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Agonists Targeting the cGAS-STING Signaling Pathway and Their Applications in Cancer Therapy
Get PDFThe cyclic GMP-AMP synthase (cGAS) serves as a pivotal component of the immune system, playing a crucial role in regulating the innate immune response elicited by both exogenous and endogenous DNA. This enzyme recognizes the aberrant presence of DNA in the cytoplasm, subsequently activating the signaling pathway mediated by the stimulator of interferon genes (STING) and thereby fulfilling a critical role in immune response mechanisms. This review delineates the mechanisms of the cGAS-STING pathway and elucidates the small-molecule agonists targeting STING, along with their combined applications in various tumor treatment strategies. The aim of this review is to provide a valuable reference framework and insights for ongoing research in related fields
Landscape Planning and Design in High-Density Cities of China: Challenges, Strategies, and International Insights
Get PDFHigh-density cities, emerging as primary hubs for human activities and products of intensified population-land dynamics, are confronting a series of ecological challenges in China, including land scarcity, urban heat island effects, and fragmented green spaces. These issues exacerbate the vulnerability of urban ecosystems through negative feedback loops. By analyzing Singapore’s transformative experience from a "Garden City" to a "City in Nature", this study systematically summarizes its ecological planning strategies, technological innovation pathways, and social governance models. Integrating China’s practical challenges—such as land constraints, heat island effects, and ecological fragmentation—this research proposes a localized implementation framework of "networked ecological restoration, three-dimensional spatial development, and smart collaborative governance," offering theoretical and practical references for the development of "Park Cities." Local practices in China, exemplified by the Qianhai case in Shenzhen, demonstrate the feasibility of Singapore’s experience through cross-regional ecological corridors, climate-resilient vertical greening, and intelligent management platforms. However, high technical costs, administrative barriers, and the lack of long-term governance mechanisms remain critical challenges. Future efforts should prioritize policy innovation, technology adaptation, and social co-governance to shift high-density cities from "quantitative greening" to "function-first" ecological transformation, fostering synergy between ecological and economic development
A Popular Participation Model to Avoid a New Governance Crisis in Venezuela and Peru: A Study of the Oil and Mining Industries
Get PDFShared governance through popular participation and social oversight represents a significant challenge and opportunity in combating corruption and enhancing public policy effectiveness. This study, which involved a survey of 35 interviews with students from Peru and Venezuela (University Mayor de San Marcos, Lima y University Carabolo, Valencia) and employed Structural Equation Modeling, proposed a theoretical model titled Popular Participation and Cultural Chage to reduce Corruption -PMRC.
Considering Venezuela's position as one of the largest oil producers in the world, the research focused on the following central question: What is the impact of Venezuelans' social participation in public policies related to gasoline supply?
Despite receiving financial aid from China and Russia to support both the public and private sectors, the Venezuelan government charges 0.035 per liter.
The study's key conclusion is that the governments of Venezuela and Peru are exploiting societal ignorance by closing educational institutions and restricting access to comprehensive knowledge, limiting citizens to only basic information.
The research model suggests that promoting knowledge-sharing within society and with other nations holds transformative potential for national cultural change, ultimately contributing to the reduction of corruption. The study emphasizes that combating corruption requires shifting from a purely legalistic approach to fostering an ethical cultural transformation, beginning with exemplary governance practices
Analysis of the Influencing Factors of Digital Transformation on Enterprise Innovation and Development
Get PDFBased on the data of Chinese listed companies from 2007 to 2022, this article deeply analyzes the catalytic effect of digital transformation on enterprise innovation and development. Research has found that digital transformation significantly promotes the improvement of enterprise innovation capabilities, and exhibits heterogeneity among different types of enterprises. After sufficient robustness testing, this conclusion still holds true; When financing constraints are high, the promotion effect of digital transformation on enterprise innovation is stronger, that is, digital transformation can effectively alleviate the financing constraints of enterprises and empower enterprise innovation; The level of human capital can positively regulate the promoting effect of digital transformation on the high-quality development of enterprises. This study not only enriches the theoretical framework of the relationship between digital transformation and enterprise innovation development, but also provides useful references and inspirations for enterprises to implement digital transformation and enhance innovation capabilities
LMDI and STIRPAT Analysis of Carbon Emissions in the Chengdu-Chongqing Region: An Industrial Advancement Perspective
Get PDFThis study investigates the driving factors of carbon emissions in the Chengdu-Chongqing urban agglomeration, a key economic region in western China, using the LMDI decomposition method and the STIRPAT model. The results reveal that energy structure optimization and energy consumption intensity reduction are the primary drivers of carbon emission reductions, highlighting the importance of clean energy adoption and improvements in energy efficiency. In contrast, economic growth and secondary industry expansion are the dominant contributors to carbon emission increases, reflecting the energy-intensive nature of industrial activities and the strong coupling between economic development and energy consumption. The tertiary industry exhibits a dual role, with its expansion reducing emissions in regions with higher levels of green transformation but increasing emissions in areas dominated by traditional service sectors. Industrial advancement (or industrial structural upgrading) emerges as a critical strategy for mitigating emissions, while population size has a relatively small direct impact, though urbanization amplifies emissions in high-density areas.
This study contributes methodologically by integrating the LMDI and STIRPAT approaches, providing a robust framework for analyzing carbon emission drivers. Empirically, it highlights significant regional heterogeneity in emission drivers across counties and districts, offering valuable insights for targeted low-carbon development strategies. The findings underscore the need to accelerate clean energy adoption, enhance energy efficiency, promote green industrial transformation, and optimize urbanization patterns. These results provide a scientific basis for formulating policies to achieve carbon neutrality and sustainable development in the Chengdu-Chongqing urban agglomeration
Validation of Translation Universals Based on Comparable Corpus: Simplification and Explicitation
Get PDFThis study aims to validate the phenomena of simplification and explicitation in translation universals using comparable corpus, providing support for translation theory and practice. By constructing a corpus encompassing multiple language pairs and text types, and employing methods such as frequency analysis and chi-square tests, the study compares translated texts with native texts. The findings reveal that translated texts tend to use more common vocabulary and simplify complex syntactic structures, as exemplified in translations of The Moon and Sixpence and The Million Pound Note. Explicitation is achieved through semantic supplementation and syntactic adjustments. This research offers insights for translation teaching and practice, contributing to the advancement of translation studies
Research on Innovative Pathways for Empowering Corporate Financial Management with Generative Artificial Intelligence
Get PDFWith the rapid advancement of digital transformation and artificial intelligence technologies, generative artificial intelligence (Generative AI) has shown broad application prospects in the domain of corporate management. Based on the Technology–Organization–Environment (TOE) theoretical framework and value-chain reengineering theory, this paper constructs an optimized model for empowering corporate financial management with Generative AI. First, it analyzes the core capabilities of generative models in data synthesis, text comprehension, and decision support, and explores innovative pathways for multi-scenario automatic budget preparation, dynamic financial forecasting, and automated compliance audit report generation within the contexts of corporate budgeting, predictive analysis, and risk control. Second, it proposes implementation strategies—such as organizational restructuring, enhancement of data-governance systems, and establishment of continuous iteration mechanisms—and, drawing on representative enterprise case studies, demonstrates how Generative AI improves forecast accuracy, optimizes risk alerts, and enhances audit efficiency. Finally, it addresses challenges related to model bias, data-privacy protection, computational resource investment, and algorithmic transparency, offering technical improvements and governance measures to guide enterprises in deploying Generative AI applications under compliance and ethical constraints. The study shows that Generative AI not only elevates the intelligence level of financial management but also drives enterprise value creation and sustained innovation through dynamic decision support
The The Present Situation and Development Trend of Financing Support for Small and Micro Enterprises in Inclusive Finance
No full textThe report of the 20th National Congress of the Communist Party of China clearly pointed out that the goal of building a socialist modern country in an all-round way is to achieve "high-quality development". The report particularly emphasizes the need to accelerate the development of the digital economy, promote its deep integration with the real economy, focus on the real economy, and further increase inclusive finance support for small and micro enterprises. As the backbone of promoting economic and social progress and safeguarding people's livelihood, small and micro enterprises face many challenges during the period of China's economic transformation and upgrading to high-quality development, among which the financing problem is the most obvious. The practice in inclusive finance provides solutions for small and micro enterprises. The purpose of this paper is to explore the current situation and development trend of financing support for small and micro enterprises in inclusive finance, so as to promote the high-quality development of inclusive finance and help small and micro enterprises achieve sustainable development
Research on the Collaborative Mechanism of the Emergency Management Industry Chain from the Perspective of Low-Altitude Economy
Get PDFIn recent years, with the rapid development of the low-altitude economy, the management and utilization of low-altitude airspace have become a new growth point for the economy. However, under the background of low-altitude economy, there are still many challenges in the collaborative mechanism of the emergency management industry chain, such as asymmetry of rescue information, weak rescue perception, difficult communication coordination and low rescue decision-making efficiency of rescue equipment, conflicts of interest among relevant departments and imperfect collaborative mechanisms. This study aims to explore the collaborative mechanism of the emergency management industry chain from the perspective of low-altitude economy, analyze the existing problems and challenges in the current collaborative mechanism of the emergency management industry chain, and propose an optimization path for the collaborative mechanism based on the stakeholder theory and the collaborative governance theory.This study adopts the methods of literature analysis and case study, aiming to provide theoretical support and practical guidance for the emergency management of low-altitude economy and promote the healthy and orderly development of low-altitude economy
The Mechanism of Population Mobility Driving Economic Development from the Perspective of Social Networks
Get PDFAs a key bridge connecting individuals and opportunities, social networks play a central driving and regulating role in the complex interaction between population mobility and economic development. The purpose of this paper is to systematically review and critically assess the research on population mobility and economic development based on the social network perspective, focusing on how the social network influences mobility decisions, patterns, and ultimate economic effects through the core mechanisms of information dissemination, trust building, resource acquisition, and social support. The study shows that social networks can not only significantly reduce the cost and risk of migration and shape the path of mobility, but also become an important force to promote regional economic development by facilitating knowledge spillover, labour market matching, consumption pattern integration and industrial linkage. At the same time, its potential closure and uneven distribution of resources may also exacerbate regional imbalance and social differentiation. Future research needs to deepen the exploration of the mechanism, pay attention to the heterogeneity and dynamic evolution of the network, and provide more operational insights for policy making