Jurnal Fakultas Farmasi Umi (Universitas Muslim Indonesia)
Not a member yet
463 research outputs found
Sort by
ANALISIS BAHAN KIMIA OBAT NATRIUM DIKLOFENAK DALAM SEDIAAN JAMU ASAM URAT YANG BEREDAR DI KOTA TIMIKA
Get PDFUric acid herbs are an alternative that is still widely used by the community as an anti-inflammatory and pain reliever. The increasing public interest in returning to traditional medicine has prompted several manufacturers to add medicinal chemicals to their preparations to produce a faster and maximum therapeutic effect, one of which is diclofenac sodium. The study aimed to analyze the chemical ingredients of the uric acid herbs circulating in Timika City and to find out the level of diclofenac sodium contained therein. The method used is High Performance Liquid Chromatography (HPLC) with reverse phase, where the mobile phase is methanol: aquabidestilata (80:20) and the stationary phase is column C-18. Based on the test results, nine uric acid herbs showed positive results with retention times at the same value as diclofenac sodium. The content of diclofenac sodium obtained were code A herb of 4.135 mg/L, B herb : 36.300 mg/L, C herb : 18.530 mg/L, herb D : 473.219 mg/L, herb E : 40.991 mg/L, herb F : 77.165 mg/L L, herb G : 93.109 mg/L, herb H : 52.700 mg/L, and herb I : 297.123 mg/L. All herb samples tested were unfit for public use because they contained the chemical drug sodium diclofenacUric acid herbs are an alternative that is still widely used by the community as an anti-inflammatory and pain reliever. The increasing public interest in returning to traditional medicine has prompted several manufacturers to add medicinal chemicals to their preparations to produce a faster and maximum therapeutic effect, one of which is diclofenac sodium. The study aimed to analyze the chemical ingredients of the uric acid herbs circulating in Timika City and to find out the level of diclofenac sodium contained therein. The method used is High Performance Liquid Chromatography (HPLC) with reverse phase, where the mobile phase is methanol: aquabidestilata (80:20) and the stationary phase is column C-18. Based on the test results, nine uric acid herbs showed positive results with retention times at the same value as diclofenac sodium. The content of diclofenac sodium obtained were code A herb of 4.135 mg/L, B herb : 36.300 mg/L, C herb : 18.530 mg/L, herb D : 473.219 mg/L, herb E : 40.991 mg/L, herb F : 77.165 mg/L L, herb G : 93.109 mg/L, herb H : 52.700 mg/L, and herb I : 297.123 mg/L. All herb samples tested were unfit for public use because they contained the chemical drug sodium diclofena
Phytochemical Screening and α-glucosidase Inhibitory of Secang Wood (Caesalpinia sappan L.)
Get PDFSecang wood (Caesalpinia sappan L.) is a part of the Secang plant which is widely used to treat various diseases, including diabetes. Based on previous research, secang wood contains flavonoids which have the potential to inhibit the α-glucosidase enzyme. The research aims to determine the potential of ethanol extracted by meseration using 96% ethanol. Inhibition of activity was tested using microplate reader which was measured at a wavelength of 405 nm with acarbose as a comparison. The results of the research show that the ethanol extract of secang wood has inhibitory activity, including it in the active category based on the % inhibition value obtained at 83.63%. Meanwhile, acarbose has inhibitory activity, including it in the very active category with a %inhibition value of 79%
Antioxidant Activity Test of Sappan (Caesalpinia sappan L.) and Chinese Teak (Senna alexandrina) Extract Combination Using DPPH (1,1 Diphenyl 2 Picrylhydrazyl) Free Radicals Scavenging Method
Get PDFSappan (Caesalpinia sappan L.) is applied as food and traditional medicine. Chinese teak (Senna alexandrina) is a plant from the tropics that can be developed as an antioxidant. This study was conducted to determine the antioxidant activity of the combination of Sappan and Chinese Teak by the DPPH (1,1 Diphenyl 2 Picrylhydrazyl) Free Radical Scavenging method. The extraction method used was maceration with Ethanol 96% as solvent. Determination of antioxidant levels was done quantitatively using the UV-Vis Spectrophotometer instrument at a wavelength of 514 nm. From the results of the study, the regression value obtained for the comparison of Quercetin is y = 3.1303x + 0.2292 with R2 = 0.9974 and IC50 value of 15.899 μg/mL. For the antioxidant activity of Sappan, the regression value y=0.5769x + 18.543 with R2=0.9969 and IC50 value of 54.53 μg/mL, Chinese Teak obtained regression value y=0.1421x + 17.506 with R2=0.9989 and IC50 value of 228.67 μg/mL, and for the combination obtained regression value y=0.4304x + 36.622 with R2=0.9954 and IC50 value of 40.38 μg/mL. The results of this study indicate that the combination of Sappan and Chinese Teak extracts has a very strong antioxidant effect (<50 μg/mL)
Determination of Routin Compound Content of Moringa Folium (Moringa oleifera) using Several Extraction Methods
Get PDFExtraction has been carried out from Moringa folium using the Microwave-Assisted Extraction (MAE), Ultrasound-Assisted Extraction (UAE) and Reflux Extraction (RE) methods. Moringa Folium has many uses, including as a chemopreventive agent. In this research, identification was carried out to determine the compounds in Moringa folium. Extraction uses the MAE, UAE, and Reflux methods. The of chemical compound content was determined using HPLC and standardized of rutin. The identification results showed that the Moringa folium spectra were similar to the routine spectra
STUDI TINGKAT PENGETAHUAN MAASYARAKAT TENTANG PENGGUNAAN ANTIBIOTIK DI KELURAHAN MALAWILI, KECAMATAN AIMAS, KABUPATEN SORONG
Get PDFIrrational use of antibiotics can lead to health problems, especially bacterial resistance to antibiotics. Improper use can be affected by lack of knowledge of antibiotics use. The study aimed to examine the public knowledge level on antibiotics use in Malawili Village, Aimas District, Sorong Regency, and the influence of community characteristics on knowledge level. This research used a descriptive study with a crosssectional survey design, involving 104 respondents. The data were obtained by purposive sampling techniques using questionnaires. The research performed data analysis using univariate and bivariate with chisquare test. The results showed that the majority of respondents were indicated to have "Enough" category (58.7% or 61 out of 104 respondents) of knowledge level. Meanwhile, the characteristics of society did not affect the knowledge level on antibiotics use at significance values (sig.>0.1
Senyawa Antiinflamasi dari Fraksi Etil Asetat Akar Pandan Wangi (Pandanus amaryllifolius Roxb.) Terhadap Udema Kaki Mencit Terinduksi Karagenan
Get PDFInflammation can occur due to insect bites, toxins, burns and blows. Inflammation can be cured using Non-Steroid Anti-Inflammatory Drugs (OIANS). Fragrant pandan root is thought to have anti-inflammatory activity because it contains alkaloids and flavonoid compounds. This study aims to determine the activity and characteristics of anti-inflammatory compounds from extracts, fractions and isolates of ethyl acetate root of fragrant pandan (Pandanus amaryllifolius Roxb.) against carrageenan-induced foot edema of mice. The process of isolation of fragrant pandan roots includes stages such as maceration, partitioning and chromatography. The results of the study The methanol extract had good activity at a dose of 200 mg/kg BB for a period of time (t3) 51.7%; the methanol fraction had good activity at a dose of 200 mg/kg BB in the time span (t3) 38.2%; the ethyl acetate fraction had good activity at a dose of 200 mg/kg BB over a period of time (t3) 56.9%; the dichloromethane fraction had good activity at a dose of 200 mg/kg BB in the time range (t3) 59.2%; the n-Hexane fraction had good activity at a dose of 200 mg/kg BB for a period of time (t3) 37.1%; and isolates had good activity at a dose of 50 mg/kg BB over a period of time (t3) 35.6%. K2 isolate from the ethyl acetate fraction was characterized using 1H-NMR with DMSO solvent at a frequency of 500 MHz and 13C-NMR with DMSO solvent at a frequency of 125 MHz. K2 isolate from the ethyl acetate fraction had similarities to Pandalisines A
Antibacterial Activity of Ethanol Extract of Purple Kencana Leaves (Ruellia tuberosa L.) Using TLC-Bioautography and Agar Diffusion Methods
Get PDFKencana Ungu Leaf (Ruellia tuberosa L.) is a traditional plant that has antibacterial activity. The purpose of this study was to determine the antibacterial activity of the ethanol extract of Kencana Ungu leaves (Ruellia tuberosa L.) using TLC-Bioautography and Agar Diffusion methods. Simplisia from Kencana Ungu leaves (Ruellia tuberosa L.) was extracted by maceration method and then evaporated to obtain a thick extract. Preliminary testing, namely the antibacterial screening test, active extract at a concentration of 0.5% against Escherichia coli, Shigella dysenteriae, and Salmonella thypi. The results of the antibacterial activity test using the TLC-Bioautography method using chloroform: methanol (7:1) as an eluent showed results with an Rf value of 0.89 which inhibited the growth of Escherichia coli, Shigella dysenteriae, and Salmonella thypi bacteria. While the results of testing the antibacterial activity using the Agar Diffusion method obtained the largest diameter of the inhibition zone at a concentration of 20% for Escherichia coli bacteria with an inhibition zone diameter of 12.15 mm, Shigella dysenteriae with an inhibition zone diameter of 11.72 mm, and Salmonella thypi with an inhibition zone diameter of 12.67 m