Jurnal Fakultas Farmasi Umi (Universitas Muslim Indonesia)
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ANTIBACTERIAL ACTIVITY TEST OF COMBINATION OF BETEL LEAF EXTRACT (PIPER BETLE) AND KERSEN LEAF EXTRACT (MUNTINGIA CALABURA) AGAINST ESCHERICHIA COLI BACTERIA
Get PDFEscherichia coli or commonly referred to as E. coli is a Gram-negative bacteria that can cause various problems in the human body, the mechanism of resistance built by E.Coli to antibiotics is a reason for the need to look for compounds that have antibacterial potential. Betel leaf and cherry leaf are two types of plants that have the potential to have compounds that can be developed as antibacterial, this study tested the two types of plants using the disc diffusion method. The compounds identified in this plant are alkaloids, saponins, and flavonoids. These three compounds are thought to provide strong antibacterial activity in the samples, although further research is still needed to confirm this
POTENTIAL PEGAGAN LEAVES (CENTELLA ASIATICA (L.)) AS BURN HEALER AND ANTIBACTERIAL AGAINST STAPHYLOCOCCUS AUREUS
Get PDFPegagan leaves (Centella asiatica (L.)) in the know contain flavonoids, saponins tannin and asiaticosides which have the effect of wound healing and antibacterial. This research aims to review scientific articles related to the potential of pegagan leaves in healing burns and as an antibacterial against Staphylococcus aureus. In this study using the literature study method where articles were obtained from the Google Scholar database, then obtained 10 articles that fit the inclusion and exclusion criteria. The review results show that pegagan leaves have activity in healing burn and antibacterial activity against Staphylococcus aureus because they contain asiatic acid, saponins, flavonoids and tannins. The conclusion of this study is that pegagan leaves have the potential as wound healing of burns with an effective extract concentration of ethanol extract concentration of 25 % and ethyl acetate extract 0.33 % and pegagan leaves potentially as antibacterial to Staphylococcus aureus with effective extract concentrations, viz ethanol extract concentrations of 100 % and ethyl acetate extracts of concentrations of 70 %
The Effect of Extraction Method on Catechin Levels in Green Tea (Camellia sinensis L.) Extract by TLC-Densitometric
Get PDFGreen tea (Camellia sinensis L.) is one of the most widely used plants in Indonesia. Green tea (Camellia sinensis L.) is rich in catechins which have many benefits including antioxidants, anticancer, can reduce stress, and reduce cholesterol levels in the blood. This study aims to determine the levels of catechins in Green Tea (Camellia sinensis L.) extract with various extraction methods. Each sample was extracted by maceration, microwave and infusion using aquadest solvent and the extract obtained in Freeze Drying. Qualitative analysis using 1% FeCl3 reagent, positive catechins are indicated by a color change to blackish blue and quantitative analysis using TLC-Densitometry. The results showed the catechin content of the extract by maceration method was 331 mg/
Postprandial Bioassay and Radical Scavenging on n-Hexane Fraction of Cordia myxa L. Leaf
Get PDFCordia myxa L. is empirically used as an antidiabetic medication. The aim of this study is to determine the in-vivo effect of Cordia myxa L. n-hexane fraction on reducing blood sugar levels and their relationship with the anti-free-radical activity assay using DPPH (1,1-diphenyl-2-Picrylhydrazyl). The n-hexane fraction of Cordia myxa L. was used as a sample in the post-prandial assay which was analyzed using the ANOVA statistical test followed by Post-Hoc test. The results showed that there were significant in the extract using a 500 mg dose. In the anti-free-radical test using DPPH (1,1-diphenyl-2-Picrylhydrazyl) at maximum wavelength of 516 nm, 16.49 µg /mL IC50 value was obtained. For comparison, Quercetin with IC50 0.13 µg/mL was used. This shows that the sample has strong anti-free radical inhibitory potential ranged from 10 µg/mL to 50 µg/mL. The data from the calculation showed that there is a correlation between its effect of lowering high blood sugar level and anti-free radical activit
Aktivitas Fraksi Air Kulit Batang Mahoni (Swietenia macrophylla King.) Dan Studi In Silico Senyawa Kimia Penghambat Enzim α-Glukosidase
Get PDFInhibition of the α-glucosidase can be used as antidiabetic therapy because it can reduce postprandial blood sugar levels. The stem bark of mahogany (Swietenia macrophylla King.) have properties as inhibitors of enzyme α-glucosidase. The purpose of this study was to determine the active compound of mahogany stem bark againstα-glucosidase enzyme in vitro and in silico. 96% ethanol extract of mahogany stem bark was partitioned with n-hexane, ethyl acetate and water. Testing of inhibition of α-glucosidase enzyme work done with substrate p-nitrophenyl-α-D-glucopyranoside. The water fraction was separated on silica gel column chromatography (SiO2 : dichloromethane-methanol = 10 : 1 ~ 1 : 1 and methanol).Molecular docking using AutoDock 4.2.6 was performed to predict the binding modes of α-glucosidase enzyme with chemical compound from water subfraction of stem bark mahogany. The results showed that water fraction of stem bark mahogany have antidiabetic activity with IC50 value of 1.51 µg/mL. Fraction Fr-1 gave an inhibition of 83.61 ± 1.11 %. Fr-1 contains chemical compound catechin, evodionol and swietenitin K. In silico study showed that catechin and evodionol free energy value (ΔG) -6.98 and -6.25 Kcal/mol and inhibition constanta (Ki) 7.61 and 26.18 µM
IDENTIFIKASI KOMPONEN KIMIA EKSTRAK ETANOL DAUN PACAR KUKU (Lawsonia inermis L.) SEBAGAI ANTIBAKTERI DAN ANTIOKSIDAN
Get PDFPrevention of the transmission of covid 19 can be done by implementing the health protocol, namely 3M (wearing masks, washing hands and social distance). Based on research, the use of masks can reduce the risk of transmission of COVID-19 by 45 percent as well as hand washing reduces the risk by 35 percent. WHO recommends washing hands with soap/antiseptic for 20-30 seconds and applying the right steps. Another effort is to maintain a distance of at least 1 meter and avoid crowds. To assist the government in preventing the transmission of covid 19, socialization of the 3M activity was carried out at the Darul Istiqamah Maros Islamic Boarding School which is located on the Maros-Makassar Street, Mandai District, Maros Regency. This location was chosen because Maros was the third highest area with the number of people who are positive for the corona virus in South Sulawesi. Islamic boarding school students are a partner group that is expected to apply the 3M health protocol so as to prevent the transmission of covid 19. The activity is carried out by providing counseling about the importance of implementing 3M, how to implement 3M and also by distributing masks, soap and disinfectants needed to implement health protocols. The activity was carried out well and received a good response from the participants with 33 participants from various classes who were students of the Darul Istiqamah Islamic Boarding School Makassar
AKTIVITAS ANTIMIKROBA EKSTRAK ETANOL BATANG WOLE WOE ASAL HALMAHERA TENGAH TERHADAP BAKTERI GRAM POSITIF Staphylococcus epidermidis DAN Staphylococcus aureus
Get PDFThe wole woe plant is one of the plants empirically used by the Weda community in Central Halmahera district as a traditional medicine to treat various diseases such as breast cancer, cysts, vaginal discharge, diabetes mellitus, wounds, dysentery, cholesterol, and gout. Therefore, a study was conducted on the antimicrobial activity of the ethanolic extract of wole woe stems against gram-positive bacteria S. epidermidis and S. aureus with the aim of determining the concentration that provides antimicrobial activity of the ethanolic extract of wole woe stems by using the agar diffusion method. The results obtained in the screening test gave activity at a concentration of 0.1% and the results of the minimum inhibitory concentration test (MIC) and the minimum killing concentration test (MBC) obtained a MIC value of 1.6% for S. epidermidis bacteria and 0.8% for S. aureus bacteria, while the MBC value is 1.6% for both bacteria. The results of statistical tests on the diameter of the inhibition zone from the antimicrobial activity test against S. epidermidis and S. aureus, showed that there was a difference in the ability to inhibit bacterial growth between the positive control and the test concentration group of 2.5%, 5% and 10%. In the ratio of the inhibitory ability of bacteria at a spesific concentration, the test results showed that S. epidermidis bacteria had different bacterial growth inhibition abilities with S. aureus bacteria. Based on the results obtained, the ethanol extract of wole woe stems has potential as an antimicrobial
AKTIVITAS ANTIOKSIDAN EKSTRAK DAUN KELOR (Moringa oleifera L.) DAN PENGEMBANGANNYA MENJADI BENTUK SEDIAAN GEL
Get PDFAntioxidants are used to prevent the oxidation of free radical compounds which have a bad impact on the body, including the skin. One source of antioxidants derived from natural ingredients is Moringa leaves. Moringa leaves have a number of benefits due to the many active chemical compounds. The antioxidant activity of Moringa leaves can be optimized by developing Moringa leaves into a gel dosage form. A literature review regarding the compound content and activity of Moringa leaves was carried out to obtain scientific data that can be used in the development of Moringa leaves as an antioxidant. Narrative review with data sources from Science Direct, Pubmed, CiterSeerX, and Google Scholars. The Inclusion and exclusion criteria were set to obtain literature according to the scope of the study. The results of the literature review showed that Moringa leaves contain the main active compounds of polyphenols and flavonoids which have strong antioxidant activity. Gel dosage form is one of the best choices to optimize the antioxidant activity of Moringa leaves. HPMC, carbopol and xanthan gum are gelling agent was produced a gel preparation with good pharmaceutical characteristics
PROFIL PENYIMPANAN OBAT DI INSTALASI FARMASI RUMAH SAKIT SCHOLOO KEYEN KABUPATEN SORONG SELATAN PAPUA BARAT
Get PDFThe drug storage stage is part of the management of pharmaceutical preparations. Storage of drugs is good and correct can maintain the quality of a drug and facilitate the search and control and can reduce the risk of loss. This study aims to examine the profile of drug storage in the Pharmacy Installation of the Keyen Scholoo Hospital, South Sorong, West Papua. This study has used a descriptive method by means of direct interviews and observations with a check list related to drug storage. The parameters are based on Peraturan Menteri Kesehatan No 72 tahun 2016 dan Kementerian Kesehatan tahun 2019 regarding technical guidelines for pharmaceutical service standards in hospitals using percentage analysis. The results of the study concluded that the storage of drugs at the Pharmacy Installation of Scholoo Keyen Hospital based on the storage location was in the poor category with a conformity percentage of 61%. Meanwhile, based on the storage method, it is in the good category with a conformity percentage of 75% and based on the storage system/principle it is in the good category with a 100% conformity percentage