4075 research outputs found
Sort by
Eksplorasi Kepuasan Hidup Laki-Laki Gay Indonesia Dengan Human Immunodeficiency Virus (HIV)
Full text linkIndonesian gay men living with human immunodeficiency virus (HIV) suffer from the effects of the human immunodeficiency virus (HIV) in the physical and psychological aspects of their lives, while also being burdened by the stigma from society related to their sexual orientation and status as people living with HIV (PLHIV). Unfortunately, this topic is inadequately explored in Indonesian academic literature. This study addresses this gap utilizing concurrent-embedded mixed method design by combining quantitative assessments (Satisfaction With Life Scale [SWLS]) with qualitative data from three open-ended questions. The instrument was administered online by adopting a snowball sampling technique to recruit study participants, being: (1) Indonesian men; (2) aged 18 and older; (3) self-identifying as gay men; and (4) living with human immunodeficiency virus (HIV). Analysis of data from 84 study participants from 16 provinces found that 60.7% of the study participants have their life satisfaction score in the Slightly Satisfied to Very Satisfied categories. Self-acceptance, gratitude, and pressure emerged as dialectical aspects of their perceived life satisfaction, with safety and social support identified as primary concerns. These findings highlight the need for further study and research into the life satisfaction of other minority groups, especially Indonesian gay men living with human immunodeficiency virus (HIV). Communities, experts, and policymakers are encouraged to raise awareness about human immunodeficiency virus (HIV)-related issues to foster safety and social support. Ensuring the availability of equitable mental health services and access to employment and entrepreneurship is also a critical concern.Laki-laki gay Indonesia dengan human immunodeficiency virus (HIV) menderita dampak human immunodeficiency virus (HIV) dalam aspek fisik dan psikologis kehidupan mereka, sementara juga dibebani oleh stigma dari masyarakat terkait dengan orientasi seksual dan status mereka sebagai orang dengan HIV (ODHIV). Sayangnya, topik ini kurang dieksplorasi dalam literatur akademis Indonesia. Studi ini mengatasi kesenjangan tersebut dengan desain concurrent-embedded mixed method yang menggabungkan asesmen kuantitatif (Satisfaction With Life Scale [SWLS]) dan data kualitatif dari tiga pertanyaan terbuka. Instrumen ini diberikan secara daring dengan mengadopsi teknik snowball sampling untuk merekrut partisipan studi, berupa: (1) laki-laki Indonesia; (2) berusia 18 tahun ke atas; (3) mengidentifikasi diri sebagai laki-laki gay; dan (4) dengan human immunodeficiency virus (HIV). Analisis data dari 84 partisipan studi dari 16 provinsi menemukan bahwa 60,7% dari partisipan studi memiliki skor kepuasan hidup dalam kategori Agak Puas hingga Sangat Puas. Penerimaan diri, rasa syukur, dan tekanan muncul sebagai aspek dialektis dari kepuasan hidup yang mereka rasakan, dengan keamanan dan dukungan sosial diidentifikasi sebagai perhatian utama. Temuan ini menyoroti perlunya studi dan penelitian lebih lanjut tentang kepuasan hidup kelompok minoritas lainnya, terutama laki-laki gay Indonesia dengan human immunodeficiency virus (HIV). Masyarakat, pakar, dan pembuat kebijakan didorong untuk meningkatkan kesadaran tentang isu terkait human immunodeficiency virus (HIV) untuk meningkatkan keamanan dan dukungan sosial. Memastikan ketersediaan layanan kesehatan mental yang adil dan akses ke pekerjaan dan kewirausahaan juga memerlukan perhatian kritis
Pimpin, Peduli, atau Kehilangan? Transformational Leadership, Ethical Climate, dan Dampak Physical Work Environment Pada Turnover Intention Pekerja Generasi Z
Full text linkGeneration Z, which currently dominates the workforce, has high expectations for work-life balance, material rewards, and supportive physical work environment (PWE). This study explores the influence of transformational leadership (TL), caring ethical climate (CEC), and physical work environment (PWE) on turnover intention (TI) among 317 Generation Z workers across various sectors in Indonesia. Study findings reveal that transformational leadership (TL) directly reduces turnover intention (TI; β = - .70; p < .05), though the mediating effect through caring ethical climate (CEC) is not significant; only evident under low physical work environment (PWE) conditions. Results also show that physical work environment (PWE) plays a significant moderating role (β = - .63; p < .05), strengthening the positive impact of caring ethical climate (CEC) in reducing turnover intention (TI). In other words, a conducive physical work environment (PWE) not only enhances comfort, but also supports the creation of an ethical culture that more effectively lowers turnover intention (TI). This highlights that physical factors in the workplace have a substantial impact, both directly and indirectly, on employee retention. This study underscores the importance of transformational leadership (TL) and the management of physical work environment (PWE) in enhancing the loyalty of Generation Z workers, with results providing strategic insights to improve retention through a holistic approach.Generasi Z yang mendominasi dunia kerja saat ini memiliki ekspektasi tinggi terhadap work-life balance, material rewards, dan physical work environment (PWE) yang mendukung. Studi ini mengeksplorasi pengaruh transformational leadership (TL), caring ethical climate (CEC), dan physical work environment (PWE) terhadap turnover intention (TI) pada 317 pekerja Generasi Z di berbagai sektor di Indonesia. Hasil studi ini menunjukkan bahwa transformational leadership (TL) secara langsung menurunkan turnover intention (TI; β = - 0,70; p < 0,05), namun efek mediasi melalui caring ethical climate (CEC) tidak signifikan; hanya tampak pada tingkat physical work environment (PWE) rendah. Temuan juga menunjukkan bahwa physical work environment (PWE) menunjukkan peran moderasi yang signifikan (β = - 0,63; p < 0,05), memperkuat pengaruh positif caring ethical climate (CEC) dalam mengurangi turnover intention (TI). Dengan kata lain, physical work environment (PWE) yang baik tidak hanya meningkatkan kenyamanan, tetapi juga mendukung terciptanya budaya etis yang lebih efektif dalam menurunkan turnover intention (TI). Hal ini menekankan bahwa faktor fisik di tempat kerja memiliki dampak besar, baik secara langsung maupun tidak langsung, terhadap retensi pekerja. Studi ini menyoroti pentingnya transformational leadership (TL) dan pengelolaan physical work environment (PWE) untuk meningkatkan loyalitas pekerja Generasi Z, dengan hasil studi yang menyediakan strategi retensi berbasis pendekatan holistik
Pengaruh kualitas audit, audit tenure dan auditor switching terhadap opini audit going concern
Full text linkPurpose – This study aims to examine the effect of audit quality, audit tenure, and auditor switching on going concern audit opinions in Indonesian state-owned enterprises (SOEs), with company size as a moderating variable.
Methods – A purposive sampling technique was used to select 145 observations from 30 SOEs between 2019 and 2023. Logistic regression analysis was conducted using SPSS version 25.
Findings - The results indicate that audit quality negatively affects the issuance of going concern opinions. Company size significantly moderates the relationship between audit quality and going concern opinions. However, audit tenure and auditor switching do not have a significant impact.
Implications - These findings provide insights for management to enhance performance to reduce the risk of receiving going concern opinions, and for auditors to maintain independence and transparent communication during audits.
Originality - This research introduces company size as a moderating variable in the relationship between auditor-related factors and going concern audit opinions, specifically in the context of SOE
Thin Layer Chromatography (TLC) Fingerprint Analysis of Moringa oleifera Leaves Extract
Full text linkMoringa oleifera is known to be rich in nutrients and phytochemicals. M.oleifera is also widely used for herbal medicine and functional food. Fingerprint profiling is one of the methods used to determine the quality and authenticity of M.oleifera leaves and prevent counterfeiting. The study aimed was to determine optimal chromatographic parameters (stationary and mobile phases, blot volume, and detection method) capable to generating the highest number of bands with good separation. The method used was Thin Layer Chromatography (TLC), accompanied by stability testing and precision testing. The results showed that fingerprint profile of M. oleifera leaves, created using the mobile phase toluene: ethyl acetate: methanol: formic acid (7:2:1:0.2), stationary phase TLC plate with silica gel 60 F254. Test solution was 70% ethanol viscous extract of M. oleifera leaves, dissolved in methanol with a blotting volume of 5μl, observed in UV 366 nm and obtained eight bands. Stability and precision testing of the TLC condition optimization method showed that the analyte was stable on the TLC plate and in solution. The analyte also showed stability results during the chromatography process, and the repeatability and intermediate precision were met the criteria. The TLC fingerprint analysis method with chromatographic conditions optimized in this study can be used as one of the quality control methods of M. oleifera leaf raw materials
Pengaruh Poloxamer 188 dan Propilen Glikol terhadap Karakteristik Fisik, Stabilitas, dan Inhibisi Tyrosinase pada NLC Bakuchiol
Full text linkPenuaan kulit merupakan proses degeneratif yang terjadi akibat faktor intrinsik dan faktor ekstrinsik, yang ditandai dengan munculnya garis halus pada kulit wajah, hiperpigmentasi, kering, keriput dan kerutan. Bakuchiol (Psoralea corylifolia) merupakan senyawa meroterpenoid yang memiliki aktivitas antipenuaan. Penelitian ini bertujuan untuk menentukan konsentrasi poloxamer 188 dan propilen glikol terhadap karakteristik fisik, stabilitas dan efektivitas inhibisi enzim tyrosinase. Variasi konsentrasi poloxamer 188 dan propilen Glikol yang digunakan yaitu 8:8 (F1), 6:10 (F2) dan 10:6 (F3). Formulasi NLC dibuat dengan metode high shear homogenation dan ultrasonikasi yang kemudian diinkorporasi ke dalam emulgel. Sediaan dievaluasi karakteristik fisiknya meliputi ukuran partikel, indeks polidispersitas, zeta potensial, organoleptik, homogenitas, tipe emulsi, pH, viskositas, daya sebar, daya lekat, stabilitas dipercepat, dan efektivitas dengan metode inhibisi enzim tyrosinase. Hasil evaluasi menunjukkan NLC bakuchiol memenuhi karakteristik fisik dan stabilitas. Formula 1 (F1) menunjukkan karakteristik paling optimal dengan ukuran partikel rendah, PDI rendah, stabilitas terbaik, dan terbukti memiliki aktivitas inhibisi enzim tyrosinase yang tinggi. Berdasarkan keseluru- han parameter tersebut, formula 1 (F1) dinyatakan sebagai formula terbaik untuk pengembangan emulgel NLC bakuchiol.
Skin aging is a degenerative process caused by intrinsic and extrinsic factors characterized by the appearance of fine lines, hyperpigmentation, dryness, wrinkles, and creases. Bakuchiol (Psoralea corylifolia) is a meroterpenoid compound with antiaging activity. This study aimed to evaluate the effect of varying concentrations of poloxamer 188 and propylene glycol on the physical characteristics, stability, and tyrosinase enzyme inhibition activity. The concentrations used were 8:8 (F1), 6:10 (F2), and 10:6 (F3). NLC formulations were prepared using the high shear homogenization and ultrasonication method, then incorporated into an emulgel base. The formulations were evaluated for particle size, polydispersity index, zeta potential, organoleptic properties, homogeneity, emulsion type, pH, viscosity, spreadability, adhesiveness, accelerated stability, and effectiveness through a tyrosinase inhibition assay. The evaluation demonstrated that the bakuchiol NLC met the physical characteristics and stability criteria requirements. Among the formulations tested, formula 1 exhibited the most optimal performance, evidenced by its smaller particle size, lower polydispersity index, superior physicochemical stability, and markedly higher tyrosinase inhibition activity. Based on these comprehensive parameters, formula 1 is identified as the most superior formulation for the development of bakuchiol NLC emulgel
PENGARUH SOCIAL MEDIA ENGAGEMENT DAN E-WOM TERHADAP MINAT DAFTAR MAHASISWA DALAM PROGRAM IISMA
Full text linkThis study aims to examine the influence of social media engagement and electronic word of mouth (e-WOM) on students’ interest in applying for the Indonesian International Student Mobility Awards (IISMA) program. Data were collected through questionnaires distributed to 152 student respondents aged under 18 to 24 years old. The data analysis used in this study includes validity testing, reliability testing with Cronbach’s Alpha, and multiple linear regression analysis to measure the influence between variables. Data were processed using confirmatory factor analysis (CFA) and regression analysis. Testing using the structural equation model (SEM) shows that students’ engagement with social media content, especially on Instagram, and the positive reviews they receive, have a positive impact on their interest in applying for the IISMA program. These findings suggest that an active, interactive, and informative communication strategy on social media can increase students’ interest in the program. Therefore, the IISMA program organizers are encouraged to develop more engaging content and expand their information outreach through social media platforms
The Impact of Food Energy Consumption and Poverty Levels on the Prevalence of Food Inadequacy in Indonesia
Full text linkFood security in Indonesia continues to face serious challenges despite the declining poverty rate, indicating that income growth alone does not necessarily translate into improved nutritional outcomes. This study examines the effects of household food energy consumption and poverty levels on the prevalence of inadequate food consumption across 34 provinces in Indonesia from 2019 - 2024. The findings reveal that higher household food energy consumption significantly reduces the prevalence of inadequate food consumption, whereas poverty levels do not exhibit a significant effect. These results diverge from much of the existing literature that positions poverty as the primary determinant of food insecurity. The novelty of this study lies in demonstrating that food energy adequacy exerts a more direct and consistent influence than poverty status in explaining food insecurity at the provincial level. The policy implication is that poverty alleviation alone is insufficient to address nutritional deficiencies. Instead, interventions should focus on improving household access to energy-dense and nutritious foods through local agricultural development, food price stabilization, and targeted nutrition programs. Such strategies are considered more effective in supporting the achievement of the Zero Hunger target in Indonesia
Curcuminoid Compounds Inhibit Macrophage Migration Inhibitory Factor: In Silico Study for Their Association to Anti-diabetic Potency
Full text linkAbstract—Diabetes mellitus is a health problem characterized by chronic inflammation causing complications in the cardiovascular, kidneys, eyes, and nervous system, with macrophage migration inhibitory factor (MIF) protein playing a crucial function in the inflammatory process chain. MIF has been known as a signaling protein involved in the development of type 1 and type 2 diabetes mellitus (DM). There are several studies indicating that the development of type 1 and type 2 DM is influenced by the accumulation of macrophages in tissues susceptible to diabetic injury or infection. Curcuminoids, the bioactive components in turmeric, are known for their ability to decrease inflammation. This in silico study is intended to analyze the potential anti-inflammatory effect of curcuminoid in DM, with a specific focus on how it may reduce proinflammatory signals through MIF. The investigation involved predicting physicochemical, pharmacokinetic and toxicity (ADMET) qualities for curcuminoids, followed by molecular docking simulations with MIF as the target protein. The ADMET results showed curcumin and bisdemethoxycurcumin had favorable properties, while dimethoxycurcumin exhibited undesirable traits like low VDss. Therefore, molecular docking simulations were performed using curcumin and bisdemethoxycurcumin as ligands. The molecular docking simulations indicated that curcumin has a negative binding affinity slightly lower than (S, R)-3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid methyl ester (ISO-1), a reference MIF inhibitor; and bisdemethoxycurcumin binds to MIF even stronger than ISO-1, with interacting MIF amino acids Lys 32, Ile 64 Asn 97, Pro 1, and Tyr 95. Hence, the curcumin and bisdemethoxycurcumin compounds were found as having the potential to inhibit MIF activity that is associated with the progression of DM.
Keywords: curcuminoids, diabetes melitus (dm), inflammation, mif inhibitors, molecular docking
Abstrak—Diabetes mellitus (DM) merupakan masalah kesehatan yang ditandai dengan peradangan kronis, yang dapat menyebabkan komplikasi pada sistem kardiovaskular, ginjal, mata, dan sistem saraf. Protein macrophage migration inhibitory factor (MIF) memiliki peran penting dalam proses peradangan. MIF diketahui sebagai protein pensinyalan yang terlibat dalam perkembangan DM tipe 1 dan tipe 2. Beberapa penelitian menunjukkan bahwa perkembangan DM tipe 1 dan tipe 2 dipengaruhi oleh akumulasi makrofag pada jaringan yang rentan terhadap cedera atau infeksi akibat diabetes. Kurkuminoid, komponen bioaktif dalam kunyit, dikenal memiliki kemampuan untuk meringankan peradangan. Studi in silico ini bertujuan untuk menganalisis potensi efek antiinflamasi kurkuminoid terhadap DM, dengan fokus pada kemampuannya dalam menurunkan sinyal proinflamasi melalui MIF. Studi ini mencakup prediksi sifat fisikokimia, farmakokinetik, dan toksisitas (ADMET) kurkuminoid, yang dilanjutkan dengan simulasi molecular docking menggunakan MIF sebagai protein target. Hasil analisis ADMET menunjukkan bahwa kurkumin dan bisdemetoksikurkumin memiliki sifat yang menguntungkan, sedangkan dimetoksikurkumin menunjukkan karakteristik yang kurang diinginkan, seperti volume distribusi (VDss) yang rendah. Oleh karena itu, simulasi molecular docking dilakukan dengan menggunakan kurkumin dan bisdemetoksikurkumin sebagai ligan. Hasil simulasi molecular docking menunjukkan bahwa kurkumin memiliki afinitas pengikatan yang sedikit lebih rendah dibandingkan dengan (S, R)-3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid methyl ester (ISO-1), senyawa referensi inhibitor MIF. Sementara itu, bisdemetoksikurkumin menunjukkan ikatan yang lebih kuat dengan MIF dibandingkan ISO-1, dengan residu asam amino MIF yang berinteraksi meliputi Lys 32, Ile 64, Asn 97, Pro 1, dan Tyr 95. Dengan demikian, senyawa kurkumin dan bisdemetoksikurkumin berpotensi menghambat aktivitas MIF yang berperan dalam perkembangan DM.
Kata kunci: kurkuminoid, diabetes melitus (dm), peradangan, inhibitor mif, molecular docking
Perbandingan Kadar Total Antosianin Pada Ekstrak dan Sediaan Lip Tint Mengandung Ekstrak Bunga Rosela
Full text linkLip tint merupakan salah satu jenis kosmetik bibir yang memiliki tekstur ringan dan cair. Salah satu zat utama dalam lip tint adalah zat warna. Bunga rosela (Hibiscus sabdariffa L.) dapat dimanfaatkan sebagai bahan baku pewarna alami karena mengandung senyawa antosianin. Tujuan dari penelitian ini untuk mengetahui kandungan total antosianin pada lip tint yang diformulasi dengan ekstrak bunga rosela sebagai pewarna alami serta membandingkan kadar total antosianin pada ekstrak bunga rosela dan lip tint. Metode analisis untuk penetapan kadar total antosianin dilakukan secara spektrofotometri UV-Vis sesuai Farmakope Herbal Indonesia II. Hasil pengujian diperoleh kadar total antosianin pada ekstrak bunga rosela dan lip tint masing-masing 5,9371 mg ⁄ L ± 0,30 dan 7,5568 mg ⁄ L ± 0,15. Perbandingan kadar total antosianin diuji statistik menggunakan uji T berpasangan dan diperoleh nilai sig. 0,038. Kesimpulan penelitian ini yaitu kadar total antosianin dalam lip tint lebih tinggi dibandingkan ekstrak murninya.
Lip tint is a type of lip cosmetic with a light and liquid texture. One of the main components in lip tint is a coloring agent. Roselle flower (Hibiscus sabdariffa L.) can be utilized as a natural coloring ingredient due to its anthocyanin content. This study aims to determine the total anthocyanin content in lip tint formulated with roselle extract as a natural colorant and compare the total anthocyanin levels between roselle extract and lip tint. The analysis method for determining total anthocyanin content was conducted using UV-Vis spectrophotometry according to the Indonesian Herbal Pharmacopoeia II. The results showed that the total anthocyanin content in roselle extract and lip tint was 5.9371 mg/L ± 0.30 and 7.5568 mg/L ± 0.15, respectively. The comparison of total anthocyanin levels was statistically analyzed using a paired t-test, resulting in a significance value of 0.038. The conclusion of this study is that the total anthocyanin content in the lip tint increased compared to its pure extract.
Submitted: 12-03-2025, Revised: 14-04-2025, Accepted: 07-05-2025, Published regularly: June 202
PENGARUH MARKETPLACE, PRICING, KUALITAS DAN INOVASI PRODUK TERHADAP PENINGKATAN PENDAPATAN UMKM SURABAYA PASCA PANDEMI COVID-19
Full text linkThe COVID-19 pandemic has shaken the economies of almost all countries, including Indonesia. The use of marketplace technology is one way to make MSMEs survive, especially during a pandemic that requires all activities to take place online or without face-to-face contact. This study aims to determine the effect of marketplace, pricing, quality and product innovation on increasing MSME income in the Surabaya Region after the COVID-19 pandemic. The method used in this research is quantitative with primary data. The sampling technique was carried out using purposive sampling technique so that the results obtained were more relevant to the research title. The sample obtained was 104 respondents in accordance with the research criteria. Researchers used the help of WarpPLS version 8.0 software using the PLS-SEM model. The research results show that Marketplace has an impact on increasing MSME income, but pricing, quality, and product innovation do not have an impact or no effect