Jurnal Fakultas Farmasi Umi (Universitas Muslim Indonesia)
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PERBANDINGAN AKTIVITAS EKSTRAK DAUN KELOR DAN TEH HIJAU SERTA KOMBINASI SEBAGAI ANTIBAKTERI PENYEBAB JERAWAT
Get PDFDaun kelor dan daun teh hijau telah terbukti berkhasiat sebagai antibakteri penyebab jerawat terhadap S. aureus dan P. acne. Kandungan yang berkhasiat sebagai antibakteri penyebab jerawat pada daun kelor adalah kuersetin dan pada daun teh hijau adalah katekin. Tujuan penelitian ini untuk mengetahui aktivitas antibakteri terhadap S. aureus dan P. acne pada berbagai konsentrasi ekstrak daun kelor dan teh hijau serta kombinasi ekstrak daun teh hijau dan kelor dengan rasio 1:2, 1:1 dan 2:1. Ekstraksi dilakukan dengan maserasi kinetic menggunakan etanol 70%. Uji aktivitas antibakteri menggunakan metode difusi agar sumuran. Hasil uji aktivitas antibakteri terhadap S. aureus menunjukan bahwa KHM ekstrak daun kelor dan daun teh hijau berturut-turut adalah 2.5% dan 1.25% dengan zona hambat 8 mm dan 7 mm dan KHM ekstrak daun kelor dan daun teh hijau berturut-turut 2.5% dan 1.25% terhadap P. acne adalah dengan zona hambat 9 mm dan 5 mm. Aktivitas antibakteri terbaik kombinasi ekstrak daun teh hijau dan kelor pada rasio 1:2 terhadap bakteri S. aureus dan P. acne dengan zona hambat berturut-turut 16 ± 0,471 mm dan 16 ± 0,942 mm. Kontrol positive yang digunakan Mediklin® dengan zona hambat 50 mm
Optimization Of Microwave-Assisted Extraction Of Flavonoids From Binahong (Anredera cordifolia) Leaves Using Respon Surface Methodology
Get PDFBinahong (Anredera scandens (L.) Moq.) leaves are one of the plants that empirically can be used for wound healing and contain flavonoids which have antibacterial and antioxidant activities. Determination of the optimum conditions of the Binahong leaf extraction process needs to be done to ensure the extraction quality of the Binahong leaves associated with the given activity. Microwave Assisted Extraction (MAE) is an extraction that utilizes microwave radiation to heat the solvent quickly and efficiently. This study aims to determine the most effective binahong leaf extraction conditions that produce optimal levels of flavonoids and antioxidant activity. The extraction process was carried out using the Microwave assisted extraction (MAE) method. Determination of optimum conditions is done based on Response Surface Method (RSM) with variable ethanol concentration (70%, 80% and 90%), extraction time (4, 12 and 20 minutes) and power (450, 600, and 800 watts) using Box- Behnken Design (BBD) with Design Expert 7.0 software. The extract quality parameters measured were total flavonoid levels and antioxidant activity. The results showed the optimum conditions with the BBD method were obtained at an ethanol concentration of 81.49%, extraction time of 13.84 minutes, and power of 626.19 watts with flavonoid levels of 3.8561% and antioxidant activity (IC50) of 95.51834 ppm with active categories
Pengembangan Ekstrak Etanol Limbah Biji Pepaya (Carica papaya L.) Sebagai Serum Antijerawat
Get PDFAcne or commonly called acne vulgaris merupahkan abnormalities in the skin that almost everyone has experienced it. Acne is a problem of skin, neck, chest, and back that occurs in times of skin-the skin of the skin will be clogged by excessive fat deposits. Propionibacterium acnes is a gram-positive bacteria as part of normal flora and fauna. Papaya seeds are agricultural waste that has antibacterial activity against the bacteria Propionibacterium acnes with a very low cost. One of the proper acts for acne problem is by using serum. Serum has a very fast absorptive effect to penetrate the inner skin without the effects of sticky effects on the skin. By knowing that the bacteria Propionibacterium acnes can cause acne that can attack various circles and know the benefits of papaya seeds that inhibit the growth of acne-causing bacteria, it is necessary to formulate papaya seed estrak as antijerawat, so this process formulates the serum preparation of papaya seed estrak which can as pen prevent the growth of acne-causing bacteria. The research method that will be done is the initial processing of the sample by extraction and then proceed with formulation of the preparation. After that, the evaluation of serum preparation and antibacterial activity test are available on the preparation
UJI AKTIVITAS PENGHAMBATAN ENZIM α-GLUKOSIDASE EKSTRAK ETANOL BIJI BUAH ALPUKAT SANGRAI (Persea americana Mill.) SECARA IN VITRO
Get PDFIt is known that the seeds of avocado (Persea americana Mill.) are one part of the avocado widely used to treat various diseases, including diabetes. Based on the previous research, avocado seeds contain flavonoids with the potency as inhibitors of the enzyme α-glucosidase. The research aimed to determine the potency of ethanol extracted by meceration using 96% ethanol. The inhibitory activity was assayed using ELISA (Enzyme-Linked Immunosorbant Assay) reader measured at the wavelength of 405 with an acarbose comparator. The results showed that the ethanol extract of avocado seeds had an inhibitory activity included in the active category based on IC50 value of 34.300 µg/mL. Meanwhile, the acarbose had inhibition activity included in the very active category with an IC50 value of 0.253 µg/mL
Pengembangan Sediaan Serbuk Antidiabetes dari Kombinasi Ekstrak Kulit Buah Manggis (Garcinia Mangostana L.) dan Ekstrak Daun Salam (Syzygium polyanthum (Wight) Walp.)
Get PDFDiabetes mellitus is a metabolic disease characterized by hyperglicemic. Mangosteen (Garcinia mangostana L.) and Salam (Syzygium polyanthum (Wight) Walp.) are plants which recognized as blood glucose controller. The study aims to determine the effectiveness of the combination of the two extract in decreasing blood sugar levels of diabetic rats. The rats divided into 6 groups: group I (normal control) without treatment, group II (negative control), group III (positive control), group IV (extract of mangosteen with dose of 400 mg), group V (extract of salam leaf with dose of 400 mg) and group VI (combination of mangosteen 200 mg and salam leaf 200 mg). Data were analyzed by One-Way Anova, followed by PostHoc Bonferroni analysis. Then the combination of the extract was formulated in powder dosage form blended with PVP, Sucralose and Lactose. The evaluation included physical test are organoleptic, water content and flowability time. The results showed that the combination of the extracts of mangosteen and salam leaf comprising half doses of eact extract could lower blood glucose levels significantly (P<0.05) with better efficacy than each single extract and the combination of extracts able to produce powder dosage form with the requirement (organoleptic, water content and flowability time)
Isolation and Identification of Free Radical Scavenging Compound from Stem Bark Soursoup (Annona muricata L.) Extract
Get PDFIsolation and Identification of free radical active compound from stem bark soursoup (Annona muricata L.) extract. The aim of this research is to observe the chemical compound of stem bark the soursoup (A. muricata L.) which is active as a free radical. 550 gram of stem bark the soursoup (A. muricata L.) was by graduate extracted using n-heksan, ethyl acetat and ethanol solvents respectively. Extract result is the extraction, it was produced 2.4 gram n-heksan extract, 8.4 gram ethyl acetat extract, 2.1 gram ethanolic extract. The isolation of ethyl acetat extract was conducted using colom chromatography (TLC) method using eluent n-hexane : ethyl acetat (7:3) and it was produced four fractions. The third fraction was isolated using preparative thin layer chromatography with mob ile phase n-hexane : ethyl acetat (6:1) and got 2 bands. The isolate identified by UV-Vis spectroscopy, IR spectroscopy and analyzed by chemistry reaction. From the data result show that isolate is acetogenin
Cytotoxicity of Kelakai (Stenochlaena palustris) Extract to MCF-7 Breast Cancer Cell
Get PDFBreast cancer is reported to rank fifth among all types of cancer with a case of death of 6.6%. In the Central Kalimantan region, early examinations of cancers including breast cancer were carried out and 247 tumors in the breast were identified (1.76%). Kelakai (Stenochlaena palustris) as one of the typical plants of Kalimantan which contain natural chemical constituents has been reported to be effective as an anti-inflammatory and antioxidant, so that with this potential can be developed to overcome diseases associated with it, one of them is breast cancer. This study aimed to examine the cytotoxicity of MCF-7 breast cancer cells using ethanol extract. The cytotoxicity assay of kelakai extract against MCF-7 cells conducted in vitro by the MTT reduction method. The variation of concentration used is 1000; 500; 250; 125; 62.5; 31.5; and 15.625 µg/ml, doxorubicin as a positive control was performed in a concentration of 1 μg / ml. The results of the cytotoxicity assay showed that the kelakai extract had a toxic effect on MCF-7 cells with an IC50 value of 493.57 µg / ml
EVALUASI POTENSI INTERAKSI OBAT ANTIBIOTIKA PADA PENYAKIT INFEKSI GASTROINTESTINAL PASIEN RAWAT INAP PERIODE JANUARI – JUNI 2016 DI RUMAH SAKIT IBNU SINA MAKASSAR
Get PDFInfective gastrointestinal is gastrointestinal tract inflammation (GIT), which is caused by microorganisms. The symptoms include diarrhea, vomit, abdominal pain, and fever. This study aimed to determine the antibiotic drug interaction potential based on the interaction mechanisms of gastrointestinal infectious diseases of in patients in the period of January to June 2016 at IbnuSina Hospital Makassar and to determine the severity of antibiotic drug interaction using the website www.drugs.com on the gastrointestinal infectious diseases. This research is non experiments conducted by dekskriptif method retrospectively. The results showed that the drug interaction in the therapeutic use along with less potential antibiotics to interact. This was shown that pharmacokinetic interaction mechanism is 3.80% cases and pharmacodynamics interactions is 6.33% cases, while the pharmacokinetic interaction instead of antibiotics is 40.51% cases, and pharmacodynamics interactions is 7.60% cases. Based on the minor or moderate severity levels, the drug interactions between antibiotics and other drugs are 11.39% cases while the drugs which is not the antibiotics of drug interaction case is 32.91% cases
ISOLASI BAKTERI PENGHASIL SELULOSA DARI BUAH-BUAHAN DIPASAR TRADISIONAL MAKASSAR
Get PDFIsolation of bacterial cellulose from fruits in traditional market of Makassar have been done. The objective of this research is to adding diversity of microorganism that can producing cellulose and observe it’s both optimum temperature and pH. First step is isolation of bacteria from Watermelon, Papaya, Cantaloupe, Mango, Dragon fruit, and Banana that found in traditional market in Makassar using Hestrin-Schramm (HS) agar. Each colony bacteria have been separated to making pure culture using HS agar then the colony was screening in HS broth to obtain colony bacteria that producing cellulose. Screening test found that 10 isolate that can produce cellulose which is MB-B02, MS-B01, MS-B03, NB-B03, PB-B01, PB-B02, PB-B03, PB-B04, PS-B01, and PS-B03. Then the colony that producing cellulose was optimize its temperature and pH. Cellulose obtained from optimization was measure it’s weight to determine optimum temperature and pH. Based from optimization found that 250C was optimum temperature for MS-B01, MS-B03, NB-B03, dan PB-B04, and 370 was optimum temperature for MB-B02, PB-B01, PB-B03, PS-B01, dan PS-B03, meanwhile for isolate PB-B02 optimum both in 250C dan 370C dan pH optimum for all isolate is pH
Potensi Ekstrak Buah Buni (Antidesma bunius (L) Spreng) Sebagai Inhibitor Enzim α-Glukosidase
Get PDFDiabetes mellitus is still a global health problem that continues to increase rapidly and become one of the major metabolic diseases throughout the world. This study aims to determine the potential of Buni fruit as an α-glucosidase inhibitor. α-glucosidase inhibition test is carried out on a blank solution (test solution without sample/standard), acarbose solution as a comparison standard and samples are carried out in accordance with the optimization conditions obtained. The rendemen percent of green and red buni fruit extract yields are 6.35% and 3.09%, respectively. The results of the identification of secondary metabolites using TLC showed that green and red buni fruit extract contains flavonoid, phenolic and alkaloid compounds. The results of the α-glucosidase enzyme inhibition test showed that the red buni fruit extract had the highest activity compared to green buni fruit extract with an IC50 value of 85.27 ppm.