Jurnal Fakultas Farmasi Umi (Universitas Muslim Indonesia)
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UJI EFEKTIVITAS EKSTRAK ETANOL KULIT PISANG MAS (Musa acuminata Colla) TERHADAP PENURUNAN KADAR KOLESTEROL TIKUS (Rattus norvegicus) HIPERLIPIDEMIA
Get PDFHyperlipidemia is the escalation level of cholesterol and triglyceride in blood. Lady finger banana peel had chemical flavonoid, tanin, and saponin contents having the activity to reduce cholesterol level. The research aimed to determine the effect of cholesterol level reduction of ethanol exctract of lady finger peel on hyperlipidemia rat. The research used twenty rats divided into five groups. Group I (negative control) was given Na. CMC of 1% b/v, group II (positive control) was given simvastatin of 1,023 mg/kgBW, group III, IV, V groups were given the extract of 500 mg/kgBW 1000 mg/kgBW, and 1500 mg/kgBW. The rats were fed a high dietary fat during treatment and induces with pristine cholesterol for twenty one days. The measurement of rat cholesterol level was conducted on day 0, 22 and 36. The result were statistically processed using One Way Anova proceeded to Post Hoc Bonferroni. The result of the research showed that the positive control group had no different tangible effect to ethanol extract of lady finger banana groups (p>0,5). In conclusion, the ethanol extract of lady finger banana had the activity in reducing cholesterol level with effective doses of 500 mg/kgBW, 1000 mg/kgBW, and 1500 mg/kgBW
ANALISIS KOMPONEN KIMIA AKTIF ISOLAT DAUN Colocasia esculenta L. IDTK01 SECARA SPEKTROFOTOMETER INFRA MERAH
Get PDFThe objective of this research is to analysis chemical coumpounds active isolate of Colocasia esculenta L.’s leaves IDTK01 using infra red spectrophotometer. The fractionation of the ethanolic extract of Colocasia esculenta L’s leaves using liquid vacuum chromatography obtained 7 fractions. Active fraction was B fraction isolated from the active coumpound by TLC-preparative from 3 different isolate, IDTK01, IDTK02 dan IDTK03. IDTK01 isolate was tested its antibacterial activity using TLC-bioautography with eluen n-hexane:ethyl acetate (10:1) and its active against Salmonella thypi with Rf value 0.98. Active isolate IDTK01 was analyze its active bacterial coumpound using infrared spectrophotometer and the results is hydrogen bond, hydroxyl functional group (OH), aryl/ aromatic (C=C), aliphatic (CH2), Ether aldehyde (C-O), and pyridin
EVALUASI TINGKAT PENGETAHUAN OBAT ANTIDIABETES PADA MASYARAKAT DI DESA BONTOKASSI GOWA
Get PDFDiabetes mellitus is one of disease caused by changes individual's lifestyle and is not in accordance with a healthy lifestyle. In addition, this is also caused by factors that cannot be ignored. Knowledge of the general public in rural areas is very minimal because of their ignorance about diabetes mellitus. The method used in this study is descriptive observational prospectively by providing a questionnaire to assess the level of knowledge of respondents and the use of diabetes medication. Data collection was carried out in two stages. As a result of this service activity, respondents who were given counseling actually experienced an increase in their understanding of diabetes. The data obtained were analyzed by statistical program with t-test analysis. This can be seen from the statistical results that there is an effect of p <0.05 on knowledge about diabetes, the use of antidiabetic drugs, the effectiveness of antidiabetic drugs, the quality of antidiabetic drugs, and adherence to taking antidiabetic drugs. With these changes, the importance of information on patients by pharmacists in the area is very important
PROFIL KADAR GLUKOSA DARAH PASIEN DIABETES MELLITUS TIPE 2 YANG MENGGUNAKAN ATORVASTATIN 20 MG DI RUMAH SAKIT MADANI, ANUTAPURA DAN UNDATA PERIODE 2015-2019
Get PDFAtorvastatin is one of the lipophilic statins that can cause diabetes through some mechanisms, such as liphophilic properties, it’s activities to insulin secretion, insulin signaling, and adiponectin levels. The purpose of this research is to know demographic data, profile of when blood sugar levels, and the time needed for atorvastatin to increase blood sugar when type 2 diabetes mellitus patients use atorvastatin for 20 mg. This research is observational descriptive research with retrospective data collection approach by looking at the usage of atorvastatin, with total samples 22 patients obtained from medical record data at Madani hospital, Anutapura and Undata in Palu in the period of 2015-2019. This research result shows that the demographic data of the average age of type 2 diabetes mellitus patients in which complications of dysplidemia that uses atorvastatin for 20 mg are in the age of 45-56 years old, female gender (57.14%), with the last education of Senior High School (38.09%) and occupation as Government Employees (33.33%), the time needed for atorvastatin 20 mg to increase blood sugar is 2 months (the difference is 26.38 mg/dl; percentage 19.52%) and the percentage of highest blood sugar increase is one year, which is 93.91%
PERBANDINGAN MEDICATION ERROR PADA PERESEPAN ELEKTRONIK DAN PERESEPAN MANUAL PADA TAHAP PRESCRIBING DI APOTEK KOTA PALU
Get PDFPrescribing drugs is now growing, as evidenced by the existence of electronic prescribing that have been applied in several hospitals and pharmacies. The development of this prescribing method does not rule out the possibility of increasing the incidence of medication errors in prescribing. So, it is necessary to identify the prescribing that has been implemented, especially in drugstore at Palu City. The purpose of this study was to look at the comparison of medication errors at the prescribing stage which included aspects of prescribing completeness and therapeutic errors in electronic prescribing at Drugstore X and manual prescribing at Drugstore Y in Palu city in 2018. This type of research is a descriptive study with retrospective data collection. Samples taken in the form of secondary data are prescribing using purposive sampling method. The results obtained in this study are, the prevalence of medication error at the prescribing stage of electronic prescribing in drugstore at Palu City includes data, patient's body weight is 2%, doctor's license 100%, doctor's telephone number 100%, doctor's initial 100%, dosage form 97% and 90% strength of the drug. While the prevalence of medication error at the prescribing stage of manual prescribing in Drugstore Palu City is data, the patient's age is 2%, the patient's body weight is 99.1%, the patient's sex is 100%, the doctor's license is 91.6%, the doctor's telephone number is 80%, initial doctor 42.7%, 88% dosage form and 65% drug strength. Based on these results, it can be concluded that the use of electronic prescribing is better than manual prescribing
Aktivitas Antiinflamasi Ekstrak Etanolik Daun Arbenan [Duchesnea indica (Jacks.) Focke]
Get PDFArbenan leaf is a medicinal plant that used in the healing of inflammation. The content of phenolic compounds, flavonoids, steroids and tannins contained in arbenan plants which play an important role in alternative medicine. Currently, scientific work of phytotherapy is an important alternative route in finding effective natural medicines with minimal side effects. The aim of this study was to determine the phytochemical properties and to determine the anti-inflammatory effect of arbenan leaf [Duchesnea indica (Jacks.) Focke] extract. In this study, nine male Wistar rats were tested in three treatment groups. Group I Na CMC, group II Na diclofenac and group III arbenan leaf extract. Inflammation in rats by inducing 1% carrageenan as much as 0.10 mL. The volume of edema per hour is known from the difference in the volume of the foot at certain hours with the volume of the normal foot. The AUC value of edema volume was calculated by the trapezoid method every one hour and the percen of anti-inflammatory power was calculated. The statistical analysis of the Least Significance Different (LSD) AUC value from the edema volume data showed that the two treatment groups, namely the Na diclofenac and the arbenan leaf extract group, were significantly different from the Na CMC group (P <0.05). So that both treatment groups have anti-inflammatory effects. The results showed that the ethanolik extract of arbenan leaves contained phenolic compounds, flavonoids and tannins. Then the ethanolic extract of arbenan leaves has anti-inflammatory activity of 0.31%
ISOLASI FUNGI ENDOFIT DAUN Srikaya (Annona muricata L.) SEBAGAI ANTIOKSIDAN SECARA KLT-AUTOGRAFI
Get PDFAntioxidants are compounds that can neutralize free radicals that produced by endophyte microbes. This study aims to isolate endophyte fungi and antioxidant activity of isolate endophyte fungi of Annona muricata L. leave used TLC-Autograph Method. The result of isolation endophyte fungi Annona muricata L. leaves obtained 7 isolates namely FES1, FES2, FES3, FES4, FES5, FES6, dan FES7 colonies. Isolates of endophytic fungi were purified by quadran steak method to obtain pure isolates. The pure isolates obtained were fermented in Maltosa Yeast Broth (MYB) medium using shaker at 200 rpm for 7 x 24 hours to obtain secondary metabolites namely mycelia and supernatant. The results of testing the antioxidant activity of the supernatant extract of endophytic fungi isolates by TLC-Autograph using 0.04% DPPH spray reagent showed that the endophytic fungi isolate FES2 had free radical activity at Rf values of 0.94 and 0.87
EVALUASI PENGGUNAAN SUPLEMEN KEHAMILAN PADA PASIEN WANITA HAMIL DI PUSKESMAS BULILI KOTA PALU PERIODE APRIL 2018-DESEMBER 2018
Get PDFAnemia in pregnant women will increase the risk of new born babies with low birth weight, miscarriage, premature, risk of bleeding before and / or during labor can cause death to both of them. This research aims to determine the evaluation before and after pregnancy supplement to pregnant women at Puskesmas Bulili, Palu, April - December 2018. This is a quantitative research with a retrospective approach. There are 44 females without the anemia and 22 at the anemia group. Pregnant women are said to be anemic when their hemoglobin or red blood levels are less than 11.0 gr%. The results, the hemoglobin levels before and after the use of pregnancy supplements in the non-anemia were 11.7 gr / dl and 11.4 gr dl (p = 0.004; p 0.005) which means no significant difference in hemoglobin levels after pregnancy supplementation