Jurnal Fakultas Farmasi Umi (Universitas Muslim Indonesia)
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AKTIVITAS ANTIOKSIDAN DARI TUMBUHAN PEPAYA (Carica papaya L.)
Get PDFPapaya (Carica papaya L.) is widely used by Indonesians due to its antioxidant contained in the fruit and leaves. Papaya is known to contain vitamin C, tocopherols, phenols, and -carotene in their leaves and fruit thus having the capability as an antioxidant. Antioxidants are compounds that can inhibit oxidation reactions by binding free radicals and highly reactive molecules so that cells will be inhibited. This study aimed to determine the antioxidant activity of papaya through free radical DPPH method (1.1 Diphenyl-2-picrylhidrazyl). Each part of papaya with different extracts produces different antioxidant activities. This study utilized a literature study using the narrative review method in which the literature was identified through the pubmed database, google scholar, MDPI, and the portal garuda. Screening was carried out based on inclusion criteria so that several journals were reviewed. The results of this study showed that the parts of papaya that possessed antioxidant activity were the flesh, peel and leaves. The highest concentration of all parts was from papaya peel with ethanol content, obtained IC50 value of 13.769 g/m
EVALUASI PENGGUNAAN ANTIBIOTIK DENGAN METODE ATC/DDD DAN DU 90% DI PUSKESMAS AUR DURI KOTA JAMBI PERIODE 2016-2018
Get PDFIntroduction: Since 23 years ago, WHO transferred ATC (Chemical Therapeutic Chemical) and DDD (Defined Daily Dose) as a global standard for the study of drug use, one of which is antibiotics. Drug Use Method 90% (DU 90%) method that shows the grouping of drugs that fall into the 90% category of use that is often used in conjunction with an analysis of the use of ATC / DDD drugs. Research Objectives: determine the use of antibiotics in Aur Duri Health Center in Jambi City based on the ATC / DDD method and DU 90% for the 2016-2018 period. Research Methods: Retrospective data collection using ATC / DDD and DU 90% methods. Results: Of the four types of antibiotics, the highest DDD value was obtained at Aur Duri Health Center for the period of 2016-2018, namely amoxicillin antibiotics. Antibiotics that entered the DU 90% segment at Aur Duri Health Center based on data for the 2016-2018 period were amoxicillin, ciprofloxacin and tetracycline. The most quantitative data using the ATC / DDD method is amoxicillin with the highest number of 39.39 DDD / 1000 KPRJ / Year in Aur Duri Puskesmas in 2017
EFEK HEPATOPROTEKTOR ANDROGRAPHOLIDE TERHADAP AKTIVITAS ALANIN AMINOTRANSFERASE DALAM SERUM Rattus norvegicus JANTAN GALUR WISTAR YANG DIINDUKSI KARBON TETRAKLORIDA
Get PDFBackground: Andrographolide is a diterpenoid bioethanol that effectively prevent liver injury by reducing liver oxidative stress response. Method : The research was randomized experimental design with pretest-posttest design. Thirty male wistar rats was randomly divided into 6 groups, normal control, negative control (0,2 ml CCl4), and positive control (500 mg/kgBW curcumin), dose I (50 mg/kgBW), dose II (100 mg/kgBW), dose III (200 mg/kgBW) given for 8 days and induced by 0,2 ml CCl4 on the first day. Data was analyzed by One-Way Anova test, LSD Post-Hoc test and paired T test. Results :All groups induced by CCl4 shows elevated of ALT activity. The posttest results shows significant differences of ALT activity between groups (p<0,05). Conclusion : Andrographolide shows hepatoprotector effect by decrease the activity of ALT in male wistar rats induced by CCl4. The effective dose of andrographolide is 200 mg/kgBW
Aktivitas Antijamur Ekstrak Etanol Daun Cengkodok (Melastoma malabathricum) Terhadap Pertumbuhan Malassezia furfur
Get PDFPityriasis versicolor (PV) is an infection on epidermal layer of skin and the common caused by a type of yeast that live on the skin named Malassezia furfur. The increasing of fungal resistant against antifungal and high reccurence rate after cured in 2 years about 80%, requires alternative treatment that come from plants. Cengkodok leaves (Melastoma malabathricum) is used conventionally as an alternative medicine. Cengkodok leaf produces secondary metabolites which have antifungal activity. The aim of this study was to investigate the antifungal activity of ethanolic extract Melastoma malabathricum leaves (EEMML). Phytochemical screening of EEMML were performed using Thin Layer Chromatography (TLC). Melastoma malabathricum leaves were extracted with maceration method using 96% ethanol. The testing of antifungal activity was determined using disc-diffusion method with the concentration of 5; 20; 50; 100; 250; 500 ppm. Ketoconazole 10 ug/disc and Itraconazole 8ug/disc was used as positive control while negative control used 10% dimethyl sulfoxide (DMSO). EEMML didn’t showed zone of inhibition against Malassezia furfur although 100% concentration extract used. EEMML have no antifungal activity against Malassezia furfu
Spectrophotometric Determination of Total Flavonoid Content in Biancaea Sappan (Caesalpinia sappan L.) Leaves
Get PDFAbstractBiancaea sappan (BS) is traditionally used to treat anticonvulsants, anti-inflammatory, antiproliferative, anticoagulant, antiviral, immunostimulant, antioxidant, and antimicrobial treatments. Flavonoids are found in Secang; flavonoids are secondary metabolites that have antioxidant activity. This study aims to identify the flavonoids using TLC and determination of flavonoids content in BS leaves. Initially, The methanol extract of BS was obtained by maceration with ethanol. The qualitative analysis of flavonoid was using TLC and visualization by sprayed with AlCl3. The determination of total flavonoid content is conducted based on the AlCl3 method with total flavonoids expressed in QE (Quercetin equivalent) at the maximum wavelength of 431 nm. The research results showed that BS leaves contain flavonoids and the total flavonoid content of BS leaf extract is 1.0318 mg QE / g extract.Keywords: Caesalpinia sappan; Flavonoid content, Spectrophotometri
IDENTIFIKASI SENYAWA BAHAN ALAM SEBAGAI INHBITOR TIROSIN KINASE EGFR: SKRINING IN SILICO BERBASIS FARMAKOFOR DAN MOLECULAR DOCKING
Get PDFEpidermal growth factor receptor (EGFR) is one of tyrosine kinase that overexpressed in many types of cancer. The ihbiition of EGFR activity has known as a rational target for cancer therapy. However, several EGFR inhibitors have limitations related to resistance problems or reduced tumor response. Therefore, the effort to develop new inhibitors with greater efficacy is very important to overcome the problems. In the present study, we designed a computational method by combining ligand based pharmacophore modeling and molecular docking for screening the potential natural compounds as EGFR inhibitors. Validation result of ligand based pharmacophore modeling and docking molecular by ROC curves showed that both of these protocols had AUC ≥ 0.7. The Redocking erlotinib to EGFR in our docking protocols gave the RMSD < 2 Å. Therefore, our computational method could be applied for virtual screening. Initial screening based on pharmacophore modeling obtained 86 out of 179.816 compounds that could be mapped with the pharmacophore features. Further screening through molecular docking showed two compounds had a lower docking score than erlotinib, i.e ZINC00941342 and ZINC72325782. However, by careful analysis of their interaction profiles, only ZINC00941342 which formed hydrogen bonds with Met769, which is known as an EGFR key residue. Additionally, it was also found to form hydrogen with Cys773. Therefore, we recommend ZINC00941342 as a potential EGFR inhibitor
PROFIL SOSIODEMOGRAFI DAN TERAPI ANTIRETROVIRAL PADA PASIEN HIV/AIDS RAWAT JALAN RSUD RADEN MATTAHER JAMBI PERIODE TAHUN 2017-2018
Get PDFAs a result of the decline in the immune system it is very susceptible to various diseases (opportunistic Infections) that can be prevented by the presence of antiretroviral therapy with various complications. Sociodemographic Profile is a human picture related to the purpose of the study, Sociodemographic research in HIV / AIDS patients is still rarely found, therefore Sociodemographic Profile is important to know as a basis for information that can be used to prevent transmission of HIV / AIDS. The purpose of this study was to determine the Sociodemographic Profile and ARV therapy in outpatient HIV / AIDS patients at Raden Mattaher Jambi Hospital in the 2017-2018 period. This research method is descriptive by retrospectively collecting data from medical record data. The results showed in the Age group 26-35 years (41.94%), Male sex (70.97%), the last high school education (61.29%), Employee / Private employment history (54.84%) , based on the highest transmission Heterosexual (84.95%), with Marital marital status (83.87%), based on the highest HIV / AIDS status namely HIV (94.62%). Based on ARV therapy, most combinations of Efavirens + Lamivudin + Tenofovir (59.14%)
UJI EFEK ANTIRHEUMATOID ARTRITIS EKSTRAK n-BUTANOL DAUN PETAI CINA (Leucaena leucocephala (Lam.) de Wit) PADA TIKUS JANTAN YANG DIINDUKSI COMPLETE FREUND`S ADJUVANT
Get PDFRheumatoid arthritis is an autoimmune disease characterized by chronic inflammation. The research animed to determine the effect of n-butanol extract of Leucaena leucocephala leaves and the effective dose as antirheumatoid arthritis. It used 15 male rats divided into 5 groups: group I (negative control) was given Na-CMC; group II (positive control) was given a suspension of Methylprednisolone; group III, IV dan V were give the extraxt with doses of 83,3 mg/kgBW, 166,6 mg/kgBW and 333,2 mg/kgBW. The treatment was started by inducing Complete Freund`s Adjuvant intraplantary of 0,1 mL and let it remain until day 16. The therapy was conduction for 14 days orally and the foot volume measurements and observation of the arthritis index were performed on day 17 and 31st. In conclusion, the n-butanol extract of Leucaena leucocephala leaves had the effect as antirheumatoi
ETHNOPHARMACY STUDY OF PLANTS WITH MEDICINAL PROPERTIES IN NORTH MALUKU PROVINCE
Get PDFNorth Maluku Province, especially in Joubela Village, Morotai Island Regency, South Morotai District, is one of the remote areas located in the eastern part of Indonesia. The tribes that still thrive on the island are the Galela and Tobelo, these tribes are some of the largest tribes in North Maluku, recorded to still preserve many plants as traditional medicine. The research aimed to find out the ethnopharmaceutical plants in the village of Joubela. This present study was conducted through direct observation to people who were known to understand the use of traditional medicinal plants such as shamans, community leaders and the public who have used plants for treatment which were selected through purpose sampling method. The results obtained 15 orders, 20 families, 26 genera and 26 species of plants that have empirical potential as medication and the most widely used plant as traditional medicine was garden shrub (Graptophyllum pictum L.), with the efficacy as an ulcer medicine
FORMULASI DAN UJI AKTIVITAS ANTIOKSIDAN BODY LOTION EKSTRAK ETANOL DAUN KEMANGI (Ocimum cannum Sims.) DENGAN METODE DPPH (1,1 – diphenyl-2- picrylhydrazyl)
Get PDFBasil leaves (Ocimum cannum Sims.) Are known to contain alkaloids, flavonoids, saponins, tannins, polyphenols, and triterpenoids. One of the compounds contained in the basil leaves (Ocimum cannum Sims.) Is a flavonoid which has antioxidant activity. Compounds that have antioxidant activity are known to prevent premature aging. This study aims to determine that the ethanol extract of basil leaves (Ocimum cannum Sims.) Can be formulated into Body Lotion with good physical stability or stable and to determine the antioxidant activity of Body Lotion ethanol extract of basil leaves (Ocimum cannum Sims.). The ethanol extract of basil leaves (Ocimum cannum Sims.) Was obtained by remaseration method using ethanol 96% with a yield percentage of 7.09%. Body lotion ethanol extract of basil leaves (Ocimum cannum Sims.) Is made in 3 formulas, which contain extracts F1 (0.5%), F2 (1%), and F3 (1.5%). Body lotion preparations were also tested for physical stability using the cycling test which included organoleptic, homogeneity, pH, dispersal, and adhesion tests. Then proceed to the determination of antioxidant activity carried out by the DPPH free radical reduction method by calculating the IC50 value. The results showed that the ethanol extract of basil leaves (Ocimum cannum Sims.) Has antioxidant activity with IC50 value of 7.05 ppm with AAI value of 14.1 and body lotion preparations can be made. The results of the body lotion antioxidant activity test of basil leaves ethanol extract (Ocimum cannum Sims.) Showed that, F3 had the strongest antioxidant activity namely IC50 18.36 ppm with AAI value of 11.9 then followed by F2 namely IC50 25.2 ppm with AAI value 3.9, and F1, namely IC50 90.5 ppm with AAI value of 14.1. Based on the research results obtained, it can be concluded that the higher the concentration of ethanol extract of basil leaves (Ocimum cannum Sims.) Added, the antioxidant activity of the body lotion will be stronge