Jurnal Fakultas Farmasi Umi (Universitas Muslim Indonesia)
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KAJIAN KOMPOSISI KIMIA, NILAI NUTRISI, DAN ETNOFARMAKOLOGIS TANAMAN GENUS KENARI
Get PDFOne species of canarium genus is Canarium indicum L which is an original plant from Indonesia. Utilization of some canarium nut species which spread around the world had been recognized, such as a source of nutritious food as well as its potency as raw material of medicine based on evidence-based scientific. In traditional medicine, was reported if canarium nut had been used for diabetes mellitus treatment, angina, hepatoprotective, anti-inflammatory, antirheumatic, expectorant, etc. This article aims to review the chemical composition, nutrient values, and potency of canarium nut as the raw material of medicine. Scientific data were obtained from online search results. From the searching was found that at least eight species of canarium nut reported which is related to chemical composition and its nutrition which also provide ethnopharmacological benefits. Overall results, all identified canarium nut species have a favorable chemical composition and nutritional values that can be utilized as functional, nutritional and medicinal food. Therefore, the result of this study also indicates if the canarium nut from Indonesia, C. indicum L., has not been thoroughly studied. That indicates by the lack of scientific paper which presented about C. indicum from Indonesia
PERBANDINGAN AKTIVITAS ANTIOKSIDAN JAHE EMPRIT (Zingiber officinale var Amarum) DAN JAHE MERAH (Zingiber officinale var Rubrum) DALAM SEDIAAN CAIR BERBASIS BAWANG PUTIH DAN KORELASINYA DENGAN KADAR FENOL DAN VITAMIN C
Get PDFGarlic (Allium sativum L.), ginger emprit (Zingiber officinale var Amarum) and red ginger (Zingiber officinale var Rubrum) contain active compounds from the phenol group which have antioxidant properties. This study aims to determine the ratio of antioxidant activity of red ginger and ginger in garlic-based liquid preparations using DPPH reagent (1.1 diphenyl-2 picrylhydrazyl) and determine its correlation with total phenol and vitamin C levels contained in both liquid preparations. Total phenol content was determined by reacting folin-ciocalteu and vitamin C levels were determined by titrimetric method. Total phenol levels are expressed as mg GAE (Gallic Acid Equivalent) per gram of preparation, antioxidant activity is expressed as IC50 (µg / mL), and vitamin C is expressed as percent (%). The results show that total phenol content of emprit and red ginger in garlic-based preparation were 80,296 mgGAE / g preparations and 159,164 mgGAE / g preparations respectively, antioxidant activity (IC50) for each preparation were 3,310 µg / mL and 2,075 µg / mL respectively and the vitamin C level were 4.338% and 6.372%. Correlation test showed the very strong and significant correlation existed between antioxidant activity and the total phenol levels in both emprit and red ginger-garlic preparation but no significant correlation detected between antioxidant activity and vitamin C levels of both preparations
SEDIAAN KRIM EKSTRAK AIR BUAH AREN (Arenga pinnata) SEBAGAI ANTIOKSIDAN
Get PDFPalm fruit (Arenga pinnata) contains galactomannan which has the potential as an antioxidant activity with an IC50 value of 20,45 ppm. This study aims to produce cream dosage forms with antioxidant activity using the scaverry DPPH radical scavenger method from arenga pinnata water extract. Palm fruit water extract is formulated in cream form with variations in the concentration of stearic acid and triethanolamine emulgators in F1 (6:4), F2 (7:3), and F3 (8:2). Evaluation of physical stability includes organoleptic testing, homogeneity, pH, emulsion type, viscosity and type of flow carried out before and after forced conditions. In the statistical analysis of viscosity, the results of each formula showed no significant changes both before and after the conditions were forced. The results of the study obtained formula 2 and formula 3 has optimal stability. The stable formula was then tested for antioxidants using the DPPH (1,1-Diphenyl-2-Picrylhydrazyl) radical scavenger method. Formula 2 and formula 3 each yield a DPPH radical inhibition percentage of 65% and 48.04%.
AKTIVITAS PENGHAMBATAN POLIMERISASI HEM DARI FRAKSI ETIL ASETAT DAUN MANURAN, Coptosapelta tomentosa Valeton ex K.Heyne (Rubiaceae)
Get PDFMalaria is a serious disease caused by Plasmodium parasites and is transmitted by the salivary glands of female Anopheles mosquito. The manuran (Coptosapelta tomentosa Valeton ex K.Heyne) is empirically used as a malarial treatment. The study aimed to determine the IC50 value of ethyl acetate fraction and the coumpounds contained on the C. tomentosa Valeton ex K. Heyne leaf ethyl acetat fraction. The identification of chemical composition used tube test method. The inhibitory activity of heme polymerization in vitro did by Basillico modified method. The identification of chemical contents on the ethyl acetate fraction of C. tomentosa leaf Valeton ex K. Heyne showed positive results containing flavonoid, tannin, saponin, terpenoid, and anthraquinone. The average percentage heme polymerization inhibition of C. tomentosa valeton ex K. Heyne leaf ethyl acetate fraction respectively from large to small concentrations of 97.94; 96.94; 95.01; 91.63; 86.19; 76.12; and 44.83 %. Result of probit analysis, that it has HPIA IC50 value of 0.252±0.009 mg/mL and chloroquine diphosphate was 0.214±0.012 mg/mL. The independent sample T-test showed that there was significant difference between IC50 value of them. The ethyl acetate fraction of C. tomentosa leaf Valeton ex K. Heyne has heme polymerization inhibition activity
ANALISIS KADAR TANIN TOTAL EKSTRAK ETANOL BUNGA CENGKEH (Syzygium aromaticum L.) MENGGUNAKAN METODE SPEKTROFOTOMETRI UV-VIS
Get PDFClove flower (Syzygium aromaticum L.) contain saponins, tannins, alkaloids, glycosides and flavonoids. The research aimed to qualitatively and quantitatively determine the existence of tannins in ethanol extract of clove flower by UV-Vis Spectrophotometry. The extraction process used was maceration using ethanol of 30% with the yield value of 4.26%. The extract obtained was measured by UV-Vis Spectrophotometer at the maximum wavelength of 649.9 nm using tanic acid as the standard. The value of the measurement result of tannin content obtained in the ethanol extract of clove flower was 300.826 mg TAE/g extract or 30.0826% b/b TAE
EFEK HEPATOPROTEKTOR EKSTRAK ETANOL RIMPANG DRINGO (Acorus calamus L.) TERHADAP PENINGKATAN KADAR SGPT TIKUS PUTIH (Rattus norvegicus)
Get PDFHepatoprotector is a liver protected-agent of hepatotoxic. This research was aimed to determine the hepatoprotector effect of ethanol extract of dringo rhizome (Acorus calamus L.) and most effective dose as a hepatoprotector. The study using 20 male rats divided into 5 groups. Group I was given the Na-CMC 1%, group II was given a herbal supplement, and group III, IV, and V were given ethanol extract of the rhizome dringo (Acorus calamus L.) with a dose of 50 mg/100 mg, kgBB/kgBB, and 200 mg/kgBB orally for 7 days. At 5th day interval 2 hours after administering the test preparations were given a single dose of 2 g of paracetamol/kgBB in all groups except the Group I. Measurement of levels of SGPT is done before and after the treatment the animal test. From the results of a statistical analysis of Kruskal-Wallis’ test followed by Man-Whitney’s test that dringo Rhizome (Acorus calamus L.) ethanol extracts has the effect of a hepatoprotector in rats. Extract 50 mg/kgBB dose has the same effect as statistically with herbal supplements’ group (˃ p 0.05)
POTENSI ANTIBAKTERI EKSTRAK ETANOL JAMUR KANCING (Agaricus bisporus) SEBAGAI ANTIBAKTERI
No full textA research had been done on antibacterial activity of extract and the aim was to determine the antibacterial activity and inhibitory potency. The research was started by screening test using Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi, Staphylococcus epidermidis, Shigella dysenteriae, Staphylococcus aureus, Streptococcus mutans and Vibrio cholerae. Results showed that the Agaricus bisporus ekstract inhibited Bacillus subtilis, Shigella dysenteriae, Staphylococcus aureus, and Vibrio cholera at concentrations 0,1% and 1%. The results obtained Minimum Inhibitory Concentration (MIC) Agaricus bisporus extract against at concentrations of 0,1%. In the Minimum Bactericidal Concentration (MBC) test Agaricus bisporus extract against at concentrations of 0,8%. Agaricus bisporus extract has antibacterial activity wich was indicated by the inhibitory zone diameter. The biggest inhibitory zone diameter of Agaricus bisporus contained in bacteria Bacillus subtilis on the concentration of 6.4% (13 mm
AKTIFITAS EKSTRAK JAHE MERAH DALAM MENURUNKAN ASAM URAT PADA KELINCI SERTA ISOLASI DAN IDENTIFIKASI SENYAWA BIOAKTIFNYA
Get PDFJahe merah (Zingiber officinalle var. Amarum) merupakan salah satu tumbuhan yang banyak digunakan sebagai bumbu makanan sehari-hari dan juga berkhasiat sebagai obat tradisional untuk mengobati berbagai penyakit termasuk asam urat. Penelitian ini bertujuan untuk menguji aktifitas biologi dari jahe merah dan mengisolasi dan mengidentifikasi senyawa bioaktif yang tekandung di dalam ekstraknya. Berdasarkan penelitian yang dilakukan terhadap ekstrak etanol jahe merah memperlihatkan kemampuannya dalam menurunkan asam urat pada kelinci yang diinduksi dengan kalium bromat (KBrO3) pada konsentrasi 0,6 b/v yang diamati pada 1 dan 3 jam setelah diinduksi dan dibandingkan dengan allopurinol yang digunakan sebagai positif kontrolnya. Ekstrak etanol jahe merah juga memperlihatkan hubungan konsentrasi dengan penurunan asam urat pada kelinci. Isolasi senyawa bioaktif dalam tanaman ini telah dilakukan dengan menggunakan metode kromatografi dan identifikasi stukturnya didasarkan pada analisis data spektrofotometri dan NMR. Berdasarkan data spectra yang diperoleh terhadap senyawa yang paling dominan yang berhasil diisolasi dan diidentifikasi adalah senyawa 6-gingerol. Hal ini menunjukkan bahwa ekstrak etanol jahe merah memiliki aktifitas dalam menurunkan kadar asam urat dengan senyawa utama 6-gingerol
EVALUASI STABILITAS FARMASETIK DAN UJI IRITASI FORMULA MASKER SARI LEMON (Citrus limon L.) DENGAN YOGURT PLAIN
Get PDFThe use of lemon juice and yogurt can provide good care for facial skin, so have the potential to be formulated into a mask to overcome skin problems. The study aimed to produce a mask dosage froms formula pharmaceutically stable and not irritating. The lemon juice extract was obtained by using freeze-drying, and optimization of anionic emulgator (TEA-Stearate) and nonionic emulgator (Tween-Span 60) are carried out. The formulation was continued with the variations in lemon extract concentrations of 0.5; 1; and 2% w/v by evaluating the physical characteristics and stability with parameters including organoleptic examination (smell, color, and consistency), centrifugation, homogeneity, pH, type of emulsion, drying time, dispersion, viscosity, and determination of flow type before and after conditions are forced at 5oC and 35oC for the 10 cycles for irritation testing using test rabbits. The results showed that the formula with an anionic emulgator (TEA-stearic) of 1:2% b/v with a lemon extract concentration of 1% was a pharmaceutically stable formula and the irritation the results showed that the formula with a lemon extract of 0.5% and 1% b/v did not cause any irritation
PERBEDAAN KEKERASAN EMAIL PADA PERENDAMAN MINUMAN BERSODA DAN ISOTONIK DI MAKASSAR TAHUN 2018
Get PDFBackground : Email is the most outer layer of the teeth, harder compared with the layer below which is dentin. Email hardness is a physical conditions that belongs of the part of dental, it’s called email that can be measured using Vicker Hardness Tester by Kg/mm. Soft drink and isotonic is consisting of various types of a acids that lower of pH in oral cavity. Objective : To know the difference of email hardness which is soaked in soft drink and isotonik.Method : Teeth post extraction, then soaked in to soft drink and isotonik for 2 hours. After that measured email hardness using Vicker Hardness Tester.Result : Based on Independent Sample T-test result the difference of email hardness which is soaked in soft drink and isotonic in Makassar 2017 obtained value of soft drink decreased of the email hardness with value p = 0,662. Conclusion : Showed there’s a difference email hardness which is soaked in soft drink and isotonic, while the result of email hardness decreased between soft drink and isotonic there’s no significant difference