Journal of Drug Delivery and Therapeutics (JDDT)
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Effect of Date Fruit Consumption in Labour Progress: A Case Report
Full text linkObjective: To investigate date fruit\u27s potential benefits on maternal and fetal outcomes in pregnancy, focusing on labor progression, maternal nutritional needs, and reduced medical interventions.
Case Report: A 35-year-old primigravida patient consumed six date fruits daily for four weeks prior to her estimated delivery date. She presented with spontaneous labor at 39 weeks, experiencing normal latent phase duration of 12 hours, and delivered a healthy male baby weighing 2.9 kg. Her pregnancy course was uncomplicated, with no significant abnormalities in antenatal scans or laboratory results.
Conclusion: This case report suggests date fruit consumption supports maternal and fetal well-being, facilitating a smooth labor process and potentially reducing labor induction and medical interventions. Aligning with existing research, dates\u27 nutritional and therapeutic benefits may enhance cervical ripening and shorten labor duration. Larger-scale trials are necessary to confirm these effects and establish standardized guidelines.
Keywords: primigravida, date fruit\u27s, smooth labor process, 3rd trimeste
Exploring the Gut Microbiome\u27s Influence on Peptic Ulcer Disease: Mechanistic Insights, Pharmacological Implications, and Emerging Therapeutic Strategies
Full text linkBackground: The gastrointestinal disorder Peptic Ulcer Disease (PUD) leads to mucosal damage in either stomach or duodenal tissue because of acid-peptic injury. The available evidence demonstrates that Helicobacter pylori (H. pylori) infection and nonsteroidal anti-inflammatory drug (NSAID) usage serve as proven ulcer causes but new research shows the gut microbiome as contributing to ulcer development and therapeutic approaches.
Objective: The purpose of this section is to examine the standard H. pylori ulcer development process while examining host immune responses through gut microbial alterations and their effect on PUD disease progression.
Methods: This study reviewed multiple research articles to examine how bacteria affect epithelial cells while studying inflammatory pathways as well as microbial metabolites particularly short-chain fatty acids (SCFAs). The review examined different pharmacy-based and natural therapies from the perspective of their ability to modulate the microbiome.
Results: The research shows Non-H. Pylori bacteria damage gastric mucosal tissue by activating pro-inflammatory cytokines which leads to gastric homeostasis disturbances because of SCFA production. The ulcer formation gets worse because dysbiosis makes the intestines more sensitive to oxidative stress while simultaneously making the protective mucosal layer weaker. Antibiotics together with proton pump inhibitors affect gut microbial composition but natural treatments including curcumin combined with ginger and probiotics both contribute to microbial recovery and healing of ulcers.
Conclusion: Previous research about the gut microbiome\u27s role in PUD pathogenesis forms a base for future development of tailored therapeutic strategies. Combining microbiome-based therapeutic methods with traditional medical protocols produces better management strategies for ulcers with improved healthcare results for patients.
Keywords:Peptic Ulcer Disease, Gut Microbiota, Microbial Dysbiosis, Immunoglobulin A (IgA), Gastrointestinal Inflammation, Mucosal Homeostasi
Multi-Omics Integration in Personalized Medicine: Advancing Laboratory Diagnostics and Precision Therapeutics in the Era of Individualized Healthcare
Full text linkPersonalized medicine is revolutionizing healthcare by shifting from a one-size-fits-all model to a tailored approach that considers individual genetic, molecular, environmental, and lifestyle factors. This review comprehensively explores the role of personalized medicine in laboratory diagnostics and patient management through the lens of emerging omics technologies such as genomics, transcriptomics, proteomics, metabolomics, and pharmacogenomics. Each omics domain offers unique insights into disease mechanisms, drug response, and biomarker discovery, enabling more accurate diagnoses, targeted therapies, and improved treatment outcomes. While genomics and pharmacogenomics focus on the genetic basis of disease and therapeutic response, transcriptomics and proteomics bridge the functional gap between genotype and phenotype, revealing dynamic changes at the RNA and protein levels. Metabolomics adds another layer of complexity by capturing small-molecule metabolites that reflect cellular physiology in real time. Despite the promise of personalized medicine, its clinical implementation is hindered by technical limitations, high costs, data integration challenges, and concerns over reproducibility and data privacy. Moreover, optimizing transcriptomic study design, especially the balance between sequencing depth and biological replication, remains crucial for generating robust, reproducible data. The integration of multi-omics data holds the potential to drive breakthroughs in diagnosis and therapy, particularly in oncology, rare diseases, and complex disorders. This article highlights the critical role of personalized medicine in laboratory practice and advocates for continued investment in multi-omics technologies and data infrastructure to advance precision healthcare.
Keywords: Personalized medicine, Multi-omics, Pharmacogenomics, Metabolomics, Transcriptomic
Pharmacologıcal Requırements For Intravenous Sedatıon in Oncologıcal Patıents Undergoıng Chronıc Opıoıd Analgesıc Treatment Durıng Percutaneous Interventıonal Procedures
Full text linkObjective: To describe the pharmacological requirements of the doses used for fentanyl, propofol and midazolam, during intravenous sedation in oncology patients with chronic opioid analgesic treatment undergoing percutaneous interventional procedures.
Materials and methods: An observational, retrospective, cross-sectional, and descriptive study was conducted after obtaining approval from the Research and Ethics Committee. Information was obtained through the review of clinical records of patients undergoing interventional procedures for oncological pain at the Pain Clinic of the National Cancer Institute between March 1st, 2020, and February 29th, 2024. A descriptive statistical analysis was performed, followed by a bivariate analysis using Chi-square and ANOVA tests to identify the association between chronic opioid analgesic treatment and pharmacological requirements in our population.
Results: A total of 494 patients were studied, of whom 68.6% were female (n = 339) and 31.4% were male (n = 155). 99% of the patients were between 45 and 70 years of age, with a mean age of 57.66 years. The most frequently identified oncological diagnoses in our population were: breast cancer (20.4% of cases) (n = 101), multiple myeloma (14.2% of cases) (n = 70), and cervical cancer (12.6%) (n = 62).
Regarding opioid analgesic treatment for pain control prior to the interventional procedure (n=494), 438 patients (88.6%) were identified as receiving opioid treatment (average Morphine Equianalgesic Daily Dose:56 mg), while only 56 patients (11.3%) were not. We found a trend toward greater use of fentanyl during intravenous sedation in patients without chronic opioid use compared to the group of patients with chronic opioid use. With respect to midazolam and propofol, similar requirements were found between the groups. No significant correlation was identified between the dose of intravenous sedation drugs and chronic drug use.
Conclusions: There was no correlation on the average doses of midazolam, fentanyl and propofol in patients with chronic pain treatment who underwent percutaneous interventional procedures, regardless of whether they were on analgesic treatment or not. Prospective studies are required to corroborate these results.
Keywords: Opioids, percutaneous interventional procedures, cancer pain, intravenous sedation
Assessment of patients\u27 knowledge of their antihypertensive treatment at the mother and child hospital ‘‘Le Luxembourg’’, Mali
Full text linkHigh blood pressure is a major public health problem regarding its prevalence and the extent of its morbidity and mortality and disability after cerebral vascular accident. Effective management requires full adhesion of the patient to the recommendations of medical staff. The adhesion requires a certain level of disease and treatment knowledge. There is a good relationship between the understanding of the disease and its treatment by the patient and good compliance and therefore the success of the treatment. We conducted a prospective cross-sectional study in the Cardiology Department of mother and child hospital of Bamako August to October 2023 to assess patients\u27 knowledge of their antihypertensive treatment. The case report form was used for data collection, entered to Excel and analyzed using SPSS software version 25.0. A total of 211 participants were included in our study. Most of them were over 65 years of age (45%), followed by the 46 to 65 age group. Moderate hypertension was found in 21.3% of patients. All patients on a strict diet were taking angiotensin converting enzyme inhibitors (21.85%), followed by diuretics and calcium channel blockers (20.85%). 40.76% of participants had a good knowledge of cardiovascular risk factors. More than half of the participants (53.6%) had an intermediate level of knowledge about their treatment, and 68.2% had poor knowledge of medication adherence. A significant association (p = 0.03) between good knowledge of cardiovascular risk factors and poor compliance was found. Participants with good knowledge of their antihypertensive treatment were not adhering well to their treatment (p = 0.002). This study reports poor adherence to treatment among patients with hypertension under observation in the cardiology unit in Luxembourg, Mali.
Keywords: Knowledge, Patients, Antihypertensive treatmen
Sexually Transmitted Diseases: An Overview of Common Diseases, Diagnosis and Treatment
Full text linkSexually transmitted diseases (STDs) are a significant global health concern, affecting millions of people worldwide. These diseases can lead to serious health complications, including infertility, cancer, and pregnancy problems. The most common STDs include gonorrhea, syphilis, chlamydia, trichomoniasis, and HIV. This review highlights the current state of STDs, their symptoms, diagnosis, treatment options, and prevention strategies. This article explores the causes, transmission, and effects of each disease, as well as the importance of early diagnosis and treatment. The review also explores the challenges in treating STDs, including antibiotic resistance and the need for effective prevention strategies. Understanding STDs is crucial for developing effective prevention and treatment programs, and this review aims to provide a comprehensive overview of the current state of STDs.
Keywords: gonorrhea, syphilis, trichomoniasis, chlymadia, HIV
Ocuserts: A novel ocular drug delivery system
Full text linkOcular drug delivery poses significant challenges due to the unique anatomy and physiology of the eye. Conventional dosage forms, such as eye drops, often suffer from poor bioavailability, short residence time, and frequent dosing. To overcome these limitations, ocular inserts have emerged as a promising solution. These inserts provide sustained and controlled drug release, increasing the contact time with the ocular surface and enhancing bioavailability. This review discusses the advantages and disadvantages of ocular inserts, their classification, mechanism of drug release, formulation methods, and evaluation parameters. Ocular inserts offer several benefits, including improved patient compliance, reduced dosing frequency, and increased therapeutic efficacy.
Keywords: Eye, Ocuserts, Controlled release, Corneal contact, Bioavailabilit
Formulation And Evaluation of Betulinic Acid Loaded Transdermal Patches
No full textMany disorders, including cardiovascular diseases, Parkinson\u27s disease, Alzheimer\u27s disease, fungal diseases, depression, anxiety, and Attention Deficit Hyperactivity Disorder (ADHD), skin cancer, female sexual dysfunction, post-menopausal bone loss, and urine incontinence, can now be treated with transdermal delivery systems. A naturally occurring pentacyclic triterpenoid, betulinic acid possesses antiretroviral, antimalarial, and anti-inflammatory qualities. More recently, it has been shown to have anticancer potential through topoisomerase inhibition. The goal of the current study was to create transdermal patches with a controlled release action that included several polymers and an anti-inflammatory medication, such as betulinic acid..The solvent evaporation approach was successfully used to create the betulinic acid transdermal patch. Betulinic acid transdermal patches for transdermal medication administration were assessed. A calibration curve was acquired, a transdermal film was made, and the drug\u27s bioavailability constraints were addressed.
Keywords: Controlled DDS, Transdermal DDS, Betulinic acid, Transdermal Patch, solvent evaporation method
Formulation and Evaluation of Herbal Face Pack
No full textObjective: The objective of this work is to formulate an herbal face pack for glowing skin. The primary goal of a herbal face pack is to harness the inherent benefits of herbs and plant-based ingredients to improve the overall health and appearance of the skin.
Methods: Natural herbal ingredients were used such as rose petal powder, Multani mitthi, dried orange peel powder, turmeric, nutmeg powder, neem powder, sandal wood powder etc. All ingredients were sieved by using #44 mesh. Weighed accurately and mixed geometrically for uniform mixture. Prepared formulation was evaluated by different parameters like organoleptic, physiochemical, physical, irritancy test along with stability examination.
Result: The formulation of combined form had passable flow property which is suitable for face pack. Herbal face pack is used to stimulate blood circulation, rejuvenates the muscle and help to maintain the elasticity of the skin and remove dirt from skin pores.
Conclusion: In this study it is concluded that formulation of face pack found to be good in physical parameter, free from skin irritation. The benefit of herbal cosmetics is their nontoxic nature, reduce the allergic reaction. Thus, in this work, we found good properties for face pack and further optimization study is required on this study to find out the useful benefits of face pack on human use as a cosmetic product.
Keywords: Face pack, Herbal, Cosmetic, Formulation, Evaluation, Appearance
Biological Activities and Mechanisms of Actions of Bioactive Compounds (BACS) Identified in Pure and Ternary Blends of Cocoyam, Soya Bean and Bambara Groundnut Flour Using Gas Chromatography-Mass Spectrometry (GC-MS) Technique: A Review
No full textBackground: functional foods contain bioactive compounds (BACS) and can be sourced from both animals and plants like cocoyam (CY), soya bean (SB) and bambara groundnut (BGN). previous studies have reported various bacs in each of these plants but literature is scanty on the types and amount, of bacs in such flour blends and formulations. when in combinations as blend, anti-oxidant, interactions occur, resulting in either potentiation, additive, synergistic or antagonistic effect, depending on several various variables. their in-vivo bioactivities which are due to various structural features of the BACS, can be antioxidant, anti-inflammatory, hypocholestrolaemic, antimicrobial and anti-diabetic activities. in this review the various bacs identified by gas chromotagraphy (GC)-mass spectrometry (MS) technique in the various formulations of CY-SB-BGN flour blends were researched for their biological activities and reported mechanisms of actions.
Methodology: a google search of a study on bacs identified using gc-ms in cy-sb-bgn flour blend was conducted and one paper was identified. the bacs reported in the study was noted and literature search of the various biological activities of such compounds and their mechanisms of actions were conducted. the results were documented and discussed.
Results and Discussion: the study revealed that thiadiazole, stilbene, aziridine, thiourea, amphetamine/phenylethylene, artemisinin, monoterpenoids, naphthalenes, i,4-diazpanes, phenols and flavanoids were the identified bacs in cy-sb-bgn flour blend formulations with both the pure and ternary blends showing different family classifications of compounds and different types of compounds in one family class. the biological activities and mechanisms of actions included antimicrobial, antioxidant, antiinflammatory and antidiabetic activities with reported mechanisms of actions for each of these invivo activities.
Conclusion: there are bacs in cy-sb-bgn formulations which are reported from studies to possess anti-microbial, anti-inflammatory, anti-oxidant and anti-diabetic properties invivo, with very established mechanisms of actions, making the use of such plant foods in disease management scientific, hence the recommendation of such plant foods use as adjunct in chronic disease management.
Keywords: Bioactive compounds, Plant foods, Cocoyam, Soya Bean, Bambara Groundnu