Central Food Technological Research Institute
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Effect of triacetin on the development of Hydroxyethyl cellulose films for food Packaging
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Western blot analysis of liver tissue to study lipid metabolism related genes in DIO- C57BL/6 mice
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Extraction and fractionation of total lipids of garcinia cambogia fruit rind and its fatty acid profile
No full textImpact of processing techniques on the nutritional quality, antinutrients, and in vitro protein digestibility of milled soybean fractions
No full textThe study analyzed the quality characteristics of roller-milled soybean fractions following germination, roasting,
and hydrothermal treatments. Roller milling influenced the distribution of nutrients and antinutrients across
fractions. Semolina fractions exhibited high nutritional value, with coarse semolina containing higher ash,
protein, fiber, iron, zinc, and phenolic content. As particle size decreased, phytic acid and trypsin inhibitor
content reduced while protein digestibility improved. Phytic acid decreased by 33.12 %, 13.38 %, and 15.92 %
after germination, roasting, and hydrothermal treatment, respectively. Trypsin inhibitor reduction was highest in
hydrothermal (82.68 %), followed by germination (64.77 %) and roasting (61.16 %). These results emphasize the
benefits of pre-milling treatments and physical separation in enhancing soybean nutritional quality
Efficacy of nutritional plant-based extracts from Aframomum citratum and Xylopia parviflora in mitigating epididymal and excrement fat accumulation in DIO-C57BL/6 mice
No full textObesity is a major global health issue, frequently exacerbated by high-fat diets (HFDs), which contribute to
adverse metabolic outcomes. This study investigates the efficacy of extracts from nutritional plants Aframomum
citratum (C.Pereira) K.Schum and Xylopia parviflora Spruce in modulating selected anthropometric parameters and
fat deposition in DIO-C57BL/6 mice. Over 30 days, we observed that the extracts significantly attenuated body
mass index (BMI) and apparent fat mass index (aFMI) in treated mice compared to HFD controls. Notably,
X. parviflora at 200 mg.kg− 1 BW (body weight) effectively reduced both visceral and subcutaneous adipose
tissues, while orlistat served as a comparative benchmark. Lipid profile assessments revealed significant de
creases in triglycerides, total cholesterol, and fatty acid contents in the epididymal fat pads of treated animals.
Gas chromatography-mass spectrometry (GC–MS) analysis confirmed these findings and also indicated that
treatment with the extracts enhanced the excretion of fatty acids, suggesting a potential mechanism of lipid
malabsorption. Furthermore, histological analyses revealed a marked decrease in adipocyte size in treated
groups, indicating a considerable decline in fat deposition. These findings suggest that bioactive compounds,
particularly phenolic acids and flavonoids, found in A. citratum and X. parviflora extracts exhibit significant anti-
obesity properties, positioning them as promising natural therapeutic agents for managing diet-induced obesity.
Future research should focus on elucidating the mechanisms responsible for these effects and assessing their
clinical applicability. This study contributes valuable insights into the role of dietary interventions in obesity
management, with implications for the development of novel therapeutic strategies
Evaluation of antioxidant properties, sensory profile of encapsulated spice oleoresins and molecular docking studies for the anti-depressive potential of their active components
No full textThis study aims to investigate the antioxidant potential, bioactive retention, and antidepressant effects of native
and encapsulated oleoresins from pepper, turmeric, and chili to enhance their therapeutic efficacy. The major
challenge in utilizing spice oleoresins is their low bioavailability and stability, which this study addresses
through nano-encapsulation using hydroxypropyl beta-cyclodextrin (HPBCD). The encapsulated oleoresins were
evaluated for their total polyphenol, flavonoid content, and antioxidant activity, revealing that turmeric oleo-
resin (TOR) demonstrated the highest antioxidant potential, followed by chili (COR) and pepper (POR). How-
ever, nano-encapsulation reduced antioxidant activity by 50–60 %, although it significantly improved the
stability and bioavailability of bioactives. Molecular docking studies further confirmed strong binding affinities
between bioactive compounds (piperine, curcumin, and capsaicin) and depression-related proteins, including
serotonin, Brain-Derived Neurotrophic Factor (BDNF), and Monoamine Oxidase (MAO), indicating potential
antidepressant effects. This study highlights the novelty of nano-encapsulation in enhancing the bioactivity and
therapeutic potential of spice oleoresins, offering promising insights for developing natural antidepressant formulations or functional foods to combat depression and neurodegenerative disorders