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Continuous Increase in Podocyte Numbers in the First 36 Months of Life - Insights from Forensic Autopsies in Japanese Children
Get PDF滋賀医科大学博士（医学）Abstract
Background: Podocyte depletion is a critical factor in glomerulosclerosis development. While podocyte numbers per glomerulus typically decline with age in adults, they are hypothesized to increase during childhood. However, studies on podocyte number progression in childhood have been limited.
Methods: This retrospective analysis examined forensic autopsy cases of Japanese children without kidney disease, aged under 192 months, between April 2010 and March 2023. Podocytes were identified using immunostaining with an anti-transducin-like enhancer of split 4 antibody and p57. Podometric parameters were estimated using the correction factor method, allowing estimation from a single histologic section.
Results: This study included 68 cases with a median age of 9 months (interquartile range [IQR], 4–78). All podometric parameters correlated with age. Children younger than 36 months displayed significantly fewer podocyte numbers per glomerulus (median, 517; IQR, 483–546) compared to those aged 36 months and older (median, 616; IQR, 595–649; p<0.001). Regression analysis revealed a significant age-related increase in podocyte numbers per glomerulus in children under 36 months (slope, 3.76; p<0.001; 95% confidence interval [CI], 2.34–5.19), but not in those aged 36 months and older (slope, 0.25; p=0.16; 95%CI, −0.10–0.61). Additionally, the change in the slope at 36 months was significant (p<0.001; 95% CI, 1.02–2.49); however, this increase did not appear linked to podocyte division.
Conclusions: Podocyte numbers per glomerulus increased from birth until 36 months and then stabilized. These findings could facilitate the development of novel treatments for chronic kidney disease caused by glomerulosclerosis and contribute to pediatric kidney health research.This version of the article has been accepted for publication, after peer review and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s00467-024-06644-7令和6年度doctoral thesi
Intravenous anesthetic propofol suppresses T cell-dependent antibody production in mice
Get PDF滋賀医科大学博士（医学）Journal of Anesthesia. 2025 Jun 20. doi: 10.1007/s00540-025-03533-7. Online ahead of print.令和7年度thesi
Contribution of Immunoscore to Survival Prediction in Pancreatic Ductal Adenocarcinoma
Get PDF滋賀医科大学博士（医学）Anticancer Research. 2024 Oct;44(10):4483-4492.令和6年度thesi
A case of adult-onset IgA vasculitis complicated with alveolar hemorrhage
Get PDF症例は80歳台，男性．蜂窩織炎を認め，入院・抗菌薬加療を開始した．同時に下肢に触知可能な紫斑を認め，皮膚病理所見からIgA血管炎と診断した．皮膚病変については自然軽快したが，経過中，血清クレアチニン値の上昇及び血痰の出現により当科紹介となった．IgA血管炎に伴う肺胞出血及び腎病変に対して本症例ではグルココルチコイド単剤による寛解導入が奏功した．成人発症のIgA血管炎に肺胞出血を合併することは稀であり，貴重な症例であると考え，若干の考察を交えて報告する．A male in his 80s was admitted to our hospital with cellulitis and received antibiotic treatment. Palpable purpura was observed on the lower extremities, and IgA vasculitis was diagnosed based on dermatopathological findings. He was referred to our department due to elevated serum creatinine level and bloody sputum, and successfully treated with glucocorticoid monotherapy as induction for alveolar hemorrhage and renal involvement associated with IgA vasculitis.departmental bulletin pape
Fibroblast Activation Protein-α Expression in Cancer-Associated Fibroblasts Shows the Poor Survival of Colorectal Cancer via Immune-Mediated Pathways
Get PDF滋賀医科大学博士（医学）Annals of Surgical Oncology. 2025 Mar;32(3):1941-1952.令和6年度thesi
Clinical outcomes and future fertility after uterine artery embolization for postpartum and post-abortion hemorrhage
Get PDF滋賀医科大学博士（医学）Acta Radiologica. 2024 Jun;65(6):670-677.令和6年度thesi