. Prescription audits is an educational activity, which promotes high-quality patient care and which should carried out regularly.. A prescription auidit is to designed to measure the compliance with the standards of the proven clinical practice and to record the required and the documented changes in the clinical practice, which are shown by the re-audits. 
A case report on steroid induced diabetes mellitus
Get PDFA steroid is a biologically active organic compound having immunosuppressive action in living organism. Different classification of steroids is available in pharmaceutical industry. Steroids are mostly suggested by clinician to the patients for the reduction of inflammation caused by immune system. Steroid can cause elevation of patient blood sugar level. Those who take steroids for a longer period of time are more susceptible to develop diabetes mellitus. The most commonly used steroids are prednisone and cortisone. These drugs promote glucose production in liver and reduce the sensitivity of cells to insulin. In this case report a 45 year old women suffering from nephrotic syndrome was advised to take Inj. Methyl prednisolone . The administration of this drug leads to a rise in her blood sugar level. It is typical case of steroid induced diabetes mellitus
Prevalence, pattern and management of tonsilitis in students-an online survey
Get PDFTonsillitis is inflammation of the tonsils, two oval-shaped pads of tissue at the back of the throat-one tonsil on each side. Signs and symptoms of tonsillitis include swollen tonsils, sore throat, difficulty swallowing and tender lymph nodes on the sides of the neck. The objective of the study is to study the prevalence of tonsillitis in adults, to evaluate which triggering factors contributes to tonsillitis and to evaluate the treatment strategy for tonsillitis. A Prospective survey will be carried out in 49 peoples using the information's gathered from students in Pharmacy colleges in Trivandrum. This study provides the prevalence of tonsillitis. Past history, medication usage, diagnosis, treatment and triggering factors was collected and analyzed properly. Also response is recorded. In the current research, a survey on prevalence of tonsillitis in adults was formulated .Approximately, 77% female are affected with tonsillitis than 22.9% of male. Among the responders, 75% have tonsillitis and remaining 25% not. About 13% of patients taken self medication, 47.8% consulting physician and 41% are taken home remedies. From this study, most of the responders were satisfied with OTC medicines and home remedies and recurrent attack of tonsillitis are increasing day by day to abolish Tonsillitis, to reduce the frequency and severity of recurrent throat infections to improve general well-being, behavior, and educational achievement with minimal adverse effects.
 
Cardioprotective effect of pulicaria wightania against isoproterenol induced myocardial infarction in experimental rats
No full textThe current study was carried out to evaluate the cardio protective activity of Pulicaria Wightiana against Isoproterenol (ISO) induced myocardial infarction (MI). Pretreatment to the different groups were given for 30 days and ISO was administered at last two days with an interval of 24 hrs. Due to chronic ionotropy ISO induces MI. Blood was collected at the last day of experimental period and biomarkers were observed. The results indicate that the extract exhibited significant cardioprotective activity
Prescription pattern of anti-hypertensive drugs among hypertensive patients at district hospital
Get PDFBackground: To conduct a prospective observational study on prescribing pattern of anti-hypertensive drug in the department of general medicine in Government District hospital, Gulbarga. In this study it was aimed to evaluate the current practice of anti-hypertensive drug by comparing with JNC-8 guidelines in population. Objectives: The objective of our study is to determine the prescription pattern of antihypertensive drugs and adherence to JNC8 guidelines and to find out the most prescribed anti-hypertensive drugs. Methods: A Prospective Observational Study of 06 months was conducted. Undertaken 174 patients data collection form of all the patients of inpatient department of age 18 ≥ years of hypertensive with or without co-morbidities. Result: The results of this analysis suggests that out of the total 174 hypertensive patients included in the study, 92 patients were males while 82 patients were females, indicating the higher prevalence of hypertension in male population than in female population, that is 10% higher prevalence in males than in females. Out of the total study subjects, 169 hypertensive patients were found to have other co morbid conditions. Considering out of the total 174 patients, majority of the patients received monotherapy (129) while remaining patients receiving the Combinational therapy are 45. However in the case of overall utilization pattern of antihypertensive agents, CCBs are the most frequently prescribed class of drugs, followed by ARBs , BBs and finally ACEIs
Prevalence of breathing difficulty and evaluating the use of inhaler among public in rural area
Get PDFAsthma and COPD are common diseases of the airways and lungs that have a major impact on the health of the population. Major limitation to the effective use of inhaled medications is the inability of many patients to use various inhaler devices correctly. Patients require appropriate education in the correct handling of inhaled medications. Objective of the study is the prevalence of breathing difficulty and evaluating the use of inhaler among public in rural area. Methodology includes a cross sectional questionnaire study carried out among 35 people in rural area. The study is mainly based on the use of inhaler techniques among peoples leave in a particular locality and taken there duration of disease, medications, frequency of using the inhaler to determine the correct way of using the inhaler. Result includes about 35 patients were responded. Among them 36.5% were female patients and 23.5% were males. Most of the patients have asthma 24%. most often people have correct knowledge about inhaler use. 59.3% people using meter dose inhaler and 37% people use rotahaler. about 63% people use inhaler whenever necessary, 25.9% people use inhaler twice a day, 3.7% use after a long journey and 7.4% use all of the above. The opportunity for technological innovation and educational interventions to reduce errors is highlighted, as well as the specific challenges faced by children