Universal Journal of Pharmaceutical Research
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Get PDFA diabetic wound is a big issue all around the world. Several researchers are working multi-disciplinary approach to finding the solution of wound healing. The healing of wound requires several stages such as hemostasis, inflammation, proliferation and tissue remodelling. The wound categorised into different types, and their therapy varies from chronic to acute. Debridement is the most crucial step in every kind of injury. The modern debridement methodologies include maggot debridement therapy, ultrasound-assisted wound debridement and solutions such as hypochlorous acid, nano copper solution. Nutritional based therapy is also famous for fast healing such as edible bird nest, Chromium and protein supplement. Acute wound could be treated with herbal ointment to reduce inflammation and modulate nitro oxide (Centella asiatica, Honey, garcina mangostana), collagen (Chitosan, hyaluronic acid), hydrogel (Indol-triazole scaffold hydrogel) whereas chronic wound is treated with modern therapies such as skin grafting, Negative-pressure wound therapy (NPWT), hyperbaric oxygen therapy, microcurrent therapy. A number of research is also going on wound dressing for faster healing such as polyurethane foam membrane dressing, Retro-Tech Dressing, activated carbon cloth, hydrocellular. For improving the granulation stage of wound healing, fish collagen, multilayer compression bandage have been used. The liquid wound dressing is also available in the market that gets solidify when exposed to air. We hope that our new articles will match the interest of the content that we currently publish and best wishes to all the team members of Universal Journal of Pharmaceutical Research
RISING INCIDENCES OF PRODUCT RECALL
Get PDFThere has been an increasing trend in the number of prescribed and over-the-counter drug recall over the last few years. The recall is usually due to company’s discovery, customer’s complaint or Food and Drug Administration (FDA) observation. The process of recall involves a planned specific course of action, which addresses the depth of recall, need for public warning, and the extent of effectiveness checks for the recall. Product recalls clashes thousands of companies every year affecting: sales, testing customer relationships and disrupting supply chains. Drug recall is incubus for pharmaceutical companies. It effects the reputation of the company. The reason for the recall can be divided into two categories: manufacturing related and safety/efficacy related. It is essential to follow all the guidelines related to drug development and manufacturing procedure so as to minimize drug recall.
Peer Review History:
Article received on- 5 August; Revised 9 September; Accepted 13 October; Available online 15 November 2016
Academic Editor: Ahmad Najib, Universitas Muslim Indonesia, Indonesia, [email protected]
Reviewer(s) detail:
Dr. Maha Khalifa Ahmed Khalifa, Al-Azhar Universit - Cairo, Egypt, [email protected]
Dr. Mohamed Derbali, Faculty of Pharmacy, Monastir, Tunisia, [email protected]
ANTIFUNGAL, CYTOTOXIC AND PHYTOTOXICITY OF AERIAL PART OF RANUNCULUS MURICATUS
Get PDFObjectives: The present research is preliminary biological screening of aerial plant of Ranunculus muricatus (Ranunculaceae). Dichloromethane and methanol extracts of the aerial plant were investigated for their antifungal, phytotoxic and cytotoxic activities.
Methods: Anti-fungal, cytotoxicity and phytotoxicity activities were performed by agar tube dilution assay, brine shrimp lethality bioassay and lemna bioassay respectively. Dichloromethane and methanolic extracts exhibited significant phytotoxicity against Lemna minor having Paraquat as standard drug and incubation condition (28±1ºC).
Results: None of extracts presented any significant cytotoxic activity having Imipenum and Etoposide as standard drug respectively. Both extract had non-significant antifungal activity but it has been noted that methanol extract showed 30% inhibition with linear growth at 70 mm, when compared with control; only against Microsporum canis. Ranunculus muricatus showed significant phytotoxicity.
Conclusion: The phytotoxicty assay is a valuable major screen for weedicide investigation. Additionally, modern studies are currently carried out to identify the allelopathic constituents by isolation, purification and structure elucidation to find out as effective herbicidal.
Peer Review History:
Article received on- 7 August; Revised 11 September; Accepted 9 October; Available online 15 November 2016
Academic Editor: Dr. Ali Abdullah Al-yahawi, Al-Razi university, Department of Pharmacy, Yemen, [email protected]
Reviewer(s) detail:
Dr. Awofisayo, O Abosede, University of Uyo, Nigeria, [email protected]
Prof. Dr. Ali Gamal Ahmed Al-kaf, Sana'a university, Yemen, [email protected]
TOLNAFTATE LOADED LIPOSOMES- DESIGN, AND IN-VITRO EVALUATION
Get PDFObjectives: Liposomes are colloidal particles formed as concentric bimolecular layers that are capable of encapsulating drugs. Liposomes have the potential for extending the duration of action for days or months. Tolnaftate is used as the topical antifungal agent. The purpose of this study was to provide the delivery of the topical drug at a sustained rate across intact skin to improve bioavailability.
Methods: In present study, four different liposomes formulations of Tolnaftate were prepared by ethanol (solvent) injection method by varying the concentrations of phospholipids. The prepared liposomes were characterized for size, shape, entrapment efficiency, zeta potential, in-vitro drug release.
Results: The % entrapment efficiency was found to be in the range of 90.24, 90.75, and 90.75%. The % entrapment efficiency of optimized batch LS4 was found to be 90.74 %. An in vitro drug release of about 82.114 % in 10 h was observed from optimum formulation of batch LS4.
Conclusion: Based on different parameters like particle size, entrapment efficiency, drug release formulations of batch LS4 was selected as best formulation. Study concludes that Tolnaftate liposomes have potential for providing sustained delivery of drug.
Peer Review History:
Article received on- 23 September 2016; Revised on- 6 November; Accepted on- 9 December; Available online 15 January 2017
Academic Editor: Dr. Amany Mohamed Alboghdadly, Princess Nourah bint abdulrahman university, Riyadh, [email protected]
Reviewer(s) detail:
Dr. Mahmut Yıldıztekin, Muğla Sıtkı Koçman University, Turkey, [email protected]
Dr. Mohamed Derbali, Faculty of Pharmacy, Monastir, Tunisia, [email protected]
DEVELOPMENT AND EVALUATION OF TRANSDERMAL GEL OF LORNOXICAM
Get PDFObjective: Transdermal drug delivery systems deliver the drug through the skin at controlled rate to the systemic circulation. It maintains the blood concentration of the drug within the therapeutic system window ensuring that drug levels neither fall below the minimum effective concentration nor exceed the minimum toxic dose. The objective of the present work was to formulate transdermal gel of Lornoxicam. It is a COX-1 and COX-2 inhibitor used in the treatment of inflammation, pain and edema, rheumatoid arthritis.
Methods: Transdermal gel of Lornoxicam was formulated using triethanolamine as solvent, HPMC K100 and EC as polymers. Formulated gel was evaluated with respect to different physiochemical parameters such as pH, viscosity, spreadability. In-vitro release study was performed for 10 hrs. Selected formulation was subjected to stability testing at different temperatures.
Results: There was good homogeneity in all formulations and no lumps were present. The pH of the gel formulations was in the range of 6.77 to 7.14. Viscosity of various formulated gels was found in the range of 2176.5 to 3468.4 centipoises. The cumulative percent drug release after 10 hrs in between 50.3 to 82.11%. Accelerated stability studies for 12 weeks revealed that the transdermal gel formulation were stable at up to 45oC.
Conclusion: Study concludes Lornoxicam can be delivered in the form of transdermal gel in an efficient way. On basis of drug content, particle size morphology, in-vitro release and stability studies, it can be concluded that formulation LTG4 was an optimum formulation.
Peer Review History:
Received 23 November 2016; Revised 6 January; Accepted 10 February, Available online 15 March 2017
Academic Editor: Dr. Amany Mohamed Alboghdadly, Princess Nourah bint abdulrahman university, Riyadh, [email protected]
Reviewer(s) detail:
Prof. Dr. Syamsudin Abdillah, Pancasila University, Indonesia, [email protected]
Noha El Baghdady, MTI University, Cairo, Egypt, [email protected]