Jurnal Fakultas Farmasi Umi (Universitas Muslim Indonesia)
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ANALISIS AKTIVITAS PERLINDUNGAN SINAR UV EKSTRAK ETANOL DAUN PANDAN WANGI (Pandanus amaryllifolius Roxb.) BERDASARKAN NILAI SUN PROTECTION FACTOR
Get PDFUV rays have a negative impact on the skin, but can be minimized by using UV-protective ingredients. The leaves of Pandan Wangi (Pandanus amaryllifolius Roxb.). Contain alkaloid compounds, flavonoids, saponins, tanins, polyphenols which function as natural antioxidants. The purpose of study is determine the UV protection activity of the ethanol extract of fragrant pandan leaves. Based on the Sun Protection Factor (SPF) value using the UV- Vis Spectrophotometric method at wavelengths 290, 295, 300, 310, 315, 320 nm. The result showed that fragrant pandanus leaves (Pandanus amaryllifolius Roxb.) Had a minimum UV protection activity value of 3,8979 at a concentration of 1%, extra protection 6,2456 at a concentration of 3%, maximum protection of 9,4603 at a concentration of 5%
PENENTUAN AKTIVITAS ANTIBAKTERI EKSTRAK ISOLAT FUNGI ENDOFIT DARI DAUN GALING-GALING (Cayratia trifolia L)
Get PDFUtilization of wild plants around us needs to be done to expand the chances of wild plants being used as traditional medicine. These plants have the main content of the active compounds in the form of steroids, terpenoids, flavonoids, tannins and is reported to have antibacterial activity. This research aims to determine the concentration of endophytic fungi isolates IDGG 02, IDGG 03 and IDGG 06 from the leaves of galing-galing (Cayratia trifolia L). The first stage purification isolates of endophytic fungi in order to obtain single isolates. Then fermented using a shaker for 21 days at room temperature. Fermented extracted with ethyl acetate solvent using a liquid-liquid extraction methods to obtain a dry extract. Testing the minimum inhibitory concentration (MIC) with concentrations of 2048, 1024, 512, 256, 128, 64, 32, 16, 8 and 4 µg / mL and testing for antibacterial activity using agar diffusion methods against bacteria Staphylococcus aureus, Staphlococcus epidermidis, Escherichia coli and Vibrio cholerae.The results obtained MIC 2048 MIC ug / mL to extract isolates IDGG 02 and IDGG 06, while the extract obtained 03 isolates IDGG 1024 MIC ug / ml against all bacteria. Results of testing the antibacterial activity of endophytic fungi isolated extract IDGG 02, 03 IDGG produce diameter zone of inhibition at a concentration of 2048 mg / mL against Staphylococcus aureus, Staphlococcus epidermidis, Escherichia coli and Vibrio cholerae
Efek Antihiperglikemik Infusa Daun Benalu Kersen (Dendrophthoe pentandra (L.) Miq) Pada Tikus Putih Jantan Yang Diinduksi Aloksan
Get PDFKersen parasite leaves (Dendropthoe pentandra (L.) Miq) is a type of parasite that is hemiparasite and contains active compounds, namely, flavonoids, terpenoids and tannins. This compound has benefits as an antihyperglycemic. The aim of this study is to determine the effect of lowering blood glucose levels from the infusion of Kersen parasite leaves (Dendrophthoe pentandra (L.) Miq) in white male rats induced by alloxan. This research was a laboratory experimental study with a randomized pre- and posttest one group design. The study used alloxan-induced male rats which were divided into 3 dosage groups (38 mg/kgBW, 77 mg/kgBW, and 154 mg/kgBW). In the results of the mean blood glucose levels of rats, there was a decrease in blood glucose levels on the 0th day of treatment, on the 7th day after the treatment there was an increase in blood glucose levels and on the 14th day after the treatment there was a decrease in blood glucose levels except in the dose II group and III. In this study, Kersen parasite leaf infusion had no effect on reducing blood glucose levels of alloxan-induced male white rats
Uji Aktivitas Antibateri Ekstrak Etanol Daun Kenikir (Cosmos caudatus kunth.) Terhadap Staphylococcus aureus
Get PDFInfeksi bakteri dapat terjadi pada manusia dan menyerang berbagai sistem organ pada tubuh, antara lain infeksi saluran pernapasan, infeksi kulit, infeksi saluran pencernaan, dan infeksi saluran urinarius. Bakteri penyebab infeksi kulit antara lain disebabkan oleh Staphylococcus aureus. Salah satu tanaman yang berkhasiat sebagai antibakteri yaitu daun kenikir (Cosmos caudatus Kunth.) karena mengandung senyawa aktif berupa minyak atsiri, steroid, tanin, flavonoid, dan alkaloid. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri dan konsentrasi minimum ekstrak etanol daun kenikir (Cosmos caudatus Kunth.) yang menunjukkan aktivitas antibakteri terhadap Staphylococcus aureus. Jenis penelitian ini adalah penelitian eksperimental, dengan menggunakan metode difusi sumuran dan diameter zona hambat. Konsentrasi ekstrak etanol daun kenikir yang digunakan pada penelitian ini adalah 20%, 30%, dan 40%. Uji dilakukan untuk mengamati ada tidaknya zona hambat dari ekstrak daun kenikir (Cosmos caudatus Kunth.) terhadap Staphylococcus aureus, setelah 24 jam inkubasi. Analisis yang digunakan adalah analisis deskriptif. Hasil penelitian menunjukkan ekstrak etanol daun kenikir (Cosmos caudatus Kunth.) dengan konsentrasi 20%, 30%, dan 40% dapat menghambat pertumbuhan bakteri Staphylococcus aureus dengan rerata masing-masing 14,11mm, 14,86mm, dan 16,05mm dari hasil peneltian konsentrasi 40% esktrak etanol daun kenikir memiliki aktivitas terbaik dalam penghambatan pertumbuhan bakteri Staphylococcus aureu
UJI EFEK EPITELISASI EKSTRAK BATANG WOLE WOE ASAL KABUPATEN HALMAHERA TENGAH TERHADAP PENYEMBUHAN LUKA BAKAR PADA TIKUS
Get PDFWole woe is a native plant of Indonesia which is widely used by the people of Central Halmahera as a medicinal plant. Empirically this plant is widely used for wound treatment. This study aims to determine the effect of epithelialization of wole woe stem extract and determine the effective concentration and duration of wound healing in rats after administration of wole woe stem extract. This research was conducted experimentally in a laboratory using 25 rats which were divided into 5 groups consisting of 1 control group, 1 comparison group, and 3 treatment groups of wole woe stem extract. Wound induction was carried out using a 100 0C hot plate measuring 2x2 cm and affixed to the surface of the rat's back skin for 2 seconds. After a burn is formed, the extract is applied 2 times a day for 21 days. Observations on wound healing were carried out macroscopically and measuring the surface area of the wound. The results showed that the administration of wole woe bark extract influenced healing second-degree burns in rats. The results of statistical analysis showed that there was no difference between the comparison group and the extract test group (p>0.05). Based on the percent reduction in wound, the most effective concentration in wound healing was 5% (99.75%). Wound healing time in rats was 21 days
UJI EFEK NEFROPROTEKTIF EKSTRAK ETANOL DAUN BINAHONG (Anredera cordifolia (Ten.) Steenis) PADA TIKUS JANTAN YANG DIINDUKSI GENTAMISIN
Get PDFNephroprotective is an attempt to protect the kidneys from damage. The research aimed tc determine the effect of nephroprotective and determine the effective dosage of ethanol extract of Anredera cordifolia (Ten.) Steenis leaf as the nephroprotective. The research used 15 male rats divided into 5 groups. Group 1 (normal) was no treatment; group 2 (negative control) was induced by gentamicin; and groups 3, 4 and 5 (test group) were provided ethanol extract of Anredera cordlfolia Ten.) Steenis leaves sequentially at the doses of 100 mg/KgBW, 150 mg/KgBW and 200 mg/KgBW. The extract was orally given once a day for 8 days; every 1 hour after the treatment, all the test rats were intraperitoneally induced by gentamicin of 80 mg/KgBW except for the normal group. The measurement of creatinine content was conducted on day 1 and 9. Based on the results of the measurement of final creatinine content, the ethanoi exiract of the Madeira-vine leaf obtained had the effect as nephroprotective. From the results of the difference in creatinine content, the analysis was conducted by One-Way ANOVA followed by the LSD test. In conclusion, the ethanol extract of Madeira-vine leaf of the doses of 100 mg/KgBW, 150 mg/KgBW and 200 mg/KgBW had relatively the same nephroprotective effect
Optimasi Dan Identifikasi Fitokimia Serta Uji Efek Hipoglikemik Kombinasi Ekstrak Daun Dandang Gendis (Clinacanthus nutans) Dan Ekstrak Ciplukan (Physalis angulata L.) Secara In Vitro
Get PDFDiabetes mellitus is a metabolic disease characterized by hyperglicemic. Dandang Gendis (Clinacanthus nutans) and Ciplukan (Physalis angulata L.) are plants which recognized as blood glucose controller. The study aims to determine the effectiveness of the combination of the two extracts in decreasing blood sugar levels in vitro. The leaves of dandang gendis and ciplukan were extracted with various solvents (hot water, cold water, 96% ethanol, 75% ethanol, 50% ethanol and 30% ethanol were used as solvents), then tested the quality of the simplicia and extract, then the phytochemical test of each extract, after that the hypoglycemic activity of each extract was tested, made several variations of the dose, then tested the antidiabetic activity of the combination extract, calculated percent protection and percent effectiveness of single extract and a combination of leaf extract of dandang gendis (Clinacanthus nutans) and ciplukan (Physalis angulata L).The results showed that inhibition of the α-amylase enzyme by extracts of Dandang Gendis, Ciplukan and their combinations included the combination of EE96% 10 mg (1:1) of 1.25 ppm; Combination of EE96% 10mg (1:2) of 6.340 ppm; Combination of EE96% 10mg (2:1) of 5.808 ppm; The combination of EE96% 10mg (2:2) was 7.115 ppm and the IC50 acarbose value was 4.23 ppm. Dandang Gendis extract, Ciplukan and their combination had α-amylase inhibitory activity which was not significantly different between the extract and the control Acarbose. Inhibition of α-amylase enzyme activity could be influenced by metabolites and total phenolic extracts of Gendis, Ciplukan and their combinations
Aktivitas Iron Chelator Ekstrak Etanol Dan Fraksi Daun Putri Malu (Mimosa pudica L) Terhadap Pasien Thalasemia Menggunakan Metode Fic (Ferrous Ion Chelating)
Get PDFThalasemia merupakan penyakit genetik yang disebabkan oleh defisiensi rantai globin α dan β yang menyusun hemoglobin. Penelitian ini bertujuan untuk mengetahui adanya kandungan senyawa mimosin dan konsentrasi optimum mimosin pada tanaman Mimosa pudica L sebagai agen pengkhelat besi pada pasien thalasemia secara in-vitro. Penelitian diawali dengan melakukan ekstraksi dan fraksinasi daun putri malu selanjutnya menguji kadar feritin menggunakan uji Ferrous Ion Chelating (FIC). Pengujian dilakukan sebanyak tiga kali. Selanjutnya dihitung kadar feritin dengan ELISA reader. Tahap akhir, yaitu mengukur kadar mimosin. Mimosin dengan konsentrasi 500 ppm memiliki aktivitas pengkhelat besi dengan persentase penurunan kadar feritin sebesar 84,48%. Fraksi n-heksan dengan konsentrasi 500 ppm memiliki aktivitas pengkhelat besi dengan penurunan aktivitas feritin sebesar 81,27%
UJI AKTIVITAS ANTIOKSIDAN FRAKSI n-HEKSAN, ETIL ASETAT, DAN AIR EKSTRAK DAUN BIWA (Eriobotrya japonica (Thunb.) Lindl.) DENGAN METODE DPPH
Get PDFLoquat leaf (Eriobotrya japonica (Thunb.) Lindl.) have been known to contain flavonoid compounds, alkaloids, tannins, saponins, triterpenoids and glycosides, these compounds have the potential to be antioxidants and can ward off free radicals. The purpose of this study was to determine the fraction of n-hexane ethyl acetate and water with extract of loquat leaf which have antioxidant activity, and to find out, respectively, which fraction had the most active activity from the IC50 value in activity antioxidant. The extraction method of loquat was macerated using 96% ethanol and then fractionated with n-hexane, ethyl acetate, and water. The obtained fraction was tested for antioxidant activity against free radicals using the DPPH method using UV-Vis spectrophotometer at the wavelength of 516 nm. The results of the loquat leaf fraction test have antioxidant activity which can be seen from the IC50 value, namely the n-hexane fraction is 1792 ppm, the ethyl acetate fraction is 89.60 ppm, the water fraction is 394.99 ppm, and quercetin is 13.03 ppm, so the most active antioxidant is obtained ethyl acetat