Universal Journal of Pharmaceutical Research
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Get PDFFor academics and researchers, the choice of the right journal to disseminate their research findings to as wide an audience and expert as possible is vital to their success. This is especially important when new discoveries, information and addition to knowledge need to be disseminated as fast as possible. Authors typically look for journals that have:
a). Competent, diverse and internationally spread editorial board; a journal run by two or three persons would not provide the needed diverse expertise especially where manuscripts are received from such diverse specialties in a particular field.
b). Author friendly and supportive editorial office without compromising quality; with clear guidelines or instructions for authors.
c). A well-designed cover with good and consistent formatting and informative masthead; easy to navigate and identify its essential contents, easy to cite and share content accurately such that it is easier for librarians and educators to access.
d). Frequent output and accessible, qualitative, sustainable
e). High visibility and citation
The incentives for choosing a journal are:
Turn-around times - how long does it take from submission to review decision to reach author(s)? The faster the better
How clear are information relating to submission?
Does journal have room for variety of reports? (such as research, short communication, review, commissioned and opinion)
How transparent is the review process (assessed by journal transparency in publishing number of received articles, rejections, revisions and acceptance. It should also declare the topics that are most accepted and rejected
UJPR aims to satisfy every author, by having the best peer reviewers, editorial office and a broad spectrum of experts in pharmaceutical research bringing their wealth of knowledge from diverse backgrounds
THE ROLE OF ANTICOAGULANTS AND ANTIPLATELETS IN PROPHYLAXIS AND/OR TREATMENT OF SEVERE SARS-COV-2 INFECTION
Get PDFSevere acute respiratory syndrome coronavirus-2(SARAS-COV-2) was reported firstly in China by the end of 2019 then disseminated vigorously worldwide and in 2020 reported by WHO as pandemic disease. It is associated by many symptoms, however; high incidence of thrombotic events was strongly correlated with SARAS-COV-2. Exploring anticoagulants to be added as thromboprophylaxis for Covid 19 patients become a must. Many options for thromboprophylaxis are available including anticoagulants, antiplatelets and fibrinolytics which were illustrated in this mini review.
Peer Review History:
Received 1 December 2020; Revised 5 January 2021; Accepted 12 February; Available online 15 March 2021
Academic Editor: Essam Mohamed Eissa, Beni-Suef University, Egypt, [email protected]
Reviewer(s) detail:
Dr. Cecilia Nwadiuto Amadi, University of Port Harcourt, Port Harcourt Rivers State, Nigeria, [email protected]
Dr. A.A. Mgbahurike, University of Port Harcourt, Nigeria, [email protected]
POTENTIAL ANIMAL POISONS FOR DEVELOPMENT OF ANTIVIRAL THERAPEUTICS
Get PDFRecent serious effects of viral infections on humans, anti-viral compound research has gained momentum and has become very important. In particular, viruses such as Cytomegalovirus/CMV, Epstein Barr virus/EBV, Hepatitis B/HBV, Hepatitis C/HCV, Herpes Simplex Virus/HSV, Human Immunodeficiency Virus/HIV, rabies virus, corona virus and Ebola virus are of high importance. Very limited antiviral medicines commercially available and can cause serious-significant side effects for patients receiving treatment. Also, viruses have the mutational capability to infect host cells. For this reason, in recent years, the possibility of producing new antiviral medicines, especially from natural sources, has increased considerably, and animal-based products are now also promising among natural products. Viral-borne infections have been known long ago. However, it was just possible to isolate these viruses that cause infection in the nineteenth century. The management of viral infection, the isolation of the virus, and the control of viral reproduction has played a role in the development of many drugs and vaccines in the studies carried out since that period. In addition to these studies, viruses continue to be one of the primary causes of human and animal diseases today. It has been stated that Antiviral Peptides/AVPs can be used as a defense barrier with previous studies. Some AVPs are known to show a broad spectrum against viruses. In this direction, many studies have been conducted on AVPs and it has been observed that these peptides inhibit the viral particle by the above-mentioned mechanisms. In this study venoms and toxins of some animals, which have antiviral activities are overviewed.
Peer Review History:
Received 2 February 2021; Revised 7 March; Accepted 10 April; Available online 15 May 2021
Academic Editor: Dr. DANIYAN Oluwatoyin Michael, Obafemi Awolowo University, ILE-IFE, Nigeria, [email protected]
Reviewer(s) detail:
Dr. Asia Selman Abdullah, Al-Razi university, Department of Pharmacy, Yemen, [email protected]
Dr. Nuray Arı, Ankara University, Turkiye, [email protected]
Dr. Terhemen Festus Swem, Department of Veterinary Physiology and Biochemistry, College of Veterinary Medicine, Federal University of Agriculture, Makurdi, Benue State, Nigeria, [email protected]
TOXOPLASMOSIS IN PREGNANT WOMEN IN YEMEN: THE IMMUNE STATUS AND POTENTIAL RISK FACTORS
Get PDFBackground and aims: Toxoplasmosis is caused as a result of intracellular protozoan organism, Toxoplasma gondii, and is a widespread disease. Toxoplasmosis can progress to a serious systemic disease (congenital form); once a mother becomes infected for the first time for the period of pregnancy, a transient haematopoietic parasite can appear with focal lesions produced within the placenta, thus infecting the fetus. Therefore, this cross-sectional study aimed at assessing the immune status of the pregnant woman towards toxoplasmosis, determining the prevalence of T. gondii in Amran city -Yemen, and identifying the potential risk factors that affect the pregnant woman towards toxoplasmosis.
Material and methods: This study included 280 pregnant women who were admitted to maternity clinics at Amran General Hospital and Family Health Center in Amran City -Yemen during the period from December 2016 to June 2017. The questionnaire was used to obtain relevant demographic data and potential risk factors. Then, blood samples were collected from pregnant women and tested for identification of IgM and IgG antibodies against T. gondii using the ELISA technique.
Results: The total positive rate for IgM antibodies was 3.6%, while for IgG was 27.9%. A high IgM rate equal to 5.3% was observed in the 31-35 age group, and a higher IgG rate (36.8%) was observed in the same age group. There were 69.3% of pregnant women susceptible to infection with toxoplasmosis, 2.9% recently infected, 27.1% protected, and 0.7% had secondary infection. The high rate of IgM positivity was observed in the second trimester of pregnancy (4.7%), while the lowest rate was in the third trimester of pregnancy (2%). A slight increase in the rate of IgG positivity was observed in the third trimester of pregnancy (32%). There was a significant association between contact with animals such as cats and infection with toxoplasmosis, where OR =5.4, CI =1.01-30.13, χ2 =4.59, p =0.04. While there was no significant association with the other studied factors.
Conclusion: Yemen has less seropositivity than other Arab and African countries as a result of variation in risk factors. Data on T. gondii infection during pregnancy is scarce in numerous countries, in particular where there is a lack of political constancy such as Yemen. The risk factors identified included proximity to the cats and domistic animals, and increased maternal age. Toxoplasmosis in pregnancy in Yemen may be a really underestimated health problem. More research is needed.
Peer Review History:
Received 2 February 2021; Revised 7 March; Accepted 10 April; Available online 15 May 2021
Academic Editor: Dr. DANIYAN Oluwatoyin Michael, Obafemi Awolowo University, ILE-IFE, Nigeria, [email protected]
Reviewer(s) detail:
Rola Jadallah, Arab American University, Palestine, [email protected]
Prof. Dr. Gorkem Dulger, Duzce University, Turkey, [email protected]
REPRODUCTIVE HORMONE LEVELS AND METABOLIC SYNDROME IN WOMEN WITH POLYCYSTIC OVARY SYNDROME IN SANA'A, YEMEN
Get PDFBackground and Objectives: Polycystic ovary syndromes (PCOs) are the most complex endocrine disorders of the female reproductive system with metabolic and psychiatric manifestations. It affects 5%-10% of women of childbearing age. There are paucity of information on PCOs. Therefore the present study aimed at the effect of reproductive hormones, metabolic syndromes, smoking and khat chewing on the PCOs among women in Sana'a
Subjects and Methods: The study included 45 Yemeni women of the age group 18-45 years with PCOS classified into two groups regarding age: Group I 18-29 years old, Group II 30-45 years old and underwent clinical assessment (waist, BMI and sex hormones, blood pressure, glucose, lipids, and insulin), and transvaginal ultrasound. Clinical data, history of other diseases and data of chewing and smoking also collected.” Also the study included 45 healthy control women matched in age with the cases.
Results: The prevalence of MS among PCOs patients was 35% and the most prevalent MS risk factors among PCOs patients were waist circumference (WC) 64.4%, and HDL-C 64.4% respectively, while prevalence of triglycerides (TG), hypertension and fasting blood sugar (FBS) were 28.9%, 20% and 13.3%, respectively. PCOs patients had significant increase in serum levels of luteinizing hormone (LH) (p<0.001), Insulin (p<0.001), HOMA-IR (p<0.001), T testosterone (TT) (p<0.001), DHEA-S (p<0.001) and FBS (p<0.016). Lean PCOs patients had a significant increase in TT than overweight/obese PCOs (p < 0.045) and dehydroepiandrosterone sulfate (DHEA-S) was found to be significantly higher in PCOs women with MS (p<0.011). Insulin resistance was significantly higher in PCOs women with hypertension as compared to PCOs women without hypertension (p<0.023).
Conclusion: There is a relationship between PCOS and reproductive hormone disorder. Patients had significant increases in serum levels of LH, LH/Follicle Stimulating Hormone (FSH), Insulin, TT, and DHEA-S. Also, a relationship was found between the syndrome and infertility, hirsutism, irregular menstruation, polycystic ovaries and multiple sclerosis.
Peer Review History:
Received: 6 June 2021; Revised: 8 July; Accepted: 11 August; Available online: 15 September 2021
Academic Editor: Prof. Cyprian Ogbonna ONYEJI, Obafemi Awolowo University, Ile-Ife, Nigeria, [email protected]
Reviewers:
Prof. Dr. Hassan A.H. Al-Shamahy, Sana'a University, Yemen, [email protected]
Dr. DANIYAN Oluwatoyin Michael, Obafemi Awolowo University, ILE-IFE, Nigeria, [email protected]
CHOLESTEROL AND ITS IMPLICATIONS- A REVIEW
Get PDFAmbiguity associated with cholesterol portrays its significance and concern. Cholesterol is a steroid biomolecule of animal cells with several important functions in living system, such as steroid hormone production, structural architecture of cell membranes, production of vitamin D, sources of bile salts and bile acids. Its sources include endogenous (de novo production by body’s tissues) and exogenous (dietary), contributing to cholesterol pool in the body. Cholesterol homeostasis is essentially regulated by the body. This review focuses on the following; basis of cholesterol, biological functions of cholesterol, structural description of cholesterol, Biosynthesis of cholesterol, cholesterol and its derivatives e.g bile acids, bile salts, steroid hormone, absorption and utilization of dietary cholesterol and current advancement in cholesterol management against risk factors. Hypercholesterolaemia is known to be an important precondition to the etiology of cardiovascular disorders which include atherosclerosis, stroke and coronary heart diseases. Interventions for the management and prevention of hypercholesterolaemia currently advocated include pharmaceuticals (drugs) and non pharmaceuticals, but more concern on non pharmacological therapeutic interventions such as the use of Medicinal Plants and herbs, Nutraceuticals, Diet and Exercises (lifestyle) and Functional and Mediterranean Foods. It is thus glaring that the disease linked implication of cholesterol can be prevented and managed using the appropriate interventions.
Peer Review History:
Received 2 October 2020; Revised 14 November; Accepted 26 December; Available online 15 January 2021
Academic Editor: Dr. Asia Selman Abdullah, Al-Razi university, Department of Pharmacy, Yemen, [email protected]
Reviewer(s) detail:
Dr. Rawaa Souhil Al-Kayali, Aleppo University, Syria, [email protected]
Dr. U. S. Mahadeva Rao, Universiti Sultan Zainal Abidin, Terengganu Malaysia, [email protected]
COVID-19: PHARMACOLOGICAL AND THERAPEUTIC APPROACHES
Get PDFIn the end of 2019, SARS-CoV-2, a new virus from Corona viruses family, has been detected in China and was responsible for COVID-19 disease. This disease has been suddenly and vigorously disseminated among individuals all over the world. Based on genetic vicinity, this novel virus is similar to SARS-CoV and MERS-CoV and it can spread from an unknown animal host to individuals. Many published clinical data and in vitro studies may offer treatment strategies of some effective antiviral and repurposed drugs, including remdesivir, favipiravir, lopinavir/ritonavir, corticosteroids, etc. This narrative review describes current pharmacological proposed treatments for COVID-19 patients and available experimental and clinical studies for these drugs. Eventually, these data may help to explain the most preferable way to treat COVID-19 and lessen the accompanied symptoms and complications.
Peer Review History:
Received 3 October 2020; Revised 12 November; Accepted 26 December; Available online 15 January 2021
Academic Editor: Prof. Cyprian Ogbonna ONYEJI, Obafemi Awolowo University, Ile-Ife, Nigeria, [email protected]
Reviewer(s) detail:
Dr. DANIYAN Oluwatoyin Michael, Obafemi Awolowo University, ILE-IFE, Nigeria, [email protected]
Dr. George Zhu, Tehran University of Medical Sciences, Tehran, Iran, [email protected]
Dr. Nuray Arı, Ankara University, Turkiye, [email protected]
ASSESSMENT OF SOME CLINICAL AND LABORATORY PROFILES AMONG DENGUE FEVER PATIENTS AT HAJJAH GOVERNMENT, YEMEN
Get PDFBackground and objective: Classical dengue (DF) is a viral disease transmitted by the bite of an infected mosquito, usually Aedes aegypti or Aedes albopictus. Residents without access to sophisticated laboratory tools need simple clinical and/or laboratory indicators that can provide a reliable diagnosis of dengue fever before admission to the hospital. Therefore, this study was designed to evaluate some clinical and laboratory features among confirmed cases with dengue fever in the government of Hajjah, Yemen to differentiate between dengue (DF) and other febrile diseases in the dengue affected population.
Methods: Clinical data and blood samples were collected from 46 confirmed cases of dengue fever, which were hospitalizedat the Yasser and Thabit Hospital from September to December 2019. The collected samples were examined for some hematological tests, including: hemoglobin (Hb), white blood cells counts (WBCs), and hematocrit (HCT), and a platelet count (PLT). Confirmation of dengue was performed with a non-structural protein tape (NS1).
Results: The results obtained showed that males have a higher infection rate (73.91%) of DF compared to females (26.09%). The recurrence rate was also highest (69.56%) among the 16-30 year-olds. Regarding clinical symptoms, fever and headache occurred in 100%, nausea in 95.65%, and vomiting in 78.26% of the patients, while rashes were less frequent (19.56%). Hematological abnormalities frequently occurred with WBC (89.1%), PLT (84.78%), and Hb (63.04%), while HCT was only abnormal in 23.91% of cases.
Conclusion: A high frequency of clinical and laboratory variants can distinguish dengue fever from other causes of infection; Dengue fever is most common in males between the ages of 16 and 30. This is the first report documenting the occurrence of dengue fever in Hajjah governorate, which requires more attention to prevent and control it. Further prospective studies are needed to build a valid and generalizable algorithm to guide the differential diagnosis of dengue fever in endemic countries such as Yemen.
Peer Review History:
Received 3 February 2021; Revised 5 March; Accepted 9 April; Available online 15 May 2021
Academic Editor: Prof. Kumud Upadhyaya, Kumaon University, Nainital, UK, India, [email protected]
Reviewer(s) detail:
Dr. Bilge Ahsen KARA, Ankara Gazi Mustafa Kemal Hospital, Turkey, [email protected]
Prof. Dr. Hassan A.H. Al-Shamahy, Sana'a University, Yemen, [email protected]
Dr. Muhammad Zahid Iqbal, AIMST University, Malaysia, [email protected]
MENOPAUSAL SYMPTOMS ON THE QUALITY OF LIFE AMONG YEMENI WOMEN IN SANA’A CITY
Get PDFBackground: Menopause is a physiological phenomenon that can strongly affect the quality of life (QOL) of women.
Objectives: To analyzes the menopausal associated symptoms among contributors and their effect on quality of life. To also investigate sociodemographic factors affecting QOL.
Methods: A cross-sectional study was conducted among 188 perimenopause and menopausal Yemeni women selected randomly from outpatient clinics of the main public hospitals in Sana'a, Yemen. Data was acquired using the Menopause-Specific Quality of Life (MENQOL) questionnaire.
Results: The mean age at menopause was found to be 47±3.4. The majority of participants were postmenopausal (71.27 %), and (71.80 %) were married. The most prevalent symptoms were aching muscles and joints (55%), dissatisfaction with personal life (37.7%), night sweat (35%) and avoidance of intimacy (30%). The total scores of menopausal quality of life for each MENQOL domain revealed that the maximum mean score was recorded for physical domain (42.81± 17.87), followed by psychosocial (14.11±5.72), then sexual (6.93±2.46), and finally vasomotor domain (4.78±3.10).
Conclusion: The physical and psychosocial domains had upper mean MENQOL scores than vasomotor and sexual domains. There is a need to educate women about menopause and its symptoms and the need to seek medical advice from specialists and find a center for that.
Peer Review History:
Received: 6 April 2021; Revised: 8 May; Accepted: 11 June; Available online: 15 July 2021
Academic Editor: Ahmad Najib, Universitas Muslim Indonesia, Makassar, Indonesia, [email protected]
Reviewers:
Dr. Gulam Mohammed Husain, National Research Institute of Unani Medicine for Skin Disorders, Hyderabad, India, [email protected]
Dr. Salfarina Ramli, Department of Pharmacology and Pharmaceutical Chemistry, Faculty of Pharmacy, Universiti Teknologi MARA, 42300 Puncak Alam, Selangor, Malaysia. [email protected]
Dr. Vanina Doris Edo’o, University of Yaounde I, Yaounde, Cameroun, [email protected]
Dr. Ahmed Mohammed Al-Haddad, Department of Medical Laboratories, College of Medicine and Health Sciences, Hadhramout University, Al-Mukalla, Yemen, [email protected]
EVALUATION OF MULTIFUNCTIONALITY IN COSMETICS
Get PDFIn recent years, developments in the field of cosmetic ingredients especially use of natural sources and carriers systems and the manufacturing methods resulted as an improvement in the effect and stability of cosmetics, and thus the performance and component-based multi-functionalities of cosmetic products. Those have partially contributed to the condition-dependent functionality, developments in the field of marketing, monitoring of expectations and their reflection on marketing and the creation of new ideas in the field of claim-driven multi-functionality. Multi-functionality in cosmetic products can be evaluated in four groups. These are performance-based multi-functionality, component-based multi-functionality, conditional multi-functionality and claim-driven multi-functionality. In the first two groups, performance related to formulation and manufacturing comes to the fore, while in the last two, safety becomes important and those are briefly given in this review.
Peer Review History:
Received: 2 April 2021; Revised: 5 May; Accepted: 12 June; Available online: 15 July 2021
Academic Editor: Ahmad Najib, Universitas Muslim Indonesia, Makassar, Indonesia, [email protected]
Reviewer(s) detail:
Dr. Govind Vyas, Compliance & Regulatory Officer Inva-Tech Pharmaceuticals LLC, New-Jersey, USA, [email protected]
Dr. Mohammad Bayan, Faculty of Pharmacy, Philadelphia University, P.O. Box: 1 Philadelphia University 19392 Jordan, [email protected]
Dr. Sally A. El-Zahaby, Pharos University in Alexandria, Egypt, [email protected]