Jurnal Fakultas Farmasi Umi (Universitas Muslim Indonesia)
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AKTIVITAS EKSTRAK ETANOL DAUN SALAM [Syzygium polyanthum (Wight) Walp.] SEBAGAI PENGHAMBAT ENZIM α-GLUKOSIDASE DAN STUDI SECARA IN SILICO
No full textDiabetes Mellitus (DM) is a degenerative disease that can cause various complications such as cardiovascular, stroke, and hypertension. Antidiabetic drugs that are commonly circulated in the market, have side effects that can harm other organs such as liver, kidneys and other organs. Bay leaves have properties as inhibitors of the α-glucosidase enzyme in vitro and in vivo. The aims of this study was determine the activity of ethanolic extract of bay leaves by ultrasonic extraction method in inhibiting the α-glucosidase enzyme in vitro and in silico. Bay leaves were extracted using 70% and 96% ethanol by ultrasonic method for 15 minutes, and filtered and concentrated using a rotary vacuum evaporator 4 times. The extract obtained was tested for phytochemical content and the activity of α-glucosidase inhibitory assay. The extract with the best IC50 value was then separated using column chromatography (SiO2, dichloromethane, methanol) and produced 7 fractions and tested for α-glucosidase enzyme inhibition. The best fraction (fraction 6) was analyzed by Liquid Chromatography Mas Spectra (LCMS-MS). The results showed that bay leaf extract containing alkaloids, flavonoids, tannins, steroids, phenols, and fraction-6 had the best IC50 of 30.82 ppm. The results of LCMS-MS analysis of chemical compounds as inhibitors of the α-glucosidase enzyme were delphinidin (m/z 303) and had a rerank score of -75.59. In the in silico test using PLANTS docking software
FORMULASI SEDIAAN GEL EKSTRAK DAUN SUKUN (Artocarpus altilis) SEBAGAI PENYEMBUHAN LUKA BAKAR PADA KELINCI DENGAN VARIASI KONSENTRASI CARBOPOL 940 SEBAGAI GELLING AGENT
Get PDFBreadfruit leaves are medicinal plants containing compounds such as flavonoids, saponins, tannins, polyphenols that function in wound healing. This study aimed to determine the variation of the concentration of the gelling agent carbopol 940 on the physical properties of the gel and the duration of the burn wound healing process on gel administration. This study used New Zealand White rabbits. They were divided into five groups. They were positive control (bioskin®), negative control, breadfruit leaf extract gel formula with variations in carbopol concentrations of 0,5%, 1%, and 2%, respectively. Burn percentage was analyzed using SPSS with Kolmogorov- Smirnov test to see normality, Levene test to see homogeneity, if the data is normally distributed and homogeneous, followed by Two Way ANOVA analysis with Post hoc Tukey significance of 0.005. The results of breadfruit leaf extract variations in the gelling agent carbopol 940 affect the physical properties. The increase in the concentration of the gelling agent causes an increase in viscosity, adhesion and decreases dispersion. Variations in the concentration of carbopol effective for healing burns was formula II (breadfruit leaf extract gel formula with variations in carbopol concentrations of 1%). Therefore, the provision of breadfruit leaf extract gel can accelerate the healing process of burn
Aktivitas Penyembuhan Luka Infeksi Krim Kombinasi Daun Sirsak (Annona muricata L.) Dan Daun Sirih (Piper betle L.) Dengan Bakteri Staphylococcus aureus Pada Punggung Kelinci New Zealand White Secara In Vivo
Get PDFSeveral types of tropical plants in Indonesia that contain anti-bacterial chemical compounds such as tannins, flavonoids and saponins, namely betel (Piper betle L.) leaves and soursop (Annona muricata L.) leaves. Objectives of the research was to determine activity of cream from soursop (Annona muricata L.) leaves ethanol extract and betel (Piper betle L.) leaves ethanol extract on the backs of rabbits infected with Staphylococcus aureus bacteria. In addition, the research conducted could also determine the stability of cream that produced and its pharmacological effects. Data analysis technique using ANOVA method, significance value did not reach 0.05. Extraction process using 70% ethanol as solvent with extraction method, namely maceration. Parameters of cream preparation were from level of storage duration for 0 days and concentration used. Then the level of cream preparation effectiveness in wounds healing could be seen from observations of wounds and pus drying time as well as edema and erythema loss. Cream preparation from combination of soursop (Annona muricata L.) leaves ethanol extract and betel (Piper betle L.) ethanol extract in formula 6 with concentration ratio of 10%: 12.5%, resulted better and faster healing rate against Staphylococcus aureus infection than other formulas. Required recovery time interval was 10 days and cream preparation had good stability
PROFIL PENYIMPANAN OBAT DI UNIT PELAKSANAAN TEKNIS DAERAH (UPTD) PENGELOLAAN OBAT DINAS KESEHATAN KOTA MAKASSAR
Get PDFThe pharmacy storage facility is responsible for maintaining the supply of medicines to avoid damage and expiration as well as maintaining the quality of medicines stored in the facility. As a result, this investigation concerning the profile of drug storage at the UPTD of Drug Management of Makassar City Health Office, is necessary. The study aimed to determine the drug storage profile in the UPTD of Makassar City Health Office. The present study employs a descriptive qualitative approach. Direct observation, in- depth interviews, and document analysis were used to collect data. The informants for this study were the head of the UPTD and pharmaceutical personnel at the UPTD of Drug Management of Makassar City Health Office. The aspects examined and percentages obtained were facilities and spatial arrangements (82.3 percent), drug stock preparation (81.8 percent), stock card recording (87.5 percent), and checking conditions and drug storage (87.5 percent). The results showed that all areas examined fell into the very good category and were consistent with the guidelines of Health Ministry of the Republic of Indonesia 2002, Regulation numbers 72, 73, 74 of 2016, and Technical Guidelines of 2019. Even though drug storage activities are not directly related to patients, ignoring them will result in significant losses for the Health Offic
Formulasi Sediaan Serum Anti Aging dengan Kombinasi dari Ekstrak Buah Tomat (Lycopersicum esculentum L.) dan Ekstrak Kulit Buah Semangka (Citrullus lanatus Thunb.)
Get PDFAging is a problem for everyone, especially those who have entered middle age and above. Aging can be caused by various factors, namely factors that come from within the body and from outside the body. One of the extrinsic factors were sun exposure, temperature / humidity and free radicals. Skin aging is mostly caused by free radicals, one of which is sunlight radiation. This study aims to produce a serum preparation that functions as an antioxidant with a combination of tomato extract and watermelon rind. The antioxidant activity of tomato extract, watermelon rind extract and combination extract was carried out using the DPPH method, then the anti aging serum was formulated using hydroxy ethyl cellulose, glycerin, DMDM hydantoin, ethoxy diglycol and aqua DM. Evaluation of serum preparations includes physical evaluation (organoleptic examination, dispersibility, homogeneity, viscosity, irritation test), chemistry (pH), and microbiology. Data were analyzed using one way Anova, the results differed significantly when the p-value was less than 0.05 (p <0.05). The results showed that the combination extract had a better IC50 value of 59.19 ppm, tomato extract 69.89 ppm, watermelon rind extract 79.29 ppm. Combined serum preparation at F1 (T: S / 1: 1) IC50 value was 97.37 ppm, F2 (T: S / 1: 2) 80.70 ppm, F3 (T: S / 2: 1) 69.81 ppm so it is included in the category of strong antioxidants
FORMULASI GEL EKSTRAK ETANOL DAUN SIRIH CINA SERTA AKTIVITASNYA TERHADAP PERTUMBUHAN BAKTERI PENYEBAB JERAWAT Propionibacterium acne DAN Staphylococcus aureus
Get PDFPepper elder is a weed plant whose leaves contain anti-bacterial compounds such as flavonoids, tannins, triterpenoids, and saponins that can be used as acne treatment therapy. Pepper elder leaves can be made into anti-acne gel preparations by formulating the right gelling agent. This study aims to obtain a gel with good physical stability from variations in the gelling agent base and its activity against acne-causing bacteria. Formulation of Pepper elder leaf extract gel is made with variations in the base of Na.CMC, Carbopol, and HPMC, further stability evaluation includes organoleptic, homogentias, pH, viscosity, scattering power, and testing of antibacterial activity against the growth of Propionibacterium acne and Staphylococcus aureus. The results obtained from the stability test obtained by the Carbopol base and HPMC have good standards for organoleptics, homogenity, pH, viscosity, and scattering power. Antibacterial testing showed clear zone diameters formed against Propionibaceterium acne in naCMC, Carbopol, and HPMC variations of 17.7 mm, 16.3 mm, and 21.3 mm and staphylococcus aureus of 13.3 mm, 15.3 mm, and 14.3 mm, respectively. Based on the results obtained, HPMC gel has the best gel stability and can all formulas inhibit the growth of acne-causing bacteria Propionibacterium acne and Staphylococcus aureus evidenced by the diameter of the bland zone formed into the strong category
LITERATURE STUDY OF ANTIBACTERIAL ACTIVITY OF THE FAMILI RUTACEA
Get PDFIndonesia has one of potential plants as an herbal medicine, called Lime (Citrus aurantifolia) and Kaffir Lime (Citrus hystrix DC), both used for different purposes such as cooking, seasoning and traditional medicine. Both plants are derived from the family of Rutaceae which belongs to shrubs that have many branches and twigs. This study aimed to carry out the antibacterial assay of the Rutaceae family. This study used a literature study approach, which references were obtained through 3 Journal sources, namely Google scholar, pubmed, and thscience direct. Furthermore the selected research article which met the criteria was reviewed. Based on the search done, it obtained 7 articles and identified antibacterial activity of lime and Kaffir Lime. The result confirmed that both have antibacterial compounds against bacteria Escherichia coli, and Staphylococcus aureus because they contain secondary metabolite compounds consisting of alkaloids, flavonoids, tannins, and essential oils
Total phenolic and flavonoid compound of crude and purified extract of green tea leaves (Camellia sinensis) from Makassar-Indonesia
Get PDFPolyphenols are a class of chemical compounds most commonly found in plants, these compounds have many health benefits associated with the character it has. The antioxidant activity of natural materials connected by polyphenol content, which can counteract free radicals. Objective: This study aims to determine the levels of total phenolic and flavonoid in crude extracts and purified extracts of the green tea leaves (Camellia sinensis). Methods: Determination of total phenolic content was using standard gallic acid by the Folin-Ciocalteau method. Total flavonoid assay using standard reference of quercetin by Chang method. Instrument used to measure the absorbance of the reaction is a UV-Visible spectrophotometer. Results: The results obtained after the measurement indicates that the sample of crude extract and purified extract of tea leaves containing total phenolic levels 40.5 and 43.9 mgGAE/g, respectively, while the levels of total flavonoids contained respectively by 2.77 and 3.14 mgQE/g. From the results obtained it can be concluded that the green tea leaves have a total phenolic content is greater than the total flavonoid content, thus it has great potential as an antioxidan
Standarisasi Ekstrak Etanol Buah Bintaro (Cerbera odollam Gaertn.) Sebagai Obat Tradisional
Get PDFThis research was conducted with the aim of examining the utilization of bintaro fruit extract (Cerbera odollam Gaertn.) as a traditional medicine that meets quality standards, so that the extract standardization process was carried out by determining specific and non-specific parameters.Based on the enormous potential of the Bintaro plant as a natural ingredient that can be used as traditional medicine, it is necessary to standardize the Bintaro fruit extract to determine the quality and safety of the extract raw materials used to support health. The research was conducted by determining the standardization of data on the determination of specific and non-specific parameters. The specific parameters that have been carried out include the identity of the extract, organoleptic test, the content of water soluble compounds 19.7%, the content of ethanol soluble compounds 6.96%, the content of positive extract compounds containing alkaloids, flavonoids, terpenoids, tannins and saponins. Non-specific parameters that have been carried out include drying shrinkage of 0.197%, moisture content of 2.124%, total ash content of 3.65%, acid soluble ash content of 1.3%, metal contamination of Pb and Cd 0.02 µg/g, microbial contamination of ALT bacteria. 0 colonies and 20 colonies of yeast. The results of the study met the standardization of extract quality.The data that will be obtained is expected to be additional information about the ethanolic extract of bintaro fruit (Cerbera odollam Gaertn.) that meets quality standards as traditional medicine, so as to maintain consistency and uniformity of efficacy and keep active compounds consistently measurable between treatments, and can maintain safety on consumers
