Jurnal Fakultas Farmasi Umi (Universitas Muslim Indonesia)
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PROFIL PENGOBATAN PENYAKIT HIPERTENSI PADA PASIEN RAWAT INAP RUMAH SAKIT UMUM DAERAH LABUANG BAJI PERIODE JANUARI-APRIL 2023
Full text link Labuang Baji Regional General Hospital in Makassar provides services for hypertension, including consultation, treatment, and monitoring of patients with hypertension. Hypertension management can be done with antihypertensive drugs, which must be used rationally to achieve target blood pressure and reduce the risk of cardiovascular complications. This study aims to analyze the profile of antihypertensive drug use in terms of correct indication, correct drug, correct dose, and correct dosing interval in inpatients at Labuang Baji Regional General Hospital. This study uses a quantitative method with a descriptive non-experimental research type with data collection carried out retrospectively from patient medical record data from January to April 2023 with a sample size of 50 people. The results of the study showed that the level of rational compliance was high where the results of the evaluation of the use of antihypertensive drugs were based on the right indication 100%, the right drug 98%, the right dose 94%, and the right time interval of administration 94%. Thus, the rational use of antihypertensive drugs is needed to achieve clinical outcomes to improve the quality of life of patients. Labuang Baji Regional General Hospital in Makassar provides services for hypertension, including consultation, treatment, and monitoring of patients with hypertension. Hypertension management can be done with antihypertensive drugs, which must be used rationally to achieve target blood pressure and reduce the risk of cardiovascular complications. This study aims to analyze the profile of antihypertensive drug use in terms of correct indication, correct drug, correct dose, and correct dosing interval in inpatients at Labuang Baji Regional General Hospital. This study uses a quantitative method with a descriptive non-experimental research type with data collection carried out retrospectively from patient medical record data from January to April 2023 with a sample size of 50 people. The results of the study showed that the level of rational compliance was high where the results of the evaluation of the use of antihypertensive drugs were based on the right indication 100%, the right drug 98%, the right dose 94%, and the right time interval of administration 94%. Thus, the rational use of antihypertensive drugs is needed to achieve clinical outcomes to improve the quality of life of patients
Studi in vitro Penghambat Enzim a-Glukosidase Kapang Endofit Yang Berasosiasi Dengan Tanaman Sirih Merah (Piper crocatum Ruiz & Pav.)
No full textSirih merah (Piper crocatum Ruiz & Pav.) merupakan salah satu tanaman yang secara tradisional digunakan untuk mengobati berbagai penyakit seperti antiseptik, antidiabetes, antihipertensi, asam urat, batu ginjal dan kolesterol. Banyak hasil penelitian menunjukkan bahwa kapang endofit terbukti mampu melakukan bioproduksi untuk menghasilkan senyawa kimia seperti tanaman inangnya. Kapang endofit yang diisolasi dari batang sirih merah dengan kode B.Pc.1F difermentasi dalam media Potato Dextro Broth (PDB) selama 12 hari dapat menghasilkan senyawa kimia yang mempunyai aktivitas sebagai penghambat enzim α-glukosidase. Pengecekan pH menunjukkan bahwa isolat B.Pc.1F berpotensi menghasilkan senyawa kimia pada pH 4-6. Fraksinasi dengan kromatografi kolom, SiO2 [(i) n-heksan-etilasetat (20 : 1 ~ 1:1); (ii) kloroform-metanol [10:1 ~ 1:1] yang berdasarkan “Bioassay guided fractionation” memberikan isolat tunggal yang mempunyai aktivitas sebagai penghambat enzim a-glukosidase dengan nilai IC50 sebesar 32.52 ppm dan pembanding control positif akarbosa sebesar 19,24 ppm. Kemudian diidentifikasi kandungan kimianya dengan metode kromatografi gas-spektrometer massa (GC-MS) dan hasil menunjukkan bahwa isolat mengandung senyawa Shogaol (1), Asam palmitat (2), Vanicol (asam stearat) (3), dan eicosene (4)
SKRINING FITOKIMIA EKSTRAK DAUN GANDARUSA (Justicia gendarussa Burm.f.): DETEKSI ALKALOID, FLAVONOID, DAN STEROID
Full text linkJusticia gendarussa Burm.f. (gandarusa), a shrub reaching 1.5 meters tall, contains bioactive compounds (flavonoids, alkaloids, steroids, terpenoids, saponins, phenolic compounds, hydrocarbons) with potential antiangiogenic, antioxidant, antibacterial, antifungal, anti-inflammatory, and antirheumatic properties. This study analyzed the phytochemical composition of gandarusa leaves from Pangkep through sample preparation, 70% ethanol extraction, stepwise fractionation (n-hexane and ethyl acetate), and compound identification via preparative TLC and column chromatography. Extraction yielded 30% efficiency from 200g dried leaves. Phytochemical analysis confirmed alkaloids, steroids, and flavonoids. Preparative TLC showed Rf values of 0.47 (green analyte) and 0.41 (yellow analyte). UV-Vis spectrophotometry indicated flavonoid content of 3.66–3.82 mg/L. Thus, gandarusa leaves contain bioactive compounds-particularly flavonoids, alkaloids, and steroids-with pharmaceutical development potentia
IDENTIFIKASI DAN PENELUSURAN SENYAWA AKTIF EKSTRAK KULIT JERUK MANIS (Citrus sinensis L. Osbeck) SEBAGAI ANTIBAKTERI TERHADAP BAKTERI PATOGEN Staphylococcus aureus DAN Staphylococcus epidermidis
Full text linkThe high prevalence of skin diseases in Indonesia necessitates the exploration of natural therapeutic alternatives, particularly utilizing sweet orange peel (Citrus sinensis L. Osbeck) waste. This study aimed to evaluate the antibacterial efficacy of sweet orange peel extract against skin infection pathogens, specifically Staphylococcus aureus and Staphylococcus epidermidis. Extraction was performed using the Ultrasonic Assisted Extraction (UAE) method. Antibacterial assays included the determination of Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) using the solid dilution method, followed by the identification of active compounds via Thin Layer Chromatography (TLC)-Bioautography. Phytochemical screening revealed the presence of alkaloids, flavonoids, saponins, tannins, and triterpenoids in the extract. The extract demonstrated antibacterial activity with an MIC value of 0.4% and an MBC value of 25.6%. TLC-Bioautography analysis detected inhibition zones corresponding to three Rf values (0.90, 0.32, 0.16) against S. aureus and four Rf values (0.90, 0.67, 0.32, 0.16) against S. epidermidis. The bioactive compounds responsible for this inhibition were identified as alkaloids and flavonoids. In conclusion, the ethanol extract of sweet orange peel exhibits effective antibacterial activity against skin pathogens, mediated by its alkaloid and flavonoid conten
PENGARUH EKSTRAK DAUN BIDARA DAN DAUN GINSENG JAWA TERHADAP GAMBARAN MAKROSKOPIK GINJAL JANTUNG DAN HATI TIKUS HIPERTENSI
Full text linkHypertension, or high blood pressure, is a condition characterized by a sustained increase in blood pressure, exceeding the normal value of ≥140/90 mmHg. Hypertension therapy aims to lower both systolic and diastolic blood pressure to restore normal levels and minimize the risk of complications. The use of herbal plants such as bidara leaves (Ziziphus mauritiana L.) and Javanese ginseng (Talinum paniculatum (Jacq.) Gaertn.) holds potential as an alternative in the management of hypertension. Medicinal plants and plant-derived compounds can exhibit various toxicological effects, including renal, cardiac, and hepatic toxicity. This study aims to investigate the effects of Bidara leaf extract and Java ginseng leaf extract on the macroscopic appearance of the kidneys, heart, and liver of prednisone-induced hypertensive rats. The study used 20 rats divided into five groups: negative control (Na-CMC 1%), positive control (Captopril 25 mg), and three groups receiving combined doses of bidara leaf and Javanese ginseng leaf ethanol extracts (EEBG 50+50 mg/kgBW, EEBG 100+100 mg/kgBW, EEBG 200+200 mg/kgBW). The results showed that the combination extract of Bidara leaves (Ziziphus mauritiana L.) and Ginseng leaves (Talinum paniculatum (Jacq.) Geartn.) at doses of 50+50, 100+100, and 200+200 mg/kgBW did not cause any macroscopic changes. Macroscopic observations showed that the kidneys, hearts, and livers of mice administered EEBG maintained a reddish-brown color with a firm consistency and smooth surfac
In Silico Screening of Chemical Compound Activity as an α-Glucosidase Inhibitor from Sweet Flag Rhizome (Acorus calamus L.)
Full text linkThe research on screening in silico of the chemical of Acorus calamus L. as an inhibitor of α-glucosidase has been conducted. This research aims to obtain an active chemical compound towards Acorus calamus L., which is potentially be inhibitor of α-glucosidase using the screening method in silico. The docking process was employed using 28 chemical compounds in the Acorus calamus L. as the ligand to the inhibitor α-glucosidase, becoming the target receptor using PyRx and ArgusLab programs. The chemical compound model of Acorus calamus L was obtained from Take Out “Jamu" KnapSack. Whereas the enzyme model of α-glucosidase was obtained from the Protein Data Bank (PDB) with the enzyme code ILWJ. Each compound, which has been docked using enzyme α-glucosidase taken from the free energy changing ΔG as the docking result, and the visualization of the docking result was conducted using the PyMol program. The evaluation result of AG indicated that 28 chemical compounds of Acarus calamus have potential as inhibitors of α-glucosidase, where Delta-Cardinene, with the lowest change, had the most potential. The approximate free energy change (ΔG) was -8.50 kcal/mol in the PyRx and -9.53 kcal/mol in the ArgusLab program
Antioxidant Activity Analysis of Endophytic Fungal Isolates IFBZ5, IFBZ6, and IFBZ7 from the Stem of Bidara (Ziziphus mauritiana Lam.)
Full text linkEndophytic fungal isolates coded IFBZ5, IFBZ6, and IFBZ7 derived from the stem of the bidara plant (Ziziphus mauritiana Lam.) have shown potential antioxidant properties. This study aims to test the antioxidant activity of endophytic fungal isolates on the bidara plant stem (Ziziphus mauritiana Lam.) by TLC-Autography method and DPPH (1,1-diphenyl-2-picrylhydrazil) free radical silencing. This study used endophytic fungi isolates code IFBZ-5, IFBZ-6 and IFBZ-7 which were fermented for 21 days using MYB medium which was then liquid-liquid extracted with ethyl acetate (1:1) and evaporated. The fermentate extract obtained was then tested for antioxidant activity qualitatively and quantitatively. Qualitative analysis using TLC plates indicated antioxidant activity in all isolates. Quantitative analysis showed that isolate IFBZ7 exhibited strong antioxidant activity with an IC50 value of 50.120 ppm, while IFBZ5 and IFBZ6 showed very weak activity with IC50 values of 2.482.363 µg/mL and 467.847 µg/mL, respectively. The BHT comparator had an IC50 value of 6.778 µg/mL. This shows that the antioxidant power of endophytic fungal isolates coded IFBZ5, IFBZ6 and IFBZ7 is lower than the antioxidant activity of BHT as a comparison
Antimicrobial Activity of Ethanol Extract of Pinang Seed (Areca catechu L.) Against the Growth of Candida albicans and Malassezia furfur Fungi Using the Agar Diffusion Method
Full text linkPinang seeds (Areca catechu L.) are known for their various benefits, including antimicrobial properties. This study aims to evaluate the antimicrobial activity of ethanol extract from pinang seed against the growth of Candida albicans and Malassezia furfur fungi using the agar diffusion method. The research involved extracting the pinang seed using maceration with 96% ethanol, followed by evaporation using a rotary vacuum evaporator to obtain a concentrated extract. Antimicrobial activity was tested across concentrations of 32%, 16%, 8%, 4%, 2%, 1%, 0.5%, and 0.1%. The results showed that at a concentration of 32%, the ethanol extract produced the largest inhibition zones: 27.78 mm against Candida albicans and 15.51 mm against Malassezia furfur, both categorized as very strong activity. These findings suggest that ethanol extract of pinang seed has significant potential as an antimicrobial agent, particularly against fungal pathogens