Jurnal Fakultas Farmasi Umi (Universitas Muslim Indonesia)
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PENGUJIAN AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN BAWANG DAYAK (Eleutherine palmifolia (L.) Merr) TERHADAP BAKTERI PENYEBAB INFEKSI SALURAN PENCERNAAN MENGGUNAKAN METODE DIFUSI AGAR
Full text linkDayak onion leaves (Eleutherine palmifolia (L.) Merr) possess various biological activities, including antibiotic, antiviral, anti-inflammatory, and antibacterial properties, attributed to their secondary metabolites such as flavonoids, saponins, tannins, and phenolics. This study aimed to determine the antibacterial activity of ethanol extract from Dayak onion leaves against gastrointestinal infection-causing bacteria. The research began with screening tests of ethanol extract at concentrations of 0.1%, 0.5%, and 1% against Escherichia coli, Shigella dysenteriae, Vibrio cholerae, and Salmonella typhi. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were determined using extract concentrations of 1%, 2%, 4%, 8%, and 16%. Antibacterial activity was evaluated using the agar diffusion method at concentrations of 5%, 10%, and 15%. Screening results indicated antibacterial activity at a 1% concentration against all tested bacteria. The MIC value for all bacteria was 2%, while the MBC was 1% for Vibrio cholerae and 2% for Escherichia coli, Salmonella typhi, and Shigella dysenteriae. The agar diffusion method revealed the largest inhibition zones at a 15% concentration, with diameters of 10.23 mm for E. coli, 10.31 mm for S. dysenteriae, 11.07 mm for V. cholerae, and 11.32 mm for S. typhi. These findings indicate the potential of ethanol extract from Dayak onion leaves as an antibacterial agent
EVALUASI PENERAPAN STANDAR PELAYANAN KEFARMASIAN PADA PUSKESMAS DI KOTA KUPANG PERIODE MARET SAMPAI DENGAN MEI TAHUN 2023
Full text linkPharmaceutical services at community health centres (puskesmas) are integral to the implementation of health efforts in advancing the quality of health services and improving the quality of life of patients, which are carried out by pharmacists directly. This study was conducted at community health centres in the Kupang City area because there has been no previous research related to the evaluation of pharmaceutical services. The purpose of this study was to determine the suitability of the implementation of pharmaceutical service standards at community health centres in the Kupang City area with Permenkes No. 74 of 2016 as a guideline in performing pharmaceutical services at community health centres. This study used an observational method with a descriptive approach using a checklist sheet. This study was conducted in the period March 2023-May 2023. The study sample was 11 respondents from Puskesmas Alak, Puskesmas Bakunase, Puskesmas Kupang Kota, Puskesmas Manutapen, Puskesmas Naioni, Puskesmas Oebobo, Puskesmas Oepoi, Puskesmas Oesapa, Puskesmas Pasir Panjang, Puskesmas Penfui, Puskesmas Sikumana. The results showed that the suitability of pharmaceutical services at Puskesmas in the Kupang City area was in accordance with Permenkes No. 74 of 2016 with the results of the checklist sheet getting an average of 78% with a good category
PROFIL PENGKAJIAN RESEP RACIKAN PEDIATRI PASIEN RAWAT JALAN DI RUMAH SAKIT MUJAISYAH KOTA PALOPO
Full text linkPrescription review is an activity in pharmaceutical services that is used to minimize errors in drug prescribing. This study aims to assess the prescription of pediatric concoctions at Mujaisyah Hospital, Palopo City. This research method is descriptive non-experimental with retrospective data collection. The population in this study were all incoming prescriptions in the pharmaceutical installation of Mujaisyah Hospital, Palopo City for the period January - June 2023 which met the inclusion criteria, namely 115 prescription sheets. The results showed the percentage of completeness of administrative aspects, namely the patient's name and age 100%, gender 0%, weight 73.04%, height 0%, name, address, initials, and doctor's license number 98.26%, prescription date 99.13%, prescription origin unit 98.26%. The suitability of pharmaceutical aspects, namely drug name, dosage form, drug dose, drug amount, rules and method of use 100%, dosage strength 10.43%, incompatibility 29.56%, hygroscopic stable drugs 52.79% and photolysis 47.21%. The suitability of clinical aspects, namely the accuracy of indications and the accuracy of time of use 100%, the accuracy of dosage 86.48%, and drug interactions 50.44%. From the results of this study, it can be concluded that the prescription at Mujaisyah Hospital, Palopo City has not fully complied with Permenkes RI No. 72 of 2016 concerning Pharmaceutical Service Standards in Hospital
Aktivitas Gastroprotektif Kombinasi Madu Dan Virgin Coconut Oil (Cocos nucifera) Pada Model Tikus Tukak Lambung
Full text linkGastric ulcers are damage that occurs to the mucosal tissue, submucosa and the muscle layer of the stomach, this condition is caused by hypersecretion of stomach acid. The substance content of VCO has a gastroprotective effect because it includes flavonoid compounds, phenols, catalase, ascorbic acid, and vitamin E, while VCO includes octanoic acid, δ-Octalactone, dodecanoic acid, δ-Decalactone, acetic acid. The aim of this research is to understand the gastroprotective activity resulting from giving a combination of honey and VCO to aspirin-induced rats. Honey and VCO in single administration include one dose, namely 14 ml/kgBW honey and 10 ml/kgBW VCO, while in combination treatment three doses are given, namely 10.5; 7; 3.5 ml/kgBB honey and 7.5; 5; 2.5 ml/kgBB VCO. Then in the combined treatment, 5 variations of doses were given, namely honey and VCO (7:7.5); (7:5); (7:2.5); (10.5:5); (3.5:5) ml/kgBB. TNFα levels before being induced by aspirin, after being induced by aspirin, after honey and VCO therapy, and macroscopic observations on a single treatment showed that administration of honey and VCO at doses of 10.5 ml/kgBW and 5 ml/kgBW showed a gastroprotective effect compared to other doses. Then, in histopathological testing, doses with gastroprotective effects can restore mucosal cell cohesion which has been previously damaged due to erosion. The combination of honey and VCO showed gastroprotective results at a dose of 10.5 ml/kgBB honey and 5 ml/kgBB VCO
Antibacterial Activity of N-Hexan and Ethyl Acetate Fractions of Gaharu Leaves (Aquilaria malaccensis) Against Bacteria Causing Skin Infection
Full text linkGaharu (Aquilaria malaccensis) leaves are plants that are useful in the treatment of infectious diseases. This study aims to obtain n-hexane and ethyl acetate fractions of Gaharu leaves that have antibacterial activity against skin infection bacteria by agar diffusion. The results of antibacterial activity screening of the n-hexane fraction and ethyl acetate fraction at a concentration of 0.1% is bacteriostatic. The test results of Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) using concentrations of 0.1%, 0.2%, 0.4%, 0.8%, 1.6%, 3.2%, 6.4% and 12.8% obtained MIC value of n-hexane fraction at 0.2% against P. acnes, P. aeurogynes bacteria and 0.4% against S. aureus, S. epidermidis bacteria, MIC value of ethyl acetate fraction was 0.2% against P. aeuroginosa, S. aureus bacteria and 0.4% against P. acnes, S. epidermidis bacteria. MBC value of n-hexan fraction was 0.4% against P. acnes, P. aeuroginosa bacteria, 0.8% against S. aureus bacteria, 1.6% against S. epidermidis bacteria, MBC value of ethyl acetate fraction was 0.4% against P. acnes, P. aeuroginosa, S. aureus bacteria, 0.8% against S. epidermidis bacteria. The results of the antibacterial activity using concentrations of 1.56%, 3.12%, 6.25%, 12.5% and 25% obtained the largest inhibition zone diameter of the n-hexane fraction was 13,99 mm and the ethyl acetate fraction was 27,68 mm against S. epidermidis bacteria at a concentration of 25%. Based on the results, it can be concluded that the antibacterial activity of the ethyl acetate fraction against all test bacteria is stronger than the n-hexane fractio
Antibacterial Activity of Keji Beling (Strobilanthes crispa) Ethanol Extract Using TLC – Bioautography
Full text linkAntibacterials are compounds that inhibit the growth of bacteria that are harm humans. Keji Beling (Strobilanthes crispa) contains secondary metabolites such as saponins, flavonoids, terpenoids, polyphenols, and potassium. One part used in traditional medicine is the leaves which can treat various diseases. In this study, the ethanol extract of Keji Beling leaves was tested using TLC-bioautography This study tested the ethanol extract of Keji Beling leaves using TLC-bioautography. The examination begins with a screening for antibacterial activity against several pathogen bacteria, with results that inhibit the growth of Bacillus subtilis, Escherichia coli, Staphylococcus aureus, Staphylococcus epidermis, Pseudomonas aeruginosa, Streptococcus mutans, Salmonella typhii, Shygella dysenteriae, and Vibrio cholera. Test results using the TLC-bioautography method using n-hexane eluent: ethyl acetate (1: 2) found that the spots were active against bacteria Pseudomonas aeruginosa and Staphylococcus aureus Rf value 0.74 and bacteria Bacillus subtilis, Escherichia coli, Salmonella thypii, Staphylococcus epidermidis, Staphylococcus mutans, Shygella dysenteriae, Vibrio cholera with an Rf value of 0.83 The results of the identification of chemical components showed the presence of positive compounds belonging to the class of flavonoids and anthraquinones. The ethanol extract of keji beling leaves contains a class of flavonoid compounds that have the potential as antibacterial agents with an Rf value of 0.8
Evaluation of Ethanol Extract Tapak Dara Leaf (Catharanthus roseus L. ) for Antibacterial Activity against Skin Pathogens
Full text linkTapak dara leaves (Catharanthus roseus L.) are known to be efficacious for relieving muscle pain, antidepressants, as well as medicine for various diseases such as relieving swelling from wasp stings, nosebleeds, and sore throats, antidotes, antibacterials, and lowering blood pressure in humans because they contain chemical compounds such as essential oils, phenolic acids, flavonoids, tannins, and alkaloids. This study aims to determine the antibacterial activity of the ethanol extract of tapak dara leaves against bacteria that cause skin infections. This type of research is done in an experimental laboratory using the agar diffusion method, which is based on inhibiting the growth of bacteria that cause skin infections. The stages of this research began with sample preparation, screening for antibacterial extract activity, and testing the antibacterial extract activity at several concentrations against the test bacteria that cause skin infections. This study obtained the results that the ethanol extract of tapak dara leaves tested positive for inhibition of the growth of Staphyloccus aureus, Staphylococcus epidermidis, Pseudomonas aeroginosa, and Propionibacterium acne based on the extract screening results. The results of this study also showed that the ethanol extract of tapak dara leaves at a concentration of 40% had the greatest inhibition using the agar diffusion method based on the diameter of the inhibition zone, with a value of 8.37 mm (Propionibacterium acne); 8.47 mm (Pseudomonas aeruginosa); 9.19 mm (Staphylococcus epidermidis); and 11.68 mm (Staphylococcus aureus
Antibacterial Potential of Ethanol Extract from White Pidada (Sonneratia alba) Leaves Against Gastrointestinal Pathogens
Full text linkThe antibacterial properties of the ethanol extract of White Pidada leaves (Sonneratia alba), a mangrove plant rich in bioactive compounds such as phenols, flavonoids, steroids, saponins, triterpenoids, tannins, and alkaloids, were evaluated in this study. The research focused on determining the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) against gastrointestinal infection-causing bacteria, including Salmonella typhii, Shigella dysenteriae, Escherichia coli, and Vibrio cholerae. The MIC results showed effective inhibition at concentrations as low as 0.025% for Shigella dysenteriae, 0.05% for Salmonella typhii and Vibrio cholerae, and 0.5% for Escherichia coli. The MBC analysis indicated bactericidal activity at higher concentrations, with significant effects observed at 1% for Salmonella typhii, 0.05% for Shigella dysenteriae and Vibrio cholerae, and 0.1% for Escherichia coli. Agar diffusion tests confirmed that increasing extract concentrations correlated positively with the inhibition zone diameter, highlighting the potential of White Pidada leaves as a natural antibacterial agent
Exploring The Antibacterial Potential of Aqueous and Ethanol Extracts from Bawang Dayak (Eleutherine palmifolia (L.) Merr) Against Skin Infectious Bacteria Through KLT-Bioautography
Full text linkDayak onion plants (Eleutherine palmifolia (L.) Merr) have chemical compounds that have potential as antibacterials such as alkaloids, glycosides, flavonoids, phenolics, steroids and tannins. This study aims to determine the antibacterial activity of water extracts and ethanol extracts of dayak onion bulbs (Eleutherine palmifolia (L.) Merr). This research was conducted with the stages of sample extraction, screening of test bacteria, bioautogram profile testing and antibacterial activity by KLT-Bioautography method. Screening test results at a concentration of 1% against test bacteria Propionibacterium acnes, Pseudomonas aeruginosa, Staphylococcus aureus and Staphylococcus epidermidis were able to inhibit the growth of test bacteria. Then continued with KLT-Bioautography testing using n-hexan: ethyl acetate (2: 1) eluent. The KLT-Bioautography test results showed that there was 1 active spot with an Rf value of 0.63 in the water extract and an Rf value of 0.60 in the ethanol extract against Pseudomonas aeruginosa, Propionibacterium acnes, Staphylococcus aureus, and Staphylococcus epidermidis bacteria. Based on the research, water extract and ethanol extract of dayak onion bulb (Eleutherine palmifolia (L.) Merr) have potential as antibacterial.Keywords: Antibacterial, KLT-Bioautography, Dayak Onion Bulb
