Journal of Tropical Pharmacy and Chemistry
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Pengaruh Ketepatan Terapi dan Kepatuhan terhadap Hasil Terapi Hipertensi Di Poliklinik Penyakit dalam RSUP Dr. Sardjito Yogyakarta
Full text linkHypertension is considered as one of the leading causes of death. Complication in blood tissue that is caused by hypertension and that is becoming the leading cause of death might include several diseases such as coronary artery disease (CAD), hearth attack, and stroke and kidney failure. The therapy of antihypertensive drug either in monotherapy or in combination therapy plays a very essential role for patients in which the therapy in this case must be given in consideration of the blood pressure and possibility of complication. This research is aimed to observe a description of antihypertensive drug treatment in policlinic of internal disease of RSUP Dr, Sardjito Yogyakarta, accurate treatment and treatment result and effect of medication adherence in decreasing blood pressure. This research is performed using a design of observational study supported by data prospectively taken in order to observe the accurate treatment and medication adherence of the hypertensive patient. The assessment for the therapy achievement was performed using The Seventh Report of Joint National Committee (JNC VII) on Detection, Evaluation, and Treatment of High Blood Pressure in 2003, meanwhile, the assessment for medication adherence was done by using questionnaire of new 8-item self report Morisky Medication Adherence Scale (MMAS). Based on the research, it is found that the antihypertensive drug could be in monotherapy and in combination therapy. The use of monotherapy was at (20%) in which it was mostly dominated by CCB category at (8%), while the use of combination therapy was at (80%) mostly dominated by the category of ARB and CCB, namely at (55%). Of 100 out-patients including the inclusion criteria, it was (93%) of them that had the accurate treatment of antihypertension and (7%) of them that did not get the accurate treatment of antihypertension. Again, it was at (91%) that had the accurate dosage of antihypertension and (9%) had no the accurate dosage of antihypertension. In the assessment of blood pressure, the number of the patients obtaining (the accurate medicine and dosage) with the blood pressure that could achieve the target of therapy was at (68%) and (68%). On the other hand, the number of the patients obtaining (the accurate medicine and dosage) but with the blood pressure not achieving the target of therapy was at (25%) and (23%). Furthermore, those obtaining (inaccurate medication and dosage) with the achievement of the blood pressure to the target of the therapy was at (6%) and (6%). It was only (1%) and (3%) for the patients not obtaining (inaccurate medication and dosage), not achieving the target of the therapy. Based on the medication adherence of patients in taking antihypertensive drug was at (50%) with a high level of adherence, (41%) with medium level and (9%) with low level. From the test of chi-square analysis and from the significant level of 0,002 (p<0,05) it is found a significant difference between adherence and the result of the decrease of blood pressure. Thus, it can be concluded that a high adherence can decrease the blood pressure.
Studi Efek Samping Obat pada Pasien Neonatus yang Menjalani Rawat Inap Di Rumah Sakit Angkatan Laut Dr. Ramelan Surabaya
Full text linkRational drug treatments to avoid adverse drug reactions in neonates are depend on physiologic immaturity and age-related changes in pharmacokinetic and pharmacodynamic factor. This condition lead neonates more prone to adverse drug reaction than adults.The aim of this study was to estimate the prevalence of adverse drug reactions that occured at Dr. Ramelan Navy Hospital\u27s NICU observed in November 26th 2007 to January 26th 2008. It was also to analyze kind of medication that caused adverse drug reactions.The study employed 94 patients (5 premature neonates and 89 term neonates) who were observed perspectively from November 26th 2007 to January 26th 2008. Demographic data, drug therapy, relevant medical histories, laboratory data were recorded in this study. The study result was assessed by literature study. The study result were analysed with Descriptive analysis. The most common adverse drug reaction occurred in this population was potential adverse drug reaction (99.5%). The most adverse drug reaction generated from this study was come from the use of ampicillin sulbactam (42.7%), gentamisin (31.4%), ceftriaxone (16.2 %), amikacin (7.6 %), aminofilin (1.1 %), ampicillin (0.5 %), and dexamethasone (0.5 %). The study showed that almost all of adverse drug reaction occurred in this study was potential adverse drug reaction (99.5%)
Kajian Dendrimer (Poly)Amidoamine (Pamam) Generasi 4 Sebagai Template Dalam Pembentukan Nanopartikel Secara In Silico
No full textDendrimers are a class of highly branched synthetic polymers that has spherical form consist of three components: core, branch and terminal functional groups. One of dendrimer that has been commercialized is (Poly)amidoamine (PAMAM). PAMAM dendrimer used as a template in the preparation of gold nanoparticles. This research was studied the streched cavities of (Poly)amidoamine (PAMAM) dendrimer generation 4 using in silico method. Structure of (Poly) amidoamine (PAMAM) dendrimers generation 4 downloaded from Building Toolkit (DBT) Library and before the simulation structure was prepared. Then molecular dynamics simulations run using the AMBER program at 37°C in aqueous conditions. From analysis, obtained that the furthest distance of streched cavities at the closest distance from the core, region between residues 2 and 3 is 23.696 Ã… and at the terminal region between residues 100 and 122 is 58.045 Ã
Efek Pemberian α-Mangostin Dari Garcinia tetranda Pierre Terhadap Morfologi P.Falciparum
Full text linkMorphological changes assay to P. falciparum from the effects of α-mangostin from G. tetranda using TEM methods has been done. This test aims to determine the effect of mangostin on P. falciparum by observing morphological ultrastructure of P. falciparum using transmission electron microscope (TEM). α-Mangostin known to cause morphological changes in ultrastructure of P.falciparum after contact with α- mangostin on the 12 and 24 hour.
Pengaruh Merokok terhadap Keefektivitasan Terapi Hipertensi pada Penderita Hipertensi Perokok Di Empat Puskesmas Tahun 2017
Full text linkHypertension is a chronic condition of the mesh where blood pressure rises above normalized blood pressure. This study aims to measure the effect of smoking on the effectiveness of hypertension therapy in patients with hypertension of smokers at Puskesmas I Sumbang, Puskesmas II Kembaran, Puskesmas Purwokerto Timur I, Puskesmas Purwokerto Selatan 2017. Type of study used prospective cohort, in terms of patient\u27s blood pressure with drug consumption Single 1st, 10th day, 30th day to assess effectiveness. Data were analyzed univariat and bivariate through Chi-square test. The result showed that p> 0,05 that p = 0,361 showed that there was no significant difference in the effectiveness of hypertension therapy between group of non smoker hypertension and smoker hypertension. Does not affect the effectiveness of therapy statistically
Studi Pendahuluan Fitokimia Tanaman Koleksi Arboretum Legok Pulus Garut
Full text linkArboretrum is a botanical garden which is an open place where there are plants that have been labeled. The purpose of this research is the preliminary study on phytochemical content of secondary metabolite compounds on the leaves of the Legok Pulus Garut arboretum collection plant. the results of the study known twenty-two types of plants contained in Arboretum Garut contain various phytochemical compounds and can be used as collection and research base of medicinal plants
Formulation and Evaluation of N-Hexane Fraction of Libo Fruit based Emulgel for Sunscreen
Full text linkLibo fruit (Ficus variegata Blume) has activity as a sunscreen. Topical form of certain pharmaceuticals can be used to protect the skin from sun exposure. This study aims to determine the best gel-emulsion formula from the libo’s N-Hexane fraction, its stability, and its sunscreen activity. The formula was consist gelling agents variations type and concentration, i.e. carbopol 940 and hydroxypropyl methylcellulose (HPMC). The best formula were chosen based on physicochemical characteristics. the freeze-thaw test deployed to check the stability, and the sunscreen activity was tested using UV-Vis spectrophotometry. The results showed that the best formula was formula 1 with carbopol 940 (1%), there were no changes in physicochemical characteristics during the stability test, and experienced a decrease in sunscreen activity after the stability test
Development of Liquid Lipstick Containing Natural Dyes from Kepok Banana Flower Peel Extract (Musa Paradisiaca L.) and Study on Its Stability
Full text linkLiquid lipstick is a decorative cosmetic preparation used to add color to the lips. This study aims to determine alternative colorants derived from natural ingredients. The peel of kepok banana flower (Musa paradisiaca L.) which contains anthocyanins can serve as a natural dye, as evidenced by the total anthocyanin content test using the differential pH method, yielding 35.958 mg/L. Three formulations were developed using varying concentrations of kepok banana flower peel extract: F1 (5%), F2 (7.5%), and F3 (10%). The formulations underwent six freeze-thaw (-21°C and 25°C) and cycling (4°C and 40°C) stability cycles, with evaluations of organoleptic properties, viscosity, pH, and spreadability after each cycle. All formulations showed good physical stability which are semi-solid texture, rose scent, homogeneity, brown color, and acceptable spreadability, viscosity, pH, and non-irritant effects. Preference testing with 30 panelists identified F2 as the most favored
Formulation And Evaluation Of Poly Herbal Nutraceutical Gummies For Diabetes
Full text linkIn this study due to the Changes in human lifestyle can have a profound impact on health, leading to a range of disorders. Poor diet, insufficient exercise, smoking, and excessive drinking are associated with chronic illnesses such as heart disease, diabetes, and some types of cancer. Nutraceuticals, which blend nutrition with pharmaceuticals, are foods or food components that are vital in altering and sustaining normal physiological functions crucial for human health. The growth of the global nutraceutical market is primarily driven by current demographic and health trends. Nutraceuticals sourced from both plants and animals present promising opportunities for the food industry to develop innovative food products in the future. In this study, we created nutraceutical gummies designed to address diabetes. These gummies were crafted using four plants known for their antidiabetic effects: panner Doda, star fruit, noni fruit, and the insulin plant
A Correlational Study of Academic Stress Levels and Total Cholesterol in Students of the Medical Laboratory Technology Study Program, Kadiri University
Full text linkStudents in the Medical Laboratory Technology (MLT) Study Program at Kadiri University often experience academic stress due to assignments, examinations, and other academic demands. Such stress may affect physiological functions, including total cholesterol levels. This study aimed to examine the relationship between academic stress levels and total cholesterol levels among MLT students at Kadiri University. The research employed a quantitative, non-experimental, cross-sectional design. A sample of 29 students was selected using simple random sampling. Academic stress levels were assessed using the DASS-42 questionnaire, while total cholesterol levels were measured through laboratory testing. Results showed that 58.62% of respondents experienced moderate stress and 41.38% experienced high stress. Regarding cholesterol levels, 86.21% had normal levels (<200 mg/dL), and 13.79% had high levels (≥240 mg/dL), with no respondents in the borderline category. Pearson’s correlation test yielded a p-value of 0.3313 (p > 0.05), indicating no significant relationship between academic stress levels and total cholesterol levels. The findings suggest that academic stress does not significantly influence total cholesterol levels among these students