Universal Journal of Pharmaceutical Research
Not a member yet
705 research outputs found
Sort by
THE RISKS AND ADVANTAGES OF ANTI-DIABETES THERAPY IN THE POSITIVE COVID-19 PATIENT
Get PDFThe new Sars-Cov-2 (COVID-19) is causing thousands of deaths worldwide and has caused a global pandemic, one of the biggest health challenges ever faced in history. in the most severe cases, Sars-Cov-2 infection can cause fatal lung injuries. In this context, it is essential to recognise effective therapeutic agents against the virus. There are currently no direct and effective vaccines and antivirals available. People with pre-existing conditions, such as diabetes, and with chronic drug therapies in place may represent complex patients difficult to manage clinically during COVID-19 infection and at high risk of major complications. The regulation of blood glucose and the adoption of appropriate measures are critical aspects to consider for the diabetic patient in this pandemic period, especially in the patient with ongoing infection. In this article we describe the current evidence in the literature on the possible risks of side effects caused by taking antidiabetic drugs in the COVID-19 patient and the data on extra homeostasis glycemic activity useful to fight viral infection.
Peer Review History:
Received 2 April 2020; Revised 8 May; Accepted 21 June; Available online 15 July 2020
Academic Editor: Essam Mohamed Eissa, Beni-Suef University, Egypt, [email protected]
Reviewer(s) detail:
Dr. Heba M. Abd El-Azim, Damanhour University, Egypt, [email protected]
Dr. George Zhu, Tehran University of Medical Sciences, Tehran, Iran, [email protected]
SURVEY OF SAFETY PRACTICES IN DIARRHEAL TREATMENT CENTERS: CHOLERA TREATMENT CENTERS IN YEMEN
Get PDFObjectives: Monitoring of Diarrheal treatment centers (DTCs) was conducted so as to assess the quality of care and help draw evidence-based decisions on the current and future support of DTCs and other cholera prevention interventions.
Methods: This monitoring exercise was included 102 DTCs, data were collected by a trained team of 18 doctors, 18 nurses, and 2 supervisors during the month of June, 2019 to cover the center’s performance in the prior month i.e. May2019. Specially designed forms were used for data collection applying mixed methods: direct observation, record review, direct and phone interviews with the staff and patients as well as discussions with the health offices and community leaders whenever feasible.
Results: No more than 23% of DTCs have water for hand washing, showering and washing clothes at all times and in all important locations such as hand washers and toilets; and 76% have one toilet for every 50 patients, but only 57% of toilets are regularly disinfected. Hazardous practices ranged from 32 to 62% leading to cholera infection among 4 out of 10 health workers and 5 visitors of the DTCs. Around 27 % of the DTCs do not have a designated area to bury body excreta from severe cases; only 23% have an isolated area for the deceased. A high of 59% of designated staff are neither trained nor equipped to deal appropriately with dead bodies and only 39% of dead bodies are disinfected with chlorine solution 2%.
Conclusions: The DTC network provides much-needed services over the width of the country. Lives are being saved on a daily basis despite the ongoing conflict and other humanitarian interventions. However, despite the efforts made so far, there are remaining areas for the quality of the improvement, most importantly availing water and strengthening the infection control measures and preventions of hazardous practices.
Peer Review History:
Received 1 June 2020; Revised 9 July; Accepted 22 August; Available online 15 September 2020
Academic Editor: Essam Mohamed Eissa, Beni-Suef University, Egypt, [email protected]
Ali Awadallah Saeed, National University, Sudan, [email protected]
Dr. Wadhah Hassan Edrees, Hajjah University, Yemen, [email protected]
SAPONINS, GLYCOSIDES AND FLAVONOIDS IN CELLS AND TISSUES OF BALANITES AEGYPTIACA CULTURED ON SOLID AND LIQUID CULTURE MEDIA
Get PDFObjectives: The main objective of the present study is to obtain callus and cell suspension culture from Balanitesa egyptiaca sterile plantlets grown in vitro and to compare growth and the biosynthetic potential of saponins, flavonoids and glycosides by callus and cell suspension culture Balanitisa egyptiaca.
Methods: Callus was induced from the mother plants on MS culture media supplemented with 2.0 mg/l BA + 2.0 mg/l 2,4-D with and without agar gelling. Total saponins, glycosides and flavonoids were estimated in both types of cultures over a period extending from 1 to 5 weeks to compare the productivity of such secondary metabolites in callus and cell suspension cultures.
Results: The results obtained indicated that both calli and cell suspension cultures were able to synthesize the target active ingredients and that cell suspension culture was superior to the callus culture in the biosynthesis and accumulation processes. By the end of the incubation period, the amount of total saponins in cell suspension culture reached up 51.97±0.26 dry biomass compared to 35.02 ±0.06 mg/g in callus culture. The amount of total flavonoids in cell suspension culture reached up 10.88±0.24 dry biomass compared to 6.40±0.02 mg/g in callus culture and of total glycosides reached up 6.11±0.25 dry biomass compared to 5.06 ±0.05 mg/g in callus culture.
Conclusions: The results obtained in this study may indicate the promising role that plant cell culture will play in the future in phytopharmaceutical industry.
Peer Review History:
Received 7 June 2020; Revised 15 July; Accepted 20 August; Available online 15 September 2020
Academic Editor:
Dr. Iman Muhammad Higazy, National Research Center, Egypt, [email protected]
Reviewer(s) detail:
Dr. Gehan Fawzy Abdel Raoof Kandeel, Researcher at pharmacognosy Department, National Research Centre, Egypt, [email protected]
Ahmad Najib, Department of Pharmacognosy-Phytochemystry Universitas Muslim Indonesia-Indonesia, [email protected]
ANTIHYPERLIPIDEMIC EFFECT OF THE ETHANOLIC EXTRACT OF SCAEVOLA TACCADA (GAERTN) ROXB. LEAVES
Get PDFObjective: The research aimed to determine the effect of ethanolic extract of Scaevola taccada (Gaertn.) Roxb leaves in hyperlipidemic rats WITH Cholesterol and triglyceride parameter.
Methods: The research used 30 samples divided into 6 groups: group I (negative control) was given Sodium Carboxymethyl cellulose of 1% w/v , group II (positive control) was given simvastatin of 1.023 mg/kg Body weight, Group III was given gemfibrozil 167.60kg/Body Weight, group IV, V and VI were respectively given ethanolic extract of Scaevola taccada (Gaertn) Roxb with the doses of 700 mg/kg body weight 900 mg/kg body weight, and 1100 mg/kg body weight. The sample was fed a high-fat diet during treatment and induced pure cholesterol for 28 days, the provision of dosage form was done orally once a day for 14 days and the measurement of rat cholesterol and triglycerides, level was done on day 0, 29, and 43. The research data were processed statistically by one way ANOVA test followed by Post Hoc Bonferroni test.
Results: The result showed that the positive control group had no significant effect compared on ethanol extract Scaevola taccada (Gaertn.) Roxb. group (p> 0,5).
Conclusion: The conclusion is the ethanolic extract of Scaevola taccada (Gaertn.) Roxb. leaves had an activity in reducing cholesterol and triglyceride level in rat hyperlipidemia and with an effective dose of 1100 mg /kg body weight.
Peer Review History:
Received: 6 August 2020; Revised: 10 September; Accepted: 21 October; Available online: 15 November 2020
Academic Editor: Prof. Kumud Upadhyaya, Kumaon University, Nainital, UK, India, [email protected]
Reviewer(s) detail:
Dr. Marwa A. A. Fayed, University of Sadat City, Egypt, [email protected]
Dr. Rashad Mohammed Musleh Alnamer, University of Thamar, Yemen, [email protected]
IN VITRO-IN VIVO BIO-EQUIVALENCE CORRELATION STUDY OF ATENOLOL, AND ITS BRANDS OF IMMEDIATE RELEASE TABLET UNDER BIO-WAIVER CONDITIONS
Get PDFObjective: The aim of present study is to examine the in vitro-in vivo correlation (IVIVC) of immediate release product. Atenolol 100mg and its brands of immediate release dosage forms. Atenolol is clearly classified into BCS class III, and could be evaluated under bio waiver conditions.
Methods: The in vitro parameters employed were hardness, weight uniformity, friability, disintegration time, absolute drug content, dissolution rate (in 0.1 N Hydrochloric acid, phosphate buffer and acetate buffer at 37ºC), and dissolution efficiencies were also analyzed. The in-vitro dissolution study was performed on the brands, according to FDA, USP dissolution profile in three different PH (1.2), (4.5), and (6.8) at 37ºC, using the USP apparatus II. A non linear relation was established which is typical for immediate release formulation, of class III.
Results: All Atenolol brands released about 90% drug in PH (6.8), where about 87% in PH (4.5), reference drug released about 91% and test drug released about 87% in pH (1.2). Dissolution efficiency of the entire brands differed by less than 10% from the innovator brand. According to MINITAM 14 statistical program, there was significant relationship between in vitro and in vivo data of reference Atenolol product.
Conclusion: By applying level A in vitro-in vivo correlation, study concluded that there is no linear correlation between percent of drug released and percent of drug absorbed, this may be due to uncontrollable permeability rate for class three Atenolol.
Peer Review History:
Received 5 October 2019; Revised 7 November; Accepted 28 December; Available online 15 January 2020
Academic Editor: Dr. Amany Mohamed Alboghdadly, Princess Nourah bint abdulrahman university, Riyadh, [email protected]
Reviewer(s) detail:
Dr. Hayriye Eda Şatana Kara, Gazi University, Turkey, [email protected]
Dr. Nicola Micale, University of Messina, Italy, [email protected]
EFFECT OF DIETARY FACTORS AND NUTRITIONAL STATUS ON SERUM CALCIUM AND PHOSPHORUS LEVELS IN CKD PATIENTS ON TREATMENT IN A TERTIARY CARE SETTING IN NORTH INDIA
Get PDFObjective: The control of phosphorus and calcium metabolism is one of the objectives in treatment protocol for CKD patients. The levels of these minerals in serum are affected by dietary patterns and nutritional status of the patients. India being a large country, diet patterns vary from one state to another. Thus, we suspect a close association between dietary intake and alterations in homeostasis of calcium and phosphorus in CKD patients. Therefore, we conduct this study to describe the effect of dietary factors and nutritional status on serum calcium and phosphorus levels in CKD patients on treatment in a tertiary care setting in North India.
Methods: In the present study 330 CKD patients coming to dialysis unit, were recorded with detailed Medical history as well as baseline demographic data. Also, biochemical analysis of serum albumin corrected, calcium, phosphorus, and serum albumin of all cases were done using fully automated equipment. All statistical analyses were performed using SPSS statistical software.
Results: Majority (58.2 %) of the study patients were vegetarians with a mean value of BMI (Mean±SD=23.75±4.70 kg/m2). A negative but significant correlation was found between corrected calcium and phosphorus with 0.05 level of confidence interval (r=-0.149, p= 0.007).
Conclusion: It was found that the well-nourished patients were more likely to be hyperphosphatemic as compared to poorly nourished patients, but statistically the values were found to be nonsignificant (Statistically p-value was not less than 0.05).
Peer Review History:
Received 2 October 2019; Revised 7 November; Accepted 28 December; Available online 15 January 2020
Academic Editor: Dr. Ali Abdullah Al-yahawi, Al-Razi university, Department of Pharmacy, Yemen, [email protected]
Reviewer(s) detail:
Dina Abd Elfattah Eldakhs, Pharos university (PUA), Egypt, [email protected]
Dr. Mohammad Tauseef, Department of Pharmaceutical Sciences, College of Pharmacy, Chicago State University, [email protected]
ETHNOBOTANY, PHYTOCHEMISTRY AND PHARMACOLOGY OF OCHNA SCHWEINFURTHIANA: A REVIEW
Get PDFOchna schweinfurthiana (Os, Family: Ochnaceae) is a small evergreen tree used in ethnomedicine to treat different ailments; it is also used in agri-horticulture and as ornaments, dyes among others. It is a rich source of complex dimers of flavonoids and used for treatment of pain, inflammation, and arthritis. Chemical investigations carried out on the different parts of the plant have been confined to phenolic compounds majorly, bioflavonoids, glycosides, steroids and terpenes. The plant, O. schweinfurthiana have shown a wide spectrum of biological and pharmacological properties which include antimicrobial, cytotoxic/antiproliferative, genotoxicity, antinociceptive, anti-inflammatory, antioxidant and antiplasmodial. This review comprehensively summarizes the potential effects of the plant O. schweinfurthiana, chemically and pharmacologically. However, more researches in the aspect of phytochemical and biological studies are needed to exhaustively isolate bioactive compounds and evaluate their effects on other ailments as claimed by the traditional healers.
Peer Review History:
Received 4 October 2019; Revised 7 November; Accepted 28 December; Available online 15 January 2020
Academic Editor: Ahmad Najib, Universitas Muslim Indonesia, Indonesia, [email protected]
Reviewer(s) detail:
Dr. Mohamed Derbali, Faculty of Pharmacy, Monastir, Tunisia, [email protected]
Ahmad Najib, Universitas Muslim Indonesia, Makassar, Indonesia, [email protected]
Message
Get PDFWith the development of science and technology, it is now possible to exchange knowledge more broadly, especially with the presence of the Universal Journal of Pharmaceutical Research (UJPR) discussing science which is currently the main topic of discussion including pharmaceutical science.
The existence of this journal is very helpful for communication between researchers in various parts of the world due to information systems which already online allow access to obtain the latest knowledge on this topic will be greater with the existence of this journal to open a wider network among the ways in which existing researchers. This journal is very useful to support the continuity of development of Pharmacy in particular and the dissemination of knowledge in general with editorial originating from various countries. UJPR guarantees the quality of the authors to make publications because editors who have extensive experience with various pharmaceutical backgrounds and also from various countries is a guarantee that this journal is a journal that has a good reputation. So that there is no doubt for researchers to publish the results of research they have done especially with the indexation of journals by a large database so as to increase the trust this journal deserves to publish your valuable research results. Hope in coming days UJPR will get indexing with some more reputable agencies
AN OVERVIEW OF ANALYTICAL METHOD VALIDATION
Get PDFIn line with the developments in the pharmaceutical field, the product range is constantly being renewed and diversified. New analytical techniques need to be developed and validated for new pharmaceutical products. The validation of an improved method is an internationally recognized scientific requirement, as these validation practices are also indicative of the competence of the analytical laboratory. The method development is a process that ensures the applicability and reliability of the data. The result is a more comprehensive understanding of the standard test methods and a further insight into the connection between test methodology and product quality. It is important to validate an advanced method. Because if the method can not be reproduced, the method is meaningless. Validation is a continuous balance among costs, risks and technical possibilities.
Peer Review History:
Received 3 December 2019; Revised 11 January 2020; Accepted 27 February; Available online 15 March 2020
Academic Editor: Dr. Asia Selman Abdullah, Al-Razi university, Department of Pharmacy, Yemen, [email protected]
Reviewer(s) detail:
Kian Navaee, Shahre Daru Pharmaceutical Co., Iran, [email protected]
Dr. Mohammad Shaheen Khan, University Malaysia Sabah, Malaysia, [email protected]
THE SCOPING REVIEW OF CHINESE AND WESTERN MEDICINE TREATMENT OF DIABETIC FOOT IN ASIA
Get PDFDiabetic foot is a common and serious chronic complication of diabetes due to the simultaneous occurrence of diabetic peripheral neuropathy and vascular lesion. Among all complications, foot ulcers in diabetic ulcers account for the first place among the reasons for hospitalization and treatment of diabetic patients. 15% of diabetic patients may have foot diseases, and 85% of patients may have foot ulcers as the cause of amputation. Diabetic foot seriously affects the quality of life of patients. Although there are many methods to treat diabetic foot, the therapeutic effect of diabetic foot is not ideal in general. The main purpose of this scoping review was analyzing the existing loopholes of researches on diabetic foot in Asia. Used Pub Med, CNKI, Wangfang data, CQVIP to search and select 5 traditional Chinese medicine literatures and 5 western medicine literature, through the comparison of various conditions between literature to analyze the lack of research. Ten pieces of literature were retained through 183 records and included 9 drugs or decoction, they were adipose-derived stem cell–hydrogel complex, hyperbaric oxygen therapy, Xenogeneic (porcine) a cellular dermal matrix, alprostadil, salvia miltiorrhiza polyphenols for injection and collagen sponge, Taohong Siwu Decoction, Simiao Yong an Decoction, Jiawei Simiao Yong an Decoction, Huangqi Guizhi Wuwu Tang, and Wuwei Xiaodu Drink. The obvious problems found by this scoping review were the quantity and quality deficiency of the research in the diabetic foot in Asia. Scoping review is an effective method of evidence identification and synthesis, which can provide a basis for the further development of a certain field. In the further study of the diabetic foot, more attention should be paid to the verification of experimental data as well as the feasibility of the researches on oral drugs.
Peer Review History:
Received 5 February 2020; Revised 11 March; Accepted 25 April; Available online 15 May 2020
Academic Editor: Dr. Ali Abdullah Al-yahawi, Al-Razi university, Department of Pharmacy, Yemen, [email protected]
Reviewer(s) detail:
Dr. Sabah Hussien El-Ghaiesh, Tanta University, Egypt, [email protected]
Dr. Mohamed Derbali, Faculty of Pharmacy, Monastir, Tunisia, [email protected]