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The Utilization and Collection Development for Library in Chung Hwa University of Medical Technology
No full textTurnover Intention to Early Childhood Teachers:An Exploration of the Model of Variables' Relationship Using LISREL
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Philosophy for Children in the Classroom—the Research of the Teaching of Thinking Discussion with Pixie
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第一章 緒論 頁碼
第一節 研究背景、目的與研究問題 01
一、研究背景、動機 01
二、研究目的與問題 04
第二節 文獻探討
一、探索團體的經營 09
第三節 兒童哲學概念及教材介紹 16
一、兒童哲學是什麼 16
二、兒童哲學教材《靈靈》簡介 18
第二章 研究方法及程序
第一節 研究方法 21
一、現象學與修正案例研究法 21
第二節 研究設計說明 25
ㄧ、進行研究的時間 25
二、課程進行的程序 26
第三節 研究對象：四年級 28
一、選擇四年級的理由 28
二、班級氣氛的轉變 31
三、學生個人特質的描述 39
四、研究者個人特質的描述 41
第三章 故事的開始
第一節 我們和《靈靈》的故事 43
一、好故事美在它的開放性 43
（一）名字、綽號、真正的名字 46
（二）真的與假的 57
（三）真的會變假的嗎？ 65
第二節 我們是我們說的故事 75
一、好故事美在它的創造力 75
（ㄧ）喜歡與不喜歡 78
（二）經驗與想像 79
（三）顯性與隱性的意涵 82
（四）想像的描述與現象學 87
第四章 故事的進行
第一節 聽別人的故事說自己的心事 95
一、秘密 98
二、「祕密」的處理 100
三、秘密與恐懼 103
四、秘密與神秘 104
第二節 說別人的故事講自己的故事 107
一、誰說的理由是藉口？ 107
二、自由與規矩 130
（ㄧ）我要的自由 132
（二）規則的例外 136
（三）規矩和規則 150
（四）遵守規矩 157
第五章 問題型態
第一節 問題的發生 163
第二節 問題的思考歷程 166
第三節 問題的選擇與問題型態 172
一、問題的選擇 172
二、問題的型態 174
（ㄧ）問題型態的內涵 174
（二）問題型態的分類 175
第六章 研究結果
第一節 研究成果 179
第二節 教學現場的困境 186
第三節 實際教學的問題及建議 191
參考文獻
參考書目
一、中文部分（按姓氏筆劃排列）
Annette Simmons 著。（2004）。說故事的力量。（陳智文譯）。台北：邦城文化
G..B.馬修斯（G..B.Matthew）（1998.02a）著。哲學與小孩（初版）（楊茂秀譯）。台北市：毛毛蟲哲學基金會
G..B.馬修斯（G..B.Matthew）（1998.02b）著。與小孩對話（初版）（陳鴻銘譯）。台北市：毛毛蟲哲學基金會
M.李普曼（Matthew Lipman）著（1996.03）。靈靈（楊茂秀譯）。台北市：毛毛蟲哲學基金會
M.李普曼（Matthew Lipman）著（1999）。靈靈教師手冊（鄭瑞玲譯）。台北市：毛毛蟲哲學基金會
Robert Coles 著。（2001.08）。故事的呼喚。（吳慧貞譯）。台北：遠流出版社
毛毛蟲兒童哲學基金會編。（2002.10）。認識裴利。台北：財團法人毛毛蟲兒童哲學基金會
加斯東.巴舍拉（Gaston Bachelard）著。（2003.08）。空間詩學（王靜慧、龔卓軍譯）。台北：張老師文化
亨利.克羅斯 著（2002.01）。故事與心理治療（劉小菁譯）。台北：張老師文化
邱恵瑛著（2001.12）。貓人。（初版四刷1999.05初版）。台北：毛毛蟲基金會
林翠華著（2007.01）。我埋在土裡的種子。（出版一刷）。台北：心靈工坊文化事業股份有限公司
林偉信著（2003.06）。何謂兒童哲學。劉仲容 林偉信 柯華倩編著，兒童哲學（第三章）（初版）。台北：國立空中大學
約翰.霍特（John Holt）著。（2005.04）孩子如何學習。（張美恵譯）。台北：張老師文化
柯華倩著（1998）。意義的探索-李普曼的兒童哲學計畫（初版）。台北：毛毛蟲基金會
高畠 純（2004.12）這是誰的腳踏車（米雅譯）。台北：經典傳訊文化股份有限公司
馬丁 柯亨（Martin Cohen）著。（2002）。101個有趣的哲學問題（黃惟郁譯）。台北：圓神出版事業機構
理查.史東（Richard.Stone）著（2000.06）。沙發上的說話課（張敏如譯）。台北：經典傳訊
黃迺毓著（1992.11）。小朋友的大朋友（初版）。台北：毛毛蟲兒童哲學基金會
楊士毅著（2001.05）。邏輯與人生-語言與謬誤。（三版六刷1987.04初版）。台北：書林出版社
楊茂秀著（2006.10）。誰說沒有人用筷子喝湯（初版）。台北：遠流出版事業股份有限公司
楊茂秀著（2005.10）。高個子與矮個子（初版）。台北：遠流出版事業股份有限公司
楊茂秀著（2006.03）。好老師是自己找的（初版）。台北：遠流出版事業股份有限公司
楊茂秀著（1992.01）。討論手冊（初版）。台北：毛毛蟲兒童哲學基金會
楊茂秀著（2007.07）重要書在這裡（初版）。台北：遠流出版事業股份有限公司
維高斯基（L.S Vygotsky）著（2000.02）。思維與語言（李維譯）。台北市：桂冠圖書
維薇安.嘉辛.裴利（Vivian Gussin Paley）著。（1996.09）。直昇機.男孩：教室裡說故事的魅力（楊茂秀、陳鴻銘、林意雪譯）。台北：成長文教基金會
維薇安.嘉辛.裴利（Vivian Gussin Paley）著。（2004）陶靈老師的教室：一所幼兒園的故事（楊茂秀譯）。台北：毛毛蟲基金會
瑪格麗特.懷茲.布朗（Margaret Wise Brown）著。李奧納德.威斯葛（Leonard Weisgard）圖。（2004.11）重要書（楊茂秀譯）。台北：經典傳訊文化股份有限公司
著。（2002.10）。
鄭樹森編（2004.09。現象學與文學批評。（二版一刷1984.07初刷）。台北：東大圖書公司
羅勃 索科羅斯基（Robert Sokolowski）著。（2004.03）現象學十四講（李維倫譯）。台北：心靈工坊文化事業
二、期刊論文
林文寶著（2000.05）。敘述、敘事與故事。兒童文學研究所主編，兒童文學學刊第三期（頁20-63）。台東：國立台東師範學院
三、碩博士論文
林師宇著（2004.06）。教室中的故事與敘事智慧。國立台東大學兒童文學研究所碩士論文。
洪曉菁著（2000.06）。說故事研究。國立台東師範學院兒童文學研究所碩士論文。
陳鴻銘著（1991.05）。探索團體。輔仁大學哲學研究所碩士論文。[[abstract]]兒童天生就有作哲學的能力。兒童談論哲學也不是一個嚴肅的不得了的事，只是順應兒童天真、不作做的自然天性。因此，兒童隨時都得以清新的口吻問出嚴肅亙古的哲學觀念。當兒童年紀漸長，開始接受義務教育之後，主動提問與自然談論的哲學觀念卻越來越少。研究者運用兒童哲學之父李普曼編著的兒童哲學教材《靈靈》帶入教學現場，了解當中發生什麼問題，同時希望重啟兒童談論哲學的能力。
研究期間與兒童共組探索團體，共同閱讀兒童哲學教材《靈靈》，並以兒童的提問，共同討論。紀錄兒童的討論過程、對話用語，分析其中的哲學觀點。同時針對提問的內容，歸納問題型態的發展。
本論文共分為六章，第一章為緒論，概述研究動機、目的與問題，探索團體的經營，兒童哲學概念與教材的介紹。第二章則是對於研究內容提出以現象學及案例修正的方法進行分析研究，並說明研究的時程以及研究對象的特質描述。進而於第三章中，將學生閱讀《靈靈》的討論過程，以故事的開放性與創造力佐以哲學概念的分析。第四章則是以闡述經由閱讀討論《靈靈》，故事可紓解個人的情緒以及建構個人的價值觀。第五章歸納思考討論中所有的提問，以問題型態學的方法分析問題的成因、問題的思考歷程與問題的分類。第六章為研究的結果，陳述研究的所得、體制教學上的困境以及實際教學可能遇到的教學問題提供建議，希望對有心從事兒童哲學教育的教師們能有所幫助。
Abstract
Children are gifted the ability to “do”philosophy. They talk about philosophy with their innocent instincts. Incidentally, they can start a question related to the serious concept about philosophy. The more they grow up, the less they spontaneously ask or talk about the philosophical concepts. The researcher uses Pixie as the teaching material written by Lipman. The researcher introduces Pixie into the classroom to observe how it functions among the children and hope to rebuild children’s ability to talk about philosophy.
During the research period, the researcher and the children forming a community of inquiry read and discuss Pixie together. The researcher records the process of the philosophical discussion and the words children use in the discussion. Moreover, the researcher analyzes the philosophical discussion and inducts the development of the their ability and style of asking questions.
This thesis consists of six chapters. The first chapter sketches the researching motivation, purpose and questions, the maintenance of the community of inquiry, the introduction of the concept and the teaching material of philosophy for children. The second chapter proposes the phenomenology and modified case method as main researching methods and explains the researching period and the personal descriptions of the researching objects. Then in the third chapter, the researcher analyzes the
discussion from children reading Pixie. The fourth chapter presents the story can relieve personal emotions and help construct the value of life through reading and discuss Pixie. In the fifth chapter, the researcher collects all the questions from children’s discussions and analyzes the reason to form the question, the thinking process of the question and the classification of the questions through the method of typology of questions and questioning. The six chapter is the research result, stating the finding of this research, the difficulty of the frame teaching. At last, the researcher tries to take some suggestions under practical teaching to help teachers who devote to being engaged with the education of philosophy for children
The role of fibroblast and Toll-like receptor in asthma animal model
No full text目錄
標題
口試委員會審定書
授權書
中文摘要
英文摘要
誌謝
縮寫表
目錄
表目錄
圖目錄
第一章 緒論
一. 過敏性氣喘介紹
二. 過敏性氣喘定義
三. 過敏性氣喘致病機轉
四. Toll-like receptor在氣喘疾病中所扮演的角色
五. 過敏原
六. 肺纖維母細胞在氣喘疾病中所扮演的角色
七. 趨化激素
第二章 論文研究目的
第三章 實驗材料與方法
1.實驗動物
2.過敏原致敏小鼠模式建立
3.小鼠肺纖維母細胞初代培養
4.流式細胞儀分析肺細胞分群
5. recombinant Der p2純化與分析
6.利用ELISA分析趨化激素與細胞激素分泌量
7.利用RT-PCR方式偵測TLR的基因表現
8.小鼠肺纖維母細胞TLR中和試驗
第四章 實驗結果
第五章 討論
第六章 圖表
參考文獻
附錄
附錄ㄧ 實驗儀器及耗材
附錄二 實驗藥品來源
附錄三 常用藥品配置方法
附錄四 核酸引子序列及最適作用溫度
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過敏性氣喘是一種呼吸道發炎疾病，當過敏原與肺組織接觸，先天性免疫反應被啟動，接著導致發炎細胞聚集與趨化激素分泌，最後導致Th2 免疫發展。肺組織最主要的4種細胞類型，包含上皮細胞、纖維母細胞、巨噬細胞及內皮細胞。為了研究先天性免疫機制在氣喘疾病，我們利用氣管內注入過敏原方式於C57BL/6小鼠，連續7日，然後評估肺泡沖洗液內的浸潤細胞。我們發現在ovalbumin (OVA)及基因重組製造的 Dermatophagoide peteronyssinus group 2蛋白 (rDer p2) 刺激後，小鼠嗜酸性白血球與淋巴球分別有增加的現象，此結果指出我們以短期刺激肺上皮組織可以造成呼吸道發炎現象。進一步研究肺纖維母細胞在過敏性致敏期的角色，我們利用初代肺纖維母細胞經OVA或rDer p2刺激後，結果發現會分泌大量RANTES、Eotaxin、TNF-a及TGF-b。有趣地，於rDer p2或OVA刺激組中亦可偵測到thymic stromal cell-derived lymphopoietin (TSLP)及nerve growth factor (NGF)的分泌量有增加現象。最後，我們利用中和試驗與C3H/HeJ小鼠來證明toll-like receptor (TLR) 2 及4是否參與了這個反應。結果發現在anti-TLR2 及anti-TLR4 抗體的作用下TNF-a分泌量有劑量相對受抑制的現象。而TLR4缺陷鼠C3H/HeJ的 TNF-a分泌表現量比正常鼠C3H/HeN低，並達到顯著差異。由此得知，TLR2及TLR4皆有參與Der p2刺激纖維母細胞分泌細胞激素的作用。分析纖維母細胞在氣喘致敏期的角色將對於先天性免疫反應在氣喘疾病的機制有更清楚的了解並希望對於疾病治療有所貢獻。
Abstract
Allergic asthma is an inflammatory disease of bronchial airways. When allergens contact with lung tissue, the innate immune response was initiated, subsequently, leaded to inflammatory cells accumulation and chemokine secretion, and finally resulted in Th2 immune development. There are four major cell types in lung tissue including epithelial cells, fibroblasts, macrophages, and endothelial cells. In order to study the mechanism of innate immunity in the asthma disease, we intratrachealy administrated allergens into C57BL/6 mice for seven days then to evaluate the infiltrated cells in bronchial alveolar lavage fluids (BALF). We found that eosinophils and lymphocytes respectively accumulated in ovalbumin (OVA)- and recombinant Dermatophagoide peteronyssinus (rDer p2)-treated mice, indicating that lung epithelium shortly stimulated by allergens caused to airway inflammation. Furthermore, primary lung fibroblasts stimulated with OVA or rDer p2 secreted higher levels of RANTES, eotaxin, TNF-a, and TGF-b. Interestingly, elevated levels of the thymic stromal cell-derived lymphopoietin (TSLP) and nerve growth factor (NGF) also detected in OVA- or rDer p2-treated groups. Finally, we use neutralizing assay to evaluate whether the toll-like receptor (TLR) involved in this phenomena. We found that using anti-TLR2 and anti-TLR4 antibodies could dose-dependently inhibited TNF-a secretion by rDer p2 stimulation, moreover. C3H/HeJ mice secreted significantly lower level of TNF-a compared to C3H/HeN mice. Summarizing the above data, TLR2 and TLR4 both involved in the cytokine secretion by rDer p2 stimulation. To study the role of lung fibroblasts on the airway sensitizing stage will contribute to more clear realization of the innate immune response in asthma disease
