Karamanoğlu Mehmetbey University
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Applications of digital twin in precision medicine: a systematic review
Get PDFDigital twin (DT) technology has emerged as a transformative tool in healthcare and precision medicine, enabling personalized care through real-time simulations, predictive modelling, and patient-specific diagnostics. This systematic review analyses 94 peer-reviewed articles from the Scopus database, highlighting the role of machine learning (ML) techniques—such as supervised, unsupervised, and hybrid methods—in advancing DT applications. The study explores the integration of emerging technologies, including blockchain and generative artificial intelligence (AI), to enhance DT functionality and data security. Spanning disciplines such as cardiology, oncology, neurology, and metabolic disorders, the research underscores the interdisciplinary applications of DTs while addressing critical ethical concerns like data privacy, algorithmic bias, and regulatory challenges. Despite limitations, including reliance on a single database and subjective categorization, this review demonstrates the transformative potential of DTs and suggests future research directions in quantum computing integration and patient-centered DT design
Effect of maternal depression and anxiety scores on the development of three-month-old babies through the assessment of general movements
Get PDFDepression and anxiety symptoms are common during pregnancy, which poses significant risks not only for mothers but also babies. Exposure of the fetus to maternal distress during pregnancy can lead to impairments of the newborn's development that persist throughout their lives. The objective of this study is to investigate whether prenatal exposure to maternal depression and anxiety symptoms has an impact on the neurological status of infants by assessing the quality of general movements at 3 months of age. Methods: In this study, 101 uncomplicated pregnant patients who completed 36 weeks of gestation and their healthy newborns were analyzed. The Beck Depression Inventory (BDI) and the State-Trait Anxiety Inventory-Trait (STAI-T) questionnaires were used to assess mothers' distress. 3 months after the birth, general movements (GMs) assessments were conducted using video recordings of their babies. The scores of the questionnaires were compared between the infants grouped as “normal GMs” and “abnormal GMs”. Results: Twenty-six infants exhibited abnormal GMs, while 75 exhibited normal. There was a statistically significant difference in maternal BDI and STAI-T scores between infants exhibiting abnormal and normal GMs. Conclusion: Our study revealed that a mother's higher anxiety and depression scores during the latter stages of pregnancy might negatively affect the early development of the newborn and this can be determined at 3 months of age by evaluating the quality of GMs. This highlights the importance of monitoring the distress experienced by the mother and the quality of GMs exhibited by newborns and taking preventative measures
Developing strategy with a multi-criteria decision-making model to ıncreasing the efficiency of ınvestments in home care services
Get PDFBu çalışmada evde bakım hizmetlerine yapılan yatırımların artırılması için uygulanması gereken en önemli stratejilerin belirlenmesi amaçlanmaktadır. Buna göre, evde bakım hizmetleri yatırımlarına etki eden literatür tabanlı 7 kriter belirlenmiştir. Bu kriterler arasından en önemli olanının belirlenebilmesi için çok kriterli karar verme tekniklerinden olan Küresel Bulanık TOP-DEMATEL tekniği uygulanmıştır. Bu çalışmanın literatüre en önemli katkılarından biri de evde bakım hizmetleri alanına yapılacak olan yatırımları etkileyen kriter setinin belirlenmesidir. Gerçekleştirilen Küresel Bulanık TOP-DEMATEL analiz sonuçlarına göre, evde bakım hizmetleri alanına yapılacak yatırımlara etki eden en önemli kriter sağlık sigortalarının kapsayıcılığı olarak bulunmuştur. Sigorta kapsayıcılığından sonra sürece en fazla etki eden kriter nüfusun demografi yapısıdır. Dolayısıyla sigorta kapsamının evde bakım hizmetlerini de içine alacak şekilde artırılması hizmet sunucuları ve hizmet alıcıları açısından önem arz etmektedir. Karar verici pozisyonunda olanları sigorta kapsayıcılığı hususunda geniş iyileştirmeler yapması önerilir.This study aims to determine the most important strategies to be implemented in order to increase investments in home care services. Accordingly, 7 literature-based criteria affecting home care services investments were determined. In order to determine the most important of these criteria, the Spherical Fuzzy TOP-DEMATEL technique, which is one of the multi-criteria decision-making techniques, was applied. One of the most important contributions of this study to the literature is the determination of the criteria set that affects the investments to be made in the field of home care services. According to the Spherical Fuzzy TOP-DEMATEL analysis results, the most important criterion affecting the investments to be made in the home care services field was the inclusion of health insurance. After insurance coverage, the most influential criterion in the process is the demographic structure of the population. Therefore, it is important for both service providers and service buyers to increase insurance coverage to include home care services. Thus, those in the position of decision-makers need to make extensive improvements in insurance coverage
Maladaptive thinking styles and suicide cognitions: Serial mediation of difficulties in emotion regulation and loneliness
Get PDFThere are many social, cultural, biological, and environmental factors that influence suicidal cognitions. Research aimed at understanding suicidal cognitions among university students may provide theoretical evidence for preventive studies on suicide. Accordingly, the present study aims to investigate how maladaptive thinking styles contribute to suicide cognitions through the serial mediating roles of difficulties in emotion regulation and loneliness. The sample consists of 617 university students (77.6% of the participants are female, Mage = 20.511, SD = 2.307). The correlation analysis revealed that maladaptive thinking styles were positively associated with difficulties in emotion regulation, loneliness, and suicide cognitions. Serial mediation analysis was conducted using the PROCESS macro (Model 6), which revealed that difficulties in emotion regulation and loneliness have a serial mediating role in the relationship between maladaptive thinking styles and suicide cognitions. The results have practical implications for developing intervention strategies targeting emotion regulation and loneliness to reduce suicide risk among university students. The research results are discussed and interpreted in the light of the literature
Public policies, digitalization and participation
No full textParticipation, along with digitalization, has an important place in the formation of public policies. Participatory public policies are implemented, especially through mechanisms such as digital participation and e-participation, and digitalization is used in public policies. Active involvement of different segments of society in the decision-making process using digital tools is important for participatory public policies. The main problem of the study is to examine how the components of digitalization play a role in shaping and implementing public policies along with digital transformation. The main claim of the study is that utilizing digitalization in the delivery of public services increases efficiency and facilitates participation. Citizens can participate more actively in the decision-making process through online platforms and mobile applications. Additionally, with egovernment applications, citizens can access public services more easily, and an accountable and transparent management approach can be implemented. The effective use of social media and online platforms allows individuals to express and discuss their opinions, and public opinions and demands can be collected through online surveys and online platforms. Active participation of citizens is enabled in policymaking. © 2025 Nova Science Publishers, Inc. All rights reserved
İnvestigation of transcription factor and cytokine gene expression levels in helper t cell subsets among turkish patients diagnosed with ıcf2 (novel zbtb24 gene variant) and ıcf3 (cdca7 variant) syndrome
No full textImmunodeficiency, centromeric region instability, facial anomalies syndrome (ICF), is a rare disease with autosomal recessive inheritance. ICF syndrome. It has been reported that ICF syndrome is caused by mutations in the DNMT3B (ICF1), ZBTB24 (ICF2), CDCA7 (ICF3), and HELLS (ICF4) genes. As a result of literature research, there are no studies on transcription factor and cytokine expressions of helper T cell subsets in ICF syndrome. In the study; Th1 (TBET, STAT1, STAT4), Th2 (GATA3, STAT6), Th17 (RORgt, STAT3), Treg (FoxP3, STAT5) transcription factors and the major cytokines of these cells (Th1; IFNG, Th2; IL4, Th17; IL17A-21-22, Treg; IL10, TGF beta) expressions were aimed to be evaluated by qRT-PCR. Patients (ICF3: three patients; ICF2: two patients), six heterozygous individual and five healthy controls were included in the study. All patients had hypogammaglobulinemia. Except for the CD19 cells of P2 from patients diagnosed with ICF3, the CD3, CD4, CD8, and CD19 cells in the other ICF3 patients were normal. However, the rates of these cells were low in patients with ICF2 syndrome. Factors belonging to patients' Th1, Th17 and Treg cells were significantly lower than the control. Additionally, novel mutation was detected in ZBTB24 gene (c.1121-2 A > T). Our study is the first molecular study on Th cell subsets in patients with ICF syndrome and a new mutation that causes ICF2 syndrome has been identified
Tini particle-reinforced magnesium matrix composites: production, microstructure, phase transformations, and mechanical properties
No full textMagnesium matrix composites reinforced with 5-25 vol% Ti49.2Ni50.8 microparticles are produced by uniaxial hot pressing technique. Powder mixtures are hot pressed in cylindrical graphite dies under 50 MPa pressure for 1 h at 600 degrees C. Density measurements show that specimens reach almost full density and do not contain any pores. Microstructural analyses demonstrate that undesired secondary phases or compounds do not form at matrix/reinforcement interface. As a result of aging heat treatment performed simultaneously with the manufacturing process, martensite phase (B19 ') and Ti3Ni4 precipitates are also observed in the microstructure of reinforcing materials in addition to the main austenite (B2) phase. The room-temperature yield strength and compressive strength of the composite materials range between 60 and 86 MPa and 232 and 296 MPa, respectively. Although the ductility values decrease with increasing reinforcement content, the decrease is less than those of ceramic and other metallic reinforced composites. The ductility is determined to be 17.6% for the composite with the highest reinforcement content. In contrast to the reference and conventional materials, the yield strengths of the composite samples produced increase significantly with the increasing temperature up to 100 degrees C. This unusual behavior is attributed to the stress-induced martensitic transformations observed in TiNi alloys.Technological Research Council of Turkey [215M808, 2015-FBE-D276]; Technological Research Council of Turkey ((TUBITAK))The authors gratefully acknowledge the financial support provided by Technological Research Council of Turkey ((TUBITAK), grant no. 215M808) and Van Yuzuncu Y & imath;l University Scientific Research Projects Unit Head ((BAP), grant no. 2015-FBE-D276)
Green synthesis of iron oxide nanoparticles from extracts of Daucus carota subsp. sativus whole vegetable, peel, pomace, and juice and their application as antibacterial agents and Fenton-like catalysts
No full textThe green synthesis of iron oxide nanoparticles (Fe-NPs) with catalytic and antimicrobial activities from the extracts of different parts of Daucus carota subsp. sativus var. atrorubens Alef. was demonstrated in this study. The extracts of whole vegetable, peel, pomace, and juice acted as a reducing agent for the bio-reduction of Fe3+ into Fe-NPs. The synthesis of Fe-NPs was indicated by surface plasmon peaks within the range of 200-300 nm, as well as characteristic iron oxide bond formation in the region of 400-850 cm-1 using an ultraviolet-visible spectrophotometer and FT-IR spectrophotometer, respectively. The green synthesised Fe-NPs from the whole vegetable and its byproduct extracts had uniform quasi-spherical structures, with average particle sizes of 87.13, 80.95, 103.14, and 86.26 nm from whole vegetable extract, peel extract, pomace extract, and juice, respectively. All synthesised particles exhibited excellent Fenton-like catalytic activities on the discoloration of methylene blue best fitting the pseudo-first order kinetic model for Fe-NPs from whole vegetable extract, pomace extract, and juice and the pseudo-second order kinetic model for Fe-NPs from peel extract. In addition to catalytic activity, Fe-NPs showed antibacterial activity against Escherichia coli, Staphylococcus aureus, and Bacillus subtilis. The antibacterial effects of Fe-NPs alone and their synergistic effects with antibiotics have been observed in both Gram-positive and Gram-negative bacteria
The appearance of external genital organs and anogenital distance in male fetal cadavers
No full textThis study aimed to determine the normal size of the male external genital organs and anogenital distance in human fetuses during the fetal period through the anatomic morphometric method. The study was performed on 104 spontaneously aborted human male fetuses aged between 10 and 39 weeks of gestation. Fetuses were divided into groups according to gestational weeks, months, and trimesters. Parameters belonging to the male external genital organs were measured, including penile length and width, transverse scrotal diameter, anterior-posterior scrotal diameter, the distance from the anterior and posterior aspect of the penis to the center of the anus, and the anogenital distance. The mean of each parameter was computed by gestational weeks, months, and trimester groups, and data were presented as mean +/- standard deviation. The mean of each parameter increased with gestational age, and statistically significant differences were observed between trimester groups. A high correlation was also determined between gestational age and the parameters measured
İmproving the efficiency of perovskite photovoltaics using a hierarchical 2d/3d/2d structure
No full textThree-dimensional (3D) organometal perovskite solar cells (PSCs) have exhibited remarkable performance. Meanwhile, the crucial hurdle to commercialization is the 3D perovskite's instability. The development of multilayered (2D/3D) junction perovskites as light absorption materials has proven to be one of the most dependable approaches for stabilizing PSCs without compromising their power conversion efficiency (PCE) owing to the passivation capability and hydrophobic nature of the massive organic cations. Herein, hierarchical 2D/3D/2D perovskites with optimized interfaces are developed by using a Dion-Jacobson (2D) phenylethylammonium dimethylammonium lead iodide (PeDAMA(4)Pb(5)I(16)) film on the top and a Ruddlesden-Popper (2D) cesium germanium di-iodide dibromide (Cs2GeI2Br2) film at the bottom of a 3D triple-cation Cs(0.07)FA(0.85)MA(0.08)Pb(IBr)(3) perovskite. The initial simulation of the 2D/3D/2D PSC obtained a PCE of 11.75%. Afterward, we systematically optimized the 2D perovskite layer by changing the thickness, bulk defect density, and p-type doping level to attain optimum values. The findings demonstrate that nonradiative recombination in the 2D/3D/2D-structured PSC is substantially suppressed, hence impeding the generation of leakage current. Further optimization of the Cs2GeI2Br2 (2D) perovskite, along with parasitic resistances and temperature, leads to a remarkable enhancement from 18.24% to 27.88%. This process can offer significant insights for the construction of perovskite structures to attain efficient and stable photovoltaic devices