Jurnal Fakultas Farmasi Umi (Universitas Muslim Indonesia)
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UJI AKTIVITAS ANTIBAKTERI EKSTRAK AIR DAN ETANOL UMBI BAWANG DAYAK (Eleutherine palmifolia (L.) Merr) TERHADAP BAKTERI PENYEBAB INFEKSI SALURAN PENCERNAAN
Get PDFUmbi bawang dayak (Eleutherine palmifolia (L.) Merr) is a traditional medicinal plant that has been used empirically to treat dysentery, stomach pain, and cancer. This plant has antimicrobial properties and contains naphthoquinone, alkaloids, flavonoids, saponins, tannins, and steroids. This study aims to assess the antibacterial effectiveness of water and ethanol extracts of umbi bawang dayak against E. coli, S. thypi, V. cholerae, and S. dysentriae. Minimum Inhibitory Concentration and Minimum Bactericidal Concentration values using the agar diffusion method with concentrations ranging from 25.6%, to 0.025% and its bioautgram profile, indicated notable antibacterial activity from both extracts. The MIC and MBC values for the aqueous extract against E. coli, S. thypi, and V. cholerae were at 1.6% concentration, while for S. dysentriae, at 0.8% concentration. The ethanol extract showed MIC values of 1.6% for E. coli, S. thypi, and V. cholerae, with 0.8% for S. dysentriae while MBC was 1.6% against all test bacteria. KLT-Bioautography analysis using n-hexane 4:1 ethyl acetate eluent revealed distinct compound profiles in both extracts, confirming efficient inhibition against the evaluated bacteria. Furthermore, while E. coli, S. thypi, and V. cholerae evidenced consistent MIC values in both extracts, S. dysentriae showcased ethanol extract superior MBC efficacy at 0.8% versus the water extract at 1.6%. Moreover, the ethanol extract demonstrated a richer compound composition with six active spots compared to the three spots apparent in the aqueous extract of umbi bawang dayak (Eleutherine palmifolia (L.) Merr)
PENGUJIAN AKTIVITAS ANALGETIK INFUSA HERBA KROKOT (Portulaca oleracea L.) PADA MENCIT PUTIH (Mus musculus) MENGGUNAKAN METODE HOT PLATE
Get PDFAnalgesics are substances that can reduce pain. However, long-term use may trigger side effects. This study aimed to evaluate the analgesic effect of purslane herb infusion (Portulaca oleracea L.) using a pain stimulation method and determine its effective concentration as an analgesic in white mice (Mus musculus). The research was conducted experimentally using male white mice divided into five treatment groups: Group I received Na-CMC as a negative control, Group II received paracetamol suspension as a positive control, and Groups III, IV, and V received the infusion at concentrations of 10%, 20%, and 30%, respectively. Test animals were placed on a hot plate at a temperature of 55°C, and the pain response time to heat stimulation was observed every 30 minutes for 3 hours. The data were statistically analyzed using one-way ANOVA followed by Bonferroni post hoc tests. The positive control group showed no significant differences compared to the groups receiving 10%, 20%, and 30% infusion concentrations. The study concluded that the purslane herb infusion has an analgesic effect in white mice, with an effective concentration of 30%
Uji Ketahanan Air Sediaan Breathable Nail Polish Ekstrak Ubi Jalar Ungu Dengan Variasi Eudragit® ® RL-100
Get PDFThe use of nail polish on Muslim women is only allowed during menstruation and postpartum, because nail polish can block water from entering the nails, making ablution and prayer invalid. Conventional nail polish cannot penetrate water and air. Purple sweet potato peel extract contains anthocyanin as a colouring agent. The main composition in the manufacture of nail polish is a polymer that acts as a film-forming material on the nails. Eudragit® RL-100 polymer used as a film-forming material that is permeable can penetrate water, and air so that it can be used as a film-forming material in breathable nail polish preparations. This study aims to formulate breathable nail polish preparations with variations of Eudragit® RL-100 as a polymer that can penetrate water and air based on the water resistance test. The formula was made in 3 variations with concentrations of Eudragit® RL-100 F1 (5%), F1 (10%), and F2 (15%). The results showed that formula 2 is the best formula that meets the water absorption test using a 4.6% glass plate, absorption using a tissue 34 seconds, water penetration using effervescent tablets 11 seconds, and water absorption using simulated hand washing colour fading.AbstractThe use of nail polish on Muslim women is only allowed during menstruation and postpartum, because nail polish can block water from entering the nails, making ablution and prayer invalid. Conventional nail polish cannot penetrate water and air. Purple sweet potato peel extract contains anthocyanin as a colouring agent. The main composition in the manufacture of nail polish is a polymer that acts as a film forming material on the nails. Eudragit® RL-100 polymer used as a film-forming material that is permeable, can penetrate water, and air so that it can be used as a film forming material in breathable nail polish preparations. This study aims to formulate breathable nail polish preparations with variations of Eudragit® RL-100 as a polymer that can penetrate water and air based on the water resistance test. The formula was made in 3 variations with concentrations of Eudragit® RL-100 F1 (5%), F1 (10%), F2 (15%). The results showed that formula 2 is the best formula that meets the water absorption test using a 4.6% glass plate, absorption using a tissue 34 seconds, water penetration using effervescent tablets 11 seconds, and water absorption using simulated hand washing colour fading. Keywords: Eudragit® ® RL-10; breathable nail polish; polymer; water resistance; purple sweet potato skin extract.
Skrining Fitokimia Ekstrak Daun Mimba (Azadirachta indica Juss) dan Kemangi (Ocimum sanctum L.) dan Evaluasinya Sebagai Hair Tonic Spray
Get PDFA phytochemical screening of Neem (Azadirachta indica Juss) and Holy Basil (Ocimum sanctum L) leaf extracts has been conducted, along with a hair tonic spray formulation. The aim of this research is to determine the chemical constituents of Neem and Holy Basil leaf extracts and formulate them into a hair tonic spray. The study included tests for flavonoids, tannins, alkaloids, steroids, and saponins in both Neem and Holy Basil extracts, as well as an evaluation of the stability of the hair tonic spray formulation. The research findings revealed that the Neem and Holy Basil extracts contain flavonoids, tannins, alkaloids, steroids, and saponins. The formulation was evaluated through organoleptic assessments, homogeneity tests, pH measurements, bulk density, and viscosity assessments, all of which Evaluation met the requirements established for a hair tonic spray
Antibacterial Activity of Extra Ethanol Kopasanda Leaves (Chromolaena Odorate L.) Against Pathogenic Bacteria of Urinary Tract Infection by TLC-Bioautography and Agar Diffusion
Get PDFKopasanda (Chromolaena odorata L.) leaves are one of the plants (herbs) containing various types of secondary metabolites, including saponins, tannins, alkaloids, and flavonoids, which function as antibacterial agents used as wound medicine for the community. This study aims to determine the antibacterial activity of the ethanol extract of Kopasanda (Chromolaena odorate L.) leaves using the TLC-bioautography and diffusion methods. The results of the antibacterial activity screening test obtained the active extract at a concentration of 0.1% against Escherichia coli and Staphylococcus aureus. The results of the antibacterial activity test using the TLC-Bioautography method with the eluent N-Hexane:Ethyl Acetate (4:1) showed results from Staphylococcus aureus bacteria with Rf values = 0.90, 0.78, 0.67, 0.52, 0.38, 0.27, 0.14, 0.05, and Escherichia coli bacteria with Rf values = 0.90, 0.52, 0.38, 0.27, 0.14, 0.05. Based on the results of testing the antibacterial activity with the agar diffusion method, the largest diameter of the inhibition zone at a concentration of 10% was obtained for Escherichia coli bacteria with an inhibition zone diameter of 13.59 mm, and Staphylococcus aureus with an inhibition zone diameter of 15.52 mm
ANALISIS MUTU PELAYANAN KEFARMASIAN PASIEN RAWAT JALAN DI INSTALASI FARMASI RUMAH SAKIT UMUM DAERAH (RSUD) MOROWALI
Get PDFThe hospital pharmacy installation is a place for managing pharmaceutical preparations and clinical pharmacy services based on the quality of pharmaceutical services. The quality of pharmaceutical services is the compatibility between pharmaceutical services and applicable standards to achieve optimal health degrees and patient satisfaction. Patient satisfaction is the match between perceptions of performance and expectations. The purpose of this study was to determine the quality of outpatient pharmacy services at the pharmacy installation of Morowali Hospital. This research is a quantitative research conducted using the Cross Sectional Survey method at the Pharmacy Installation of the Morowali Regional General Hospital. Assessment of the quality of pharmaceutical services and the level of patient satisfaction was carried out by collecting questionnaires from 95 patients. The results of the research on the quality of pharmaceutical services showed that 81.1% felt good, while the results of the study for the level of patient satisfaction, as many as 97.9% stated that they were satisfied with pharmaceutical services. The results of this study illustrate that the level of satisfaction of outpatients with services at the pharmacy installation of Morowali Hospital is very good with a value of 97.9% feeling satisfied and there is a relationship between service quality and patient satisfaction level with a constant value (a) of 19.534 and the value of the quality variable coefficient service of 0.00
PENGGUNAAN OBAT TRADISIONAL DALAM PENGOBATAN MALARIA DI KELURAHAN BENYOM JAYA KABUPATEN JAYAPURA
Get PDFTraditional medicine is an active ingredient of a plant, or more than one ingredient used for treatment, as for the treatment of Malaria. Malaria is a disease caused by Plasmodium. This research was conducted to find out the use of traditional medicine for malaria treatment in Benyom Jaya Subdistrict, Jayapura Regency. This type of research was descriptive using questioner as a tool for data collecting. From the Benyom Jaya subdistrict, Jayapura Regency population, there were 87 respondents who participated in this study. The research was conducted in April 2021. The results of the study obtained characteristics of the respondent as follow, respondents mostly were in the age group 36 - 45 years (31%), male (53%), most of them had high school level of education (55%), and work as private workers (32%). The most common type of plant used by the community for antimalaria was papaya leaves with 58 respondents (48%). The reason for using traditional medicine for malaria treatment was because it was made from natural ingredients 48 respondents (41%). The processing of traditional medicine for malaria treatment was boiled by 67 respondents (71%). The place where respondents get traditional medicine for malaria treatment was in the home yard with 54 respondents (46%). Malaria usually being treated with traditional medicine among the Benyom Jaya populatio
ISOLATION OF SKY ROOT ENDOPHITE (Helminthostachys zeylanica (L.) Hook) PRODUCING ANTIBIOTICS DIFFERENTLY AGAR
No full textTunjuk Langit (Helminthostachys Zelanica (L) Hook.) is a plant with family Opioglossaceae traditionally and empirically used as antibacterial with chemical compound flavonoid and saponin. This research aims to determine antibacterial activity of endophytic fungi isolate of Tunjuk Langit (Helminthostachys Zelanica (L) Hook.) root on bacteria that cause gastrointestinal infections. The result of the isolation endophytic fungi against from Tunjuk Langit (Helminthostachys Zelanica (L) Hook.) root using PDA+C medium and purification isolate obtained 7 pure isolates and analysis macroscopic from 8 isolates (IFATL-01, IFATL-02, IFATL-03, IFATL-04, IFATL-05, IFATL-05, IFATL-06, IFATL-07 and IFATL-08) obtained different charasteristics. Production of secondary metabolites of isolate active (IFATL05) by fermentation unsing maltose yeast broth (MYB) obtained supernatant and miselia. Metabolites supernatant were extracted using ethyl acetat, so obtained extract ethyl acetate supernatan. The result of the antibacterial activity of isolate endophytic fungi against V. cholerae, S. dysenteriae and E. coli bacteria by Agar diffusion obtained the largest diameter of the inhibition zone in isolate IFATL-05 = 29.13 mm active against S. dysenteriae bacteria. Based on phytochemical screening
Karakterisasi Senyawa Penghambat Polimerisasi Heme Dari Ekstrak Etanol Buah Pare (Momordica charantia L.)
Get PDFMalaria, which is caused by a parasitic infection of the genus Plasmodium, is still reported as a disease that contributes a high mortality rate in the world. However, there is another problem currently being faced, namely the incidence of patient resistance to antimalarial drugs on the market, causing an urgent need to develop new antimalarial drugs that are safe and inexpensive. Research on the ethanol extract of bitter melon (Momordica charantia L.) was carried out with the aim of providing information as an alternative antimalarial drug based on the mechanism of heme polymerization inhibition according to the method of Huy et. al and to identify the compound isolate fraction which is predicted to have the antimalarial activity. The ethanol extract of bitter melon (Momordica charantia L.) was prepared by maceration method using 96% pharmaceutical grade ethanol, partitioned using ethyl acetate and distilled water. Part of the partition which was soluble in ethyl acetate was fractionated using column chromatography (SiO2; i. n-hexane-ethyl acetate = 10 : 1 ~ 1 : 1; CH2Cl2-MeOH = 10 : 1 ~ 1 : 1 The results of heme polymerization inhibition test obtained isolate fraction 8.5 which had the highest activity, namely IC50 302.78 ppm and IC50 (chloroquine diphosphate as a positive control IC50 218.71 ppm).The results of identification by LCMS/MS spectroscopy showed that isolate fraction 8.5 contained several chemical compounds such as momordicoside L; momordicoside I and momordicoside F2 and quercetin The chemical compound that is predicted to play a role in inhibiting Heme polymerization is querceti
GC-MS Analysis of Lemongrass with Various Extraction Methods
Get PDFLemongrass (Cymbopogon citratus) is one plant producing bioactive essential oil. This research aims to determine the percentage yield of extracts and GC-MS analysis of chemical compound profiles of lemon grass with various extraction methods. Lemongrass bioactive compounds are extracted using maceration, ultrasonic, and distillation. The highest percentage extract yield was from maceration extraction, namely 14.83%, ultrasonic extraction was 4.68%, and distillation extraction was 6.00%. The GC-MS results showed that the secondary metabolite compounds resulting from maceration, ultrasonic, and distillation contained geraniol, citronellal, and citronellol. The citronella compound group was obtained with the highest percentage from distillation extraction at 14.83%, followed by ultrasonic extraction at 2.23% and maceration extraction at 0.37%