Jurnal Fakultas Farmasi Umi (Universitas Muslim Indonesia)
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PENGARUH PEMBERIAN EKSTRAK DAUN BIDARA (Zizipus mauritiana Lam.) TERHADAP FUNGSI HATI TIKUS DENGAN PARAMETER SGPT
Full text linkRepeated administration of traditional medicines can be potentially poisonous and damage vital organs such as the heart, lungs, liver and kidneys. Tests of safety need to be carried out. Bidara leaves are used traditionally used as antimicrobial, analgesic, antipyretic, anti-inflammatory, anti-diabetic. This study aims to determine safety of ethanol extract of bidara leaves on liver function. This research used wistar rats as test animals which were divided into 4 groups. Test animals were given ethanol extract of bidara leaves at a dose of 50 mg/kgBW, 500 mg/kgBW and 2000 mg/kgBW given orally for 14 days. SGPT rate checks are carried out before and after administering the extract. The results showed that giving ethanol extract of bidara leaves for 14 days did not have a significant effect on rat SGPT levels (p<0.05)
EVALUASI PENYIMPANAN VAKSIN BERDASARKAN PRINSIP SYARIAT ISLAM DI PUSKESMAS MANYARAN KOTA SEMARANG
Full text linkVaccine management at the health Center still needs special attention where it is known that there are still many cold chain managements, especially vaccines, which have not been managed properly so that there is a lot of damage to the vaccine. The purpose of this study is to determine the description of the suitability and evaluation of vaccine storage based on the principles of Islamic law at Manyaran Health Center, Semarang City. The variable used in this study is a single variable with observations related to vaccine storage, facilities and infrastructure, refrigerator conditions (cold chain management) at Manyaran Healt Center using a checklist sheet for observation. The results showed that each evaluation of vaccine storage, facilities and infrastructure, and the state of the refrigerator at Manyaran Health Center in Semarang City was categorized as good with a percentage of 100%
Daun Cempaka Kuning (Michelia champaca Linn) sebagai Kandidat Penghambat Enzim α-glukosidase secara In Silico
Full text linkDiabetes Mellitus (DM) is a chronic disease that occurs worldwide and continues to increase rapidly. The purpose of this study was to determine the activity and mechanism of action of the antioxidant compounds in cempaka kuning leaves as an antidiabetic using the in silico method. This study used 8 antioxidant compounds from cempaka kuning leaves, namely octadecadienoic acid, butanoic acid, oleic acid, camphorsulfonic acid, pimaric acid, phenol, andrographolide, and benzoic acid. The α-glucosidase enzymes used in this study were obtained from the Protein Data Bank website with the PDB ID codes 3A4A and 2QMJ. Ligand-macromolecule docking using AutoDockTools (ADT) and AutoDock Vina programs. The results showed that the antioxidant compounds in cempaka kuning leaves that had the lowest ΔGbind values were pimaric acid (-8.9 kcal/mol) and andrographolide (-8.6 kcal/mol) in PDB ID 3A4A. The docking results used PDB ID 2QMJ, the compound with the smallest ΔGbind was andrographolide (-7.4 kcal/mol). The results of visualization of the interaction of the ligand with the macromolecular amino acid residue PDB ID 3A4A showed that the residues Arg315, Arg442, and Tyr158 were found in the compound with the smallest ΔGbind. In the PDB ID 2QMJ macromolecule, Asp542 residue was found in all compounds with the smallest ΔGbind. Based on these results, the compounds pimaric acid and andrographolide have potential as antidiabetic drugs compared to other compounds with a mechanism of action of inhibiting the α-glucosidase enzyme
Antibacterial Activity of Tunicata Ethanol Extract Polycarpa Aurata gainst Escherichia Coli and Salmonella Typhi by TLC-Bioautography and Agar Diffusion
Full text linkTunicata Polycarpa aurata contains chemical compounds in the form of peptides and alkaloids that are cytotoxic and have the ability as antibacterial against several pathogenic bacteria. The aims of this study was to determine the antibacterial activity of the ethanol extract of Tunicata Polycarpa aurata using the TLC-bioautography and diffusion method. Tunicata Polycarpa aurata was extracted by maceration and then evaporated to obtain a thick extract. The results of the antibacterial screening test showed the active extract at a concentration of 0.1% against Escherichia coli and Salmonella typhi. The results of testing for antibacterial activity using the TLC-bioautography with using ethanol: ethyl acetate (1:4) eluent showed results of Salmonella typhi bacteria with an Rf value = 0.27 and Escherichia coli bacteria with an Rf value = 0.27. While the results of testing the antibacterial activity the using the agar diffusion method showed the largest inhibition zona diameter at a concentration of 4% for Escherichia coli bacteria with an inhibition zone diameter of 12.55 mm, and Salmonella typhi with an inhibition zone diameter of 12.3 mm. Phytochemical screening tests on the ethanol extract of Tunicata Polycarpa aurata revealed the presence of flavonoids, tannins, steroids/terpenoids, alkaloids and saponins
Antibacterial Activity of Ethanol Extract Red (Jatropha gossypifolia) Leaves Against Bacterial Skin Infections by Agar Diffusion
Full text linkRed Jatropha gossypifolia plant is a type of Jatropha with purplish red leaves which the chemical compounds are found are calcium oxalate, jatroidene, interquinones, flavonoids, flobatin and phenolics, and these compounds can be used as an anticoagulant, anti-inflammatory, analgesic and antibacterial. The aim of this research is to determine the antibacterial activity of red Jatropha leaves ethanol extract against bacteria causes skin infections by Agar Diffusion. The result of screening antibacterial test of red Jatropha leaves ethanol extract with a concentration of 0,1% active against bacteria Staphylococcus aureus, Staphylococcus epidermidis, Propionibacterium acne and Pseudomonas aeruginosa. The result of analysis Minimum Inhibitor Concentration (MIC) and Minimum Bactericidal Concentration (MBC) ethanol extract obtained MIC value = 0.1% to bacteria acid, MBC value = 0.05% to bacteria acid, and the result of antibacterial activity of ethanol extract obtained the largest inhibitory zone diameter at a concentration of 12.8% was 13.577 mm against Staphylococcus aureus
EVALUASI WAKTU KONTAK ADSORPSI TIMBAL (Pb) OLEH ADSORBEN DAUN NANAS (Ananas comosus) PADA OLI YANG DIGUNAKAN LANGSUNG
Full text linkMotor vehicle users in Indonesia are among the highest in Southeast Asia. The increase in the population of motor vehicles can lead to increased use of vehicle lubricants. However, it also threatens the environment by leaving lead (Pb) waste on the oil that has been used, which, if not properly managed, can harm the environment. Because used oil contains some heavy metals, one of them is Pb metal, or lead. It's one of the B3 wastes, which is a dangerous and toxic material that will cause pollution in the environment. Using pineapple leaves is one way to handle waste with natural ingredients. The aim of this study was to find out whether the pineapple leaf can adsorb lead metal (Pb) from waste oil and how the contact time of the adsorptive leaf best affects the amount of Pb ions adsorbed into waste oil. The study was conducted using experimental in vitro techniques. The first process in this study was to activate the pineapple leaf with 2% NaOH. Then, the adsorbent from the activated pineapan leaf was linked to the used oil at different times (10, 20, 30, and 40 minutes) to cause the Pb metal adsorption. (timbal). With the cellulose contained in pineapple leaves, heavy metals can be reduced in waste oils through adsorption or absorption processes. Contact time is the component that affects the adsorption proces
Uji Oligosakarida Ekstrak Tepung Buah Semu Jambu Mete (Anacardium occidentale L.) Terhadap Pertumbuhan Baketri Lactobacillus casei Sebagai Altenatif Prebiotik
Full text linkCashew pseudo-fruit (Anacardium occidentale L.) is rich in carbohydrates. Carbohydrates can be chemically hydrolyzed into simple monomers such as oligosaccharides. This study aims to ensure the effectiveness of cashew pseudo-fruit flour oligosaccharide extract as an alternative to prebiotics that are able to stimulate the growth of lactic acid bacteria such as Lactobacillus casei. The test was carried out on the growth of Lactobacillus casei bacteria using a 4% concentration cashew pseudo-fruit flour oligosaccharide solution with a dilution of 10-10 using the pour plate method and incubated at a temperature of 37°C for 48 hours to determine the ALT value. The results of the prebiotic parameter test showed the growth of the number of eligible bacterial colonies, namely 25-250 colonies found in dilution 10-4 - 10-8 with an ALT result of 7.3 x 10-6 so it can be concluded that The oligosaccharides extracted from the cashew pseudo-fruit have met the characteristics and criteria as an alternative prebiotic
Pengaruh Ekstrak Pogostemon cablin Benth terhadap Interleukin-6, Glukosa Darah, Hemoglobin dan Hematokrit pada Tikus Wistar yang Diinduksi Dietilnitrosamin
Full text linkMortality and morbidity rates of hepatocellular carcinoma continue to rise worldwide. The role of inflammation, regulation of glucose metabolism, and anemia is widely studied concerning the development and life expectancy of patients with hepatocellular carcinoma. In several cancers, efforts to develop Pogostemon cablin benth plant potential drug candidates for hepatocellular carcinoma have been carried out at metabolomic, proteomic, and molecular levels. However, no studies have been found regarding the study of anti-inflammatory effects, metabolism, and anemic conditions of Pogostemon cablin benth intervention in hepatocellular carcinoma. This study is a pre-post experimental in-vivo study aimed at looking at the ability of Pogostemon cablin benth extract against interleukin-6 (IL-6) as an inflammatory marker, blood glucose levels as a marker of metabolic regulation and hemoglobin and hematocrit levels at as markers of anemia in hepatocellular carcinoma. A model of hepatocellular carcinoma was performed in 25 peritoneal-induced diethylnitrosamine-induced Wistar rats. The mice were divided into five groups, namely group 1 (K1), group 2 (K2), group 3 (K3), positive control (KP), and negative control (KN). Pogostemon cablin benth ethanol extract was administered orally to mice K1 40mg/kg body weight; K2:80mg/kg rat body weight; K3:120mg/kg body weight, while the positive control group was given Sorafenib. Interleukin-6 levels were measured using the enzyme-linked immunoassay principle, while glucose, hemoglobin, and hematocrit levels were measured using the enzymatic principle of glucose dehydrogenase-flavin adenine dinucleotide (GDH-FAD). The study showed no difference in blood glucose levels of mice between pre- and post-induction diethylnitrosamine. Induction of diethylnitrosamine obtained significantly led to a significant decrease in hemoglobin levels (15.54 g/dl ±1.28 vs. 14.31 g/dl ±1.11) and hematocrit (45.83% ±3.77 vs 42.20% ±3.25) levels between pre and post-induction. Mice in group 1 (K1) showed a significant increase in blood glucose levels between pre and post-oral Pogostemon cablin benth extract (p<0.05). There was no significant difference in hemoglobin and hematocrit levels in the treatment group between pre-intervention Pogostemon cablin benth extract. However, KN that did not receive Pogostemon cablin benth extract intervention significantly decreased hemoglobin and hematocrit levels (p<0.01). Decreased levels of the pro-inflammatory cytokine IL-6 occurred in K2 (p<0.05) after receiving oral Pogostemon cablin benth extract intervention. Based on this study, Pogostemon cablin benth extract may decrease IL-6 levels and is thought to influence hemoglobin and hematocrit levels in diethylnitrosamine-induced Wistar rats
Antibacterial Activity of Endophytic Fungi Isolated from Parang Romang (Boehmeria virgata (G.Forst) Guill) Leaves Against Gastrointestinal Pathogens
Full text linkParang romang (Boehmeria virgata (G.Forst) Guill) is a plant traditionally used for treating various digestive tract infections. However, obtaining bioactive compounds directly from the plant requires significant biomass. Therefore, endophytic fungi, sourced from specific plant parts, are explored for their ability to produce similar bioactive compounds. The research examined the potential antibacterial activity of endophytic fungi isolated from parang romang leaves against common gastrointestinal pathogens. The methods used in was, characterization of endophytic fungal isolates, and antagonistic activity was evaluated using the agar diffusion method. The results showed that the endophytic fungal strains, namely isolates IFBV 6, IFBV 7, and IFBV 10 could inhibit the bacteria Escherichia coli, Salmonella typhi, Shigella dysenteriae, and Vibrio cholera. With an average zone of inhibition for each strains isolate against Esherichia coli respectively 11.53 mm, 10.49 mm, and 14.85 mm; Salmonella typhi 14.47 mm, 8.66 mm, and 15.51 mm; Shigella dysenteriae 22.28 mm, 13.76 mm, and 15.33 mm; and Vibrio cholera 16.91mm, 11.94mm, 15.16mm. In conclusion, isolated endophytic fungal strains hold promise as potential as antibacterialn agents