Jurnal Fakultas Farmasi Umi (Universitas Muslim Indonesia)
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ANTIBACTERIAL ACTIVITY OF BIDARA LEAVES (Ziziphus mauritiana L.) ETHANOL EXTRACT AGAINST SOME TEST BACTERIA
Get PDF ABSTRACTBidara leaves (Ziziphus mauritiana L.) are one of the traditional plants that contain antibacterial compounds such as alkaloids, flavonoids, saponins, tannins and phenols. This study aimed to determine the antibacterial activity of the ethanol extract of bidara leaves (Ziziphus mauritiana L.) against several test bacteria using the agar diffusion method. This test begins with a screening test using 10 test bacteria and the result is inhibiting the growth of bacteria at a concentration of 0.1%. Then the MIC test was carried out and the result was that a concentration of 0.1% could inhibit and kill the growth of the test bacteria. Then the KBM test was carried out and the results obtained at a concentration of 12.8% could inhibit and kill Eschercia coli and Pseudomonas aeruginosa bacteria, a concentration of 6.4% could inhibit and kill Staphylococcus epidermidis and Vibrio cholerae bacteria, a concentration of 3.2% could inhibit and kill bacteria Staphylococcus aureus, Bacillus sublitis and Streptococcus mutans, a concentration of 1.6% can inhibit and kill Salmonella typhi and Propionibacterium acnes bacteria, and a concentration of 0.8% can inhibit and kill Shigella dysenteriae bacteria. Then, the antibacterial activity of the ethanol extract of bidara leaves (Ziziphus mauritiana L.) was tested using the agar diffusion method and the results showed that the ethanolic extract of bidara leaves (Ziziphus mauritiana L.) had strong potential as an antibacterial against test bacteria with the largest diameter of the inhibition zone at a concentration of 12 ,8% by 15.64 mm.Key Words: Antibacterial, Bidara Leaf (Ziziphus mauritiana L.), Agar diffusio
INVENTARISASI TANAMAN OBAT UNTUK PENYAKIT HIPERTENSI PADA MASYARAKAT KECAMATAN BAREBBO, KABUPATEN BONE, PROVINSI SULAWESI SELATAN
Get PDFInventory of medicinal plants is an activity to collect data related to the types of medicinal plants in an area or region. People in Barebbo District still use plants as traditional medicines to treat various diseases, one of which is hypertension. Hypertension is ranked first in the 10 cases of the most common disease suffered by the community in Barebbo District. This study was conducted with the aim of collecting data on medicinal plants used by the community in Barebbo District and how to use these plants for the treatment of hypertension. This research was conducted using the snowball sampling method and the respondents were obtained based on key-informant references. From this study, it was found that there were 21 species of plants used by the community in Barebbo District to treat hypertension and Apiaceae family was the most widely used. The people in Barebbo District utilized leaves, tubers, fruit, water, rhizomes, seeds, stems and herbs. They mostly used the plant by drinking it 1-2 times a day. Besides, they cultivated these plants by boiling, brewing, squeezing, and also consuming them directly
LITERATURE STUDY OF ANTIBACTERIAL ASSAY OF AVERRHOA BILIMBI L. AGAINST GRAM POSITIVE BACTERIA
Get PDFAverrhoa bilimbi L. is one of the traditional medicines that people empirically use as medicine to treat various diseases such as cough, diabetes, rheumatism, mumps, canker sores, toothache, bleeding gums, acne, diarrhea to high blood pressure. The research aimed to determine the antibacterial activity of Averrhoa bilimbi L. against gram-positive bacteria. This research applied a literature study method in which the references were obtained from 3 data bases, namely google scholar, pubmed and mdpi, then selected journals that metthe criteria in the literature study. From the journal exploration, 7 journals were obtained. Then the antibacterial activity of Averrhoa bilimbi L. against gram-positive bacteria was observed. The results confirmed that the fruit and leaves of Averrhoa bilimbi L. had an antibacterial activity against Staphylococcus aureus, Streptococcus mutans, Staphylococcus epidermidis, and Propionibacterium acnes due to the presence of secondary metabolites, namely saponins, tannins, alkaloids and flavonoid
POTENSI ANTIBAKTERI EKSTRAK ETANOL BATANG WOLE WOE ASAL HALMAHERAH TENGAH TERHADAP BAKTERI Pseudomonas aeruginosa dan Bacillus subtilis MENGGUNAKAN METODE DIFUSI AGAR
Get PDFThe wole woe plant empirically in the community in Central Halmaherah district is used to treat various diseases, such as breast anticancer, cysts, vaginal discharge, diabetes mellitus, wounds, dysentery, cholesterol, and uric acid, which is thought to have bioactive compounds, that is antibacterial compounds. Therefore, a study was conducted to determine the antibacterial potential of the ethanol extract of wole woe stems against Pseudomonas aeruginosa and Bacillus subtilis bacteria using the agar diffusion method. The results of the screening test showed activity at a concentration of 0.1% and the results of the minimum inhibitory concentration test (MIC) and the minimum killing concentration test (MBC) obtained 1.6% for Pseudomonas aeruginosa bacteria. For Bacillus subtilis bacteria, the MIC value is 0.2% and the MBC value is 3.2%. The statistical test results of the inhibition zone diameter data from the antibacterial activity test against Pseudomonas aeruginosa and Bacillus subtilis bacteria showed that there was a difference in the ability to inhibit bacterial growth between the positive control and the test concentration group of 2.5%, 5% and 10%. The results obtained from the ethanol extract of wole woe stems have potential as antibacterial
KAJIAN ETNOFARMASI DENGAN PENGGUNAAN TANAMAN OBAT TRADISIONAL DI KECAMATAN TANRALILI, KABUPATEN MAROS, PROVINSI SULAWESI SELATAN
Get PDFThe study of ethnopharmaceuticals is a scientific approach that can assist in exploring the knowledge of the local tribe towards traditional plants that are efficacious as medicine and still rely on or use plants as medicine. This study aims to determine the use of medicinal plants which include the parts of the plants used, processing methods and usage methods. The method used in this research is purposive sampling method. The results of the study obtained as many as 42 species spread into 28 and have 3 plants that have frequency values, Use Value (UV) and percent of plants including soursop, kaposanda and papaya plants and the lowest values are bandotan, chicken dung, cinnamon, gedi, tapak liman plants used by the people of Tanralili sub-district, Maros district as traditional medicine. The conclusion is that the level of knowledge related to the use of traditional medicinal plants tends to still use and utilize and as an alternative treatment.This plant has the highest parameter of frequency 28, Use Value (UV) is 0.28 and plant percent is 11.97% on soursop plants and has the lowest value with a frequency value of 1, Use value (UV) is 0.01 and percent of plants namely 0.43% on bandotan, chicken dung, cinnamon, gedi, tapak liman and sweet potato plant
UJI TOKSISITAS EKSTRAK ETANOL BATANG KAYU WOLE WOE TERHADAP LARVA Artemia salina Leach MENGGUNAKAN METODE Brine Shrimp Lethality Test (BSLT)
Get PDFThe Wole Woe plant is one of the plants that is empirically used as traditional medicine by the Weda community in Central Halmahera Regency. The stem part of the Wole Woe plant is used to treat various diseases. This study aims to determine the toxicity of Wole Woe logs using the Brine Shrimp Lethality Test (BSLT) method. This research was started by extracting Wole Woe logs using ethanol 70% solvent with the reflux method and then carried out phytochemical screening which showed that Wole Woe logs contained alkaloids, flavonoids, saponins, triterpenoids, and tannins compounds. Toxicity testing of Wole Woe wood stem ethanol extract against Artemia salina Leach larvae was divided into 5 test groups, namely 4 treatment groups (concentrations of 250 ppm, 500 ppm, 750 ppm, and 1000 ppm) and 1 control or comparison group (sea water). Each concentration was made in 3 vials containing 10 larvae of Artemia salina Leach. Observations were made by looking at the mortality of Artemia salina Leach larvae after 24 hours of treatment. The results of the study can be seen through probit analysis by calculating the LC50 value. The LC50 of the ethanol extract of Wole Woe logs is 453.942 ± 59.564 g/mL. This indicated that the ethanolic extract of Wole Woe logs had a toxic effect on Artemia salina Leach larvae because the LC50 value was< 1000 pp
Uji Aktivitas In Vivo Antinosiseptif Kombinasi Ekstrak Daun Dandang Gendis [Clinacanthus nutans (Burn F) Lindau] dan Daun Bakung (Crinum asiaticum L)
Get PDFAlmost all diseases in the body cause pain. Currently the most widely used analgetic has not regardless from side effects. The development of new and effective pain medications that are natural is expected to have the benefits of treatment. 75% ethanol extract of dandang gendis leaf (Clinacanthus nutans (Burn F) Lindau) dosage 279,3 mg/kg BW and 96% ethanol fraction of bakung leaf (Crinum asiaticum) dosage 250 mg/kg BW were shown to have antinociceptive activity. The purpose of this study was to determine the antinociceptive effectiveness of a combination of 75% ethanol extract from dandang gendis leaves and 96% ethanol fraction of bakung leaf. In this study was used chemical method induction (Sigmund's method) in 25 male mice which were divided into 5 treatment groups, namely treatment group I as negative control was given CMC 0.5%, treatment group II as positive control was given acetosal 100 mg / kg BW, treatment groups III, IV and V were given combinationsextract. Each group was given treatment orally, thirty minutes then induced with 0.6% acetic acid intraperitonially, after which it was observed and counted for the amount of stretching for sixty minutes. Data were analyzed by one-way ANOVA to see differences in antinociceptive effects in each treatment group. The results of this study showed that all treatment groups had a significant difference (p <0.05), the combination of 75% ethanol extract dandang gendis leaf and 96% ethanol fraction of bakung leaf with a dose of 100 mg / kg BW had good effectiveness with a percent effectiveness value of 92.50%. The results of this study indicate that the combination of 75% ethanol extract from dandang gendis leaf (Clinacanthus nutans (Burn F) Lindau) and 96% ethanol fraction from bakung leaf (Crinum asiaticum) with the same concentration ratio, have relatively higher antinociceptiveof the activity of each extract, in other words both of them work together
PENGARUH INFUSA REBUSAN DAUN KELOR (Moringa oleifera) TERHADAP PENURUNAN KADAR ASAM URAT DALAM DARAH PADA HEWAN COBA MENCIT JANTAN (Mus musculus)
Get PDFGout is the result of metabolism in the body whose levels should not be excessive, everyone has uric acid in their body, because every normal metabolism will produce uric acid while the trigger is food factors and other compounds that contain lots of purines. The purpose of this study was to determine the effect of giving Moringa oleifera leaf infusion on blood uric acid levels in mice using 25 mice which were divided into 5 groups, namely the positive control group, the infusion 20%, and the infusion 40%, infusion 60% and negative control with treatment for 3 weeks. Measurement of uric acid levels using an autocheck tool. The results of the measurement of uric acid levels in the infusion group 20% showed an average decrease of 0.16 mg/dl, in the 40% group the infusion showed an average value of 0.62 mg/dl and in the infusion group 60% showed an average value of 0.92 mg/dl. The higher the concentration of Moringa oleifera infusion, the lower the uric acid leve
PENETAPAN KADAR VITAMIN C LIMBAH KULIT BUAH APEL MANALAGI (Pyrus malus L.) DENGAN METODE SPEKTROFOTOMETRI UV-VIS
Get PDFVitamin C is a vitamin that is water soluble and one vitamin that is needed by the body. To meet the intake of vitamin C needed source of vitamin a derived from fruits, one of which is Appel Part of the appel , which is still rarely used is its skin. Apple peel is very beneficial for health however the situation is only considered as waste that has not been utilized well. This study aims to determine the levels of vitamin C on the skin of the Apple (Pyrus mallus L) by the method of spectrofotometry uv-visible wavelength 243 nm. This research uses experiments with purely research stage comprised sample preparation, qualitative test, making the solution of the parent raw, quantitative test, determination of wavelength of maximum vitamin and creation of calibration surve. Based on the research that has been done, the result of the qualitative test to prove the presence of high content of vitamin C contained in appel peels, with the highest level obtained in the skin of the plantain by 13,534 mg/g extrac
Formulasi Dan Karakterisasi Tablet Effervescent Ekstrak Etanol Bawang Dayak (Eleutherine Palmifolia L. Merr)
Get PDFBawang Dayak (Eleutherine palmifolia L. Merr) dalam bentuk segar maupun ekstrak telah dipergunakan secara tradisional oleh masyarakat untuk pengobatan berbagai penyakit. Saat ini sediaan ekstrak etanol bawang Dayak dalam bentuk tablet effervescent belum tersedia. Berdasarkan hal tersebut maka tujuan penelitian adalah formulasi dan karakterisasi tablet effervescent dari ekstrak etanol bawang Dayak. Ekstraksi bawang Dayak dilakukan dengan metode maserasi menggunakan etanol 96%. Ekstrak etanol yang dihasilkan diuji toksisitas dengan metode Brine Shrimp Lethality Test dan karakterisasi fitokimia. Pembuatan tablet effervescent menggunakan metode granulasi basah dengan variasi konsentrasi polivinilpirolidon (0%, 1%, 2%, 3%, dan 4%). Karakterisasi tablet effervescent meliputi penampilan, keseragaman ukuran, keseragaman bobot, kekerasan, dan waktu melarut. Hasil penelitian menunjukan bahwa rendemen estrak etanol yang dihasilkan adalah 8,45%. Ekstrak etanol bawang Dayak tidak bersifat toksik dengan LC50 sebesar 1.241 ppm. Uji fitokimia dari esktrak etanol memberikan hasil positif pada flavonoid, alkaloid, polifenol, dan tannin. Hasil uji keseragaman ukuran dan uji keseragaman bobot tablet effervescent tidak berbeda nyata. Hasil uji kekerasan dan uji waktu melarut tablet effervescent menunjukkan bahwa variasi konsentrasi PVP berpengaruh terhadap kekerasan dan waktu melarut tablet. Tablet effervescent dengan waktu melarut paling cepat diperoleh dengan menggunakan 1% PVP