Archivio Istituzionale della Ricerca- Università del Piemonte Orientale
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Comparative Analysis of the Performance of Automated Digital Cell Morphology Analyzers for Leukocyte Differentiation in Hematologic Malignancies: Mindray MC‐80 Versus West Medical Vision Hema
No full textIntroduction: The use of artificial intelligence in hematology laboratories has improved the diagnostic evaluation of peripheral blood cells. The aim of this study is to compare the performance of two automated digital cell morphology analyzers, the Mindray MC-80 and the West Medical Vision Hema Pro, with manual microscopy, the gold standard, for leukocyte differentiation in patients with hematologic malignancies and infections. Methods: Peripheral blood smears from 75 patients were analyzed, including cases of acute lymphoblastic leukemia (ALL, 4), chronic lymphocytic leukemia (CLL, 20), acute myeloid leukemia (AML, 20), chronic myeloid leukemia (CML, 5), other lymphoproliferative disorders (LPD, 20), and infections (6). The agreement between microscopy, Vision Hema, and MC-80 was assessed by Bland-Altman analysis for eight leukocyte populations (neutrophils, lymphocytes, monocytes, eosinophils, basophils, band cells, myelocytes, and metamyelocytes). Results: Vision Hema demonstrated better agreement with manual microscopy for eight normally expected leukocyte populations (neutrophils, lymphocytes, monocytes, eosinophils, basophils, band cells, myelocytes, and metamyelocytes), whereas MC-80 exhibited greater biases, particularly in lymphocytes, basophils, and immature granulocytes. For pathologic cells, VH significantly overestimated blasts, while MC-80 classified them more accurately, showing better agreement with manual microscopy in acute leukemias. Additionally, MC-80 showed potential clinical value in detecting abnormal lymphocytes and promyelocytes, which may be relevant for hematologic malignancies. Conclusion: Vision Hema provides more reliable classification of normally expected leukocyte populations, while MC-80 shows advantages in detecting abnormal cells, particularly in hematologic malignancies
Postfazione a Giuseppe Di Luca: "La fede in tempo di pandemia"
No full textIl lavoro di Giuseppe Di Luca affronta il tema del rapporto tra religione e pandemia con un approccio sociologico ed empirico. La pandemia ha risollevato un po' ovunque molte questioni rimaste in precedenza sopite, e ha sollecitato il ruolo delle Chiese e delle religioni nell'organizzare le chiusure e nel creare modalità alternative non solo per esercitare il culto, ma anche per garantire il supporto spirituale e materiale ai propri fedeli. Lo studio indaga tutto ciò in un caso particolare, quello del cattolicesimo in una piccola diocesi del Nord d'Italia, la diocesi di Alessandria
Comparative assessment of physicochemical properties, functional diversity and enzymatic activities in three Opuntia ficus-indica soils across diverse climatic regions in Morocco
Get PDFIn Morocco, Opuntia ficus-indica is grown in various climatic zones, each of which can greatly impact the soil quality and functioning. This study assesses the soil characteristics, bacterial load, functional microbial diversity, and enzymatic activities in O. ficus-indica soils from three distinct regions: Tafrant (subhumid), Fez (semi-arid), and Chichaoua (arid). Soil samples from these regions exhibited varying physicochemical properties, with neutral to alkaline pH, high concentrations of K, Na, and Ca, and biological activities, including microbial metabolic preferences and enzymatic activities. The data analysis and principal component analysis (PCA) revealed significant correlations in O ficus-indica soils across three regions of Morocco. In the subhumid region of Tafrant, there was a notable correlation between Shannon evenness index, amino acid metabolism by the microbial community, and β-galactosidase activity, with high levels of Fe, NH4+, and Cu. Conversely, in the semi-arid region of Fez, strong associations were observed between organic matter content, Mg, P, NO3-N, and increased microbial load, average well color development (AWCD), carbohydrate and polymer metabolism, and elevated phosphatase activity. The arid region of Chichaoua exhibited a distinct correlation between K and Zn levels, urease activity, and
the metabolism of amines and amides substrates. Our results highlight distinct variations in the physicochemical properties, microbial community function, and enzymatic activities of O. ficusindica soils across the three Morocco’s regions. These findings highlight ecosystem uniqueness and offer key insights for biodiversity conservation and soil fertility management
Impact of a personalized, strike early and strong approach on non-HDL-cholesterol levels and outcome in patients with acute myocardial infarction
No full textAims: We retrospectively evaluated the impact on non-HDL-cholesterol (non-HDL-C) levels of the systematic introduction in our institution of an individualized, pre-defined, strike early and strong (SES) strategy for lipid-lowering therapy (LLT) in patients with acute myocardial infarction (MI). Methods: We analyzed data from 500 consecutive patients admitted across three periods: Period A (N = 198, January-June 2019), when the non-HDL-C goal was <100 mg/dL and a stepwise LLT approach was indicated; Period B (N = 180, January-June 2021), when the non-HDL-C goal was <85 mg/dL and a stepwise approach was recommended; Period C (N = 122, January-June 2023), when the SES protocol was introduced. Primary endpoints were the percentage of patients reaching the non- HDL-C goal during follow-up and the incidence of major adverse cardiovascular events (MACE) at one year. Results: Compared to the other periods, the prevalence of prescription at discharge of potent statins, alone or in combination with ezetimibe, and PCSK9 inhibitors was greater in Period C. The achievement of the non-HDL-C goal in Period C was higher (87 % vs 67 % and 58 % in Periods A and B, respectively; p < 0.001). This achievement was associated with a lower occurrence of MACE (7 % vs. 13 % in patients not at target; log-rank p = 0.027). MACE incidence was the lowest in patients with early and sustained non-HDL-C < 85 mg/dL during follow-up. Conclusion: The systematic introduction of an individualized, SES approach for LLT in patients with acute MI led to higher achievement of the non-HDL-C goal and this translated into a lower risk of MACE
Bonds
No full textIn the context of a modern commercial law handbook, the topic of obligations issued by joint-stock companies is discussed, including the various types of allowed issuances, the limits on issuing them, the authority to issue obligations, the form of the related resolution, the organization of bondholders, and aspects of the regulation of bond loans
Agrivoltaics as a Sustainable Strategy to Enhance Food Security Under Water Scarcity
Get PDFAgrivoltaic offers a promising solution to integrate photovoltaic energy production
with ongoing agricultural activities. This research investigates the impact of agrivoltaic
on food security, using a transdisciplinary approach to study the responses of crop production
in terms of biomass and food quality produced. Mainly chicory plants were grown
in full sunlight (control plot) and shade plots generated by potential photovoltaic panels.
Two water regimes (high and low water supply) were used to analyze variations in food
security in both plots. The results showed that agrivoltaic systems effectively mitigate
crop water stress caused by high temperatures and heat waves, improving food security
by increasing biomass production and preserving food quality. While previous research
has attributed the benefits of agrivoltaics primarily to improved soil moisture, this study
demonstrates that the positive effects are primarily driven by differences in light intensity
and air temperature between the shaded and control plots. The results have strong implications
for water resource management, showing that agrivoltaics can reduce water use by
approximately 50% compared to traditional agroecosystems without compromising food
security. Agrivoltaics can address the challenges of water scarcity due to declining rainfall
and reduce production costs associated with water use. Properly designed agrivoltaic
systems offer a cleaner, more sustainable alternative to traditional agricultural practices,
helping to adapt agriculture to climate change
Bilateral Tax Competition and Regional Spillovers in Tax Treaty Formation
No full textThis paper investigates tax competition in withholding tax rates signed under double
tax treaties between developed and developing countries. We document a decline in
average withholding tax rates since 1990 and attribute this trend to tax competition.
As opposed to traditional tax competition, where every foreign investor benefits
from lower tax rates, tax treaties allow countries to compete bilaterally, cutting tax
rates for investors from a specific country and leaving taxes for everyone else unaffected.
We test our predictions empirically for the four different types of withholding
tax rates on passive income in more than 900 double tax treaties. We find strong
support for a positive relationship in withholding tax rates in tax treaties signed by
developing countries in relation to the same origin country of investment, supporting
the notion of tax competition
Modified TASE Runge-Kutta methods for integrating stiff differential equations
No full textWe propose a new class of numerical methods, called MTRK for short, derived by an appropriate modification of the Time-Accurate and highly-Stable Explicit (TASE) Runge-Kutta methods introduced by Bassenne, Fu, and Mani [J. Comput. Phys., 424 (2021), 109847] and then extended by Calvo, Montijano, and Randez [J. Comput. Phys., 436 (2021), 110316]. The MTRK methods are very efficient for dealing with the stiffness of differential problems without resorting to implicit methods, which incur high computational costs as they require the solution of nonlinear algebraic equations at each step. An in-depth analysis of the stability and consistency properties of MTRK methods via Butcher trees shows not only that they definitely improve existing TASE Runge-Kutta methods, but also that they can be advantageous compared to some well-known methods such as W-methods and Rosenbrock methods. This is confirmed by numerical experiments performed with nonlinear partial differential equations from applications
Il rispetto dovuto a ogni essere umano e l’obbligo di porre rimedio a tutte le privazioni in grado di distruggere o mutilare la vita umana nella Dichiarazione degli obblighi verso l’essere umano di Simone Weil
Get PDFNella Dichiarazione degli obblighi verso l’essere umano di Simone Weil, testo che qui si ripubblica integralmente accompagnato da un breve commento introduttivo, è centrale il tema del rispetto dovuto ad ogni essere umano, che per Weil si traduce nell’obbligo di porre rimedio a tutte le privazioni dell’anima e del corpo in grado di distruggere o mutilare la vita umana. Con un radicale capovolgimento dello sguardo, Weil fonda la legittimità del potere e dello Stato non sulla garanzia dei diritti, ma sull’adempimento degli obblighi verso gli esseri umani, richiamando a una responsabilità che coinvolge non solo i titolari di potere politico, ma tutti coloro che su questo potere, anche in minima parte, possono incidere. Un potere che non si fonda sul rispetto verso l’essere umano è, per Weil, un potere criminale e illegittimo, in quanto tradisce la sua funzione. Un testo breve, ma denso, che ci ricorda come per parlare di “rispetto dell’altro” sia indispensabile partire dai nostri doveri nei suoi confronti, prima che dai suoi diritti
Esdebitazione. Cap. I - Esdebitazione dopo la liquidazione giudiziale; Cap. II - Esdebitazione dopo la liquidazione controllata; Cap. III - Esdebitazione dell’incapiente
No full textIl d.lg. n. 14/2019, in attuazione dell’art. 8 della legge delega n. 155/2017, ha previsto un ampliamento dell’esdebitazione, coerente con la filosofia di tutta la riforma e con il confronto internazionale, dal quale emerge che negli ultimi anni l’istituto ha assunto un’importanza crescente (ne fa fede la particolare attenzione che vi dedicano la Raccomandazione 2014/135/UE e la Direttiva UE n. 1023/2019).
Scopo del capitolo è mettere in luce la fisionomia dell’istituto, gli elementi di novità (sul piano soggettivo e oggettivo, sostanziale e processuale) della disciplina e le ricadute sistematiche