Journal of Drug Delivery and Therapeutics (JDDT)
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Role of Husbands in Antenatal Care, Delivery and Postnatal Care of Their Wives in Panchkhal, Nepal
No full textThe present study has assessed the involvement of husbands in antenatal care, delivery, and postnatal care among married women of reproductive age in Panchkhal Municipality, Kavre district, Nepal. Emphasizing the impactful role of a male in the circle of reproductive health, this research tries to address high maternal mortality and morbidity rates in Nepal by showing that a better understanding and support from the husband is highly essential for an improved outcome of maternal health. Data were originally collected through the use of a self-administered structured questionnaire with probability cluster sampling from 96 women who had at least one child aged five years or younger. Results showed that while all respondents received antenatal care, the number of women who received postnatal care was significantly lower, as many reportedly gave birth at home. Educated husbands were more likely to provide nutritional and emotional support during pregnancy. This has also shown that spousal communication about maternal and Child Health issues regarding child spacing, immunization, breastfeeding, and contraceptive use was important. This research found out positive results regarding the role of husbands in maternal care before and after pregnancy.
Keywords: Spousal participation, maternal health, family health, role of father
Exploring the Role of Paeonia emodi (Ood-e-Saleeb) in Neurological Health: Traditional Uses and Modern Pharmacological Insights: A Review
Full text linkOod-e-Saleeb, derived from Paeonia emodi Wall. (Ranunculaceae), is a medicinal herb extensively used in Unani medicine, particularly for neurological disorders. Found in the western temperate Himalayas, its roots, seeds, and flowers exhibit significant therapeutic properties. Traditionally, it has been utilized as a nervine tonic, nerve stimulant, and antispasmodic agent in conditions like paralysis (Fālij), facial palsy (Laqwa), tremors (Ri‘sha), epilepsy (Ṣar‘), and hysteria (Ikhtināq al-Raḥim). Recent pharmacological studies highlight its neuroprotective potential, particularly in diabetic peripheral neuropathy, where it modulates oxidative stress, inflammation, and neuronal apoptosis. Bioactive compounds such as paeoniflorin, flavonoids, and tannins contribute to its effects by enhancing neurogenesis, regulating neurotransmitter activity, and protecting against neuronal degeneration. Its ability to improve nerve function in diabetic neuropathy is linked to mechanisms involving advanced glycation end products (AGEs) and NF-κB pathway modulation. This review consolidates its traditional and modern pharmacological relevance, emphasizing its role in neurological disorders, including diabetic peripheral neuropathy, and its potential for further research and therapeutic applications.
Keywords: Ood-e-Saleeb, Neurological Disorders, Diabetic Peripheral Neuropathy, Paeonia emodi, Neuroprotectio
A Comprehensive Review on Nano-Scaffolds in Regenerative Medicine: Types, Preparation Methods and Applications
Full text linkNano-scaffolds are a major advancement in biomedical engineering, providing essential support for tissue repair, drug delivery, and regenerative medicine. These tiny structures have a high surface area, making them suitable for promoting cell growth and interaction with biological systems. They are created using methods like electrospinning, 3D printing, solvent casting, and biomimetic techniques, which allow for controlled strength, porosity, and biodegradability. Nano-scaffolds are extensively utilized in medicine to improve drug delivery by providing accurate and sustained release of therapeutic substances. In wound healing, they help tissue repair while reducing infections and inflammation. Bone regeneration benefits from scaffolds containing bioactive materials like hydroxyapatite, which support new bone formation. Additionally, conductive Nano-Scaffolds assist in nerve repair by guiding nerve growth and maintaining synaptic connections. Their potential in gene therapy is also significant, as they allow for controlled genetic modifications. Despite their many benefits, challenges such as large-scale production, immune response, and long-term stability still exist. Ongoing research aims to improve scaffold durability, incorporate smart biomaterials, and refine manufacturing techniques. With continuous advancements, Nano-Scaffolds hold great potential in revolutionizing regenerative medicine and personalized healthcare. This review covers the history of nano-scaffolds, types, preparation methods, and their uses in drug delivery, wound healing, bone regeneration, nerve repair, and gene therapy. It also highlights recent research and innovations, showing their future potential in medicine.
Keywords: Nano-scaffolds, Nanofibers, Hydrogels, Nanoparticles, Electrospinnin
Formulation and Evaluation of Arjuna Bark Chocolate for Heart Disease Condition
Full text linkThe research focuses on the formulation and development of Arjuna bark chocolate, a functional food product utilizing the therapeutic properties of Arjuna bark (Terminalia arjuna). Arjuna bark is renowned for its cardiovascular benefits, including its ability to improve heart health, reduce cholesterol, and enhance overall blood circulation. The study explores various formulations combining Arjuna bark extract with cocoa, sweeteners, and other functional ingredients to create a palatable and health-beneficial chocolate product. Through sensory evaluations, stability tests, and antioxidant analysis, the formulations are assessed for taste, texture, shelf-life, and health benefits. The aim is to develop a chocolate that not only satisfies the taste buds but also provides potential therapeutic effects, particularly for individuals looking to enhance heart health naturally. The findings suggest that Arjuna bark chocolate could serve as an innovative health snack, offering both enjoyment and functional benefits.
Keywords: Herbal Chocolate, Arjuna Bark Extract, Heart Disease, Cocoa Butter
Phytochemical Profile and Antioxidant Potential of Berberis aristata Bark in Diabetes Mellitus Management
Full text linkDiabetes mellitus is a long known metabolic disorder that is afflicting millions of people all over the world. High levels of blood sugar (also known as glucose) in the blood that can develop into other health problems if untreated, this is the main feature. In this case the body cannot make enough insulin to regulate blood sugar or does not use insulin properly. Diabetes have two types, i.e. diabetes 1st type and diabetes 2nd type. Chronic diseases both are called diabetes that affect how glucose is processed in the body causing blood sugar levels to be high. They however have different causes, symptoms, and treatment options.A plant of the Berberidaceae family, Berberis aristata is often called Indian Barberry or Tree Turmeric. The traditional use of Berberis aristata has been very long. One of its many active ingredients, berberine has shown antimicrobial, anti inflammatory as well as antioxidant and antidiabetic properties. The plant is used for treating numerous medical conditions, e.g. digestive problems, respiratory infections, skin conditions, diabetes. The Berberis aristata in ayurvedic medicine is used in diabetes and diabetes related complications. It is understood to improve insulin sensitivity and to promote glucose uptake by the cells to help with blood sugar levels. Berberis aristata is a long traditional medicine. Antimicrobial, antidiabetic, antioxidant and anti-inflammatory properties have been demonstrated for one of its many active ingredients, berberine, although it is not believed to be the most important one when it comes to diabetes. The plant is used for treatment of numerous medical conditions such as digestive, respiratory infection, skin, and diabetes.
Keywords: Diabetes mellitus, Antioxidant, Berberine, Berberis aristat
Overview of Ulva fasciata: Its Distribution, Phytochemical Constituents and Applications in Health and Industry
Full text linkUlva fasciata is a green macroalga in the Ulvaceae family that has attracted attention from researchers across different sectors owing to its pile of biochemical compounds and its versatility. In recent years, Ulva fasciata has emerged as a subject of interest due to its extensive biological properties and potential applications in the field of medicine. Known for its rich nutritional profile and diverse bioactive compounds, it has demonstrated a range of beneficial effects, including antimicrobial, antioxidant, and anti-inflammatory activities. The following review encapsulates an account of the general features of Ulva fasciata, its location, chemistry and the versatility of its uses. The paper is structured into two main parts: the first part provides general information about seaweeds and, more specifically, about Ulva fasciata, such as its classification, global distribution, seasonal distribution, nutritional value, especially its amino acid contents, and its bioactive compounds. The second section focuses on the myriad of uses associated with the Ulva fasciata, with special focus on its medical and pharmaceutical uses, cosmetic uses, as well as its uses in industries.
Keywords: Ulva fasciata, Phytochemicals, Antimicrobial, Antioxidant, Functional food, Sustainable resource
Imidazole Phenanthroline Derivatives: A Promising Application in Modern Medicine
Full text linkPurpose: The primary objective of this study is to create a new class of imidazole phenanthroline compounds that target the 1,10-phenanthroline core for its antifungal and antibacterial properties.
Methods: Commercially available 1,10-phenanthroline (phen) was nitrated with potassium bromide in the presence of sulfuric and nitric acids to get 1,10-phenanthroline-5,6-dione (phendione), an intermediate molecule, which served as the starting compound for the synthesis of 1H-imidazo [4,5-f] [1,10] phenanthroline compounds. This intermediate product was dissolved in glacial acetic acid and then reacted with different benzaldehydes while ammonium acetate acted as a catalyst. Thin Layer Chromatography (TLC) was used to track the reaction\u27s progress and the purity of the product. Their biological efficacy against in vitro bacterial and fungal growth was also investigated. The antimicrobial potential of the investigated compounds when compared to the standards Clotrimazole and Streptomycin, respectively, revealed impressive antifungal and antibacterial properties.
Results: A series of compounds were synthesized successfully and characterized by various analytical techniques such as NMR, IR and ESI-mass spectroscopy. The compounds possess remarkable antibacterial and antifungal potential.
Conclusion: A series of imidazole phenanthrolines were synthesized and found to have antimicrobial activities.
Keywords: phenanthrene, imidazole phenanthroline, 1,10-phenanthroline, potassium bromide, 1,10-phenanthroline-5,6-dione, 1H-imidazo [4,5-f] [1,10] phenanthrolin
Effect of Rhizobium-entomophilous insect interaction on groundnut production in Doba, southern Chad
Full text linkThis study investigated the combined effect of Rhizobium inoculation and flower-visiting insects on the productivity of groundnut (Arachis hypogaea) in Doba, southern Chad. Groundnut is a nutritionally and economically important crop, particularly in sub-Saharan Africa where protein-rich food is often scarce. Improving yields through eco-friendly practices like biofertilization and biological pollination can significantly enhance food security. A field experiment was conducted using three treatments : plots with Rhizobium, plots with chemical fertilizer, and control plots. Additionally, flowers were either left open to insect visits or protected to determine the effects of pollinators. Insects such as Amegilla calens, Apis mellifera, and Braunsapis sp. were identified as key pollinators, with Amegilla sp. being the most frequent visitor. Key parameters analyzed included number and weight of pods and seeds. Results showed that both Rhizobium inoculation and pollinator activity significantly increased yields. In plots exposed to pollinators, Rhizobium inoculation led to a marked improvement in pod and seed production compared to controls. The combined presence of Rhizobium and floral insects significantly enhanced groundnut yield components such as pod number, seed number, and seed weight. The findings underscore the potential of integrated agroecological practices specifically the synergistic use of biofertilizers and insect pollinators to sustainably boost crop productivity in regions like southern Chad.
Keywords: Rhizobium, entomophilous, insect, Arachis hypogaea, Doba
Formulation and Characterization of Intranasal Mucoadhesive Gel of Antiallergic Drug Loratadine for Improved Bioavailability
No full textThe present study aimed to formulate and characterize an intranasal mucoadhesive gel of loratadine to enhance its bioavailability. Loratadine, an antihistamine, is commonly used for the treatment of allergic conditions, but its low bioavailability due to extensive first-pass metabolism can limit its effectiveness. To address this issue, an in situ gel formulation was developed using Poloxamer 407 and Carbopol 934 as excipients. The gel\u27s physicochemical properties, including pH, drug content, viscosity, gel strength, gelation temperature, and drug release profile, were evaluated. FT-IR analysis revealed no significant chemical interaction between the drug and excipients, confirming the stability of the formulation. The gel exhibited shear-thinning behavior and gelation temperatures suitable for nasal administration. In vitro drug release studies showed a sustained release profile, with higher Carbopol concentrations resulting in slower drug release. The mucoadhesion time increased with Carbopol 934 concentration, ensuring prolonged retention at the nasal site. Stability studies demonstrated that the formulations remained stable under standard storage conditions. The results suggest that the loratadine-loaded mucoadhesive gel has the potential to improve the bioavailability of loratadine through intranasal delivery, offering a promising alternative to conventional oral dosage forms.
Keywords: Loratadine, Mucoadhesive Gel, Poloxamer 407, Carbopol 934, In Situ Gel, Bioavailability, Drug Release, Nasal Delivery, Stability, FT-I
Unravelling the Medicinal Secrets of Khashkhaash (Papaver somniferum L.) Seeds: A Powerful Blend of Unani Wisdom and Modern Science
No full textPapaver somniferum, a member of the Papaveraceae family, is also referred to as Khashkhash. It is among the traditional plants that have been used for medicinal purposes for a very long time. The health advantages of the poppy seeds (Papaver somniferum L.) are widely recognized. Proteins, oil content, dietary fiber, antioxidants, tocopherols, and other micronutrients are among its many nutrients. It is also being investigated because of its in vitro bioactive potential to treat a number of illnesses, including cancer, pain, and hypertension. With particular relation to Unani medicine, we have reviewed habitat, pharmacological activities, and phytochemicals in this paper.
Keywords: Papaver somniferum, Khashkhash, Unani medicine, pharmacological activities