Shiga University of Medical Science Repository BI WAKO / 滋賀医科大学機関リポジトリ
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Flexible ureteroscope capable of acute-angled and balanced omnidirectional bending based on soft and flexible porous tube and crossed control wiring.
No full textFlexible ureteroscopes (fURSs) have performance limitations in accessing acute-angled calyxes and omnidirectional bending. We propose and develop a fURS based on a soft and flexible porous tube and crossed control wiring to overcome these limitations. The fURS prototype comprises a flexible solid polyamide-12 tube and a stretch-retractable expanded polytetrafluoroethylene distal tube with 40% porosity connected by a unique cylindrical wire-routing hook (CWH). The series tube includes four crossed but not contacting loop-formed control wires to provide balanced omnidirectional bending and optimized distal tube bending performance. Bending performance was assessed compared with a conventional fURS, and feasibility studies were performed using a renal phantom. The prototype achieved a 275° omnidirectional maximum bend angle by combining up-down and right-left directions. The bent shape was more compact than the conventional fURS. Thus, the prototype achieved approximately a 1.6-fold larger maximal active bending angle within the restricted environment and a 5.5-fold larger passive bending angle. The crossed control wiring design reduced CWH offset distance by about 75% compared with conventional straight wire routing. The prototype exhibited considerably improved steering performance, exemplified by its ability to access an acutely angled calyx. Our design could improve treatment outcomes and shorten operation times associated with calyceal stone removal.Journal Articlejournal articl
Depletion of tumor-associated macrophages inhibits the lung cancer growth and enhances the antitumor effect of cisplatin
Get PDF滋賀医科大学博士（医学）application/pdfThesis or DissertationCancer science. 2023 Mar;114(3):750-763.令和4年度thesi
Ventricular Premature Complexes and Their Associated Factors in a General Population of Japanese Men
Get PDF滋賀医科大学博士（医学）application/pdfThesis or DissertationThe American journal of cardiology. 2022 Apr 15;169:51-56.令和4年度thesi
Retinol dehydrogenase 10 contributes to cancer stemness and intracellular carbohydrate storage in ovarian clear cell carcinomas
Get PDF滋賀医科大学博士（医学）application/pdfThesis or DissertationCancer Biomarkers. 2022;34(4):673-679.令和4年度thesi
Association between dietary patterns and serum low density lipoprotein cholesterol in Japanese women and men: The Japan Multi-Institutional Collaborative Cohort(J-MICC)Study
Get PDF滋賀医科大学博士（医学）application/pdfThesis or DissertationJournal of Atherosclerosis and Thrombosis. 2023 Feb 2.令和4年度thesi
Incidence and In-Hospital Mortality of Acute Myocardial Infarction: A Report from a Population-Based Registry in Japan
Get PDF滋賀医科大学博士（医学）application/pdfThesis or DissertationJournal of Atherosclerosis and Thrombosis. 2022 Dec 29.令和4年度thesi
Decreased Fertility in Women with Cesarean Scar Syndrome Is Associated with Chronic Inflammation in the Uterine Cavity
Get PDF滋賀医科大学博士（医学）application/pdfThesis or DissertationThe Tohoku journal of experimental medicine. 2022 Oct 26;258(3):237-242.令和4年度thesi
厚生労働統計を用いた日本における高齢者終末期に関連する状況と課題～看取りケアと死亡場所に着眼して～
Get PDF滋賀医科大学修士（看護学）application/pdfThesis or Dissertation令和4年度thesi
Increased blood group 2 innate lymphoid cells are associated with the clinical severity of Kimura disease.
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RhoA rescues cardiac senescence by regulating Parkin-mediated mitophagy
Get PDFapplication/pdfHeart failure is one of the leading causes of death worldwide. RhoA, a small GTPase, governs actin dynamics in various tissue and cell types, including cardiomyocytes; however, its involvement in cardiac function has not been fully elucidated. Here, we generated cardiomyocyte-specific RhoA conditional knockout (cKO) mice, which demonstrated a significantly shorter lifespan with left ventricular dilation and severely impaired ejection fraction. We found that the cardiac tissues of the cKO mice exhibited structural disorganization with fibrosis and also exhibited enhanced senescence compared with control mice. In addition, we show that cardiomyocyte mitochondria were structurally abnormal in the aged cKO hearts. Clearance of damaged mitochondria by mitophagy was remarkably inhibited in both cKO cardiomyocytes and RhoA-knockdown HL-1 cultured cardiomyocytes. In RhoA-depleted cardiomyocytes, we reveal that the expression of Parkin, an E3 ubiquitin ligase that plays a crucial role in mitophagy, was reduced, and expression of N-Myc, a negative regulator of Parkin, was increased. We further reveal that the RhoA-Rho kinase axis induced N-Myc phosphorylation, which led to N-Myc degradation and Parkin upregulation. Re-expression of Parkin in RhoA-depleted cardiomyocytes restored mitophagy, reduced mitochondrial damage, attenuated cardiomyocyte senescence, and rescued cardiac function both in vitro and in vivo. Finally, we found that patients with idiopathic dilated cardiomyopathy without causal mutations for dilated cardiomyopathy showed reduced cardiac expression of RhoA and Parkin. These results suggest that RhoA promotes Parkin-mediated mitophagy as an indispensable mechanism contributing to cardioprotection in the aging heart.Journal Articlejournal articl