Bioscientia Medicina - Journal of Biomedicine and Translational Research
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Are Parent Education Level Have Influence to Choose First Facility / Helper for Fracture in Children with Osteogenesis Imperfecta
Get PDFIntroduction: Osteogenesis Imperfecta (OI) disease can develop fractures with or without trauma. Initial management of fracture cases depends on the patients' parents and it may affect the results. Various kinds of factors can influence parents' decision making in health issues, one of which is the level of education.
Methods: This research was conducted by analyzing the results of the questionnaire for the parental education level. Patients that fulfilled the inclusion criteria were part of the study from January to March 2020.
Results: The data showed that 38 (31%), 31 (26%), 29 (24%), and 23 (19%) patients were treated by bonesetters, hospitals, primary health care centers, and private clinics. There were 38 (31%) parents who took their children to bonesetters, mostly have intermediate education level. Mostly parents with high level of education bring their children treated in hospitals (49%). There was a significant correlation between their education level (P = 0.000) regarding decision making in the first fracture case.
Conclusion: The parents' educational level of patients diagnosed with OI affects decision making in determining the first treatment facility for managing cases of fracture.
Practice Implication : Parental education level plays an important role in making appropriate decisions for medical treatmen
Risk Factors of Congenital Anomalies in South Sumatera Indonesia
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Introduction. Congenital anomaly is one of the leading causes of neonatal death. It is the third leading cause of neonatal death in Indonesia. More than half of all congenital anomalies can’t be related to a specific cause, suggesting multiple risk factors. This study aims to identify patterns and risk factors of congenital anomalies in RSUP Dr. Mohammad Hoesin Palembang.
Methods. This observational descriptive study with a cross-sectional design used 100 patients’ medical records, taken at RSUP Dr. Mohammad Hoesin Palembang, as samples. Missing data were complemented with a phone interview. Samples were picked using a proportional random sampling method. Collected data were counted within each category of congenital anomalies.
Results. There were 366 neonatal patients diagnosed with congenital anomalies at RSUP Dr. Mohammad Hoesin Palembang in 2015. The most prevalent (44,8%) congenital anomalies belonged to congenital anomalies of the digestive system, followed by congenital anomalies of the circulatory system (18,6%), and cleft lip/palate (11,5%). Following risk factors were found: the history of maternal active or passive smoking (41%), maternal exposure to chemicals or solvents (31%), family member with congenital anomalies of the same category (27%), maternal drug consumption (26%), maternal infection (22%), maternal diabetes mellitus (4%), and maternal hypertension (4%).
Conclusion. History of maternal active or passive smoking was the most frequently found risk factors among patients of congenital anomalies
Diagnosis and Management of Female Pattern Hair Loss
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Female pattern hair loss (FPHL) is the most common hair loss in post-puberty female. Prevalence of this nonscarring alopecia increases with age. The etiology of FPHL is still unclear, but hormonal and genetic factors are associated with pathogenesis of FPHL. Hormonal factor in FPHL is not as strong as in male pattern hair loss (MPHL). Clinical manifestations of FPHL are characterized by nonscarring baldness with shortening anagen phases and miniaturization of hair follicles, predominantly occur at the vertex, middle, and frontal regions. Hair shedding occurs progressively. The diagnosis of FPHL is established based on clinically. Classification of FPHL is according to Ludwig's criteria. Current FDA-approved FPHL therapy is topical minoxidil 2%, hair transplantation, and low level laser therapy (LLLT). Anti-androgen therapy still needs to be investigated further. The prognosis of FPHL is poor because the progressiveness continues with age. Long term treatment required for FPHL because it is a chronic residif disease. The treatment only prevents the progression of hair loss and does not cure. 
Polymorphism of the Klotho G-395a Gene Promoter with the Incidence of Preeclampsia
Get PDFA B S T R A C TIntroduction. Preeclampsia is one of the leading causes of maternal and perinatalmorbidity and mortality and is still a disease of theory. Klotho is a new gene, inseveral biological processes in the pathophysiology of preeclampsia that play a rolein regulating endothelial nitric oxide production, angiogenesis, production ofantioxidant enzymes and protection against endothelial dysfunction. The Klotho G-395A genotype AA promoter polymorphism is the cause of hypertension. This studyaims to determine the relationship of the Klotho G-395A promoter polymorphism tothe incidence of preeclampsia. Methods. This study is an analytical study with acase-control design. The research was conducted at Pembina community healthcentre of Palembang and the public hospital of Prabumulih in February - July 2020and involving 50 case group and 50 control group. To determine the genotype andallotype of the Klotho G-395A gene promoter polymorphism, using polymerase chainreaction examination. Result. The results showed that the risk factors for maternalage and maternal gestational age had a significant relationship with the incidence ofpreeclampsia (p-value 0.015; p-value 0.000). There was a significant relationshipbetween the Klotho G-395A genotype GA + AA promoter polymorphism and theincidence of preeclampsia (p-value 0.024; OR = 2.571; 95% CI = 1.122-5.895), whileallotypes in the study sample also had a significant relationship with the incidenceof preeclampsia. preeclampsia (p-value 0.025; OR = 1.978; 95% CI = 1.087-3.599).Conclusion: There is a significant relationship between the Klotho G-395A genepromoter polymorphism and the incidence of preeclampsia
The Role of Self Stigma towards Psychological Well-Being in Leprosy Patient
Get PDFIntroduction. This study aims to determine the role of self-stigma towardspsychological well-being to the people who have had leprosy in South Sumatera. Thestudy hypothesis that there is a role for self-stigma towards psychological well-beingviewed from psychological distress in people who have had leprosy in SouthSumatera. Methods. The participants of this study were people who have hadleprosy who finished their medical treatment. The research sample was 112 peoplewho have had leprosy. This study used the consecutive sampling technique.Psychological well-being and self-stigma were measured by the scale. The researchused simple regression analysis. Results. The result obtained by the value of R=0.442, R square= 0.178, F= 11.821, and P= 0,000 (p<0,05). It was proved that self-stigma has a significant role in 17.8% towards psychological well-being. Conclusion.There is no difference in psychological distress based on the role of self-stigma andpsychological well-being of people who have had leprosy in South Sumatera
Prevention of Irritant Contact Dermatitis Due to Hand Hygiene in The Era of COVID 19 Pandemic
No full textIrritant contact dermatitis (ICD) is an inflammatory epidermal disorder associated with physical or immunological provocation that results in impaired skin barrier. The prevalence of ICD is found to be 17-30% in healthcare workers compared to general population. The first-line management strategies of ICD is based on prevention. Intensive hand cleansing is one of the causes of ICD. Hand hygiene is general term that refers to any action of hand cleansing. Hand hygiene practices include hand washing and hand rubbing with antiseptics. Hand hygiene is the most effective preventive measure in preventing infection control, especially in the era of coronavirus (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) since December 2019. This disease is transmitted through inhalation or contact with infected droplets. Prevention and mitigation actions are key in controlling infection
Cancer Progression : Focus on Platelet
Get PDFPlatelets are an important component in the process of hemostasis and coagulation. It’snow known that high platelets count closely related to poor prognosis of patients withcancer, due to their role in the hematogenous spread of cancer cells. Platelet can beactivated by cancer cells into tumor educated platelet and then cause thrombosis throughtumor induced platelet aggregation. Platelet also protect cancer cells in the blood circulationfrom natural killer cells and help the transition of cancer cells from epithelial tomesenchymal and vice versa, resulting in the process of metastasis. In the next stage ofmetastasis, platelets trigger extravasation of cancer cells from primary cancer and helpadhesion of cancer cells to distant organs
The Effect of Meniran Herbs Extract (Phyllanthus niruri Linn) on The Histological Spectrum of The Uterus and Oviduct Rats (Rattus Norvegicus)
Get PDFBackground The use of plants as natural medicinal ingredients isincreasingly in demand by the public because the plants are consideredto have lower negative effects than chemical drugs. The effect of mineranherbs extract (Phyllanthus niruri Linn) on the histological spectrum of theuterus and oviduct rat (Rattus Norvegicus) had been studied.Aim ofStudy Aim of this study to explore the effect of meniran herbs extract(Phyllanthus niruri Linn) on the histological spectrum of the uterus andoviduct rat (Rattus Norvegicus) Methods Wistar rats have been challengedwith 2% NaCl in drinking water to result in fibrotic uterus and oviduct.Phyllanthus niruri extract (200 mg/Kg) turned into given orally for 4weeks. Matrix extracellular abundance turned into decided via way ofmeans of HE Staining and measured via way of means of METAVIRFibrosis Score. The result of this examine have been assayed via way ofmeans of SPSS 16. Results P. niruri extract was potent to reduce thematrix extracellular in 2% NaCl-induced rats compared to control group(p<0.05) in uterus. Meanwhile, P. niruri extract was not able to decreasethe matrix extracellular in 2% NaCl-induced rats compared to controlgroup (p>0.05) in oviduct. Conclusion P. niruri extract was potent todecrease the matrix extracellular in the uterus of the rats, but in oviduct
The Effectiveness Test of Betel Leaf Ethanol Extract Cream (Piper Betle Linn) Toward Propionibacterium acnes Bacterial Growth
No full textBackground: One of skin diseases that is frequently taking attention among teenagers and young adults is acne or in medical term called acne vulgaris. Acne treatment can be treated by repairing follicular abnormalities, decreasing sebum production, decreasing the number of Propionibacterium acnes colonies and reducing inflammation of the skin. The bacterial population of Propionibacterium acnes can be reduced by giving an antibacterial substance such as erythromycin, clindamycin and benzoyl peroxide. In the treatment of acne we can get antibacterial originating from nature, one of which can be obtained in the secondary metabolism of plants. The extracts and essential oils of betel leaf contain antibacterial and antifungal activities. The effectiveness of the use of betel leaf ethanol extract (Piper betle Linn) in acne treatment can be improved by creating formulations in form of cream preparations. Formulations in cream preparations will affect the amount and speed of active substances that can be absorbed. Objectives: To determine the effectiveness of the ethanol extract cream of betel leaf (piper betle linn) cream in formulas with what percentage of active substance has the most-inhibitory effect on the growth of Propionibacterium acnes. Methods:The study used experimental research. Propionibacterium acnes samples were diluted in 0.9% physiological NaCl sterile and embedded in Nutrient Agar (NA) media. The media was inserted into an incubator at 37 ° C for 24 hours. The test of antibacterial activity used the disk diffusion method. The antibacterial activity test results were statistically analyzed using the Statistical Product Services Solution (SPSS 17) program with a confidence level of 95% (α = 0.05). Results: The three creams containing betel leaf ethanol extracts at percentages of 5%, 10% and 15% for each had inhibitory zones: 9.8 mm, 15.85 mm, 17.35 mm. Conclusion: Cream that contains 15% active substance has the strongest inhibition
Dermatologic Lesions in Geriatric Patient with Diabetes Mellitus
Get PDFIntroduction: In geriatrics, there are changes in structure and function results in histopathological, physiological and clinical skin changes. The conditions can cause morbidity and decreases the quality of life of patients. This study was the first study that provide the characteristics of geriatric skin disorders in Dr. Mohammad Hoesin Hospital Palembang.
Methods: This study was descriptive observational with cross-sectional design using total sampling method performed among patients in Geriatric Outpatient Clinic, Dermatology and Venereology Outpatient Clinic and geriatric inpatient room in Dr. Mohammad Hoesin Hospital on July-September 2019.
Results: Physiological skin changes in geriatrics include xerosis cutis (13,95%), seborrheic keratosis (13,17%), guttate hypomelanosis (8,5%), senile lentigen (6,97%), freckle (2,32%), periorbital hyperpigmentation (1,55%), senile purpura (0,77%) and poikiloderma civatte (0,77%). The most skin disorder found were lichen simplex chronicus (11,1%), pressure ulcers (9,25%), senile pruritus (8,32%), asteatotic dermatitis (6.47%) and candidiasis (3,7%). The most common comorbid condition were diabetes mellitus in 16 patients (22,5%), CVD in 7 patients (9,9%), hypertension in 6 patients (8,5%), AKI in 6 patients (8,5 %), and HHD in 4 patients (5,6%). Diabetes mellitus was significantly associated with xerosis cutis (p = 0,0007), senile pruritus (p = 0,015), and guttate hypomelanosis (p = 0,016).
Conclusion: The most physiological skin changes found in geriatric patients in Dr. Mohammad Hoesin Hospital were xerosis cutis, seborrheic keratosis, and guttate hypomelanosis, while skin disorder were lichen simplex chronicus, pressure ulcer, and senile pruritus. Diabetes mellitus was significantly associated with skin disorders