Osaka Dental University Academic Repository / 大阪歯科大学学術リポジトリ
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市販の嚥下調整食の摂取時における超音波診断装置による舌運動の観察-舌の押しつぶし動作での検討-
Get PDF大阪歯科大学Osaka Dental University博士（歯学）Different standards for physical property are often mixed when evaluating commercially available swallowing control diets. We determined whether subjects were compressing food with their tongues as intended when they consumed a swallowing adjusted diet. Four types of food were used for the qualitative evaluation of tongue movement. The time from the start of tongue mastication to the first swallow (eating time) and the time
when the tongue pressed against the palate (compressing time were measured in subjects who showed compressing movements with the tongue, for all of the foods. We found that tofu had significantly longer eating and compressing times. Even within the
category of tonguecompressible regulated swallowing foods, compressing and eating times were longer than for other foods, suggesting that there are foods that may not meet their desired goals.doctoral thesi
Analysis of implant osseointegration, bone repair, and sinus mucosa integrity using Bio-Oss® and Hyaluronic Acid-Polynucleotide Gel (Regenfast®) in maxillary sinus augmentation in rabbits.
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Beneficial outcomes of immunoenhancing nutritional interventions in perioperative care for oral cancer: a systematic review and meta-analysis.
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Biological impacts of essential amino acid deficiency on human gingival fibroblast.
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2型糖尿病発症前の歯周疾患管理が医療費に及ぼす影響
Get PDF大阪歯科大学Osaka Dental University博士（歯学）Objective: Although periodontal disease management has been shown to reduce the medical costs of diabetes mellitus, no studies have investigated management before the onset of type 2 diabetes mellitus. Therefore, this study examined the association between periodontal disease management before the onset of type 2 diabetes mellitus and medical costs. Methods: We extracted information for periodontal disease management status from Japanese medical claims and specific health check-up databases among 4010 patients with periodontal disease and type 2 diabetes mellitus aged ≥ 30 years who had continued periodontal disease management for 2 years after diabetes onset. We divided patients into two groups: those who had received periodontal disease management for 2 years before and 2 years after onset and those who had received periodontal disease management for only 2 years after the onset of type 2 diabetes mellitus. Results: The HbA1c level in patients without periodontal disease management during the year of diabetes onset improved by 0.13 % in male and 0.24% in female 2 years later, while that in the group with periodontal disease management improved by 0.49 % and 0.74%, respectively. The medical costs were significantly lower in the group with periodontal disease management 2 years later than in the group with no periodontal disease management. Conclusions: Regular periodontal disease prevention and management under professional care before type 2 diabetes mellitus onset contribute to improved health and reduced medical costs.doctoral thesi
Lループを使用した異なる圧下力による歯根尖吸収の組織形態分析
Get PDF大阪歯科大学Osaka Dental University博士（歯学）Purpose: This study aimed to conduct a histomorphometric analysis on the impact of varying intrusive forces on external apical root resorption (EARR) in rat molars, using an L-loop was employed to apply intrusion forces, artificially inducing EARR in the maxillary left first molar (M1) of rats. Materials and methods: The L-loop was bent on a plaster rat model using stainless steel round wires with diameters of 0.014 and 0.016 inches. Using a universal test force measuring device, L-loops were calibrated to 4 N/mm and 6 N/mm for the 0.014-inch and 0.016-inch diameter stainless steel round wires, respectively. Fifteen-week-old Sprague-Dawley (SD) male rats were used and divided into the control (no loop) and experimental (0.014 and 0.016) groups (n=5 for each group). The L-loop was attached to the left maxillary molar, applying an intrusive force to M1. After 15 days, the rats were euthanised. Maxillary bones were analysed using micro-computed tomography (μCT), evaluating M1 intrusive distance of vertical tooth movement and counting the number of tartrate-resistant acid phosphatase (TRAP)-positive cells on the surface of the mesial root apex and alveolar bone.
Results: The L-loop groups exhibited significantly increased M1 intrusive distance and TRAP-positive cell counts compared to controls. Specifically, the 0.016 group demonstrated greater M1 intrusive distance and more TRAP-positive cells than the 0.014 group. The M1 intrusive distance and TRAP-positive cells increased when intrusive forces were applied using L-loops of different diameters.
Conclusion: Greater intrusive forces enhance TRAP-positive cell activity, influencing EARR and vertical tooth movement.doctoral thesi
咬合性外傷を伴う重度歯周炎におけるRANKL+骨芽細胞及びTh17細胞の細胞老化
Get PDF大阪歯科大学Osaka Dental University博士（歯学）Purpose: Excessive occlusal forces resulting from inadequate dental prosthesis, along with periodontal infection (PI), lead to severe periodontitis; however, the roles of senescent cells and their involvement in the mechanisms underlying this process remain unclear. Therefore, this study aimed to elucidate the roles of senescent cells and their cell types in severe periodontitis with excessive force (occlusal trauma [OT]). Methods: To determine whether senescent cells exacerbate alveolar bone resorption, we developed a severe periodontitis rat model by inducing PI and OT and assessed the presence of senescent cells and bone resorption. Senolytics (dasatinib + quercetin [DQ]) were administered to evaluate the changes in the appearance of senescent cells and bone resorption. Results: PI and OT + PI increased senescent cells as well as osteoclasts. Furthermore, p21 and receptor activator of nuclear factor-kappa B ligand (RANKL) co-expressing cells were observed in the OT + PI group rats, suggesting a correlation between bone resorption and senescent cells. Cell type analysis identified osteoblasts and Th17 cells as RANKL+ cells expressing p21 or p16. DQ administration reduced senescent cells and osteoclasts, thereby preventing alveolar bone resorption. Conclusions: RANKL+ senescent osteoblasts and Th17 cells are involved in osteoclastogenesis and bone resorption. Our findings highlight a new target for the prosthetic treatment of severe periodontitis.doctoral thesi
歯肉上皮細胞における機械的ストレスにより誘発されるpro-IL-1β産生のシグナル経路
Get PDF大阪歯科大学Osaka Dental University博士（歯学）Objectives: Mechanical stress on the teeth and alveolar bone caused by bruxism, orthodontics, and implants affects the periodontal tissues, causing gingival recession and alveolar bone resorption, and entire body, including the heart and vascular system. Although the same forces exerted on the alveolar bone and teeth are exerted on gingival epithelial cells, little is known about the effects of mechanical stress on these cells. This study investigated the effects of mechanical stress on gingival epithelial cells.
Methods: Ca9-22 cells (human gingival epithelial cells) were used. They were seeded onto the silicone and stretched cyclically. Mechanical stress-stimulated Ca9-22 cells were evaluated for pro-inflammatory interleukin (pro-IL)-1β production using Western blotting and analyzed to assess the phosphorylation level of intracellular signaling molecules.
Results: Mechanical stress induced pro-IL-1β upregulation in Ca9-22 cells, which was significantly inhibited by ruthenium red. Ruthenium red significantly inhibited mechanical stress-induced phosphorylation of focal adhesion kinase (FAK), P130Cas, and extracellular signal-regulated kinase 1 and 2 (ERK1/2) induced by mechanical stress. Additionally, Y15 significantly inhibited the upregulation of pro-IL-1β expression and phosphorylation of FAK, P130Cas, and ERK1/2 stimulated by mechanical stress.
Conclusions: In Ca9-22 cells, mechanical stress may increase pro-IL-1β production via mechanosensitive ion channels and FAK. These findings revealed the mechanisms of inflammation in mechanically-stressed Ca9-22 cells and may aid in the development of therapeutic approaches to prevent bone resorption.doctoral thesi
