Journals of Badan Penelitian dan Pengembangan Kesehatan
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Efek Ekstrak Etanol Daun Kelor terhadap Kadar Kreatinin Serum dan Superoksida Dismutase Tikus Model 5/6 Subtotal Nefrektomi
Full text linkChronic Kidney Disease (CKD) is still a major problem in the health sector in the world, including in Indonesia. One of the main pathomechanisms in CKD is oxidative stress. Superoxide dismutase (SOD) is an enzyme that plays a role in fighting oxidative stress. Oxidative stress can be overcome with antioxidants both from inside the body and from the outside obtained from natural materials. Moringa leaves (Moringa oleifera L.) have the potential to prevent the progressivity of CKD because of their flavonoid content which has an antioxidant effect. This study aimed to analyze the effect of Moringa leaf ethanol extract (MLEE) on serum creatinine and SOD levels in rat model 5/6 subtotal nephrectomy. This research is an experimental study with a post-test only with a control group design. A total of 30 male white rats were randomly divided into 5 groups. Group A: sham control, B: subtotal nephrectomy, C, D, and E: treatment groups with MLEE of 200, 400, and 800 mg/kg BW, respectively. On the 15th day after the administration of extracts or aqua dest, sham surgery was carried out in group A, and 5/6 of subtotal nephrectomy in groups B, C, D, and E continued to administer extracts and aqua dest until the 21st day. A blood sample is taken on the 22nd day after surgery, checked serum creatinine levels and SOD. Data were analyzed using One-way ANOVA. The results showed that there was a significant difference in the average serum creatinine levels (
Efektivitas Ekstrak Daun Kemangi (Ocimum sanctum Linn) Terhadap Mortalitas Larva Aedes aegypti
Full text linkBasil leaf (Ocimum sanctum Linn) are known to have the ability as natural larvicides because there are various compounds including tannins, eugenol, flavonoids, essential oils, hexauronic acid, saponins, pentose, xylose, metal homocytic acid, mulludistin, ursolic acid and methyl clavical. This study aims to determine the effectiveness of basil leaf extract (O. sanctum Linn) on mortality of Aedes agypti larvae. This research is a true experimental type with posttest only with control group design. Aedes aegypti larvae obtained from Balitbangkes Banjarnegara were used in this study as many as 450 larvae. This study consisted of 6 groups with 2 control groups (positive control/temefos 1% and negative control/distilled water) and 4 other groups receiving treatment with basil leaf extract concentrations of 1.5%, 1.8%, 2.1%, and 2.4%. Each group contained 25 larvae of Ae. aegypti with three repetitions and observation time with 10th, 40th, 60th, 120th, 240, 720, and 1440 minute intervals. Larval mortality of Ae. aegypti occurred from the 120th minute with a concentration of 2.4% with a mortality percentage of 5.6%. The results of the Kruskal Wallis test showed that there were differences in the mortality of Ae. aegypti at 60, 120, 240, 720, and 1440 minutes. The LC50 value was 2.329% at 720 minutes while the LC90 test was 7.043% at 720 minutes. Basil leaf extract has not been effective as a larvicide because mortality occurred from the 120th minute
Efektivitas Ikan Asin, Limbah Ikan dan Umpan Alami Sebagai Umpan Lalat pada Perangkap Lalat Ramah Lingkungan (Eksperimen Lapangan di Kandang Ternak Rumah Pemotongan Hewan Pegirian Surabaya Tahun 2022)
Full text linkDensity of flies was a health problem that must be controlled so as not to cause health problems. One of the control methods was by physically controlling using ecofriendly flytrap with organic bait, namely fish waste, which is a salted fish and natural bait. The research objective was to analyze the effectiveness of fish waste, salted fish, and natural bait as fly bait on ecofriendly flytrap. This type of research is quasi-experimental using the post test group design. The results of the data were based on the calculation of the number of flies and measurements of physical environmental factors in the field for 9 days. Then, the data were analyzed using the Kruskall Wallis statistical test with α of 5%. The results showed that fish waste bait attracted more flies than salted fish bait and natural bait, while statistical tests showed that there were differences in the number of flies caught in fly traps with various baits according to the hypothesis, namely p value <0.05. Fish waste was effectively used as bait in an ecofriendly flytrap
Analisis Efektifitas Biaya Terapi Pengobatan Pasien Diabetes Mellitus Tipe 2 terhadap Kontrol Glukosa Darah
Full text linkDiabetes mellitus (DM) is a chronic disease characterized by blood glucose levels exceeding normal. The length of therapy in DM patients causes the large amount of treatment costs incurred, although in Indonesia BPJS insurance is used but this puts the burden of health financing on the Indonesian government, so there is a need for an analysis of costs associated with therapeutic outcomes. The purpose of this study was to analyze the Cost Effectiveness of Type 2 DM patients in a hospital in the South Surabaya area. The method used is observation, with retrospective observation on type 2 DM patients in outpatient internal polyclinics for the period April – December 2021. The results obtained were 30 patients who routinely controlled 2, 3, 4, 5, 6, 7, 8 and 9 months, receiving single therapy or a combination of antidiabetic drugs. In this study, a cost and effectiveness analysis was carried out with the measurement of therapeutic outcomes, namely pre-post GDP and pre-post GD2PP. The conclusion of this study were 30 female patients (100%), age > 45 years 24 people (80%). The effectiveness of sulfonylurea single therapy is 50% with an ACER of between Rp. 4,392.48 – Rp. 18,686.86 routine control 2, 3 and 9 months. For the treatment of 2 combinations of Thiazolidinediones + Insulin has an effectiveness value of 100% with ACER Rp. 42,490.08 routine control 6 months. While the 3 combinations that have a 100% effectiveness value are the combination of Sulfonylurea + Thiazolidinedione + Biguanide with an ACER price of Rp. 6,668.4 routine follow-up for 3 months. In 3 combinations of oral antidiabetic with insulin (Insulin + Sulfonylurea + Thiazolidioine + alpha glucosidase inhibitor) has a 100% effectiveness value, the ACER price is Rp. 36,082.36 routine control 7 months
Epidemiological Assessment of Lymphatic Filariasis in Pekalongan City, Central Java, Indonesia
Full text linkLymphatic filariasis is an infectious disease caused by filarial worms and transmitted by mosquitoes. Pekalongan City is the highest filariasis endemic area caused by Wuchereria bancrofti in Central Java. This is indicated by the microfilaria rate of 2.8% in 2016. To reduce the number of filariasis cases, mass drug administration has been carried out since 2011. The aim of the study was to describe the epidemiology of the distribution of filariasis endemic areas, microfilaria rate, treatment coverage. mass and the correlation of sociodemographic factors with the incidence of filariasis. The research variables used secondary data in the form of filariasis cases, education, population density, gender and land use. Data analysis used Spearman's correlation. The results showed that cases of filariasis were spread across all districts with an increasing number of endemic areas during 2011-2016. Efforts to mass treatment have not been successful (mf rate > 1% and treatment coverage < 65%) and must be repeated in 2017-2019. Sociodemographic factors were not related to the incidence of clinical or chronic cases of filariasis. To accelerate the achievement of filariasis elimination, it is necessary to add vector control efforts in integrated filariasis management
Deteksi Plasmodium knowlesi Menggunakan Nested Polymerase Chain Reaction (PCR) di Kecamatan Muara Komam Kalimantan Timur
Full text linkPlasmodium knowlesi is a parasite of the genus plasmodium that naturally infects long-tailed macaques (Macaca fascicularis), but currently reported has ability to infect humans. The identification/detection of P. knowlesi can be done using RDT, microscopic, or molecular examinations using nested PCR. Nested PCR is the most sensitive and specific method of examination to date. This study aimed to detect P. knowlesi in humans by RDT, microscopic, and nested PCR examinations. The study was descriptive with a cross-sectional approach, carried out from March to July 2019. The samples in this study were 123 patients who were suspected of being infected with malaria and who underwent laboratory tests at the Muara Komam Health Center. Microscopic examination and RDT examination were carried out at the Muara Komam Health Center, while nested PCR was carried out at the Eijkman Molecular Biology Laboratory Jakarta. The results of RDT and microscopic examinations showed as many as 16 of 123 (13%) malaria-positive samples of P. falciparum and P. vivax, and 10 of 123 (8.1%) malaria-positive samples of P. falciparum and P. vivax. Nested PCR tests targeting the rRNA SSU gene were able to identify P. knowlesi by 6 out of 123 (4.87%). In conclusion, the study showed that Plasmodium knowlesi was detected in humans in Muara Komam, East Kalimantan through nested PCR examination
Potential of Leaf Extracts Sonneratia alba and Avicennia alba as a Biolarvacide of Aedes aegypti Mosquito
Full text linkThe continuous use of synthetic larvacides as an effort to control the vector mosquito population of Dengue Hemorrhagic Fever (DHF) can cause negative impacts on the environment and humans. Bioactive compounds from animals and plants can be used as an alternative to natural larvacides (biolarvacides). Mangrove species Sonneratia alba and Avicennia alba are known to have several bioactive types, so they are potential as biolarvacides. This study aimed to determine the potential of S. alba and A. alba leaf extracts as biolarvacides against Aedes aegypti mosquito larvae. This research was true experimental with a post-test-only group design. The larvicidal toxicity test of the leaf extracts of S. alba and A. alba against Ae. aegypti larvae to obtain the LC50 value was carried out by treating the extract concentrations at 500 ppm, 1,000 ppm, and 1,500 ppm. Synthetic larvicide (abate) was used as a positive control and Aquadest as a negative control. Data analysis was carried out descriptively and statistically (probit analysis). The results showed that the leaf extracts of S. alba and A. alba had potential as biolarvacides. Based on the LC50 value, the extracts of A. alba (LC50: 1,053 ppm) were more potent as biolarvacides than the extracts of S. alba (LC50: 14,112 ppm). Physical damage and behavioral changes in mosquito larvae movement indicated that the toxicity of A. alba leaf extract was acute while that of S. alba leaf extract was chronic
Systematic Review: Prevalensi dan Dampak Infeksi Malaria pada Wanita Hamil dan Neonatal
Full text linkGlobally, malaria cases in the world reached 241 million cases in 2020 and increase from the previous year. Malaria infection in pregnant women was reported in 33 countries, and the cases were estimated at 11.6 million (34%). Malaria infection can increase maternal and fetal morbidity and mortality, including anemia in pregnancy, low birth weight, premature birth, stillbirth, and small gestation age, and congenital malaria. This article discusses pregnant women's malaria infection prevalence and maternal and neonatal outcomes. This paper is a systematic review by searching for articles using electronic databases from Pubmed and ScienceDirect using keywords “Malaria” and “Pregnancy” or “Pregnant Women” and “Outcome” or “Impact” and “Maternal” or “Neonatal”. The selection of articles used the PRISMA guidelines which were then analyzed in a narrative manner. Based on the article search results obtained 10 articles that meet the criteria for analysis. The prevalence of malaria infection in pregnancy is still high. Reported outcomes in pregnancy, birth, and neonates include preterm birth, low birth weight, small gestation age, maternal anemia, and maternal and neonatal mortality. The role of health workers is very important to prevent malaria infection in pregnancy so that it does not result in adverse health impacts for maternal and neonatal