E-Jurnal Universitas Tunas Husada Tasikmalaya
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Karakterisasi Simplisia dan Minyak Atsiri pada Daun Kirinyuh (Chromolaena odorata L.)
No full textIntroduction: Kirinyuh leaves (Chromolaena odorata L.) are a wild plant that has a distinctive odor.The presence of a distinctive odor indicates the presence of essential oil compounds. Characterizationtesting of simplicia and essential oils is needed to guarantee quality before being used as raw materials.Objective: This study aims to determine the characteristics of simplicia and the essential oil of kirinyuhleaves (Chromolaena odorata L.). Methods: The research stage begins with examining the qualitycharacteristics of simplicia including microscopic, macroscopic, water content, drying loss andphytochemical screening. The essential oil isolation method was carried out using soxhletation with nhexanesolvent, then purified using the ECC method using 70% ethanol solvent. The essential oilproduced was tested for refractive index, optical rotation, specific gravity, viscosity acid number andcompound component analysis using GC-MS. Results: Kirinyuh leaf simplicia has a distinctive odor, isgreen with a rough and densely hairy leaf surface, has a round leaf shape with a tapered tip and serratededges, then the characteristic fragments of the leaves are covering hairs, vascular bundles with spiralthickenings, stomata, upper epidermis with oil drops, lower epidermis with stomata and trachea, has awater content of 4% ± 0,0000%, drying shrinkage of 5,53% ± 0,5026%, and is positive for polyphenols,steroids, monoterpenoids/sesquiterpenoids. Essential oil quality testing has a refractive index of 1,336± 0,0001 (nD200), optical rotation 0,1730 ± 0,1100, acid number 2,1674 mg KOH/g, specific gravity1,1133 g/mL, viscosity 1,50 cP. The components of essential oil consist of 3-Penten-2-ONE,Nigakilactone F and Hexachlorocyclohexane. Conclusion: Based on the results, the essential oil ofkirinyuh leaves has a characteristic odor, clear yellow color, with the largest percentage shown byNigakilactone F
Pemanfaatan Arang Aktif Tempurung Kemiri (Aleurites moluccanus L. Willd) yang Dimodifikasi dengan Cremophor RH 40 sebagai Adsorben Limbah Parasetamol
No full textParacetamol has the potential to pollute water bodies, hence requiring wastewater treatment to reducecontamination. One of the methods employed is adsorption using activated carbon as the adsorbent.This research investigates the characteristics of activated carbon, activated carbon modified withCremophor RH 40, adsorption kinetics, and adsorption isotherms. The batch method was utilized forthis purpose. Based on functional group analysis, cellulose hydroxyl groups (O-H) play a crucial rolein adsorption. Morphological analysis of modified activated carbon reveals larger pores than pure andactivated carbon. The crystallinity analysis shows an amorphous structure. The adsorption kineticsmechanism for the three modifications follows the pseudo-second-order kinetic model (Ho) with R²values of 0.9998, 0.9999, and 1. Adsorption isotherms for modifications 10:25 and 10:50 follow theFreundlich equation with R² values of 0.9981 and 0.9803, respectively, while modification 10:75 followsthe Langmuir equation with an R² value of 0.9913. The adsorption capacity of modified candlenut shellactivatedcarbon with Cremophor RH 40 is 0.0359 mmol/g
Pembentukan dan Karakterisasi Kokristal Celecoxib Menggunakan Koformer Nikotinamid
No full textIntroduction Cocrystals can be used as an approach based on crystal engineering to improve thespecific physicochemical and biopharmaceutical properties of active pharmaceutical ingredients (APIs)that are difficult to dissolve in water. Solubility is also a very important parameter for API developmentto obtain good and stable physicochemical and biopharmaceutical properties. Celecoxib is a nonsteroidal anti-inflammatory drug that is included in BCS (Biopharmaceutical Classification System) class II with high permeability and low solubility in water. Nicotinamide has been widely used as a coformer in making cocrystals, because it has a very large opportunity to form cocrystals with various active pharmaceutical ingredients. Objective of this research is to determine the formation, increase solubility and characterization using Hot Stage Microscopy (HSM), Fourier Transform Infra-Red (FTIR),Differential Scanning Calorimetry (DSC) dan Powder X-ray Diffraction (PXRD). instruments. Methodused is the Solvent Evaporation method. The results of the characterization of the Hot Stage Microscopy (HSM) instrument have a new crystal phase, Fourier Transform Infra-Red (FTIR) whether there is a shift in functional groups in the cocrystal, Differential Scanning Calorimetry (DSC) where the melting point decreases, Powder X-ray Diffraction (PXRD) there is a new peak which indicates a difference in the X-rays. Results of the solubility test and dissolution test showed an increase in the solubility test and an increase in the dissolution test. Conclusion from the characterization results from the HSM, FTIR, DSC and PXRD instruments shows that there are cocrystal characteristics from each instrument result, and there is an increase in solubility and an increase in the dissolution test of pure celecoxib
Prediksi In Silico Aktivitas Antikanker Payudara dari Metabolit Sekunder Tanaman Babandotan (Ageratum conyzoides L.)
No full textBackground: Cancer is a disease in which cells can grow and develop uncontrollably in specific areas of the body, and are malignant, capable of attacking and destroying surrounding tissues. Breast cancer in women has surpassed lung cancer as the most commonly diagnosed cancer. Receptors involved in breast cancer treatment include estrogen and progesterone receptors. Objective: This study aims to explore the potential of compounds in the Ageratum conyzoides L. as candidates for new anti-cancer drugs through molecular docking on estrogen and progesterone receptors. Methods: Molecular docking methods were used to analyze the interactions of 33 compounds from Ageratum conyzoides with estrogen (PDB: 5W9C) and progesterone (PDB: 1ZUC) receptors, with cyclophosphamide as a reference drug. Conclusion: The results indicate that the compound kaempferol has the lowest binding energy on receptor 1ZUC, while stigmasterol has the lowest binding energy on receptor 5W9C compared to the reference and natural ligands. Molecular dynamics simulations confirmed the stability of these compounds over 100 ns. These findings suggest that compounds in the babandotan plant have promising potential as anti-breast cancer agents for further development in breast cancer treatment
FORMULASI DAN UJI AKTIVITAS ANTIOKSIDAN SEDIAAN SERUM EKSTRAK ETANOL BIJI KOPI HIJAU (Coffea canephora pierre)
Get PDFThe use of natural ingredients in cosmetics as anti-aging is becoming a popular trend in Indonesia. One of the plants that can be used to make natural cosmetic ingredients is green coffee beans (Coffea canephora pierre), where green coffee beans contain alkaloids, tannins, phenolics, flavonoids, triterpenoids and glycosides which are believed to be antioxidant agents. Green coffee beans (Coffea canephora pierre) have poor solubility, so serum preparations were chosen to be able to deliver active compounds quickly and effectively into the skin. The method used in this research was carried out using the DPPH (2,2 -diphenyl-1-) method. picrylhdrazil). In this research, the results showed that green coffee beans (Coffea canephora pierre) contain alkaloids, tannins, saponins, quinones, steroids/terpenoids and flavonoids. In F3 with a concentration of 1% green coffee extract, it has the strongest antioxidant activity with an IC50 value of 17,302 ppm, and in the physical evaluation of ethanol serum preparations of green coffee beans (Coffea canephora pierre) it can be concluded that the four formulations of ethanol extract serum preparations of green coffee beans (Coffea canephora pierre) is stabl
PROFIL PENGELOLAAN OBAT DI PUSKESMAS MAKALE KECAMATAN MAKALE KABUPATEN TANA TORAJA SULAWESI SELATAN
Get PDFABSTRACT Drug management is a series in health development that involves several aspects, namely planning, requesting, receiving, storing, distributing, destroying and withdrawing, controlling, administering, monitoring and evaluating. The purpose of this study was to determine the profile of drug management at the Makale Health Center, Makale District, Tana Toraja Regency, South Sulawesi and its compliance with the Regulation of the Minister of Health of the Republic of Indonesia Number 74 of 2016 concerning Pharmaceutical Service Standards at Health Center. This research is descriptive, data collection through observation, document review and interviews with the person in charge of the Makale Health Center pharmacy. The results showed that the suitability value of drug management in the aspects of planning, requesting, receiving, storing, distributing, destroying and withdrawing, controlling, administering, monitoring and evaluating was 100%. This indicates that drug management at the Makale Health Center has met the Pharmaceutical Service Standards at the Health Center. Keywords: Drug Management, Makale Health Center. ABSTRAK Pengelolaan obat merupakan suatu rangkaian dalam pembangunan kesehatan yang menyangkut beberapa aspek yakni perencanaan, permintaan, penerimaan, penyimpanan, pendistribusian, pemusnahan dan penarikan, pengendalian, administrasi, pemantauan dan evaluasi. Tujuan penelitian ini untuk mengetahui profil pengelolaan obat di Puskesmas Makale Kecamatan Makale Kabupaten Tana Toraja Sulawesi Selatan dan kesesuaiannya terhadap Peraturan Menteri Kesehatan Republik Indonesia Nomor 74 Tahun 2016 Tentang Standar Pelayanan Kefarmasian di Puskesmas. Penelitian ini bersifat deskriptif, pengumpulan data melalui observasi, telaah dokumen dan wawancara dengan penanggung jawab farmasi Puskesmas Makale. Hasil penelitian diperoleh bahwa nilai kesesuaian pengelolaan obat pada aspek perencanaan, permintaan, penerimaan, penyimpanan, pendistribusian, pemusnahan dan penarikan, pengendalian, administrasi, pemantauan dan evaluasi adalah 100%. Hal ini mengindikasikan bahwa pengelolaan obat di Puskesmas Makale telah memenuhi Standar Pelayanan Kefarmasian di Puskesmas. Kata Kunci : Pengelolaan Obat, Puskesmas Makale
PENGARUH PEMBERIAN BAHAN ALAM PADA PENGOBATAN DIABETES MELITUS DENGAN GLIBENKLAMID
Get PDFDiabetes adalah kelainan metabolik heterogen yang ditandai dengan hiperglikemia akibat gangguan sekresi insulin, gangguan kerja insulin, atau keduanya. Salah satu pengobatan diabetes mellitus tipe 2 golongan antidiabetik yang paling banyak digunakan adalah golongan sulfonilurea yaitu glibenklamid yang jumlahnya mencapai 29,9% serta bekerja dengan cara merangsang sel β pankreas untuk mengeluarkan insulin. Tujuan dari review jurnal ini adalah untuk membandingkan efektivitas pengobatan diabetes mellitus secara obat sintesis yaitu glibenklamid dengan obat herbal yaitu Daun salam (Syzygium Polyanthum Wight), Daun Tamoenju (Hibiscus Syrattensis L), Daun Senggani (Melastomapolyanthum .Bl), Daun Sambiloto (Andrographis paniculata (Burm.F.)Ness), Daun Ramania (Bouea macrophylla Griffith), Daun Sirsak (Annona muricata L), Biji Habbatussauda (Nigella sativa), Lidah Buaya (Aloe vera), Ekstrak Etanol Meniran (Phyllanthus niruri L.), Biji Mahoni (Swietenia mahogani (L.) Jacq. Berdasarkan hasil perbandingan beberapa kombinasi obat herbal dan glibenklamid, kombinasi dari ekstrak daun salam dan glibenklamid dapat membantu mengontrol kadar glukosa darah yang tinggi dan lebih efektif daripada obat herbal lainnya
Review: Potensi Serum Antiaging dari Berbagai Jenis Tanaman
Get PDFKulit manusia berperan penting dalam menjaga keseimbangan tubuh dan melindungi dari berbagai faktor eksternal, namun seiring bertambahnya usia, kulit mengalami proses penuaan yang dipicu oleh faktor internal dan eksternal seperti radikal bebas. Radikal bebas mudah bereaksi dengan komponen sel, menyebabkan kerusakan pada membran sel dan organel, sehingga mempercepat proses penuaan. Antioksidan adalah molekul yang mampu mencegah oksidasi molekul lain dan menetralisir radikal bebas, dan dapat berasal dari sumber endogen maupun eksogen. Penelitian ini bertujuan mengkaji potensi tanaman sebagai sumber antioksidan dalam formulasi serum anti-aging. Melalui kajian pustaka, ekstrak tanaman seperti kulit kopi, biji kopi hijau, dan kulit apel diidentifikasi memiliki aktivitas antioksidan yang signifikan dengan nilai IC50 rendah, menunjukkan kemampuannya dalam menetralisir radikal bebas. Metode pengujian DPPH dan FRAP digunakan untuk mengukur efektivitas antioksidan dari ekstrak tersebut. Selain itu, uji mutu, SPF, dan antibakteri dilakukan untuk memastikan kualitas, keamanan, dan efektivitas serum yang diformulasikan. Hasil kajian ini menunjukkan bahwa ekstrak tanaman memiliki potensi besar sebagai bahan aktif dalam serum anti-aging, memberikan manfaat dalam mencegah penuaan dini dan melindungi kulit dari kerusakan akibat radikal bebas. Dengan demikian, penggunaan ekstrak tanaman dalam produk kosmetik dapat menjadi solusi alami dan efektif dalam perawatan kuli
PENGARUH LAMA PENYIMPANAN KANTONG DARAH DENGAN ANTIKOAGULAN CPDA-1 TERHADAP JUMLAH ERITROSIT di UUD PMI KOTA TASIKMALAYA
Get PDFEritrosit atau sel darah merah (RBC) adalah komponen fungsional darah yang bertanggung jawab untuk mengangkut gas dan nutrisi ke seluruh tubuh manusia. Bentuk dan komposisinya yang unik memungkinkan sel-sel khusus ini menjalankan fungsi esensialnya. Penyimpanan kantung darah harus tetap dijaga dengan baik untuk menjamin kualitas eritrosit. Penelitian ini bertujuan untuk mengetahui pengaruh lama penyimpanan jumlah eritrosit pada komponen kantong darah yang ditambahkan antikoagulan CPDA-1 dengan rentang waktu 1, 7, 14 dan 28 hari. Jumlah sampel yang digunakan sebanyak 5 kantong darah dengan mengukur jumlah eritrosit dengan alat Hematology Analyzer. Hasil penelitian menunjukan adanya penurunan persentase dan jumlah eritrosit pada hari ke-1, 7, 14, 21 dan 28 hari berturut-turut yaitu sebesar 4,51 juta/mm3 (1,30%), 4,36 juta/mm3 (4,59 %),3,97 juta/mm3 (13,95%), 3,71 juta/mm3 (22,42%), dan 3,46 juta/mm3 (30,45 %)
Studi In Silico Senyawa Katekin Terhadap Reseptor Alpha Glukosidase (3POC) Sebagai Antidiabetes Tipe 2
Get PDFReseptor alpha-Glucosidase berperan dalam proses metabolisme karbohidrat terletak dibagian tepi permukaan sel usus halus. Glukosidase bekerja dengan cara memecah karbohidrat menjadi glukosa. Pada diabetes senyawa katekin dapat menghambat pembentukan glukosa. Tujuan dari penelitian ini adalah untuk mengidentifikasi dan mengembangkan penggunaan senyawa katekin sebagai antidiabetes dengan studi in silico terhadap reseptor α-glukosidase. Metode yang digunakan yaitu preparasi reseptor, docking dengan AutoDockTools, preparasi ligan (senyawa catechin), docking ligan uji terhadap reseptor, analisa dan visualisasi hasil docking. Senyawa uji catechin terhadap reseptor alpha-Glucosidase (3POC) dengan nilai energi bebas Gibss -7,81 kcal/mol melebihi energi bebas Gibss senyawa pembanding acarbose yaitu -5,02 kcal/mol, sehingga senyawa catechin berpotensi sebagai antidiabetes tipe 2